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Reported zinc, but not copper, intakes influence whole-body bone density, mineral content and T score responses to zinc and copper supplementation in healthy postmenopausal women

  • Forrest H. Nielsen (a1), Henry C. Lukaski (a2), LuAnn K. Johnson (a1) and Z. K. (Fariba) Roughead (a3)
  • DOI: http://dx.doi.org/10.1017/S0007114511002352
  • Published online: 01 July 2011
Abstract

A supplementation trial starting with 224 postmenopausal women provided with adequate vitamin D and Ca was conducted to determine whether increased Cu and Zn intakes would reduce the risk for bone loss. Healthy women aged 51–80 years were recruited for a double-blind, placebo-controlled study. Women with similar femoral neck T scores and BMI were randomly assigned to two groups of 112 each that were supplemented daily for 2 years with 600 mg Ca plus maize starch placebo or 600 mg Ca plus 2 mg Cu and 12 mg Zn. Whole-body bone mineral contents, densities and T scores were determined biannually by dual-energy X-ray absorptiometry, and 5 d food diaries were obtained annually. Repeated-measures ANCOVA showed that bone mineral contents, densities and T scores decreased from baseline values to year 2. A priori contrasts between baseline and year 2 indicated that the greatest decreases occurred with Cu and Zn supplementation. Based on 5 d food diaries, the negative effect was caused by Zn and mainly occurred with Zn intakes ≥ 8·0 mg/d. With Zn intakes < 8·0 mg/d, Zn supplementation apparently prevented a significant decrease in whole-body bone densities and T scores. Food diaries also indicated that Mg intakes < 237 mg/d, Cu intakes < 0·9 mg/d and Zn intakes < 8·0 mg/d are associated with poorer bone health. The findings indicate that Zn supplementation may be beneficial to bone health in postmenopausal women with usual Zn intakes < 8·0 mg/d but not in women consuming adequate amounts of Zn.

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*Corresponding author: Dr Forrest H. Nielsen, fax +1 701 795 8240, email forrest.nielsen@ars.usda.gov
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2J Eaton-Evans , EM McIlrath , WE Jackson , (1996) Copper supplementation and the maintenance of bone mineral density in middle-aged women. J Trace Elem Exp Med 9, 8794.

3 CR Paterson & J Burns (1988) Copper deficiency in infancy. J Clin Biochem Nutr 4, 175190.

4 DM Danks (1988) Copper deficiency in humans. Ann Rev Nutr 8, 235257.

5 MA Chaudhri , W Kemmler , I Harsch , (2009) Plasma copper and bone mineral density in osteopenia: an indicator of bone mineral density in osteopenic females. Biol Trace Elem Res 129, 9498.

6DM Medeiros , J Ilich , J Ireton , (1997) Femurs from rats fed diets deficient in copper or iron have decreased mechanical strength and altered mineral composition. J Trace Elem Exp Med 10, 197203.

10 RG Erben , K Lausmann , P Roschger , (2009) Long-term marginal zinc supply is not detrimental to the skeleton of aged female rats. J Nutr 139, 703709.

16FH Nielsen & DB Milne (2004) A moderately high intake compared to a low intake of zinc depresses magnesium balance and alters indices of bone turnover in postmenopausal women. Eur J Clin Nutr 58, 703710.

17RK Rude , FR Singer & HE Gruber (2009) Skeletal and hormonal effects of magnesium deficiency. J Am Coll Nutr 28, 131141.

21A Cerovic , I Miletic , S Sobajic , (2007) Effects of zinc on the mineralization of bone nodules from osteoblast-like cells. Biol Trace Elem Res 116, 6171.

23KJF Oliveira , CM Donangelo , AV Oliveira Jr, (2009) Effect of zinc supplementation on the antioxidant, copper, and iron status of physically active adolescents. Cell Biochem Funct 27, 162166.

24FH Nielsen (2009) Marginal zinc deficiency increases magnesium retention and impairs calcium utilization in rats. Biol Trace Elem Res 128, 220231.

25N Leone , D Courbon , P Ducimetiere , (2006) Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality. Epidemiology 17, 308314.

26H Spencer , C Norris & D Williams (1994) Inhibitory effects of zinc on magnesium balance and magnesium absorption in man. J Am Coll Nutr 13, 479484.

27RK Rude & HE Gruber (2004) Magnesium deficiency and osteoporosis: animal and human observations. J Nutr Biochem 15, 710716.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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