1. A study was undertaken to investigate the role of vitamin E in the aetiology of phrynoderma (follicular hyperkeratosis). Fifty-six children with the disease and twenty-one normal children were investigated for this purpose.
2. Plasma vitamin E levels (mean±SE; mg/l) were found to be low in phrynoderma (3.7±0.19) in contrast with normal children (6.6±0.40) and therapy with a combination of vitamin E and B-complex brought about complete cure.
3. The increase in plasma vitamin E levels after the administration of vitamin E at a dose of 100 mg three times daily for 4 weeks was higher than that obtained when vitamin E at the same dose was administered together with vitamin B-complex for 4 weeks, suggesting an interaction between the two vitamins. Further studies are necessary to find out the exact nature of this interrelationship.
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