1. Nieuwenhuizen, AG & Rutters, F (2008) The hypothalamic–pituitary–adrenal-axis in the regulation of energy balance. Physiol Behav 94, 169–177.
2. McEwen, BS & Wingfield, JC (2003) The concept of allostasis in biology and biomedicine. Horm Behav 43, 2–15.
3. Sapolsky, RM, Romero, LM & Munck, AU (2000) How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 21, 55–89.
4. Cintra, DE, Ropelle, ER, Moraes, JC, et al. (2012) Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PLOS ONE 7, e30571.
5. Nascimento, LFR, Souza, GFP, Morari, J, et al. (2016) n-3 Fatty acids induce neurogenesis of predominantly POMC-expressing cells in the hypothalamus. Diabetes 65, 673–686.
6. Shewchuk, BM (2014) Prostaglandins and n-3 polyunsaturated fatty acids in the regulation of the hypothalamic–pituitary axis. Prostaglandins Leukot Essent Fatty Acids 91, 277–287.
7. Ferraz, AC, Delattre, AM, Almendra, RG, et al. (2011) Chronic ω-3 fatty acids supplementation promotes beneficial effects on anxiety, cognitive and depressive-like behaviors in rats subjected to a restraint stress protocol. Behav Brain Res 219, 116–122.
8. Hennebelle, M, Balasse, L, Latour, A, et al. (2012) Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress. PLOS ONE 7, e42142.
9. Nemeth, M, Millesi, E, Wagner, KH, et al. (2014) Effects of diets high in unsaturated fatty acids on socially induced stress responses in guinea pigs. PLOS ONE 9, e116292.
10. Morgese, MG, Tucci, P, Mhillaj, E, et al. (2017) Lifelong nutritional omega-3 deficiency evokes depressive-like state through soluble beta amyloid. Mol Neurobiol 54, 2079–2089.
11. Chen, HF & Su, HM (2013) Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic–pituitary–adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life. J Nutr Biochem 24, 70–80.
12. Lam, TKT, Schwartz, GJ & Rossetti, L (2005) Hypothalamic sensing of fatty acids. Nat Neurosci 8, 579–584.
13. Oh, YT, Kim, J, Kang, I, et al. (2014) Regulation of hypothalamic–pituitary–adrenal axis by circulating free fatty acids in male Wistar rats: role of individual free fatty acids. Endocrinology 155, 923–931.
14. Lanfranco, F, Giordano, R, Pellegrino, M, et al. (2004) Free fatty acids exert an inhibitory effect on adrenocorticotropin and cortisol secretion in humans. J Clin Endocrinol Metab 89, 1385–1390.
15. Coiro, V, Casti, A, Rubino, P, et al. (2007) Free fatty acids inhibit adrenocorticotropin and cortisol secretion stimulated by physical exercise in normal men. Clin Endocrinol 66, 740–743.
16. Mai, K, Bobbert, T, Kullmann, V, et al. (2006) No effect of free fatty acids on adrenocorticotropin and cortisol secretion in healthy young men. Metabolism 55, 1022–1028.
17. Widmaier, EP, Margenthaler, J & Sarel, I (1995) Regulation of pituitary-adrenocortical activity by free fatty acids in vivo and in vitro. Prostaglandins Leukot Essent Fatty Acids 52, 179–183.
18. Foss, B & Dyrstad, SM (2011) Stress in obesity: cause or consequence? Med Hypotheses 77, 7–10.
19. McNay, DEG, Briancon, N, Kokoeva, MV, et al. (2012) Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. J Clin Invest 122, 142–152.
20. Xie, X, Wang, X, Mick, GJ, et al. (2016) Effect of n-3 and n-6 polyunsaturated fatty acids on microsomal P450 steroidogenic enzyme activities and in vitro cortisol production in adrenal tissue from Yorkshire boars. Endocrinology 157, 1512–1521.
21. Nemeth, M, Millesi, E, Puehringer-Sturmayr, V, et al. (2016) Sex-specific effects of dietary fatty acids on saliva cortisol and social behavior in guinea pigs under different social environmental conditions. Biol Sex Differ 7, 51.
22. Nemeth, M, Pschernig, E, Wallner, B, et al. (2016) Non-invasive cortisol measurements as indicators of physiological stress responses in guinea pigs. PeerJ 4e, 1590.
23. USDA (2016) US Department of Agriculture, Agricultural Research Service, Nutrient Data Laboratory. USDA National Nutrient Database for standard reference, release 28. Version current: September 2015, slightly revised May 2016. https://ndb.nal.usda.gov/ndb/ (accessed October 2017).
24. Nemeth, M, Millesi, E, Wagner, KH, et al. (2015) Sex-specific effects of diets high in unsaturated fatty acids on spatial learning and memory in guinea pigs. PLOS ONE 10, e0140485.
25. Palme, R & Möstl, E (1997) Measurement of cortisol metabolites in faeces of sheep as a parameter of cortisol concentration in blood. Z Saeugetierkd 62, 192–197.
26. Rood, J (1972) Ecological and behavioural comparisons of three genera of Argentine cavies. Anim Behav Monogr 5, 1–83.
27. R Core Team (2017) R: A Language and Environment for Statistical Computing. Vienna: R Foundation for Statistical Computing. http://www.R-project.org/ (accessed November 2017).
31. Willis, LM, Shukitt-Hale, B, Cheng, V, et al. (2009) Dose-dependent effects of walnuts on motor and cognitive function in aged rats. Br J Nutr 101, 1140–1144.
32. Tapsell, LC, Gillen, LJ, Patch, CS, et al. (2004) Including walnuts in a low-fat/modified-faf diet improves HDL cholesterol-to-total cholesterol ratios in patients with type 2 diabetes. Diabetes Care 27, 2777–2783.
33. Dahms, I, Bailey-Hall, E & Salem, N Jr (2016) Kinetics of docosahexaenoic acid ethyl ester accumulation in dog plasma and brain. Prostaglandins Leukot Essent Fatty Acids 113, 1–8.
34. Chen, CT, Kitson, AP, Hopperton, KE, et al. (2015) Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain. Sci Rep 5, 15791.
35. Salem, N Jr, Litman, B, Kim, HY, et al. (2001) Mechanisms of action of docosahexaenoic acid in the nervous system. Lipids 36, 945–959.
36. Sinclair, AJ, Attar-Bashi, NM & Lib, D (2002) What is the role of α-linolenic acid for mammals? Lipids 37, 1113–1123.
37. Simopoulos, AP (2002) The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 56, 365–379.
38. Rabinovitz, S, Mostofsky, DI & Yehuda, S (2004) Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3). Psychoneuroendocrinology 29, 113–124.
39. Oh, YT, Oh, KS, Kang, I, et al. (2012) A fall in plasma free fatty acid (FFA) level activates the hypothalamic–pituitary–adrenal axis independent of plasma glucose: evidence for brain sensing of circulating FFA. Endocrinology 153, 3587–3592.
40. Raclot, T (2003) Selective mobilization of fatty acids from adipose tissue triacylglycerols. Prog Lipid Res 42, 257–288.
41. Delarue, J, Matzinger, O, Binnert, C, et al. (2003) Fish oil prevents the adrenal activation elicited by mental stress in healthy men. Diabetes Metab 29, 289–295.
42. Martin, ME, Vranckx, R, Benassayag, C, et al. (1986) Modifications of the properties of human sex steroid-binding protein by nonesterified fatty acids. J Biol Chem 261, 2954–2959.
43. Sibbons, CM, Thomas Brenna, J, Lawrence, P, et al. (2014) Effect of sex hormones on n-3 polyunsaturated fatty acid biosynthesis in HepG2 cells and in human primary hepatocytes. Prostaglandins Leukot Essent Fatty Acids 90, 47–54.
44. Extier, A, Perruchot, MH, Baudry, C, et al. (2009) Differential effects of steroids on the synthesis of polyunsaturated fatty acids by human neuroblastoma cells. Neurochem Int 55, 295–301.
45. Sanz, M, Lopez-Bote, CJ, Menoyo, D, et al. (2000) Abdominal fat deposition and fatty acid synthesis are lower and β-oxidation is higher in broiler chickens fed diets containing unsaturated rather than saturated fat. J Nutr 130, 3034–3037.
46. Song, C, Li, X, Leonard, BE, et al. (2003) Effects of dietary n-3 or n-6 fatty acids on interleukin-1β-induced anxiety, stress, and inflammatory responses in rats. J Lipid Res 44, 1984–1991.
47. DuRant, SE, Arciniega, ML, Bauer, CM, et al. (2016) A test of the reactive scope: reducing reactive scope causes delayed wound healing. Gen Comp Endocrinol 236, 115–120.
48. Cohen, S, Janicki-Deverts, D, Doyle, WJ, et al. (2012) Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci U S A 109, 5995–5999.
49. Chrousos, GP (2009) Stress and disorders of the stress system. Nat Rev Endocrinol 5, 374–381.
50. Dearden, L & Ozanne, SE (2015) Early life origins of metabolic disease: developmental programming of hypothalamic pathways controlling energy homeostasis. Front Neuroendocrinol 39, 3–16.
51. Delgado-Lista, J, Perez-Martinez, P, Lopez-Miranda, J, et al. (2012) Long chain omega-3 fatty acids and cardiovascular disease: a systematic review. Br J Nutr 107, S201–S213.
52. Stables, MJ & Gilroy, DW (2011) Old and new generation lipid mediators in acute inflammation and resolution. Prog Lipid Res 50, 35–51.
53. Simopoulos, AP (2008) The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med 233, 674–688.