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The short-term prognosis of severe primary infantile malnutrition

Published online by Cambridge University Press:  09 March 2007

J. S. Garrow
Medical Research Council, Tropical Metabolism Research Unit, Jamaica, West Indies
M. C. Pike
Medical Research Council Statistical Research Unit, University College Hospital Medical School, London
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1. Among a series of 343 children with severe primary malnutrition there were 248 for whom, on admission, there were reliable records of age, weight, height, liver size, severity of oedema, skin lesions and angular stomatitis, and concentration of total serum protein, haemoglobin and sodium. For eighty-four of these children the serum bilirubin concentration was also known.

2. The correlations of these characteristics of the children on admission, with mortality, and with the rate of recovery were investigated.

3. Age, weight, oedema and haemoglobin concentration were not significantly related to mortality or to rate of recovery. A multiple regression analysis showed that an increased serum bilirubin concentration and a decreased serum sodium concentration indicated a bad prognosis, and these two factors contributed almost the whole of the multiple correlation coefficient of 0.63 with respect to mortality and 0.59 with respect to speed of rccovery.

4. We conclude that in our series of children death was more closely associated with liver failure or overhydration than with protein depletion, and suggest that the administration of ton much protein or water to an acutely ill malnourished child may precipitate death.

5. This analysis shows that the mortality observed in our series cannot be adequately explained by any combination of the characteristics considered above; there must, therefore, be other factors of importance for which we do not have suitable measurements.

Research Article
Copyright © The Nutrition Society 1967


Dumm, M. E., Webb, J. K. G., Pereira, S., Begum, A. & Isaac, T. (1963). Int. Congr. Nutr. VI. Edinburgh p. 87.Google Scholar
Garrow, J. S. (1965). Lancet ii, 455.CrossRefGoogle Scholar
Garrow, J. S., Picou, D. & Waterlow, J. C. (1962). W. Indian med. J. 11, 217.Google Scholar
Gómez, F., Ramos-Galv´n, R., Bienvenú, B. & Cravioto-Muñoz, J. (1950). Boln. Hosp. Inf. Mexico 7, 485.Google Scholar
Gómez, F., Ramos-Galv´n, R., Cravioto, J. & Frenk, S. (1955). Adv. Pediat. 7, 131.CrossRefGoogle Scholar
Gómez, F., Ramos-Galv´n, R., Cravioto, J. & Frenk, S. (1958). Ann. N.Y.Acad. Sci. 69, 969.CrossRefGoogle Scholar
Gomez, F., Ramos-Galv´n, R., Frenk, S., Cravioto-Munoz, J., Ch´vez, R. & V´zquez, J. (1956). J. trop. Pediat. 2, 77.CrossRefGoogle Scholar
Jelliffe, D. B. (1961). J. trop. Pediat. 7, 29.CrossRefGoogle Scholar
Kahn, E. (1959 a). Am. J. clin. Nutr. 7, 161.CrossRefGoogle Scholar
Kahn, E. (1959 b). S. Afr. med. J. 33, 501.Google Scholar
McLean, A. E. M. (1962). Lancet ii, 1292.CrossRefGoogle Scholar
McLean, A. E. M. (1965). Clin. Sci. 30, 129.Google Scholar
Nelson, W.E. (1959). Textbook of Pediatrics, 7th ed., p. 50. Philadelphia: W. B. Saunders.Google Scholar
Paque, C. (1958). Maroc. méd. 37, 1063.Google Scholar
Ramos-Galván, R. & Calderon, J. M. (1965). Am. J. clin. Nutr. 16, 351.CrossRefGoogle Scholar
Schendel, H. E., Hansen, J. D. L. & Brock, J. F. (1962). S. Afr. J. Lab. clin. Med. 8, 23.Google Scholar
Sénécal, J. (1958). Ann. N.Y. Acad. Sci. 69, 916.CrossRefGoogle Scholar
Smith, R. (1960 a). Clin. Sci. 19, 275.Google Scholar
Smith, R. (1960 b). Total body water in infantile malnutrition. MD Thesis, University of CambridgeGoogle Scholar
Smith, R. (1963). Lancet i, 771.CrossRefGoogle Scholar
Trowell, H. C., Davies, J. N. P. & Dean, R. F. A. (1954). Kwashiorkor. London: Edward Arnold.CrossRefGoogle ScholarPubMed
Waterlow, J. C. & Wills, V. G. (1960). Br. J. Nutr. 14, 183.CrossRefGoogle Scholar