Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 72
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Drissi, Fatima Raoult, Didier and Merhej, Vicky 2016. Metabolic role of lactobacilli in weight modification in humans and animals. Microbial Pathogenesis,


    Kim, Yoo Kim, Jonggun Whang, Kwang-Youn and Park, Yeonhwa 2016. Impact of Conjugated Linoleic Acid (CLA) on Skeletal Muscle Metabolism. Lipids, Vol. 51, Issue. 2, p. 159.


    Kuhl, Gabriela and De Dea Lindner, Juliano 2016. Biohydrogenation of Linoleic Acid by Lactic Acid Bacteria for the Production of Functional Cultured Dairy Products: A Review. Foods, Vol. 5, Issue. 1, p. 13.


    Shen, Wan and McIntosh, Michael K. 2016. Nutrient Regulation: Conjugated Linoleic Acid's Inflammatory and Browning Properties in Adipose Tissue. Annual Review of Nutrition, Vol. 36, Issue. 1, p. 183.


    Al-Khudairy, Lena Hartley, Louise Clar, Christine Flowers, Nadine Hooper, Lee Rees, Karen and Rees, Karen 2015. Cochrane Database of Systematic Reviews.


    Benjamin, Sailas Prakasan, Priji Sreedharan, Sajith Wright, Andre-Denis G and Spener, Friedrich 2015. Pros and cons of CLA consumption: an insight from clinical evidences. Nutrition & Metabolism, Vol. 12, Issue. 1, p. 4.


    Bilal, Mohammad Patel, Yogesh Burkitt, Micheal and Babich, Michael 2015. Linoleic Acid Induced Acute Hepatitis: A Case Report and Review of the Literature. Case Reports in Hepatology, Vol. 2015, p. 1.


    Derakhshande-Rishehri, Seyede-Masome Mansourian, Marjan Kelishadi, Roya and Heidari-Beni, Motahar 2015. Association of foods enriched in conjugated linoleic acid (CLA) and CLA supplements with lipid profile in human studies: a systematic review and meta-analysis. Public Health Nutrition, Vol. 18, Issue. 11, p. 2041.


    Dong, Gui-Fang Liu, Wen-Zuo Wu, Lin-Zhou Yu, Deng-hang Huang, Feng Li, Peng-Cheng and Yang, Yan-ou 2015. Conjugated linoleic acid alters growth performance, tissue lipid deposition, and fatty acid composition of darkbarbel catfish (Pelteobagrus vachelli). Fish Physiology and Biochemistry, Vol. 41, Issue. 1, p. 73.


    Hooper, Lee Martin, Nicole Abdelhamid, Asmaa Davey Smith, George and Hooper, Lee 2015. Cochrane Database of Systematic Reviews.


    Hooper, Lee Abdelhamid, Asmaa Bunn, Diane Brown, Tracey Summerbell, Carolyn D Skeaff, C Murray and Hooper, Lee 2015. Cochrane Database of Systematic Reviews.


    Kim, Jun Ho Kim, Young Jun and Park, Yeonhwa 2015. Conjugated Linoleic Acid and Postmenopausal Women's Health. Journal of Food Science, Vol. 80, Issue. 6, p. R1137.


    Poudyal, Hemant and Brown, Lindsay 2015. Should the pharmacological actions of dietary fatty acids in cardiometabolic disorders be classified based on biological or chemical function?. Progress in Lipid Research, Vol. 59, p. 172.


    Szumacher-Strabel, Malgorzata El-Sherbiny, Mohamed Cieslak, Adam Szczechowiak, Joanna and Winiarska, Hanna 2015. Biotechnology of Bioactive Compounds.


    Williams, R. L. Wood, L. G. Collins, C. E. and Callister, R. 2015. Effectiveness of weight loss interventions - is there a difference between men and women: a systematic review. Obesity Reviews, Vol. 16, Issue. 2, p. 171.


    Yang, Bo Chen, Haiqin Stanton, Catherine Ross, R. Paul Zhang, Hao Chen, Yong Q. and Chen, Wei 2015. Review of the roles of conjugated linoleic acid in health and disease. Journal of Functional Foods, Vol. 15, p. 314.


    Cresswell, Lynne and Mander, Adrian P. 2014. How to use published complete case results from weight loss studies in a missing data sensitivity analysis. Obesity, Vol. 22, Issue. 4, p. 996.


    Miranda, Jonatan Arias, Noemi Fernández-Quintela, Alfredo and del Puy Portillo, María 2014. Are conjugated linolenic acid isomers an alternative to conjugated linoleic acid isomers in obesity prevention?. Endocrinología y Nutrición (English Edition), Vol. 61, Issue. 4, p. 209.


    Miranda, Jonatan Arias, Noemi Fernández-Quintela, Alfredo and del Puy Portillo, María 2014. ¿Son los isómeros del ácido linolénico conjugado una alternativa a isómeros del ácido linoleico conjugado en la prevención de la obesidad?. Endocrinología y Nutrición, Vol. 61, Issue. 4, p. 209.


    Park, Yeonhwa 2014. Nutrition in the Prevention and Treatment of Abdominal Obesity.


    ×

Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese

Abstract

Long-term supplementation with conjugated linoleic acid (CLA) reduces body fat mass (BFM) and increases or maintains lean body mass (LBM). However, the regional effect of CLA was not studied. The study aimed to evaluate the effect of CLA per region and safety in healthy, overweight and obese adults. A total of 118 subjects (BMI: 28–32 kg/m2) were included in a double blind, placebo-controlled trial. Subjects were randomised into two groups supplemented with either 3·4 g/d CLA or placebo for 6 months. CLA significantly decreased BFM at month 3 (Δ = − 0·9 %, P = 0·016) and at month 6 (Δ = − 3·4 %, P = 0·043) compared with placebo. The reduction in fat mass was located mostly in the legs (Δ = − 0·8 kg, P < 0·001), and in women (Δ = − 1·3 kg, P = 0·046) with BMI >30 kg/m2 (Δ = − 1·9 kg, P = 0·011), compared with placebo. The waist–hip ratio decreased significantly (P = 0·043) compared with placebo. LBM increased (Δ = +0·5 kg, P = 0·049) within the CLA group. Bone mineral content was not affected (P = 0·70). All changes were independent of diet and physical exercise. Safety parameters including blood lipids, inflammatory and diabetogenic markers remained within the normal range. Adverse events did not differ between the groups. It is concluded that supplementation with CLA in healthy, overweight and obese adults decreases BFM in specific regions and is well tolerated.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr J.-M. Gaullier, fax +47.63893211, email j-m@scr.no
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

G Aasen , H Fagertun & J Halse (2006) Body composition analysis by dual X-ray absorptiometry: in vivo and in vitro comparison of three different fan-beam systems. Scand J Clin Lab Invest 66, 659666.

A Akahoshi , Y Goto , K Murao , T Miyazaki , M Yamasaki , M Nonaka , K Yamada & M Sugano (2002) Conjugated linoleic acid reduces body fats and cytokine levels of mice. Biosci Biotech Biochem 66, 916920.

R Albers , R van der Wielen , E Brink , H Hendriks , V Dorovska-Taran & I Mohede (2003) Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men. Eur J Clin Nutr 57, 595603.

J Bassaganya-Riera , K Reynolds , S Martino-Catt , YZ Cui , L Hennighausen , F Gonzalez , J Rohrer , AU Benninghoff & R Hontecillas (2004) Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology 127, 777791.

S Basu , U Riserus , A Turpeinen & B Vessby (2000 a) Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity. Clin Sci (Lond) 99, 511516.

S Basu , A Smedman & B Vessby (2000 b) Conjugated linoleic acid induces lipid peroxidation in humans. FEBS Lett 468, 3336.

G Berven , A Bye , O Hals , H Blankson , H Fagertun , E Thom , J Wadstein & O Gudmundsen (2000) Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers. Eur J Lipid Sci Technol 102, 455462.

M Cook , C Miller , Y Park & M Pariza (1993) Immune modulation by altered nutrient metabolism: nutritional control of immune-induced growth depression. Poult Sci 72, 13011305.

KL Cox , V Burke , AR Morton , LJ Beilin & IB Pudley (2003) The independent and combined effect of 16 weeks of vigorous exercise and energy restriction on body mass and composition in free-living overweight men – a randomized controlled trial. Metabolism 52, 107115.

M Dugan , J Aalhus , A Schaefer & J Kramer (1997) The effects of conjugated linoleic acid on fat to lean repartitioning and feed conversion in pigs. Can J Anim Sci 77, 723725.

M Evans , C Geigerman , J Cook , L Curtis , B Kuebler & M McIntosh (2000) Conjugated linoleic acid suppresses triglyceride accumulation and induces apoptosis in 3T3-L1 preadipocytes. Lipids 35, 899910.

J-M Gaullier , G Berven , H Blankson & O Gudmundsen (2002) Clinical trial results support a preference for using CLA preparations enriched with two isomers rather than four isomers in human studies. Lipids 37, 10191025.

SG Glickman , CS Marn , MA Supiano & DR Dengel (2004) Validity and reliability of dual-energy X-ray absorptiometry for the assessment of abdominal adiposity. J Appl Physiol 97, 509514.

L Granlud , L Juvet , J Pedersen & H Nebb (2003) Trans 10, cis 12 conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARgamma modulator. J Lipid Res 44, 14411452.

M Hara , T Saikawa , M Kurokawa , T Sakata & H Yoshimatsu (2004) Leg fat percentage correlates negatively with coronary atherosclerosis. Circ J 68, 11731178.

K Houseknecht , J Vanden Heuvel , S Moya-Camarena , C Portocarrero , L Peck , K Nickel & M Belury (1998) Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun 244, 678682.

CB Kallen & MA Lazar (1996) Antidiabetic thiazolidinediones inhibit leptin ob gene expression in 3T3-L1 adipocytes. Proc Natl Acad Sci USA 93, 57935796.

S Kirchengast , D Gruber , M Sator , W Knogler & J Huber (1998) The impact of nutritional status on body fat distribution patterns in pre- and postmenopausal females. J Biosoc Sci 30, 145154.

K Lee , D Kritchevsky & M Pariza (1994) Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 108, 1925.

C Liew , H Schut , S Chin , M Pariza & R Dashwood (1995) Protection of conjugated linoleic acids against 2-amino-3-methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms. Carcinogenesis 16, 30373043.

L Lowery , P Appicelli & P Lemon (1998) Conjugated linoleic acid enhances muscle size and strength gains in novice bodybuilders. (Abstract 1038). Med Sci Sports Exerc 30, 182.

C Miller , Y Park , M Pariza & M Cook (1994) Feeding conjugated linoleic acid. Biochem Biophys Res Commun 198, 11071112.

WH Mueller & SK Joos (1985) Android (centralized) obesity and somatotypes in men: association with mesomorphy. Ann Hum Biol 12, 377–381.

E Noone , H Roche , A Nugent & M Gibney (2002) The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. Br J Nutr 88, 243–251.

E Ostrowska , D Suster , M Muralitharan , RF Cross , BJ Leury , DE Bauman & FR Dunshea (2003) Conjugated linoleic acid decreases fat accretion in pigs: evaluation by dual-energy X-ray absorptiometry. Br J Nutr 89, 219–229.

Y Park , K Albright , J Storkson , W Liu , M Cook & M Pariza (1999) Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 34, 243248.

Y Park & M Pariza (2001) Lipoxygenase inhibitors inhibit heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes and enhance body fat reduction in mice by conjugated linoleic acid. Biochim Biophys Acta 1534, 27–33.

S Rahman , Y Wang , S Han , J Cha , N Fukuda , H Yotsumoto & T Yanagita (2001) Effects of short-term administration of conjugated linoleic acid on lipid metabolism in white and brown adipose tissues of starved/refed Otsuka Long-Evans Tokushima Fatty rats. Food Res Int 34, 515520.

JD Ramakers , J Plat , JL Sebedio & RP Mensink (2005) Effects of the individual isomers cis-9, trans-11 vs. trans-10,cis-12 of conjugated linoleic acid (CLA) on inflammation parameters in moderately overweight subjects with LDL-phenotype B. Lipids 40, 909918.

G Reaven (2005) All obese individuals are not created equal: insulin resistance is the major determinant of cardiovascular disease in overweight/obese individuals. Diab Vasc Dis Res 2, 105–112.

U Riserus , P Arner , K Brismar & B Vessby (2002 a) Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care 25, 15161521.

U Riserus , S Basu , S Jovinge , G Fredrikson , J Arnlov & B Vessby (2002 b) Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid-induced insulin resistance. Circulation 106, 19251929.

U Riserus , L Berglund & B Vessby (2001) Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrome: a randomised controlled trial. Int J Obes Relat Metab Disord 25, 1129–1135.

U Riserus , B Vessby , P Arner & B Zethelius (2004 a) Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity. Diabetologia 47, 1016–1019.

HJ Song , I Grant , D Rotondo , I Mohede , N Sattar , SD Heys & KW Wahle (2005) Effect of CLA supplementation on immune function in young healthy volunteers. Eur J Clin Nutr 59, 508–517.

JM Soriano , E Ioannidou , J Wang , JC Thornton , MN Horlick , D Gallagher , SB Heymsfield & RN Pierson (2004) Pencil-beam vs fan-beam dual-energy X-ray absorptiometry comparison across four systems: body composition and bone mineral. J Clin Densitom 7, 281–289.

B Szymczyk , P Pisulewski , W Szczurek & P Hanczakowski (2001) Effects of conjugated linoleic acid on growth performance, feed conversion efficiency, and subsequent carcass quality in broiler chickens. Br J Nutr 85, 465473.

E Thom , J Wadstein & O Gudmundsen (2001) Conjugated linoleic acid reduces body fat in healthy exercising humans. J Int Med Res 29, 392–396.

SJ Wallner , N Luschnigg , WJ Schnedl , T Lahousen , K Sudi , K Crailsheim , R Möller , E Taifet & R Horejsi (2004) Body fat distribution of overweight females with a history of weight cycling. Int J Obes Relat Metab Disord 28, 11431148.

E Wargent , MV Sennit , C Stocker , (2005) Prolonged treatment of genetically obese mice with conjugated linoleic acid improves glucose tolerance and lowers plasma insulin concentration: possible involvement of PPAR activation. Lipids Health Dis 4, 3.

LD Whigham , M O'Shea , ICM Mohede , HP Walaski & RL Atkinson (2004) Safety profile of conjugated linoleic acid in a 12-month trial in obese humans. Food Chem Toxicol 42, 17011709.

LJ Woodhouse , N Gupta , M Bhasin , AB Singh , R Ross , J Phillips & S Bhasin (2004) Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men. J Clin Endocrinol Metab 89, 718–726.

S Yusuf , S Hawken , S Ounpuu , (2005) Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet 366, 16401649.

JJ Zachwieja , DM Ezell , AD Cline , JC Ricketts , PC Vicknair , SM Schorle & DH Ryan (2001) Short-term dietary energy restriction reduces lean body mass but not performance in physically active men and women. Int J Sports Med 22, 310–316.

K Zambell , N Keim , M Van Loan , B Gale , P Benito , D Kelley & G Nelson (2000) Conjugated linoleic acid supplementation in humans: effects on body composition and energy expenditure. Lipids 35, 777–782.

H Zu & H Schut (1992) Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adduct formation in CDF1 mice by heat-altered derivatives of linoleic acid. Food Chem Toxicol 30, 9–16.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: