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Substitution of saturated with monounsaturated fat in a 4-week diet affects body weight and composition of overweight and obese men

Published online by Cambridge University Press:  09 March 2007

L. S. Piers*
Affiliation:
Menzies School of Health Research, Casuarina, Northern Territory, Australia
Karen Z. Walker
Affiliation:
Nutrition and Dietetics, Department of Medicine, Monash University, Monash Medical Centre, Clayton, Victoria, Australia
Rachel M. Stoney
Affiliation:
The Nutrition Department, The Alfred Hospital, Prahran, Victoria, Australia
Mario J. Soares
Affiliation:
Department of Nutrition, Dietetics and Food Science, Curtin University of Technology, School of Public Health, Perth, Western Australia, Australia
Kerin O'Dea
Affiliation:
Menzies School of Health Research, Casuarina, Northern Territory, Australia
*
*Corresponding author: Dr L. S. Piers, present address, Health Surveillance and Evaluation Section, Rural and Regional Health and Aged Care Services, Department of Human Services, Level 18, 120 Spencer Street, Melbourne, Victoria 3000, Australia, fax +61 3 9637 4763, email leonard.piers@dhs.vic.gov.au
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Abstract

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A randomised crossover study of eight overweight or obese men (aged 24–49 years, BMI 25.5–31.3 kg/m2), who followed two diets for 4 weeks each, was performed to determine whether substitution of saturated fat with monounsaturated fat affects body weight and composition. Subjects were provided with all food and beverages as modules (selected ad libitum) of constant macronutrient composition, but differing energy content. The % total energy from saturated fat, monounsaturated fat and polyunsaturated fat was 24, 13 and 3% respectively on the saturated fatty acid (SFA)-rich diet and 11, 22 and 7% respectively on the monounsaturated fatty acid (MUFA)-rich diet. MUFA accounted for about 80% of the unsaturated fats consumed on both diets. Body composition, blood pressure, energy expenditure (resting and postprandial metabolic rates, substrate oxidation rate, physical activity), serum lipids, the fatty acid profile of serum cholesteryl esters and plasma glucose and insulin concentrations were measured before and after each diet period. Significant (P≤0·05) differences in total cholesterol and the fatty acid composition of serum cholesteryl esters provided evidence of dietary adherence. The men had a lower weight (-2·1 (se 0·4) kg, P=0·0015) and fat mass (-2·6 (se 0·6) kg, P= 0·0034) at the end of the MUFA-rich diet as compared with values at the end of the SFA-rich diet. No significant differences were detected in energy or fat intake, energy expenditure, substrate oxidation rates or self-reported physical activity. Substituting dietary saturated with unsaturated fat, predominantly MUFA, can induce a small but significant loss of body weight and fat mass without a significant change in total energy or fat intake.

Type
Research Article
Copyright
Copyright © The Nutrition Society 2003

References

Bell, RR, Spencer, MJ & Sherriff, JL (1997) Voluntary exercise and monounsaturated canola oil reduce fat gain in mice fed diets high in fat. J Nutr 127, 20062010.Google Scholar
Ben-Porat, M, Sideman, S & Bursztein, S (1983) Energy metabolism rate equation for fasting and postabsorptive subjects. Am J Physiol 244, R764R769.Google Scholar
Berrino, F, Bellati, C, Secreto, G, et al. (2001) Reducing bioavailable sex hormones through a comprehensive change in diet: the diet and androgens (DIANA) randomized trial. Cancer Epidemiol Biomarkers Prev 10, 2533.Google Scholar
Bligh, EG & Dyer, WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Pharmacol 37, 911917.Google Scholar
Blundell, JE & MacDiarmid, JI (1997) Fat as a risk factor for over-consumption: satiation, satiety, and patterns of eating. J Am Diet Assoc 97, S63S69.Google Scholar
Bonanome, A & Grundy, SM (1988) Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels. N Engl J Med 318, 12441248.Google Scholar
Bray, GA & Popkin, BM (1998) Dietary fat intake does affect obesity! Am J Clin Nutr 68, 11571173.Google Scholar
Callaway, CW, Chumlea, WC, Bouchard, C, et al. (1988) In Anthropometric Standardisation Reference Manual, pp. 3954 [Lohman,, TG, Roche, AFMartorell, R, editors]. Champaign, IL: Human Kinetics Books.Google Scholar
DeLany, JP, Windhauser, MM, Champagne, CM & Bray, GA (2000) Differential oxidation of individual dietary fatty acids in humans. Am J Clin Nutr 72, 905911.Google Scholar
deLorgeril, M & Salen, P (2000) Modified Cretan Mediterranean diet in the prevention of coronary heart disease and cancer. World Rev Nutr Diet 87, 123.Google Scholar
deLorgeril, M, Salen, P, Martin, JL, Monjaud, I, Delaye, J & Mamelle, N (1999) Mediterranean diet traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation 99, 779785.Google Scholar
Elia, M & Livesey, G (1988) Theory and validity of indirect calorimetry during net lipid synthesis. Am J Clin Nutr 47, 591607.Google Scholar
English, R & Lewis, J (1991) Nutritional Values of Australian Foods. Canberra: Australian Government Printing Service.Google Scholar
Flatt, JP (1995) Use and storage of carbohydrate and fat. Am J Clin Nutr 61, 952S959S.Google Scholar
Food and Agriculture Organization/World Health Organization/ United Nations University (1985) Energy and Protein Requirements: Report of a Joint FAO/WHO/UNU Expert Consultation. Technical Report Series no. 724, Geneva: WHO.Google Scholar
Fuentes, F, Sanchez, E, Sanchez, F, et al. (2001) Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men. Ann Intern Med 134, 11151119.Google Scholar
Garg, A (1994) High-monounsaturated fat diet for diabetic patients. Is it time to change the current dietary recommendations? Diabetes Care 17, 242246.Google Scholar
Halvorsen, B, Rustan, AC, Madsen, L, et al. (2001) Effects of long-chain monounsaturated and n−3 fatty acids on fatty acid oxidation and lipid composition in rats. Ann Nutr Metab 45, 3037.Google Scholar
Hegsted, DM, Ausman, LM, Johnson, JA & Dallal, GE (1993) Dietary fat and serum lipids: an evaluation of the experimental data. Am J Clin Nutr 57, 875883.Google Scholar
Jones, PJ, Pencharz, PB & Clandinin, MT (1985) Whole body oxidation of dietary fatty acids: implications for energy utilization. Am J Clin Nutr 42, 769777.Google Scholar
Jones, PJ, Ridgen, JE, Phang, PT & Birmingham, CL (1992) Influence of dietary fat polyunsaturated to saturated ratio on energy substrate utilization in obesity. Metab Clin Exp 41, 396401.Google Scholar
Jones, PJ & Schoeller, DA (1988) Polyunsaturated:saturated ratio of diet fat influences energy substrate utilization in the human. Metab Clin Exp 37, 145151.Google Scholar
Kliewer, SA, Sundseth, SS, Jones, SA, et al. (1997) Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc Natl Acad Sci USA 94, 43184323.Google Scholar
Lissner, L & Heitmann, BL (1995) Dietary fat and obesity: evidence from epidemiology. Eur J Clin Nutr 49, 7990.Google Scholar
Livesey, G & Elia, M (1988) Estimation of energy expenditure, net carbohydrate utilization, and net fat oxidation and synthesis by indirect calorimetry: evaluation of errors with special reference to the detailed composition of fuels. Am J Clin Nutr 47, 608628.Google Scholar
McCarron, DA & Reusser, ME (1996) Body weight and blood pressure regulation. Am J Clin Nutr 63, 423S425S.Google Scholar
McManus, K, Antinoro, L & Sacks, F (2001) A randomized controlled trial of a moderate-fat, low-energy diet compared with a low fat, low-energy diet for weight loss in overweight adults. Int J Obes Relat Metab Disord 25, 15031511.Google Scholar
Mata, P, Garrido, JA, Ordovas, JM, et al. (1992) Effect of dietary monounsaturated fatty acids on plasma lipoproteins and apolipoproteins in women. Am J Clin Nutr 56, 7783.Google Scholar
Matsuo, T, Shimomura, Y, Saitoh, S, Tokuyama, K, Takeuchi, H & Suzuki, M (1995) Sympathetic activity is lower in rats fed a beef tallow diet than in rats fed a safflower oil diet. Metab Clin Exp 44, 934939.Google Scholar
Piers, LS, Walker, KZ, Stoney, RM, Soares, MJ & O'Dea, K (2002) The influence of the type of dietary fat on postprandial fat oxidation rates: monounsaturated (olive oil) versus saturated fat (cream). Int J Obes Relat Metab Disord 26, 814821.Google Scholar
Raison, JM, Achimastos, AM & Safar, ME (1992) Sex-dependence of body fat distribution in patients with obesity and hypertension. Clin Exper Hypertens 14A, 505525.Google Scholar
Sanders, K, Johnson, L, O'Dea, K & Sinclair, AJ (1994) The effect of dietary fat level and quality on plasma lipoprotein lipids and plasma fatty acids in normocholesterolemic subjects. Lipids 29, 129138.Google Scholar
Sarkkinen, ES, Agren, JJ, Ahola, I, Ovaskainen, ML & Uusitupa, MI (1994) Fatty acid composition of serum cholesterol esters, and erythrocyte and platelet membranes as indicators of long-term adherence to fat-modified diets. Am J Clin Nutr 59, 364370.Google Scholar
Sinclair, AJ, O'Dea, K, Dunstan, G, Ireland, PD & Niall, M (1987) Effects on plasma lipids and fatty acid composition of very low fat diets enriched with fish or kangaroo meat. Lipids 22, 523529.Google Scholar
Storlien, LH, Hulbert, AJ & Else, PL (1998) Polyunsaturated fatty acids membrane function and metabolic diseases such as diabetes and obesity. Curr Opin Clin Nutr Metab Care 1, 559563.Google Scholar
Storlien, LH, Tapsell, LC, Fraser, A, et al. (2001) Insulin resistance. Influence of diet and physical activity. World Review Nutr Diet 90, 2643.Google Scholar
Stubbs, RJ (1998) Nutrition Society Medal Lecture. Appetite, feeding behaviour and energy balance in human subjects. Proc Nutr Soc 57, 341356.Google Scholar
Stubbs, RJ, Harbron, CG, Murgatroyd, PR & Prentice, AM (1995) Covert manipulation of dietary fat and energy density: effect on substrate flux and food intake in men eating ad libitum. Am J Clin Nutr 62, 316329.Google Scholar
Takeuchi, H, Matsuo, T, Tokuyama, K, Shimomura, Y & Suzuki, M (1995) Diet-induced thermogenesis is lower in rats fed a lard diet than in those fed a high oleic acid safflower oil diet, a safflower oil diet or a linseed oil diet. J Nutr 125, 920925.Google Scholar
Vessby, B, Unsitupa, M, Hermansen, K, et al. (2001) Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study. Diabetologia 44, 312319.Google Scholar
Walker, KZ, O'Dea, K, Johnson, L, et al. (1996) Body fat distribution and non-insulin-dependent diabetes: comparison of a fiber-rich, high-carbohydrate, low-fat (23%) diet and a 35% fat diet high in monounsaturated fat. Am J Clin Nutr 63, 254260.Google Scholar
Walker, KZ, O'Dea, K, Nicholson, GC & Muir, JG (1995) Dietary composition, body weight, and NIDDM. Comparison of high-fiber, high-carbohydrate, and modified-fat diets. Diabetes Care 18, 401403.Google Scholar
Willet, WC (2002) Dietary fat plays a major role in obesity: no. Obes Rev 3, 5968.Google Scholar
Williams, CM, Francis-Knapper, JA, Webb, D, et al. (1999) Cholesterol reduction using manufactured foods high in monounsaturated fatty acids: a randomized crossover study. Br J Nutr 81, 439446.Google Scholar
Yandell, BS (1997) Practical Data Analysis for Designed Experiments. Boca Raton, FL: CRC Press.Google Scholar