1 Bedogni, G, Miglioli, L, Masutti, F, et al. (2005) Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology 42, 44–52.
2 Yang, SQ, Lin, HZ, Mandal, AK, et al. (2001) Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology. Hepatology 34, 694–706.
3 Adams, LA, Lymp, JF, St Sauver, J, et al. (2005) The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 129, 113–121.
4 Clark, JM, Brancati, FL & Diehl, AM (2003) The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 98, 960–967.
5 Clark, JM (2006) The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol 40, Suppl. 1, S5–S10.
6 Mencin, A, Kluwe, J & Schwabe, RF (2009) Toll-like receptors as targets in chronic liver diseases. Gut 58, 704–720.
7 Akira, S, Takeda, K & Kaisho, T (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2, 675–680.
8 Takeda, K & Akira, S (2001) Roles of toll-like receptors in innate immune responses. Genes Cells 6, 733–742.
9 Alexopoulou, L, Holt, AC, Medzhitov, R, et al. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by toll-like receptor 3. Nature 413, 732–738.
10 Hayashi, F, Smith, KD, Ozinsky, A, et al. (2001) The innate immune response to bacterial flagellin is mediated by toll-like receptor 5. Nature 410, 1099–1103.
11 Poltorak, A, He, X, Smirnova, I, et al. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085–2088.
12 Heil, F, Hemmi, H, Hochrein, H, et al. (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303, 1526–1529.
13 Hemmi, H, Takeuchi, O, Kawai, T, et al. (2000) A toll-like receptor recognizes bacterial DNA. Nature 408, 740–745.
14 Nagata, K, Suzuki, H & Sakaguchi, S (2007) Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis. J Toxicol Sci 32, 453–468.
15 Nagy, LE (2003) Recent insights into the role of the innate immune system in the development of alcoholic liver disease. Exp Biol Med (Maywood) 228, 882–890.
16 Spruss, A & Bergheim, I (2009) Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease. J Nutr Biochem 20, 657–662.
17 Abdelmalek, MF, Suzuki, A, Guy, C, et al. (2010) Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology 51, 1961–1971.
18 Ackerman, Z, Oron-Herman, M, Grozovski, M, et al. (2005) Fructose-induced fatty liver disease: hepatic effects of blood pressure and plasma triglyceride reduction. Hypertension 45, 1012–1018.
19 Armutcu, F, Coskun, O, Gurel, A, et al. (2005) Thymosin alpha 1 attenuates lipid peroxidation and improves fructose-induced steatohepatitis in rats. Clin Biochem 38, 540–547.
20 Bergheim, I, Weber, S, Vos, M, et al. (2008) Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin. J Hepatol 48, 983–992.
21 Faeh, D, Minehira, K, Schwarz, JM, et al. (2005) Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men. Diabetes 54, 1907–1913.
22 Spruss, A, Kanuri, G, Wagnerberger, S, et al. (2009) Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. Hepatology 50, 1094–1104.
23 Haub, S, Kanuri, G, Volynets, V, et al. (2010) Serotonin reuptake transporter (SERT) plays a critical role in the onset of fructose-induced hepatic steatosis in mice. Am J Physiol Gastrointest Liver Physiol 298, G335–G344.
24 Niscigorska-Olsen, J, Wodecka, B, Moranska, I, et al. (2008) Genospecies of Borrelia burgdorferi sensu lato in patients with erythema migrans. Ann Agric Environ Med 15, 167–170.
25 Christensen, JE, Stencil, JA & Reed, KD (2003) Rapid identification of bacteria from positive blood cultures by terminal restriction fragment length polymorphism profile analysis of the 16S rRNA gene. J Clin Microbiol 41, 3790–3800.
26 Wigg, AJ, Roberts-Thomson, IC, Dymock, RB, et al. (2001) The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis. Gut 48, 206–211.
27 Abid, A, Taha, O, Nseir, W, et al. (2009) Soft drink consumption is associated with fatty liver disease independent of metabolic syndrome. J Hepatol 51, 918–924.
28 Ouyang, X, Cirillo, P, Sautin, Y, et al. (2008) Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol 48, 993–999.
29 Zelber-Sagi, S, Nitzan-Kaluski, D, Goldsmith, R, et al. (2007) Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based study. J Hepatol 47, 711–717.
30 Assy, N, Nasser, G, Kamayse, I, et al. (2008) Soft drink consumption linked with fatty liver in the absence of traditional risk factors. Can J Gastroenterol 22, 811–816.
31 Arteel, GE (2003) Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology 124, 778–790.
32 Gustot, T, Lemmers, A, Moreno, C, et al. (2006) Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver. Hepatology 43, 989–1000.
33 Velayudham, A, Hritz, I, Dolganiuc, A, et al. (2006) Critical role of toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury. J Hepatol 45, 813–824.
34 Hosoi, T, Yokoyama, S, Matsuo, S, et al. (2010) Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice. PLoS One 5, e12537.
35 Kohli, R, Kirby, M, Xanthakos, SA, et al. (2010) High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology 52, 934–944.
36 Ueberham, E, Bottger, J, Ueberham, U, et al. (2010) Response of sinusoidal mouse liver cells to choline-deficient ethionine-supplemented diet. Comp Hepatol 9, 8.
37 Tirosh, O, Artan, A, Haroni-Simon, M, et al. (2010) Impaired liver glucose production in a murine model of steatosis and endotoxemia: protection by inducible nitric oxide synthase. Antioxid Redox Signal 13, 13–26.
38 Basciano, H, Federico, L & Adeli, K (2005) Fructose, insulin resistance, and metabolic dyslipidemia. Nutr Metab (Lond) 2, 5.
39 Brun, P, Castagliuolo, I, Di Leo, V, et al. (2007) Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 292, G518–G525.
40 Cani, PD, Delzenne, NM, Amar, J, et al. (2008) Role of gut microflora in the development of obesity and insulin resistance following high-fat diet feeding. Pathol Biol (Paris) 56, 305–309.
41 Miele, L, Valenza, V, La, TG, et al. (2009) Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 49, 1877–1887.
42 Cani, PD & Delzenne, NM (2007) Gut microflora as a target for energy and metabolic homeostasis. Curr Opin Clin Nutr Metab Care 10, 729–734.