Hashempur, Mohammad Hashem Khademi, Fatemeh Rahmanifard, Maryam and Zarshenas, Mohammad M. 2017. An Evidence-Based Study on Medicinal Plants for Hemorrhoids in Medieval Persia. Journal of Evidence-Based Complementary & Alternative Medicine, p. 215658721668859.
Roche, Andrea Ross, Erika Walsh, Nicole O'Donnell, Kierin Williams, Alyssa Klapp, Marjorie Fullard, Nova and Edelstein, Sari 2017. Representative literature on the phytonutrients category: Phenolic acids. Critical Reviews in Food Science and Nutrition, Vol. 57, Issue. 6, p. 1089.
Abboud, Y. Tanane, O. Bouari, A. El Salghi, R. Hammouti, B. Chetouani, A. and Jodeh, S. 2016. Corrosion inhibition of carbon steel in hydrochloric acid solution using pomegranate leave extracts. Corrosion Engineering, Science and Technology, p. 1.
Amarowicz, Ryszard Gong, Yi and Pegg, Ronald B. 2016. Wild Plants, Mushrooms and Nuts.
Choi, Jin Park, Gunhyuk Kim, Hyo Oh, Dal-Seok Kim, Hocheol and Oh, Myung 2016. In Vitro and in Vivo Neuroprotective Effects of Walnut (Juglandis Semen) in Models of Parkinson’s Disease. International Journal of Molecular Sciences, Vol. 17, Issue. 1, p. 108.
de Oliveira, Marcos Roberto 2016. The Effects of Ellagic Acid upon Brain Cells: A Mechanistic View and Future Directions. Neurochemical Research, Vol. 41, Issue. 6, p. 1219.
Figueroa, Fernando Marhuenda, Javier Zafrilla, Pilar Villaño, Débora Martínez-Cachá, Adela Tejada, Luis Cerdá, Begoña and Mulero, Juana 2016. High-Performance Liquid Chromatography-Diode Array Detector Determination and Availability of Phenolic Compounds in 10 Genotypes of Walnuts. International Journal of Food Properties, p. 1.
Han, Qi-an Yan, Chunhong Wang, Lingfang Li, Guanghui Xu, Yunfeng and Xia, Xiaodong 2016. Urolithin A attenuates ox-LDL-induced endothelial dysfunction partly by modulating microRNA-27 and ERK/PPAR-γ pathway. Molecular Nutrition & Food Research, Vol. 60, Issue. 9, p. 1933.
Hayes, David Angove, Michael J. Tucci, Joe and Dennis, Christina 2016. Walnuts (Juglans regia) Chemical Composition and Research in Human Health. Critical Reviews in Food Science and Nutrition, Vol. 56, Issue. 8, p. 1231.
Klafke, Jonatas Zeni Pereira, Roberta Lelis Dias Hirsch, Gabriela Elisa Parisi, Mariana Migliorini Porto, Fernando Garcez de Almeida, Amanda Spring Rubin, Fabiane Horbach Schmidt, Aline Beutler, Henrique Nascimento, Sabrina Trevisan, Gabriela Brusco, Indiara de Oliveira, Sara Marchesan Duarte, Marta Maria Medeiros Frescura Duarte, Thiago and Viecili, Paulo Ricardo Nazário 2016. Study of oxidative and inflammatory parameters in LDLr-KO mice treated with a hypercholesterolemic diet: Comparison between the use of Campomanesia xanthocarpa and acetylsalicylic acid. Phytomedicine, Vol. 23, Issue. 11, p. 1227.
Liu, Ming-Chuan Yang, Sheng-Jie Hong, Da Yang, Jin-Ping Liu, Min Lin, Yun Huang, Chia-Hui and Wang, Chao-Jih 2016. A simple and convenient method for the preparation of antioxidant peptides from walnut (Juglans regia L.) protein hydrolysates. Chemistry Central Journal, Vol. 10, Issue. 1,
Mele, Laura Mena, Pedro Piemontese, Antonio Marino, Valentina López-Gutiérrez, Noelia Bernini, Franco Brighenti, Furio Zanotti, Ilaria and Del Rio, Daniele 2016. Antiatherogenic effects of ellagic acid and urolithins in vitro. Archives of Biochemistry and Biophysics, Vol. 599, p. 42.
Nour, Violeta Trandafir, Ion and Cosmulescu, Sina 2016. Optimization of ultrasound-assisted hydroalcoholic extraction of phenolic compounds from walnut leaves using response surface methodology. Pharmaceutical Biology, Vol. 54, Issue. 10, p. 2176.
Panth, Nisha Paudel, Keshav Raj and Karki, Rajendra 2016. Phytochemical profile and biological activity of Juglans regia. Journal of Integrative Medicine, Vol. 14, Issue. 5, p. 359.
Farbood, Yaghoob Mansouri, Seyyed Mohammad Taghi Ahmadian, Seyyed Mostafa Mard, Seyyad Ali and Sarkaki, Alireza 2015. Effect of Ellagic Acid on Animal Behavior in Elevated Plus Maze and Open Field Tests. Jentashapir Journal of Health Research, Vol. 6, Issue. 6,
Kaur, Ramandeep Mehan, Sidharth Khanna, Deepa Kalra, Sanjeev and Parveen, Shaba 2015. Precautionary Ellagic Acid Treatment Ameliorates Chronically Administered Scopolamine Induced Alzheimer's Type Memory and Cognitive Dysfunctions in Rats. Pharmacologia, Vol. 6, Issue. 5, p. 192.
Laubertová, Lucia Koňariková, Katarína Gbelcová, Helena Ďuračková, Zdeňka and Žitňanová, Ingrid 2015. Effect of walnut oil on hyperglycemia-induced oxidative stress and pro-inflammatory cytokines production. European Journal of Nutrition, Vol. 54, Issue. 2, p. 291.
Li, Yong Zhao, Xiuhua Zu, Yuangang Zhang, Yin Ge, Yunlong Zhong, Chen and Wu, Weiwei 2015. Preparation and characterization of micronized ellagic acid using antisolvent precipitation for oral delivery. International Journal of Pharmaceutics, Vol. 486, Issue. 1-2, p. 207.
Nankar, Rakesh P. and Doble, Mukesh 2015. Ellagic acid potentiates insulin sensitising activity of pioglitazone in L6 myotubes. Journal of Functional Foods, Vol. 15, p. 1.
Sánchez-González, Claudia Ciudad, Carlos Noé, Véronique and Izquierdo-Pulido, Maria 2015. Health benefits of walnut polyphenols: An exploration beyond their lipid profile. Critical Reviews in Food Science and Nutrition, p. 00.
Epidemiological studies suggest that the incidence of CVD and postmenopausal osteoporosis is low in the Mediterranean area, where herbs and nuts, among others, play an important role in nutrition. In the present study, we sought a role of walnuts (Juglans regia L.) in endothelial and bone-cell function. As the endothelial cell expression of adhesion molecules has been recognised as an early step in inflammation and atherogenesis, we examined the effect of walnut methanolic extract and ellagic acid, one of its major polyphenolic components (as shown by HPLC analysis), on the expression of vascular cell adhesion molecule (VCAM)-1 and intracellular adhesion molecule (ICAM)-1 in human aortic endothelial cells. After incubating the cells with TNF-α (1 ng/ml) in the absence and in the presence of walnut extract (10–200 μg/ml) or ellagic acid (10− 7–10− 5m), the VCAM-1 and ICAM-1 expression was quantified by cell-ELISA. We further evaluated the effect of walnut extract (10–50 μg/ml), in comparison with ellagic acid (10− 9–10− 6m), on nodule formation in the osteoblastic cell line KS483.Walnut extract and ellagic acid decreased significantly the TNF-α-induced endothelial expression of both VCAM-1 and ICAM-1 (P < 0·01; P < 0·001). Both walnut extract (at 10–25 μg/ml) and ellagic acid (at 10− 9–10− 8m) induced nodule formation in KS483 osteoblasts. The present results suggest that the walnut extract has a high anti-atherogenic potential and a remarkable osteoblastic activity, an effect mediated, at least in part, by its major component ellagic acid. Such findings implicate the beneficial effect of a walnut-enriched diet on cardioprotection and bone loss.
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