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Whole grain consumption has a modest effect on the development of diabetes in the Goto–Kakisaki rat

  • Moonyeon Youn (a1), A. Saari Csallany (a1) and Daniel D. Gallaher (a1)
Abstract

Epidemiological evidence suggests that whole grain intake is associated with reduced risk of type 2 diabetes. However, studies of individual whole grains on the prevention of type 2 diabetes are lacking. The objective of the present study was to examine the effect of different whole grains on type 2 diabetes in an animal model of type 2 diabetes, the Goto–Kakisaki (GK) rat. GK rats were fed either a basal diet or a whole grain-containing diet for 5 months. Whole grain diets contained 65 % whole grain flours of wheat, barley, oats or maize. After 2 months of feeding, fasting plasma glucose concentrations were lower in the wheat, barley and oats groups, compared with the basal group, whereas glycated Hb was significantly greater in the wheat group compared with other groups. Feeding of whole barley and maize increased plasma C-peptide concentrations compared with whole wheat at 2 months. There was a trend in the improvement of insulin resistance with a consumption of barley and oats diets at 2 months (P = 0·06) compared with the basal diet. Oxidative stress markers, urinary thiobarbituric acid-reactive substances and 8-isoprostane, did not improve with whole grain intake at 2 months. At 5 months, whole grain diets did not differ from the basal diet in glycaemic control, insulin secretion, oxidative stress and preservation of pancreatic β-cell mass. These results suggest that the consumption of whole grains may offer modest benefit early in the development of type 2 diabetes, but this benefit is lost with further development of the disease.

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*Corresponding author: Dr D. D. Gallaher, fax +1 612 625 5272, email dgallahe@umn.edu
References
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1 Wild S, Roglic G, Green A, et al. (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27, 10471053.
2 US Department of Health and Human Services, Center for Disease Control and Prevention (2007) 2007 National Diabetes Fact Sheet. http://www.cdc.gov/diabetes/pubs/estimates07.htm.
3 van Dam RM (2003) The epidemiology of lifestyle and risk for type 2 diabetes. Eur J Epidemiol 18, 11151125.
4 Meyer KA, Kushi LH, Jacobs DR Jr, et al. (2000) Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr 71, 921930.
5 Fung TT, Hu FB, Pereira MA, et al. (2002) Whole-grain intake and the risk of type 2 diabetes: a prospective study in men. Am J Clin Nutr 76, 535540.
6 Montonen J, Knekt P, Jarvinen R, et al. (2003) Whole-grain and fiber intake and the incidence of type 2 diabetes. Am J Clin Nutr 77, 622629.
7 Jang Y, Lee JH, Kim OY, et al. (2001) Consumption of whole grain and legume powder reduces insulin demand, lipid peroxidation, and plasma homocysteine concentrations in patients with coronary artery disease: randomized controlled clinical trial. Arterioscler Thromb Vasc Biol 21, 20652071.
8 Pereira MA, Jacobs DR Jr, Pins JJ, et al. (2002) Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. Am J Clin Nutr 75, 848855.
9 Andersson A, Tengblad S, Karlstrom B, et al. (2007) Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects. J Nutr 137, 14011407.
10 Tighe P, Duthie G, Vaughan N, et al. (2010) Effect of increased consumption of whole-grain foods on blood pressure and other cardiovascular risk markers in healthy middle-aged persons: a randomized controlled trial. Am J Clin Nutr 92, 733740.
11 Hallfrisch J, Facn & Behall KM (2000) Mechanisms of the effects of grains on insulin and glucose responses. J Am Coll Nutr 19, 320S325S.
12 Pick ME, Hawrysh ZJ, Gee MI, et al. (1996) Oat bran concentrate bread products improve long-term control of diabetes: a pilot study. J Am Diet Assoc 96, 12541261.
13 Jenkins AL, Jenkins DJ, Zdravkovic U, et al. (2002) Depression of the glycemic index by high levels of beta-glucan fiber in two functional foods tested in type 2 diabetes. Eur J Clin Nutr 56, 622628.
14 Torsdottir I, Alpsten M, Andersson H, et al. (1989) Dietary guar gum effects on postprandial blood glucose, insulin and hydroxyproline in humans. J Nutr 119, 19251931.
15 Leclere CJ, Champ M, Boillot J, et al. (1994) Role of viscous guar gums in lowering the glycemic response after a solid meal. Am J Clin Nutr 59, 914921.
16 Rainbird AL, Low AG & Zebrowska T (1984) Effect of guar gum on glucose and water absorption from isolated loops of jejunum in conscious growing pigs. Br J Nutr 52, 489498.
17 Mayer-Davis EJ, Costacou T, King I, et al. (2002) Plasma and dietary vitamin E in relation to incidence of type 2 diabetes: The Insulin Resistance and Atherosclerosis Study (IRAS). Diabetes Care 25, 21722177.
18 Montonen J, Knekt P, Jarvinen R, et al. (2004) Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 27, 362366.
19 Halvorsen BL, Holte K, Myhrstad MC, et al. (2002) A systematic screening of total antioxidants in dietary plants. J Nutr 132, 461471.
20 Bruce B, Spiller GA, Klevay LM, et al. (2000) A diet high in whole and unrefined foods favorably alters lipids, antioxidant defenses, and colon function. J Am Coll Nutr 19, 6167.
21 Movassat J, Bailbe D, Lubrano-Berthelier C, et al. (2008) Follow-up of GK rats during prediabetes highlights increased insulin action and fat deposition despite low insulin secretion. Am J Physiol Endocrinol Metab 294, E168E175.
22 Miller HE, Rigelhof F, Marquart L, et al. (2000) Antioxidant content of whole grain breakfast cereals, fruits and vegetables. J Am Coll Nutr 19, 312S319S.
23 Goldstein DE, Little RR, Lorenz RA, et al. (2004) Tests of glycemia in diabetes. Diabetes Care 27, 17611773.
24 Mihara M & Uchiyama M (1978) Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86, 271278.
25 Lee HS, Shoeman DW & Csallany AS (1992) Urinary response to in vivo lipid peroxidation induced by vitamin E deficiency. Lipids 27, 124128.
26 Haffner SM, Kennedy E, Gonzalez C, et al. (1996) A prospective analysis of the HOMA model. The Mexico City Diabetes Study. Diabetes Care 19, 11381141.
27 Gundersen HJ, Bendtsen TF, Korbo L, et al. (1988) Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96, 379394.
28 Goto Y, Kakizaki M & Masaki N (1975) Spontaneous diabetes produced by selective breeding of normal Wistar rats. Proc Jpn Acad 51, 8085.
29 Hughes SJ, Suzuki K & Goto Y (1994) The role of islet secretory function in the development of diabetes in the GK Wistar rat. Diabetologia 37, 863870.
30 Movassat J, Saulnier C, Serradas P, et al. (1997) Impaired development of pancreatic beta-cell mass is a primary event during the progression to diabetes in the GK rat. Diabetologia 40, 916925.
31 Hussain MA (1997) Polygenic models of non-insulin-dependent diabetes mellitus. Eur J Endocrinol 137, 453454.
32 Sachidanandam K, Elgebaly MM, Harris AK, et al. (2008) Effect of chronic and selective endothelin receptor antagonism on microvascular function in type 2 diabetes. Am J Physiol Heart Circ Physiol 294, H2743H2749.
33 Tappy L, Gugolz E & Wursch P (1996) Effects of breakfast cereals containing various amounts of beta-glucan fibers on plasma glucose and insulin responses in NIDDM subjects. Diabetes Care 19, 831834.
34 Bunn HF, Gabbay KH & Gallop PM (1978) The glycosylation of hemoglobin: relevance to diabetes mellitus. Science 200, 2127.
35 Lapolla A, Traldi P & Fedele D (2005) Importance of measuring products of non-enzymatic glycation of proteins. Clin Biochem 38, 103115.
36 Jain SK (1998) Glutathione and glucose-6-phosphate dehydrogenase deficiency can increase protein glycosylation. Free Radic Biol Med 24, 197201.
37 Balamurugan R, Selvaraj N, Bobby Z, et al. (2007) Increased glycated hemoglobin level in non-diabetic nephrotic children is associated with oxidative stress. Indian J Physiol Pharmacol 51, 153159.
38 Jain SK & Palmer M (1997) The effect of oxygen radicals metabolites and vitamin E on glycosylation of proteins. Free Radic Biol Med 22, 593596.
39 Horwitz DL, Starr JI, Mako ME, et al. (1975) Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood. J Clin Invest 55, 12781283.
40 Kimura K, Toyota T, Kakizaki M, et al. (1982) Impaired insulin secretion in the spontaneous diabetes rats. Tohoku J Exp Med 137, 453459.
41 Ohneda M, Johnson JH, Inman LR, et al. (1993) GLUT2 expression and function in beta-cells of GK rats with NIDDM. Dissociation between reductions in glucose transport and glucose-stimulated insulin secretion. Diabetes 42, 10651072.
42 Mari A, Ahren B & Pacini G (2005) Assessment of insulin secretion in relation to insulin resistance. Curr Opin Clin Nutr Metab Care 8, 529533.
43 Milne GL, Musiek ES & Morrow JD (2005) F2-isoprostanes as markers of oxidative stress in vivo: an overview. Biomarkers 10, Suppl. 1, S10S23.
44 Adom KK & Liu RH (2002) Antioxidant activity of grains. J Agric Food Chem 50, 61826187.
45 Martinez-Tome M, Murcia MA, Frega N, et al. (2004) Evaluation of antioxidant capacity of cereal brans. J Agric Food Chem 52, 46904699.
46 Liyana-Pathirana CM & Shahidi F (2006) Importance of insoluble-bound phenolics to antioxidant properties of wheat. J Agric Food Chem 54, 12561264.
47 Adam A, Crespy V, Levrat-Verny MA, et al. (2002) The bioavailability of ferulic acid is governed primarily by the food matrix rather than its metabolism in intestine and liver in rats. J Nutr 132, 19621968.
48 Miralles F & Portha B (2001) Early development of beta-cells is impaired in the GK rat model of type 2 diabetes. Diabetes 50, Suppl. 1, S84S88.
49 Movassat J, Calderari S, Fernandez E, et al. (2007) Type 2 diabetes – a matter of failing beta-cell neogenesis? Clues from the GK rat model. Diabetes Obes Metab 9, Suppl. 2, 187195.
50 Koyama M, Wada R, Sakuraba H, et al. (1998) Accelerated loss of islet beta cells in sucrose-fed Goto–Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus. Am J Pathol 153, 537545.
51 Harmon JS, Gleason CE, Tanaka Y, et al. (2001) Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats. Diabetes 50, 24812486.
52 Prentki M, Joly E, El-Assaad W, et al. (2002) Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. Diabetes 51, Suppl. 3, S405S413.
53 Mogensen CE & Andersen MJ (1975) Increased kidney size and glomerular filtration rate in untreated juvenile diabetes: normalization by insulin-treatment. Diabetologia 11, 221224.
54 Garcia Puig J, Mateos Anton F, Grande C, et al. (1981) Relation of kidney size to kidney function in early insulin-dependent diabetes. Diabetologia 21, 363367.
55 Nobrega MA, Fleming S, Roman RJ, et al. (2004) Initial characterization of a rat model of diabetic nephropathy. Diabetes 53, 735742.
56 Seyer-Hansen K (1977) Renal hypertrophy in experimental diabetes: relation to severity of diabetes. Diabetologia 13, 141143.
57 Gallaher DD, Olson JM & Larntz K (1992) Dietary guar gum halts further renal enlargement in rats with established diabetes. J Nutr 122, 23912397.
58 Kim SS, Gallaher DD & Csallany AS (2000) Vitamin E and probucol reduce urinary lipophilic aldehydes and renal enlargement in streptozotocin-induced diabetic rats. Lipids 35, 12251237.
59 Kim CS, Sohn EJ, Kim YS, et al. (2007) Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto–Kakizaki rats. J Ethnopharmacol 111, 240247.
60 Sato N, Komatsu K & Kurumatani H (2003) Late onset of diabetic nephropathy in spontaneously diabetic GK rats. Am J Nephrol 23, 334342.
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