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Whole grain consumption has a modest effect on the development of diabetes in the Goto–Kakisaki rat

  • Moonyeon Youn (a1), A. Saari Csallany (a1) and Daniel D. Gallaher (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114511002741
  • Published online: 30 June 2011
Abstract

Epidemiological evidence suggests that whole grain intake is associated with reduced risk of type 2 diabetes. However, studies of individual whole grains on the prevention of type 2 diabetes are lacking. The objective of the present study was to examine the effect of different whole grains on type 2 diabetes in an animal model of type 2 diabetes, the Goto–Kakisaki (GK) rat. GK rats were fed either a basal diet or a whole grain-containing diet for 5 months. Whole grain diets contained 65 % whole grain flours of wheat, barley, oats or maize. After 2 months of feeding, fasting plasma glucose concentrations were lower in the wheat, barley and oats groups, compared with the basal group, whereas glycated Hb was significantly greater in the wheat group compared with other groups. Feeding of whole barley and maize increased plasma C-peptide concentrations compared with whole wheat at 2 months. There was a trend in the improvement of insulin resistance with a consumption of barley and oats diets at 2 months (P = 0·06) compared with the basal diet. Oxidative stress markers, urinary thiobarbituric acid-reactive substances and 8-isoprostane, did not improve with whole grain intake at 2 months. At 5 months, whole grain diets did not differ from the basal diet in glycaemic control, insulin secretion, oxidative stress and preservation of pancreatic β-cell mass. These results suggest that the consumption of whole grains may offer modest benefit early in the development of type 2 diabetes, but this benefit is lost with further development of the disease.

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Corresponding author
*Corresponding author: Dr D. D. Gallaher, fax +1 612 625 5272, email dgallahe@umn.edu
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1S Wild , G Roglic , A Green , (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27, 10471053.

3RM van Dam (2003) The epidemiology of lifestyle and risk for type 2 diabetes. Eur J Epidemiol 18, 11151125.

7Y Jang , JH Lee , OY Kim , (2001) Consumption of whole grain and legume powder reduces insulin demand, lipid peroxidation, and plasma homocysteine concentrations in patients with coronary artery disease: randomized controlled clinical trial. Arterioscler Thromb Vasc Biol 21, 20652071.

10P Tighe , G Duthie , N Vaughan , (2010) Effect of increased consumption of whole-grain foods on blood pressure and other cardiovascular risk markers in healthy middle-aged persons: a randomized controlled trial. Am J Clin Nutr 92, 733740.

11J Hallfrisch , Facn & KM Behall (2000) Mechanisms of the effects of grains on insulin and glucose responses. J Am Coll Nutr 19, 320S325S.

12ME Pick , ZJ Hawrysh , MI Gee , (1996) Oat bran concentrate bread products improve long-term control of diabetes: a pilot study. J Am Diet Assoc 96, 12541261.

13AL Jenkins , DJ Jenkins , U Zdravkovic , (2002) Depression of the glycemic index by high levels of beta-glucan fiber in two functional foods tested in type 2 diabetes. Eur J Clin Nutr 56, 622628.

17EJ Mayer-Davis , T Costacou , I King , (2002) Plasma and dietary vitamin E in relation to incidence of type 2 diabetes: The Insulin Resistance and Atherosclerosis Study (IRAS). Diabetes Care 25, 21722177.

18J Montonen , P Knekt , R Jarvinen , (2004) Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 27, 362366.

20B Bruce , GA Spiller , LM Klevay , (2000) A diet high in whole and unrefined foods favorably alters lipids, antioxidant defenses, and colon function. J Am Coll Nutr 19, 6167.

21J Movassat , D Bailbe , C Lubrano-Berthelier , (2008) Follow-up of GK rats during prediabetes highlights increased insulin action and fat deposition despite low insulin secretion. Am J Physiol Endocrinol Metab 294, E168E175.

22HE Miller , F Rigelhof , L Marquart , (2000) Antioxidant content of whole grain breakfast cereals, fruits and vegetables. J Am Coll Nutr 19, 312S319S.

23DE Goldstein , RR Little , RA Lorenz , (2004) Tests of glycemia in diabetes. Diabetes Care 27, 17611773.

25HS Lee , DW Shoeman & AS Csallany (1992) Urinary response to in vivo lipid peroxidation induced by vitamin E deficiency. Lipids 27, 124128.

26SM Haffner , E Kennedy , C Gonzalez , (1996) A prospective analysis of the HOMA model. The Mexico City Diabetes Study. Diabetes Care 19, 11381141.

27HJ Gundersen , TF Bendtsen , L Korbo , (1988) Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96, 379394.

29SJ Hughes , K Suzuki & Y Goto (1994) The role of islet secretory function in the development of diabetes in the GK Wistar rat. Diabetologia 37, 863870.

30J Movassat , C Saulnier , P Serradas , (1997) Impaired development of pancreatic beta-cell mass is a primary event during the progression to diabetes in the GK rat. Diabetologia 40, 916925.

31MA Hussain (1997) Polygenic models of non-insulin-dependent diabetes mellitus. Eur J Endocrinol 137, 453454.

32K Sachidanandam , MM Elgebaly , AK Harris , (2008) Effect of chronic and selective endothelin receptor antagonism on microvascular function in type 2 diabetes. Am J Physiol Heart Circ Physiol 294, H2743H2749.

33L Tappy , E Gugolz & P Wursch (1996) Effects of breakfast cereals containing various amounts of beta-glucan fibers on plasma glucose and insulin responses in NIDDM subjects. Diabetes Care 19, 831834.

34HF Bunn , KH Gabbay & PM Gallop (1978) The glycosylation of hemoglobin: relevance to diabetes mellitus. Science 200, 2127.

35A Lapolla , P Traldi & D Fedele (2005) Importance of measuring products of non-enzymatic glycation of proteins. Clin Biochem 38, 103115.

36SK Jain (1998) Glutathione and glucose-6-phosphate dehydrogenase deficiency can increase protein glycosylation. Free Radic Biol Med 24, 197201.

38SK Jain & M Palmer (1997) The effect of oxygen radicals metabolites and vitamin E on glycosylation of proteins. Free Radic Biol Med 22, 593596.

39DL Horwitz , JI Starr , ME Mako , (1975) Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood. J Clin Invest 55, 12781283.

40K Kimura , T Toyota , M Kakizaki , (1982) Impaired insulin secretion in the spontaneous diabetes rats. Tohoku J Exp Med 137, 453459.

41M Ohneda , JH Johnson , LR Inman , (1993) GLUT2 expression and function in beta-cells of GK rats with NIDDM. Dissociation between reductions in glucose transport and glucose-stimulated insulin secretion. Diabetes 42, 10651072.

42A Mari , B Ahren & G Pacini (2005) Assessment of insulin secretion in relation to insulin resistance. Curr Opin Clin Nutr Metab Care 8, 529533.

43GL Milne , ES Musiek & JD Morrow (2005) F2-isoprostanes as markers of oxidative stress in vivo: an overview. Biomarkers 10, Suppl. 1, S10S23.

44KK Adom & RH Liu (2002) Antioxidant activity of grains. J Agric Food Chem 50, 61826187.

45M Martinez-Tome , MA Murcia , N Frega , (2004) Evaluation of antioxidant capacity of cereal brans. J Agric Food Chem 52, 46904699.

46CM Liyana-Pathirana & F Shahidi (2006) Importance of insoluble-bound phenolics to antioxidant properties of wheat. J Agric Food Chem 54, 12561264.

48F Miralles & B Portha (2001) Early development of beta-cells is impaired in the GK rat model of type 2 diabetes. Diabetes 50, Suppl. 1, S84S88.

49J Movassat , S Calderari , E Fernandez , (2007) Type 2 diabetes – a matter of failing beta-cell neogenesis? Clues from the GK rat model. Diabetes Obes Metab 9, Suppl. 2, 187195.

50M Koyama , R Wada , H Sakuraba , (1998) Accelerated loss of islet beta cells in sucrose-fed Goto–Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus. Am J Pathol 153, 537545.

51JS Harmon , CE Gleason , Y Tanaka , (2001) Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats. Diabetes 50, 24812486.

52M Prentki , E Joly , W El-Assaad , (2002) Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. Diabetes 51, Suppl. 3, S405S413.

53CE Mogensen & MJ Andersen (1975) Increased kidney size and glomerular filtration rate in untreated juvenile diabetes: normalization by insulin-treatment. Diabetologia 11, 221224.

55MA Nobrega , S Fleming , RJ Roman , (2004) Initial characterization of a rat model of diabetic nephropathy. Diabetes 53, 735742.

56K Seyer-Hansen (1977) Renal hypertrophy in experimental diabetes: relation to severity of diabetes. Diabetologia 13, 141143.

58SS Kim , DD Gallaher & AS Csallany (2000) Vitamin E and probucol reduce urinary lipophilic aldehydes and renal enlargement in streptozotocin-induced diabetic rats. Lipids 35, 12251237.

59CS Kim , EJ Sohn , YS Kim , (2007) Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto–Kakizaki rats. J Ethnopharmacol 111, 240247.

60N Sato , K Komatsu & H Kurumatani (2003) Late onset of diabetic nephropathy in spontaneously diabetic GK rats. Am J Nephrol 23, 334342.

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