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Executive Function Assessment in Young Hospitalized Schizophrenic Patients with the “CANTAB Schizophrenia Battery” (Russian Sample)

Published online by Cambridge University Press:  23 March 2020

G. Rupchev
Affiliation:
Federal State Budgetary Scientific Institution “Mental Health Research Center”, Laboratory of Psychopharmacology, Moscow, Russia
A. Alekseev
Affiliation:
Federal State Budgetary Scientific Institution “Mental Health Research Center”, Laboratory of Psychopharmacology, Moscow, Russia
M. Morozova
Affiliation:
Federal State Budgetary Scientific Institution “Mental Health Research Center”, Laboratory of Psychopharmacology, Moscow, Russia
V. Kaleda
Affiliation:
Federal State Budgetary Scientific Institution “Mental Health Research Center”, Laboratory of Psychopharmacology, Moscow, Russia
A. Tkhostov
Affiliation:
Moscow State University, Department of clinical psychology, Moscow, Russia
D. Tikhonov
Affiliation:
Federal State Budgetary Scientific Institution “Mental Health Research Center”, Laboratory of Psychopharmacology, Moscow, Russia
A. Listova
Affiliation:
Moscow State University, Department of clinical psychology, Moscow, Russia

Abstract

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Introduction

Impairment of executive function is the fundamental feature of the cognitive dysfunction in schizophrenia has to be measured throughout the illness regularly. Computerized technologies for assessment of cognitive dysfunction are widely used. However, their applicability in hospitalized schizophrenic patients setting should be specially examined.

Objective

Executive function in schizophrenia.

Aims

To test the applicability of “CANTAB” neurocognitive battery for measurement of executive function in young hospitalized schizophrenic patients in Russian sample.

Methods

Fifteen inpatients diagnosed with schizophrenia according to ICD-10 (F 20.хх), 13 males and 2 females, aged 23.5(SD 3.2), disease duration is 5(SD 1.6) years and 16 healthy individuals, 7 males and 9 females, aged 21.3(SD 0.7). Spatial Working Memory (SWM) (Mnemonic Executive function), Stockings of Cambridge (OTS) (Planning Executive function), Intra/Extra-Dimensional Shift (IED) (Cognitive flexibility) were administered.

Results

The majority of patients and controls easily understood the test instructions. Both groups did not have any difficulties with the touchpad. The “CANTAB” demonstrated sensitivity to the impairments of executive function. As a group, patients with schizophrenia performed significantly worse than controls on almost all tests: SWM–Between errors (P = 0.028), Total errors (P = 0.019), Strategy (P = 0.03), Mean time to last response (P = 0.001); OTS–Mean choices to correct (P = 0.044), Problems solved on first choice (P = 0.009), Probability of error given correct (P = 0.021); IED–Total errors (P = 0.015), Total trials (P = 0.002).

Conclusion

The “CANTAB” is an applicable instrument for assessment of the executive function in young hospitalized schizophrenic patients. It can be used both for experimental and clinical needs.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Walk: Schizophrenia and Other Psychotic Disorders–Part 4
Copyright
Copyright © European Psychiatric Association 2017
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