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Biotechnology and the lifetime of technical civilizations

  • John G. Sotos (a1)

The number of people able to end Earth's technical civilization has heretofore been small. Emerging dual-use technologies, such as biotechnology, may give similar power to thousands or millions of individuals. To quantitatively investigate the ramifications of such a marked shift on the survival of both terrestrial and extraterrestrial technical civilizations, this paper presents a two-parameter model for civilizational lifespans, i.e. the quantity L in Drake's equation for the number of communicating extraterrestrial civilizations. One parameter characterizes the population lethality of a civilization's biotechnology and the other characterizes the civilization's psychosociology. L is demonstrated to be less than the inverse of the product of these two parameters. Using empiric data from PubMed to inform the biotechnology parameter, the model predicts human civilization's median survival time as decades to centuries, even with optimistic psychosociological parameter values, thereby positioning biotechnology as a proximate threat to human civilization. For an ensemble of civilizations having some median calculated survival time, the model predicts that, after 80 times that duration, only one in 1024 civilizations will survive – a tempo and degree of winnowing compatible with Hanson's ‘Great Filter.’ Thus, assuming that civilizations universally develop advanced biotechnology, before they become vigorous interstellar colonizers, the model provides a resolution to the Fermi paradox.

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Author for correspondence: John G. Sotos, E-mail:
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Ambartsumian, VA and Sagan, C (1973) Prospect. In Sagan, C (ed.), Communication with Extraterrestrial Intelligence. Cambridge, MA: MIT Press, pp. 17.
Anonymous (2002) The history of the Bulletin clock. Bulletin of the Atomic Scientists 58(2), 3637. (
Armstrong, S and Sandberg, A (2013) Eternity in six hours: intergalactic spreading of intelligent life and sharpening the Fermi paradox. Acta Astronautica 89, 113. (
Billingham, J, Oliver, BM and Wolfe, JH (1979) A review of the theory of interstellar communication. Acta Astronautica 6(1), 4757.
Bostrom, N (2008) Where are they? Why I hope the search for extraterrestrial life finds nothing. Technology Review 7277. (
Bostrom, N and Cirkovic, MM (2011) Global Catastrophic Risks. Oxford: Oxford University Press.
Burchell, MJ (2006) W(h)ither the Drake equation?. International Journal of Astrobiology 5(3), 243250.
Cassan, A, Kubas, D, Beaulieu, J-P, Dominik, M, Horne, K, Greenhill, J, Wambsganss, J, Menzies, J, Williams, A, Jorgensen, UG, Udalski, A, Bennett, DP, Albrow, MD, Batista, V, Brillant, S, Caldwell, JAR, Cole, A, Coutures, C, Cook, KH, Dieters, S, Prester, DD, Donatowicz, J, Fouque, P, Hill, K, Kains, N, Kane, S, Marquette, J-B, Martin, R, Pollard, KR, Sahu, KC, Vinter, C, Warren, D, Watson, B, Zub, M, Sumi, T, Szymanski, MK, Kubiak, M, Poleski, R, Soszynski, I, Ulaczyk, K, Pietrzynski, G and Wyrzykowski, L (2012) One or more bound planets per milky way star from microlensing observations. Nature 481(7380), 167169. (
Cohen, F (1987) Computer viruses: Theory and experiments. Computers & Security 6, 2235.
Cooper, J (2013) Bioterrorism and the Fermi Paradox. International Journal of Astrobiology 12(2), 144148.
Drake, FD (1961) Discussion of Space Science Board, National Academy of Sciences Conference on Extraterrestrial Intelligent Life. Green Bank, West Virginia.
Drexler, KE (1987) Engines of Creation. New York: Anchor, pp. 172173.
Duncan, RC (1991) The life-expectancy of industrial civilization, in ‘System Dynamics ’91: Proceedings of the 1991 International System Dynamics Conference, Bangkok, Thailand, August 27 through 30, 1991', pp. 173–181.
Dyson, FJ (1960) Search for artificial stellar sources of infrared radiation. Science 131(3414), 16671668. (
European Hospital and Healthcare Federation (2009) Hospitals in the 27 Member States of the European Union. Paris: Dexia Editions, p. 47. (
Farnsworth, KD, Nelson, J and Gershenson, C (2013) Living is information processing: from molecules to global systems. Acta Biotheoretica 61(2), 203222. (
Forgan, D (2009) A numerical testbed for hypotheses of extraterrestrial life and intelligence. International Journal of Astrobiology 8(2), 121131.
Frank, A and Sullivan, WT (2016) A new empirical constraint on the prevalence of technological species in the universe. Astrobiology 16(5), 359362.
Hanson, R (n.d.) The great filter - are we almost past it?, Downloaded from: (, Accessed June 12, 2017.
Herfst, S, Schrauwen, EJA, Linster, M, Chutinimitkul, S, de Wit, E, Munster, VJ, Sorrell, EM, Bestebroer, TM, Burke, DF, Smith, DJ, Rimmelzwaan, GF, Osterhaus, ADME and Fouchier, RAM (2012) Airborne transmission of influenza A/H5N1 virus between ferrets. Science 336(6088), 15341541. (
Imai, M, Watanabe, T, Hatta, M, Das, SC, Ozawa, M, Shinya, K, Zhong, G, Hanson, A, Katsura, H, Watanabe, S, Li, C, Kawakami, E, Yamada, S, Kiso, M, Suzuki, Y, Maher, EA, Neumann, G and Kawaoka, Y (2012) Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature 486(7403), 420428. (
Jackson, RJ, Ramsay, AJ, Christensen, CD, Beaton, S, Hall, DF and Ramshaw, IA (2001) Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox. Journal of Virology 75(3), 12051210. (
Johansson, F et al. (2013) mpmath: a Python library for arbitrary-precision floating-point arithmetic (version 0.18), December 2013. (
Jones, EM (1981) Discrete calculations of interstellar migration and settlement. Icarus 46(3), 328336. (
Kardashev, NS (1964) Transmission of Information by Extraterrestrial Civilizations. Soviet Astronomy, 8(2), 217221.
Kompanichenko, VN (2000) Average lifetime of an intelligent civilization estimated on its global cycle, in ‘Bioastronomy 99: A New Era in the Search for Life’, Vol. 213 of Astronomical Society of the Pacific Conference Series, pp. 437–440.
Maccone, C (2010) The statistical Drake Equation. Acta Astronautica 67, 13661383.
McNeill, WH (1976) Plagues and Peoples. Garden City, NY: Anchor. p. 94, 113ff, 152, 180, 186.
National Cancer Institute (2018) Cancer moonshot.
Oliver, BM and Billingham, J (1971) Life in the universe, in Project Cyclops: A Design Study of a System for Detecting Extraterrestrial Intelligent Life, Stanford/NASA/Ames Research Center. NASA report CR 114445, pp. 328. (
Organisation for Economic Cooperation and Development European Union (2016) Health at a Glance: Europe 2016, Paris: OECD Publishing, p. 193. (
Perelson, AS, Rong, L and Hayden, FG (2012) Combination antiviral therapy for influenza: predictions from modeling of human infections. The Journal of Infectious Diseases 205(11), 16421645. (
Phillips, JA (1978) Mushroom: The Story of the A-bomb Kid. New York: Morrow.
President's Council of Advisors on Science and Technology (2016) Action needed to protect against biological attack.
Rozo, M and Gronvall, GK (2015) The reemergent 1977 H1N1 strain and the gain-of-function debate. mBio 6(4), e0101315.
Rubin, CT (2001) L factor: hope and fear in the search for extraterrestrial intelligence. Proc. SPIE 4273, 230239. (
Sandberg, A, Armstrong, S and Cirkovic, MM (2017) That is not dead which can eternal lie: the aestivation hypothesis for resolving Fermi's paradox. arXiv:1705.03394.
Schenkel, P (1999) The nature of ETI, its longevity and likely interest in mankind - the human analogy re-examined. Journal of the British Interplanetary Society 52, 1318.
Shklovskii, IS and Sagan, C (1966) Intelligent Life in the Universe. New York: Delta, pp. 409418.
Suskind, R (2006) The One Percent Doctrine. New York: Simon and Schuster, p. 62.
Tipler, FJ (1980) Extraterrestrial intelligent beings do not exist. Q J R Astro Soc 21, 267281.
Turnbull, MC and Tarter, JC (2003) Target selection for SETI. II. Tycho-2 dwarfs, old open clusters, and the nearest 100 stars. Astrophysical Journal Supplement Series 149, 423436.
Vakoch, DA and Dowd, MF (2015) The Drake Equation: Estimating the Prevalence of Extraterrestrial Life through the Ages. New York: Cambridge University Press.
von Hoerner, S (1961) The search for signals from other civilizations. Science 134, 18391843.
Watson, C, Sell, TK, Watson, M, Rivers, C, Hurtado, C, Shearer, MP, Geleta, A and Inglesby, T (2018) Technologies to Address Global Catastrophic Biological Risks. Baltimore: Johns Hopkins University Bloomberg School of Public Health/Center for Health Security, p. 8. (
Webb, S (2015) If the Universe Is Teeming with Aliens ... Where is Everybody?, 2nd Edn. Cham, Switzerland: Springer.
Wertheim, JO (2010) The re-emergence of H1N1 influenza virus in 1977: A cautionary tale for estimating divergence times using biologically unrealistic sampling dates. PLOS ONE 5(6), 14. (
Zimmer, SM and Burke, DS (2009) Historical perspective – emergence of influenza A (H1N1) viruses. New England Journal of Medicine 361(3), 279285. PMID: 19564632. (
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International Journal of Astrobiology
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