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A review of neuroimaging findings of apathy in Alzheimer's disease

  • Christos Theleritis (a1) (a2) (a3), Antonios Politis (a1) (a4), Kostas Siarkos (a1) and Costantine G. Lyketsos (a4)
  • DOI: http://dx.doi.org/10.1017/S1041610213001725
  • Published online: 18 October 2013
Abstract
ABSTRACTBackground:

Apathy is one of the most frequent “behavioral and psychological signs and symptoms of dementia” (BPSD) encountered in Alzheimer's disease (AD). There is a growing interest in the early diagnosis of apathetic elderly patients in the community since apathy has been associated with reduced daily functioning, caregiver distress, and poor outcome. The generalization of neuroimaging techniques might be able to offer help in this domain.

Methods: Within this context we conducted an extensive electronic search from the databases included in the National Library of Medicine as well as PsychInfo and Google Scholar for neuroimaging findings of apathy in AD.

Results:

Neuroimaging findings lend support to the notion that frontal-subcortical networks are involved in the occurrence of apathy in AD.

Conclusions: Longitudinal studies comparing patients and normal individuals might allow us to infer on the association between apathy and neurodegenerative diseases and what can brain imaging markers tell us about the characterization of this association, thus revealing disease patterns, helping to distinguish clinically distinct cognitive syndromes, and allowing predictions.

Copyright
Corresponding author
Correspondence should be addressed to: Christos Theleritis, MD, 1st Psychiatry Department, University of Athens Medical School, Eginition Hopsital, 72–74 Vas. Sofias Avenue, 11528 Athens, Greece. Phone: +30 210 7289324. Email: chtheler@med.uoa.gr; christos.theleritis@kcl.ac.uk.
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

J. M. Allman , A. Hakeem , J. M. Erwin , E. Nimchinsky and P. Hof (2001). The anterior cingulate cortex. The evolution of an interface between emotion and cognition. Annals of the New York Academy of Sciences, 935, 107117. doi:10.1111/j.1749-6632.2001.tb03476.x.

L. G Apostolova . et al. (2007). Structural correlates of apathy in Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 24, 9197. doi:10.1159/000103914.

M. Benoit et al. (1999). Behavioral and psychological symptoms in Alzheimer's disease. Relation between apathy and regional cerebral perfusion. Dementia and Geriatric Cognitive Disorders, 10, 511517. doi:10.1159/000017198.

M. Benoit , S. Clairet , P. M. Koulibaly , J. Darcourt and P. H. Robert (2004). Brain perfusion correlates of the apathy inventory dimensions of Alzheimer's disease. International Journal of Geriatric Psychiatry, 19, 864869. doi:10.1002/gps.1163.

M. Benoit , P. M. Koulibaly , O. Migneco , J. Darcourt , D. J. Pringuey and P. H. Robert (2002). Brain perfusion in Alzheimer's disease with and without apathy: a SPECT study with statistical parametric mapping analysis. Psychiatry Research: Neuroimaging, 114, 103111. doi:10.1016/S0925-4927(02)00003-3.

P. D. Bruen , W. J. McGeown , M. F. Shanks and A. Venneri (2008). Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease. Brain, 131, 24552463. doi:10.1093/brain/awn151.

D. E. Clarke , J. Y. Ko , C. Lyketsos , G. W. Rebok and W. W. Eaton (2010). Apathy and cognitive and functional decline in community-dwelling older adults: results from the Baltimore ECA longitudinal study. International Psychogeriatrics, 22, 819829. doi:10.1017/S1041610209991402.

A. H. Craig et al. (1996). Cerebral blood flow correlates of apathy in Alzheimer disease. Archives of Neurology, 53, 11161120. doi:10.1001/archneur.1996.00550110056012.

J. L. Cummings (1997). The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology, 48 (Suppl. 6), s1016. doi:10.1212/WNL.48.5_Suppl_6.10S.

R. David et al. (2008). Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases: a SPECT study with partial volume effect correction. Clinical Neurology and Neurosurgery, 110, 1924. doi:10.1016/j.clineuro.2007.08.007.

R. L. Drijgers , F. R. Verhey , A. F. Leentjens , S. Köhler and P. Aalten (2011). Neuropsychological correlates of apathy in mild cognitive impairment and Alzheimer's disease: the role of executive functioning. International Psychogeriatrics, 23, 13271333. doi:10.1017/S1041610211001037.

H. C. Guimaraes , R. Levy , A. L. Teixeira , R. G. Beato and P. Caramelli (2008). Neurobiology of apathy in Alzheimer's disease. Arquivos de Neuro-Psiquiatria, 66, 436443. doi:10.1590/S0004-282X2008000300035.

V. A. Holthoff et al. (2005). Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression. Biological Psychiatry, 57, 412421. doi:10.1016/j.biopsych.2004.11.035.

J. Y. Kang et al. (2012). Regional cerebral blood flow abnormalities associated with apathy and depression in Alzheimer disease. Alzheimer Disease and Associated Disorders, 26, 217224. doi:10.1097/WAD.0b013e318231e5fc.

J. W. Kim et al. (2011). Microstructural alteration of the anterior cingulum is associated with apathy in Alzheimer disease. American Journal of Geriatric Psychiatry, 19, 644653. doi:10.1097/JGP.0b013e31820dcc73.

K. L. Lanctôt et al. (2007). A SPECT study of apathy in Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 24, 6572. doi:10.1159/000103633.

A. M. Landes , S. D. Sperry , M. E. Strauss and D. S. Geldmacher (2001). Apathy in Alzheimer's disease. Journal of the American Geriatrics Society, 49, 17001707. doi:10.1046/j.1532-5415.2001.49282.x.

H. Lavretsky et al. (2008). The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementia. International Journal of Geriatric Psychiatry, 23, 10401050. doi:10.1002/gps.2030.

R. Levy and B. Dubois (2006). Apathy and the functional anatomy of the prefrontal cortex-basal Ganglia circuits. Cerebral Cortex, 16, 916928. doi:10.1093/cercor/bhj043.

O. L. Lopez , S. Zivkovic , G. Smith , J. T. Becker , C. C. Meltzer and S. T. DeKosky (2001). Psychiatric symptoms associated with cortical-subcortical dysfunction in Alzheimer's disease. The Journal of Neuropsychiatry and Clinical Neurosciences, 13, 5660. doi:10.1176/appi.neuropsych.13.1.56.

C. Lyketsos (2007). Apathy and agitation: challenges and future directions. American Journal of Geriatric Psychiatry, 15, 361364. doi:10.1097/JGP.0b013e31803d15c1.

C. G. Lyketsos , O. Lopez , B. Jones , A. L. Fitzpatrick , J. Breitner and S. DeKosky (2002). Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA, 288, 14751483. doi:10.1001/jama.288.12.1475.

C. G. Lyketsos , A. Rosenblatt and P. Rabins (2004). Forgotten frontal lobe syndrome or “Executive Dysfunction Syndrome”. Psychosomatics, 45, 247255. doi:10.1176/appi.psy.45.3.247.

C. G. Lyketsos , M. Steinberg , J. T. Tschanz , M. C. Norton , D. C. Steffens and J. C. Breitner (2000). Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging. American Journal of Psychiatry, 157, 708714. doi:10.1176/appi.ajp.157.5.708.

G. A. Marshall , L. A. Fairbanks , S. Tekin , H. V. Vinters and J. L. Cummings (2006). Neuropathologic correlates of apathy in Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 21, 144147. doi:10.1159/000090674.

G. A. Marshall , L. Monserratt , D. Harwood , M. Mandelkern , J. L. Cummings and D. L. Sultzer (2007). Positron emission tomography metabolic correlates of apathy in Alzheimer disease. Archives of Neurology, 64, 10151020. doi:10.1001/archneur.64.7.1015.

M. S. Mega , J. L. Cummings , T. Fiorello and J. Gornbein (1996). The spectrum of behavioral changes in Alzheimer's disease. Neurology, 46, 130135. doi:10.1212/WNL.46.1.130.

M. S. Mega et al. (2005). Metabolic patterns associated with the clinical response to galantamine therapy: a fludeoxyglucose f 18 positron emission tomographic study. Archives of Neurology, 62, 721728. doi:10.1001/archneur.62.5.721.

O. Migneco et al. (2001). Perfusion brain SPECT and statistical parametric mapping analysis indicate that apathy is a cingulate syndrome: a study in Alzheimer's disease and nondemented patients. Neuroimage, 13, 896902. doi:10.1006/nimg.2000.0741.

E. Mulin et al. (2011). Diagnostic criteria for apathy in clinical practice. International Journal of Geriatric Psychiatry, 26, 158165. doi:10.1002/gps.2508.

C. U. Onyike et al. (2007). Epidemiology of apathy in older adults: the Cache County Study. American Journal of Geriatric Psychiatry, 15, 365375. doi:10.1097/01.JGP.0000235689.42910.0d.

M. Ota , N. Sato , Y. Nakata , K. Arima and M. Uno (2012). Relationship between apathy and diffusion tensor imaging metrics of the brain in Alzheimer's disease. International Journal of Geriatric Psychiatry, 27, 722726. doi:10.1002/gps.2779.

A. M. Politis , L. S. Mayer , M. Passa , A. Maillis and C. G. Lyketsos (2004). Validity and reliability of the newly translated Hellenic Neuropsychiatric Inventory (H-NPI) applied to Greek outpatients with Alzheimer's disease: a study of disturbing behaviors among referrals to a memory clinic. International Journal of Geriatric Psychiatry, 19, 203208. doi:10.1002/gps.1215.

P. H. Robert et al. (2006). Lack of initiative and interest in Alzheimer's disease: a single photon emission computed tomography study. European Journal of Neurology, 13, 729735. doi:10.1111/j.1468-1331.2006.01088.x.

P. Robert et al. (2009). Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders. European Psychiatry, 24, 98104. doi:10.1016/j.eurpsy.2008.09.001.

M. L. Schroeter et al. (2011). Dissociating behavioral disorders in early dementia – An FDG-PET study. Psychiatry Research: Neuroimaging, 194, 235244. doi:10.1016/j.pscychresns.2011.06.009.

S. E. Starkstein , G. Petracca , E. Chemerinski and J. Kremer (2001). Syndromic validity of apathy in Alzheimer's disease. American Journal of Psychiatry, 158, 872877. doi:10.1176/appi.ajp.158.6.872.

S. E. Starkstein , R. Mizrahi , A. A. Capizzano , L. Acion , S. Brockman and B. D. Power (2009). Neuroimaging correlates of apathy and depression in Alzheimer's disease. The Journal of Neuropsychiatry and Clinical Neurosciences, 21, 259265. doi:10.1176/appi.neuropsych.21.3.259.

M. Tanaka et al. (2004). Prediction of psychiatric response to donepezil in patients with mild to moderate Alzheimer's disease. Journal of the Neurological Sciences, 225, 135141. doi:10.1016/j.jns.2004.07.009.

S. Tekin et al. (2001). Orbitofrontal and anterior cingulate cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease. Annals of Neurology, 49, 355361. doi:10.1002/ana.72.

S. K. Tighe et al. (2012). Diffusion tensor imaging of neuropsychiatric symptoms in mild cognitive impairment and Alzheimer's dementia. The Journal of Neuropsychiatry and Clinical Neurosciences, 24, 484488. doi:10.1176/appi.neuropsych.11120375.

C. Tunnard et al. (2011). Apathy and cortical atrophy in Alzheimer's disease. International Journal of Geriatric Psychiatry, 26, 741748. doi:10.1002/gps.2603.

J. D. Wallis (2007). Orbitofrontal cortex and its contribution to decision-making. Annual Review of Neuroscience, 30, 3156. doi:10.1146/annurev.neuro.30.051606.094334.

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International Psychogeriatrics
  • ISSN: 1041-6102
  • EISSN: 1741-203X
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