Hostname: page-component-5d59c44645-7l5rh Total loading time: 0 Render date: 2024-02-21T02:52:56.866Z Has data issue: false hasContentIssue false

Assessment of regional MR diffusion changes in dementia with Lewy bodies and Alzheimer's disease

Published online by Cambridge University Press:  16 December 2013

James O'Donovan
Affiliation:
Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle-upon-Tyne, UK
Rosie Watson
Affiliation:
Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle-upon-Tyne, UK
Sean J. Colloby*
Affiliation:
Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle-upon-Tyne, UK
Andrew. M. Blamire
Affiliation:
Newcastle Magnetic Resonance Centre and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
John T. O'Brien
Affiliation:
Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle-upon-Tyne, UK Department of Psychiatry, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK
*
Correspondence should be addressed to: Dr. Sean Colloby, Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle-upon-Tyne, UK. Phone: +44-191-248-1321; Fax: +44-191-248-1301. Email: sean.colloby@ncl.ac.uk.

Abstract

Background:

Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are common forms of dementia, yet diagnosis is often difficult. Diffusion tensor imaging (DTI) is an MR technique used to assess neuronal microstructural integrity that may help develop a better understanding of the differences between the conditions.

Methods:

We recruited subjects with DLB (n = 35), AD (n = 36), and similar aged healthy controls (n = 35). T1 weighted anatomical and diffusion MR images were acquired at 3 Tesla. Region of interest (ROI) analysis was used to measure fractional anisotropy (FA) and mean diffusivity (MD) in five structures: precuneus, thalamus, pons, midbrain, and amygdala. Where appropriate diffusivity measures (FA, MD) were correlated with selected clinical measures.

Results:

Compared to controls, DLB subjects were characterized by reduced FA (p = 0.016) and increased MD (p = 0.007) in the precuneus. Amygdala diffusivity was positively correlated with UPDRS-III score in DLB (p = 0.003). In AD, reduced FA in the precuneus was also observed compared to controls (p = 0.026), and was associated with impaired global cognition (MMSE score) (p = 0.03).

Conclusions:

Our findings highlight the potential importance of the precuneus in the pathogenesis of DLB as well as AD. Diffusion tensor MRI may shed new light on the different neurobiological changes underpinning the key clinical features of DLB and AD.

Type
Research Article
Copyright
Copyright © International Psychogeriatric Association 2013 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bozzali, M. et al. (2005). Brain tissue damage in dementia with Lewy bodies: an in vivo diffusion tensor MRI study. Brain, 128, 15951604.Google Scholar
Bucks, R. S., Ashworth, D. L., Wilcock, G. K. and Siegfried, K. (1996). Assessment of activities of daily living in dementia: development of the Bristol Activities of Daily Living Scale. Age Ageing, 25, 113120.Google Scholar
Cavanna, A. E. and Trimble, M. R. (2006). The precuneus: a review of its functional anatomy and behavioural correlates. Brain, 129, 564583.Google Scholar
Colloby, S. J. et al. (2002). A comparison of 99mTc-HMPAO SPET changes in dementia with Lewy bodies and Alzheimer's disease using statistical parametric mapping. European Journal of Nuclear Medicine, 29, 615622.Google Scholar
Cummings, J. L. et al. (1994). The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology, 44, 23082314.Google Scholar
Fahn, S., Elton, R. and Members of the UPDRS Development Committee (1987). Unified Parkinson's Disease Rating Scale. Florham Park, NJ: Macmillan Healthcare Information.Google Scholar
Firbank, M. J. et al. (2007). Diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease. Psychiatry Research - Neuroimaging, 155, 135145.Google Scholar
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.Google Scholar
Frisoni, G. B. et al. (2002). Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry. Journal of Neurology Neurosurgery and Psychiatry, 73, 657664.Google Scholar
Goldman, W. P. et al. (2001). Absence of cognitive impairment or decline in preclinical Alzheimer's disease. Neurology, 56, 361367.Google Scholar
Kantarci, K. et al. (2010). Dementia with Lewy bodies and Alzheimer disease: neurodegenerative patterns characterized by DTI. Neurology, 74, 18141821.Google Scholar
Kemp, P. M. et al. (2005). The contribution of statistical parametric mapping in the assessment of precuneal and medial temporal lobe perfusion by 99mTc-HMPAO SPECT in mild Alzheimer's and Lewy body dementia. Nuclear Medicine Communications, 26, 10991106.Google Scholar
Kiuchi, K. et al. (2011). White matter changes in dementia with Lewy bodies and Alzheimer's disease: a tractography-ased study. Journal of Psychiatric Research, 45, 10951100.Google Scholar
Le Bihan, D. (2007). The “wet mind”: water and functional neuroimaging. Physics in Medicine and Biology, 52, R57–R90.Google Scholar
Le Bihan, D., Breton, E. and Lallemand, D. (1986). MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology, 161, 401407.Google Scholar
Lee, J. E. et al. (2010). A comparative analysis of cognitive profiles and white-matter alterations using voxel-based diffusion tensor imaging between patients with Parkinson's disease dementia and dementia with Lewy bodies. Journal of Neurology, Neurosurgery and Psychiatry, 81, 320326.Google Scholar
Litvan, I., Bhatia, K., Burn, D. J., Goetz, C. G., Lang, A. E. and Mckeith, I. G. (2003). Movement Disorders Society Scientific Issues Commitee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinson disorders. Movement Disorders, 18, 467486.Google Scholar
Mai, J., Assheuer, J. and Paxinos, G. (1997). Atlas of the Human Brain. San Diego, CA: Academic Press.Google Scholar
McKeith, I. G. et al. (1996). Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology, 47, 11131124.Google Scholar
McKeith, I. G. et al. (2005). Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium. Neurology, 65, 18631872.Google Scholar
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. and Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34, 939944.CrossRefGoogle ScholarPubMed
Medina, D. A. and Gaviria, M. (2008). Diffusion tensor imaging investigations in Alzheimer's disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain. Neuropsychiatric Disease and Treatment, 4, 737742.Google Scholar
Minati, L., Grisoli, M. and Bruzzone, M. G. (2007). MR spectroscopy, functional MRI, and diffusion-tensor imaging in the aging brain: a conceptual review. Journal of Geriatric Psychiatry and Neurology, 20, 321.Google Scholar
Mori, S. and Zhang, J. (2006). Principles of diffusion tensor imaging and its applications to basic neuroscience research. Neuron, 51, 527539.Google Scholar
Ota, M. et al. (2009). Degeneration of dementia with Lewy bodies measured by diffusion tensor imaging. NMR in Biomedicine, 22, 280284.Google Scholar
Popescu, A., Lippa, C. F., Lee, V. M. Y. and Trojanowski, J. Q. (2004). Lewy bodies in the amygdala: increase of α-synuclein aggregates in neurodegenerative diseases with tau-based inclusions. Archives of Neurology, 61, 19151919.Google Scholar
Ringman, J. M. et al. (2007). Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations. Brain, 130, 17671776.Google Scholar
Rodrigue, K. M. et al. (2012). β-amyloid burden in healthy aging: regional distribution and cognitive consequences. Neurology, 78, 387395.Google Scholar
Sheikh, J. I. and Yesavage, J. A. (1986). Geriatric Depression Scale (GDS): Recent evidence and development of a shorter version. Clinical Gerontology, 5, 165173.Google Scholar
Shen, Y. et al. (2004). Correction of high-order eddy current induced geometric distortion in diffusion-weighted echo-planar images. Magnetic Resonance in Medicine, 52, 11841189.Google Scholar
Smith, S. M. et al. (2004). Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage, 23, S208–S219.Google Scholar
Vasconcelos, L. G., Brucki, S. M. D., Jackowiski, A. P. and Bueno, O. F. A. (2009). Diffusion tensor imaging for Alzheimer's disease: a review of concepts and potential clinical applicability. Imagem do tensor de difusão na doença de Alzheimer: Revisão De Conceitos e Potenciais Aplicabilidades Clínicas, 3, 268274.Google Scholar
Walker, M. P. et al. (2000). Quantification and characterisation of fluctuating cognition in dementia with Lewy bodies and Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 11, 327335.Google Scholar
Watson, R. and O'Brien, J. T. (2012). Differentiating dementia with Lewy bodies and Alzheimer's disease using MRI. Neurodegenerative Disease Management, 2, 110.Google Scholar
Watson, R. et al. (2012a). Characterizing dementia with Lewy bodies by means of diffusion tensor imaging. Neurology, 79, 906914.Google Scholar
Watson, R., O'Brien, J. T., Barber, R. and Blamire, A. M. (2012b). Patterns of gray matter atrophy in dementia with Lewy bodies: a voxel-based morphometry study. International Psychogeriatrics, 24, 532540.Google Scholar
Whitwell, J. L. et al. (2007). Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer's disease. Brain, 130, 708719.Google Scholar
Yushkevich, P. A. et al. (2006). User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. Neuroimage, 31, 11161128.Google Scholar