Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 4
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Fiacconi, Chris M. Barkley, Victoria Finger, Elizabeth C. Carson, Nicole Duke, Devin Rosenbaum, R. Shayna Gilboa, Asaf and Köhler, Stefan 2014. Nature and extent of person recognition impairments associated with Capgras syndrome in Lewy body dementia. Frontiers in Human Neuroscience, Vol. 8,


    Goldman, Jennifer G. Williams-Gray, Caroline Barker, Roger A. Duda, John E. and Galvin, James E. 2014. The spectrum of cognitive impairment in Lewy body diseases. Movement Disorders, Vol. 29, Issue. 5, p. 608.


    Krolak-Salmon, P. and Xie, J. 2014. Malattia a corpi di Lewy. EMC - Neurologia, Vol. 14, Issue. 4, p. 1.


    Zweig, Yael R and Galvin, James E 2014. Lewy body dementia: the impact on patients and caregivers. Alzheimer's Research & Therapy, Vol. 6, Issue. 2, p. 21.


    ×

Capgras syndrome in Dementia with Lewy Bodies

  • Papan Thaipisuttikul (a1), Iryna Lobach (a1), Yael Zweig (a1), Ashita Gurnani (a1) and James E. Galvin (a1)
  • DOI: http://dx.doi.org/10.1017/S1041610212002189
  • Published online: 05 December 2012
Abstract
ABSTRACT

Background: Capgras syndrome is characterized by the recurrent, transient belief that a person has been replaced by an identical imposter. We reviewed clinical characteristics of Dementia with Lewy Bodies (DLB) patients with Capgras syndrome compared to those without Capgras.

Methods: We identified 55 consecutive DLB patients (11 cases with Capgras syndrome (DLB-C) and 44 cases without evidence of Capgras (DLB). Semi-structured interviews with the patient and an informant, neurological exams, and neuropsychological testing were performed. Caregivers were assessed for caregiver burden and depression. Primary comparisons were made between DLB-C and DLB. Exploratory analyses using stepwise logistic regression and bootstrap analyses were performed to determine clinical features associated with Capgras.

Results: DLB-C patients experienced more visual hallucinations and self-reported anxiety, had higher scores on the Neuropsychiatric Inventory, and were less likely to be treated with cholinesterase inhibitors at time of initial evaluation. Extrapyramidal symptoms and depression were not associated with Capgras. Caregivers of DLB-C patients had higher caregiver burden. DLB-C was associated with self-reported anxiety (OR = 10.9; 95% CI = 2.6–47.6). In a bootstrap analysis, clinical findings that were predictors of Capgras included visual hallucinations (log(OR) = 18.3; 95% CI = 17.9–19.3) and anxiety (log(OR) = 2.9; 95% CI = 0.31–20.2).

Conclusions: Our study suggests that Capgras syndrome is common in DLB and usually occurs in the presence of anxiety and visual hallucinations, suggesting related etiopathogenesis. Early appreciation of Capgras syndrome may afford the opportunity to alleviate caregiver burden and improve patient and caregiver outcomes.

Copyright
Corresponding author
Correspondence should be addressed to: James E. Galvin, MD, MPH, Comprehensive Center on Brain Aging, Alzheimer Disease Center, New York University Langone Medical Center, 145 East 32nd St, 2nd Floor, New York 10016, NY. Phone: +212-263-3210; Fax: +212-263-3273. Email: James.Galvin@nyumc.org.
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

J. J. Barton (2011). Disorders of higher visual processing. Handbook of Clinical Neurology, 102, 223261.

B. F. Boeve et al. (2011). Validation of Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort. Sleep Medicine, 12, 445453.

J. Brandt , J. Corwin and L. Krafft (1992). Is verbal recognition memory really different in Huntington's and Alzheimer's disease. Journal of Clinical and Experimental Neuropsychology, 14, 773784.

D. B. Carr , S. Gray , J. Baty and J. C. Morris (2000). The value of informant vs. individual's complaints of memory impairment in early dementia. Neurology, 55, 17241726.

A. R. Conway et al. (2005). Working memory span tasks: a methodological review and user's guide. Psychonomic Bulletin Review, 12, 769786.

J. L. Cummings et al. (1987). Neuropsychiatric aspects of multi-infarct dementia and dementia of the Alzheimer type. Archives of Neurology, 44, 389393.

T. J. Ferman et al. (2004). DLB fluctuations: specific features that reliably differentiate DLB from AD and normal aging. Neurology, 62, 181187.

T. E. Fienberg and D. M. Roane (2005). Delusional misidentification. Psychiatric Clinics of North America, 28, 665683.

M. F. Folstein , S. E. Folstein and P. R. McHugh (1975). Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.

S. J. Frazer and J. M. Roberts (1994). Three cases of Capgras’ syndrome. British Journal of Psychiatry, 164, 557559.

J. E. Galvin et al. (2010a). Lewy body dementia: caregiver burden and unmet needs. Alzheimer's Disease and Associated Disorders, 24, 177181.

J. E. Galvin et al. (2010b). Lewy body dementia: the caregiver experience of clinical care. Parkinsonism & Related Disorders, 16, 388392.

M. Harciarek and A. Kertesz (2008). The prevalence of misidentification syndromes in neurodegenerative diseases. Alzheimer's Disease and Associated Disorders, 22, 163169.

A. J. Harding , A. Broe and G. M. Halliday (2002). Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe. Brain, 125, 391403.

K. A. Josephs (2007). Capgras syndrome and its relationship to neurodegenerative disease. Archives of Neurology, 64, 17621766.

D. I. Kaufer et al. (2000). Validation of the NPI-Q: a brief clinical form of the neuropsychiatric inventory. Journal of Neuropsychiatry and Clinical Neuroscience, 12, 233239.

K. Kroenke , R. L. Spitzer and J. B. Williams (2001). The PHQ-9 validity of a brief depression severity measure. Journal of General Internal Medicine, 16, 606613.

A. N. Leggett et al. (2011). Stress and burden among caregivers of patients with Lewy Body Dementia. The Gerontologist, 51, 7685.

A. MacKay , L. T. Connor and M. Storandt (2005). Dementia does not explain correlation between age and scores on Boston Naming Test. Archives of Clinical Neuropsychology, 20, 129133.

I. G. McKeith et al. (2005). Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium. Neurology, 65, 18631872.

E. L. Merrin and P. M. Silberfarb (1976). The Capgras phenomenon. Archives of General Psychiatry, 33, 965968.

J. C. Morris (1993). The Clinical Dementia Rating (CDR) - current version and scoring rules. Neurology, 43, 24122414.

R. M. Reitan (1958). Validity of the Trail Making test as an indicator of organic brain damage. Perception and Motor Skills, 8, 271276.

D. M. Roane et al. (1998). Delusional misidentification in association with parkinsonism. Journal of Neuropsychiatry and Clinical Neuroscience, 10, 194198.

C. K. Rosenberg et al. (2001). Dementia with Lewy Bodies and Alzheimer's disease. Acta Neuropathologica, 102, 621626.

R. P. Snaith (2003). The Hospital Anxiety and Depression Scale. Health and Quality of Life Outcomes, 1, 29.

J. Todd , K. Dewhurst and G. Wallis (1981). The syndrome of Capgras. British Journal of Psychiatry, 139, 319327.

A. K. Troyer et al. (1998). Clustering and switching on verbal fluency tests in Alzheimer's and PD disease. Journal of the International Neuropsychological Society, 4, 137143.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

International Psychogeriatrics
  • ISSN: 1041-6102
  • EISSN: 1741-203X
  • URL: /core/journals/international-psychogeriatrics
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: