Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 58
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Bailey, Whitney A. and Gordon, Sarah R. 2016. Family Caregiving Amidst Age-Associated Cognitive Changes: Implications for Practice and Future Generations. Family Relations, Vol. 65, Issue. 1, p. 225.


    Kim, Sangha Woo, Sook Young Kang, Hyo Shin Lim, Shin Won Choi, Seong Hye Myung, Woojae Jeong, Jee Hyang Lee, Yunhwan Hong, Chang Hyung Kim, Jong Hun Na, HaeRi Carroll, Bernard J. and Kim, Doh Kwan 2016. Factors related to prevalence, persistence, and incidence of depressive symptoms in mild cognitive impairment: vascular depression construct. International Journal of Geriatric Psychiatry, Vol. 31, Issue. 7, p. 818.


    Potter, Guy G. McQuoid, Douglas R. Whitson, Heather E. and Steffens, David C. 2016. Physical frailty in late-life depression is associated with deficits in speed-dependent executive functions. International Journal of Geriatric Psychiatry, Vol. 31, Issue. 5, p. 466.


    St-Hilaire, Alexandre Hudon, Carol Préville, Michel and Potvin, Olivier 2016. Utilization of healthcare services among elderly with cognitive impairment no dementia and influence of depression and anxiety: a longitudinal study. Aging & Mental Health, p. 1.


    Szot, Patricia Franklin, Allyn Miguelez, Cristina Wang, Yangqing Vidaurrazaga, Igor Ugedo, Luisa Sikkema, Carl Wilkinson, Charles W. and Raskind, Murray A. 2016. Depressive-like behavior observed with a minimal loss of locus coeruleus (LC) neurons following administration of 6-hydroxydopamine is associated with electrophysiological changes and reversed with precursors of norepinephrine. Neuropharmacology, Vol. 101, p. 76.


    Wu, Kuan-Yi Liu, Chia-Yih Chen, Cheng-Sheng Chen, Chia-Hsiang Hsiao, Ing-Tsung Hsieh, Chia-Ju Lee, Chin-Pang Yen, Tzu-Chen and Lin, Kun-Ju 2016. Beta-amyloid deposition and cognitive function in patients with major depressive disorder with different subtypes of mild cognitive impairment: 18F-florbetapir (AV-45/Amyvid) PET study. European Journal of Nuclear Medicine and Molecular Imaging, Vol. 43, Issue. 6, p. 1067.


    O'Shea, Deirdre M. Fieo, Robert A. Hamilton, Jamie L. Zahodne, Laura B. Manly, Jennifer J. and Stern, Yaakov 2015. Examining the association between late-life depressive symptoms, cognitive function, and brain volumes in the context of cognitive reserve. International Journal of Geriatric Psychiatry, Vol. 30, Issue. 6, p. 614.


    Peters, Amy T. Jacobs, Rachel H. Crane, Natania A. Ryan, Kelly A. Weisenbach, Sara L. Ajilore, Olusola Lamar, Melissa Kassel, Michelle T. Gabriel, Laura B. West, Amy E. Zubieta, Jon-Kar and Langenecker, Scott A. 2015. Domain-specific impairment in cognitive control among remitted youth with a history of major depression. Early Intervention in Psychiatry, p. n/a.


    Diniz, Breno Satler Reynolds, Charles F. Begley, Amy Dew, Mary Amanda Anderson, Stewart J. Lotrich, Francis Erickson, Kirk I. Lopez, Oscar Aizenstein, Howard Sibille, Etienne L. and Butters, Meryl A. 2014. Brain-derived neurotrophic factor levels in late-life depression and comorbid mild cognitive impairment: A longitudinal study. Journal of Psychiatric Research, Vol. 49, p. 96.


    Ismail, Zahinoor Malick, Arfeen Smith, Eric E Schweizer, Tom and Fischer, Corinne 2014. Depression versus dementia: is this construct still relevant?. Neurodegenerative Disease Management, Vol. 4, Issue. 2, p. 119.


    Koenig, Aaron M. and Butters, Meryl A. 2014. Cognition in Late-Life Depression: Treatment Considerations. Current Treatment Options in Psychiatry, Vol. 1, Issue. 1, p. 1.


    Reinlieb, Michelle Ercoli, Linda M. Siddarth, Prabha St. Cyr, Natalie and Lavretsky, Helen 2014. The Patterns of Cognitive and Functional Impairment in Amnestic and Non-amnestic Mild Cognitive Impairment in Geriatric Depression. The American Journal of Geriatric Psychiatry, Vol. 22, Issue. 12, p. 1487.


    Rushing, Nicole C. Sachs-Ericsson, Natalie and Steffens, David C. 2014. Neuropsychological indicators of preclinical Alzheimer’s disease among depressed older adults. Aging, Neuropsychology, and Cognition, Vol. 21, Issue. 1, p. 99.


    Steffens, David C R McQuoid, Douglas and Potter, Guy G 2014. Amnestic mild cognitive impairment and incident dementia and Alzheimer's disease in geriatric depression. International Psychogeriatrics, Vol. 26, Issue. 12, p. 2029.


    Verma, Rohit Kumar Min, Tan Hui Chakravarthy, Srikumar Barua, Ankur and Kar, Nilamadhab 2014. Sociodemographic Correlates of Unipolar Major Depression among the Chinese Elderly in Klang Valley, Malaysia: An Epidemiological Study. The Scientific World Journal, Vol. 2014, p. 1.


    Wu, Kuan-Yi Hsiao, Ing-Tsung Chen, Cheng-Sheng Chen, Chia-Hsiang Hsieh, Chia-Ju Wai, Yau-Yau Chang, Chee-Jen Tseng, Hsiao-Jung Yen, Tzue-Chen Liu, Chia-Yih and Lin, Kun-Ju 2014. Increased brain amyloid deposition in patients with a lifetime history of major depression: evidenced on 18F-florbetapir (AV-45/Amyvid) positron emission tomography. European Journal of Nuclear Medicine and Molecular Imaging, Vol. 41, Issue. 4, p. 714.


    Leggett, Amanda Zarit, Steven H. Hoang, Chuong N. and Nguyen, Ha T. 2013. Correlates of cognitive impairment in older Vietnamese. Aging & Mental Health, Vol. 17, Issue. 8, p. 915.


    Potter, Guy G. Madden, David J. Costello, Mathew C. and Steffens, David C. 2013. Reduced comparison speed during visual search in late life depression. Journal of Clinical and Experimental Neuropsychology, Vol. 35, Issue. 10, p. 1060.


    Royall, Donald R. and Palmer, Raymond F. 2013. Alzheimer's disease pathology does not mediate the association between depressive symptoms and subsequent cognitive decline. Alzheimer's & Dementia, Vol. 9, Issue. 3, p. 318.


    Zurkovsky, Lilia Taylor, Warren D. and Newhouse, Paul A. 2013. Cognition as a therapeutic target in late-life depression: Potential for nicotinic therapeutics. Biochemical Pharmacology, Vol. 86, Issue. 8, p. 1133.


    ×

Persistent mild cognitive impairment in geriatric depression

  • Jung Sik Lee (a1), Guy G. Potter (a2), H. Ryan Wagner (a2), Kathleen A. Welsh-Bohmer (a2) (a3) and David C. Steffens (a2)
  • DOI: http://dx.doi.org/10.1017/S1041610206003607
  • Published online: 01 July 2006
Abstract

Background: Cognitive impairment often occurs with geriatric depression and impairments may persist despite remission of depression. Although clinical definitions of mild cognitive impairment (MCI) have typically excluded depression, a neuropsychological model of MCI in depression has utility for identifying individuals whose cognitive impairments may persist or progress to dementia.

Methods: At baseline and 1-year follow-up, 67 geriatric patients with depression had a comprehensive clinical examination that included depression assessment and neuropsychological testing. We defined MCI by a neuropsychological algorithm and examined the odds of MCI classification at Year 1 for remitted depressed individuals with baseline MCI, and examined clinical, functional and genetic factors associated with MCI.

Results: Fifty-four percent of the sample had MCI at baseline. Odds of MCI classification at Year 1 were four times greater among patients with baseline MCI than those without. Instrumental activities of daily living were associated with MCI at Year 1, while age and APOE genotype was not.

Conclusions: These results confirm previous observations that MCI is highly prevalent among older depressed adults and that cognitive impairment occurring during acute depression may persist after depression remits. Self-reported decline in functional activities may be a marker for persistent cognitive impairment, which suggests that assessments of both neuropsychological and functional status are important prognostic factors in the evaluation of geriatric depression.

Copyright
Corresponding author
Correspondence should be addressed to: David C. Steffens, Duke University Medical Center, Box 3903, Durham, NC 27710, U.S.A. Phone: +1 919 684 3746; Fax: +1 919 681 7668. Email: steff001@mc.duke.edu.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

International Psychogeriatrics
  • ISSN: 1041-6102
  • EISSN: 1741-203X
  • URL: /core/journals/international-psychogeriatrics
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: