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Twelve-year depressive symptom trajectories and their predictors in a community sample of older adults

  • Carmen Andreescu (a1) (a2), Chou-Chung H. Chang (a3) (a4), Benoit H. Mulsant (a1) (a2) (a5) and Mary Ganguli (a1) (a6) (a7)
Abstract
ABSTRACT

Introduction: The aim of this study is to understand the long-term course and outcomes of depressive symptoms among older adults in the community by examining trajectories of depressive symptoms over time and identifying profiles of depressive symptoms predicting different trajectories.

Method: We measured depressive symptoms biennially for up to 12 years, using the modified Center for Epidemiological Studies-Depression (mCES-D) scale, in 1260 community-based adults aged 65+ years. We determined latent trajectories of total mCES-D scores over time. We identified symptom profiles based on subgroups of baseline depressive symptoms derived from factor analysis, and examined their associations with the different trajectories.

Results: Six trajectories were identified. Two had one or no depressive symptoms at baseline and flat trajectories during follow-up. Two began with low baseline symptom scores and then diverged; female sex and functional disability were associated with future increases in depressive symptoms. Two trajectories began with high baseline scores but had different slopes: the higher trajectory was associated with medical burden, higher overall baseline score, and higher baseline scores on symptom profiles including low self-esteem, interpersonal difficulties, neurovegetative symptoms, and anhedonia. Mortality was higher among those in the higher trajectories.

Conclusions: In the community at large, those with minimal depressive symptoms are more likely to experience future increases in symptoms if they are women and have functional disability. Among those with higher current symptom levels, depression is more likely to persist over time in individuals who have greater medical burden and specific depressive symptoms.

Copyright
Corresponding author
Correspondence should be addressed to: Dr. Carmen Andreescu, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213, U.S.A. Phone +1 412 383 5164; Fax: +1 412 383 5458. Email: andreescuc@upmc.edu.
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A. T. Beekman , J. R. Copeland and M. J. Prince 1999. Review of community prevalence of depression in later life. British Journal of Psychiatry, 174, 307311.

M. L. Bruce , T. E. Seeman , S. S. Merrill and D. G. Blazer 1994. The impact of depressive symptomatology on physical disability: MacArthur Studies of Successful Aging. American Journal of Public Health, 84, 17961799.

D. S. Charney 2003. Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life. Archives of General Psychiatry, 60, 664672.

M. G. Cole and N. Dendukuri 2003. Risk factors for depression among elderly community subjects: a systematic review and meta-analysis. American Journal of Psychiatry, 160, 11471156.

M. A. Dew 1997. Temporal profiles of the course of depression during treatment: predictors of pathways toward recovery in the elderly. Archives of General Psychiatry, 54, 10161024.

J. J. Gallo , P. V. Rabins and J. C. Anthony 1999. Sadness in older persons: 13-year follow-up of a community sample in Baltimore, Maryland. Psychological Medicine, 29, 341350.

M. Ganguli 1993. Sensitivity and specificity for dementia of population-based criteria for cognitive impairment: the MoVIES project. Journal of Gerontology: Medical Sciences, 48, M152161.

M. Ganguli , J. Gilby , E. Seaberg and S. Belle 1995. Depressive symptoms and associated factors in a rural elderly population: the MoVIES Project. American Journal of Geriatric Psychiatry, 3, 144160.

L. L. Judd , P. J. Schettler and H. S. Akiskal 2002. The prevalence, clinical relevance, and public health significance of subthreshold depressions. The Psychiatric Clinics of North America, 25, 685698.

K. S. Kendler , M. Gatz , C. O. Gardner and N. L. Pedersen 2006. Personality and major depression: a Swedish longitudinal, population-based twin study. Archives of General Psychiatry, 63, 11131120.

K. R. Krishnan 2002. Comorbidity of depression with other medical diseases in the elderly. Biological Psychiatry, 52, 559588.

E. J. Lenze 2005. The course of functional decline in older people with persistently elevated depressive symptoms: longitudinal findings from the Cardiovascular Health Study. Journal of the American Geriatrics Society, 53, 569575.

K. M. Mehta , K. Yaffe , K. M. Langa , L. Sands , M. A. Whooley and K. E. Covinsky 2003. Additive effects of cognitive function and depressive symptoms on mortality in elderly community-living adults. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 58, M461467.

R. T. Mulder , P. R. Joyce and S. E. Luty 2003. The relationship of personality disorders to treatment outcome in depressed outpatients. Journal of Clinical Psychiatry, 64, 259264.

E. S. Paykel 1999. Prevention of relapse in residual depression by cognitive therapy: a controlled trial. Archives of General Psychiatry, 56, 829835.

L. Radloff 1977. The CES-D Scale: a self-report depression scale for research in the general population. Applied Psychological Measurement, 1, 385401.

A. B. Shafer 2006. Meta-analysis of the factor structures of four depression questionnaires: Beck, CES-D, Hamilton, and Zung. Journal of Clinical Psychology, 62, 123146.

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International Psychogeriatrics
  • ISSN: 1041-6102
  • EISSN: 1741-203X
  • URL: /core/journals/international-psychogeriatrics
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