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Matters of the heart

  • Rajat Mittal (a1)
Abstract

The contraction of the heart muscle combines with the opening and closing of the cardiac valves to generate a complex flow in the heart. Predicting this flow presents a significant challenge for computational models, a challenge that Meschini et al. (J. Fluid Mech., vol. 834, 2018, pp. 271–307) tackle head-on by simulating not only the flow in a modelled left ventricle of the heart, but also the coupled dynamics of the mitral valve. The model is validated against a well-designed companion experiment and the authors then proceed to examine the effects of cardiac and valvular dysfunction, as well as prosthetic valves, on ventricular haemodynamics. The insights provided by this study extend from the functional morphology of the left ventricle to the implications of the choice of valve implant on ventricular function.

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Copyright
Corresponding author
Email address for correspondence: mittal@jhu.edu
References
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Choi, Y.-J., Vedula, V. & Mittal, R. 2014 Computational study of the dynamics of a bileaflet mechanical heart valve in the mitral position. Ann. Biomed. Engng 42 (8), 16681680.
Meschini, V., de Tullio, M. D., Querzoli, G. & Verzicco, R. 2018 Flow structure in healthy and pathological left ventricles with natural and prosthetic mitral valves. J. Fluid Mech. 834, 271307.
Mittal, R., Seo, J.-H., Vedula, V., Choi, Y. J., Liu, H., Huang, H. H., Jain, S., Younes, L., Abraham, T. & George, R. T. 2016 Computational modeling of cardiac hemodynamics: current status and future outlook. J. Comput. Phys. 305, 10651082.
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Vedula, V., Seo, J.-H., Lardo, A. C. & Mittal, R. 2016 Effect of trabeculae and papillary muscles on the hemodynamics of the left ventricle. Theor. Comput. Fluid Dyn. 30 (1–2), 321.
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Journal of Fluid Mechanics
  • ISSN: 0022-1120
  • EISSN: 1469-7645
  • URL: /core/journals/journal-of-fluid-mechanics
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