Skip to main content
×
Home
    • Aa
    • Aa

Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress

  • Yoshitaka Hirose (a1), Yoshihiro Yamamoto (a1), Yasunobu Yoshikai (a2) and Shinji Murosaki (a1)
Abstract
Abstract

The immunomodulatory effects of live or non-viable lactic acid bacteria have been extensively investigated. We reported that oral intake of heat-killed Lactobacillus plantarum L-137 (HK L-137) augmented innate and acquired immunity in mice and human subjects. To examine the effects of HK L-137 intake on upper respiratory tract infection (URTI) symptoms and immune functions in human subjects, a randomised, double-blind, placebo-controlled, parallel study was conducted in subjects with high psychological stress levels. A total of seventy-eight healthy subjects (thirty-three men and forty-five women; mean age 50·6 years) with scores of >41 on eighteen-item subscales of psychological distress in the Brief Job Stress Questionnaire were randomly assigned to receive a tablet containing HK L-137 (10 mg) or a placebo tablet daily for 12 weeks. The URTI symptoms were rated once daily on the validated twenty-one-item Wisconsin Upper Respiratory Symptom Survey-21. Immune functions, such as concanavalin A-induced proliferation and percentages of interferon (IFN)-γ- and IL-4-producing CD4 T cells of peripheral blood mononuclear cells (PBMC), and serum IFN-β concentrations were measured every 4 weeks. URTI incidence was significantly lower in the HK L-137 group than in the control group. URTI incidence, duration and severity, and duration of medication showed significant negative correlations with duration of HK L-137 intake. The percentage change from baseline of concanavalin A-induced proliferation of PBMC was significantly greater in the HK L-137 group than in the control group. These findings suggest that daily HK L-137 intake can decrease URTI incidence in healthy subjects, possibly through augmentation of immune functions.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress
      Available formats
      ×
Copyright
The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution license <http://creativecommons.org/licenses/by/3.0/>.
Corresponding author
*Corresponding author: Dr Y. Hirose, fax +81 72 778 0892, email Hirose_Yoshitaka@house-wf.co.jp
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

3. N Yasui , M Watanabe , Y Iwao , (1999) Laparoscopically assisted bowel resection for primary mucosa-associated lymphoid tissue lymphoma of the cecum. Surg Laparosc Endosc Percutan Tech 9, 156159.

4. R Clancy (2003) Immunobiotics and the probiotic evolution. FEMS Immunol Med Microbiol 38, 912.

5. S Murosaki , Y Yamamoto , K Ito , (1998) Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen-specific IgE production by stimulation of IL-12 production in mice. J Allergy Clin Immunol 102, 5764.

6. S Murosaki , K Muroyama , Y Yamamoto , (2000) Antitumor effect of heat-killed Lactobacillus plantarum L-137 through restoration of impaired interleukin-12 production in tumor-bearing mice. Cancer Immunol Immunother 49, 157164.

8. T Fujiki , Y Hirose , Y Yamamoto , (2012) Enhanced immunomodulatory activity and stability in simulated digestive juices of Lactobacillus plantarum L-137 by heat treatment. Biosci Biotechnol Biochem 76, 918922.

10. N Maeda , R Nakamura , Y Hirose , (2009) Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice. Int Immunopharmacol 9, 11221125.

11. Y Arimori , R Nakamura , Y Hirose , (2012) Daily intake of heat-killed Lactobacillus plantarum L-137 enhances type I interferon production in healthy humans and pigs. Immunopharmacol Immunotoxicol 34, 937943.

12. S Kaminogawa & M Nanno (2004) Modulation of immune functions by foods. Evid Based Complement Alternat Med 1, 241250.

13. MR Irwin & SW Cole (2011) Reciprocal regulation of the neural and innate immune systems. Nat Rev Immunol 11, 625632.

15. S Cohen , DA Tyrrell & AP Smith (1993) Negative life events, perceived stress, negative affect, and susceptibility to the common cold. J Pers Soc Psychol 64, 131140.

17. JR Kerr & DL Mattey (2008) Preexisting psychological stress predicts acute and chronic fatigue and arthritis following symptomatic parvovirus B19 infection. Clin Infect Dis 46, e83e87.

18. RM Douglas (1999) Respiratory tract infections as a public health challenge. Clin Infect Dis 28, 192194.

20. B Barrett , RL Brown , MP Mundt , (2009) Validation of a short form Wisconsin Upper Respiratory Symptom Survey (WURSS-21). Health Qual Life Outcomes 7, 76.

22. M Gleeson , NC Bishop , M Oliveira , (2011) Daily probiotic's (Lactobacillus casei Shirota) reduction of infection incidence in athletes. Int J Sport Nutr Exerc Metab 21, 5564.

23. NP West , DB Pyne , AW Cripps , (2011) Lactobacillus fermentum (PCC®) supplementation and gastrointestinal and respiratory-tract illness symptoms: a randomised control trial in athletes. Nutr J 10, 30.

24. V Neville , M Gleeson & JP Folland (2008) Salivary IgA as a risk factor for upper respiratory infections in elite professional athletes. Med Sci Sports Exerc 40, 12281236.

25. P Openshaw , EE Murphy , NA Hosken , (1995) Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J Exp Med 182, 13571367.

26. M Friedman (1937) The use of ranks to avoid the assumption of normality implicit in the analysis of variance. J Am Stat Assoc 32, 675701.

27. WJ Conover & RL Iman (1981) Rank transformation as a bridge between parametric and non-parametric statistics. Am Statistician 35, 124129.

28. K Hatakka , E Savilahti , A Ponka , (2001) Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial. BMJ 322, 1327.

32. K Van Puyenbroeck , N Hens , S Coenen , (2012) Efficacy of daily intake of Lactobacillus casei Shirota on respiratory symptoms and influenza vaccination immune response: a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents. Am J Clin Nutr 95, 11651171.

34. H Besedovsky , A del Rey , E Sorkin (1986) Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233, 652654.

36. F Berkenbosch , J van Oers , A del Rey , (1987) Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science 238, 524526.

37. DM Nance & VM Sanders (2007) Autonomic innervation and regulation of the immune system (1987–2007). Brain Behav Immun 21, 736745.

38. HJ Lee , N Takemoto , H Kurata , (2000) GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. J Exp Med 192, 105115.

39. P Panina-Bordignon , D Mazzeo , PD Lucia , (1997) Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12. J Clin Invest 100, 15131519.

42. SW Cole , JM Arevalo , R Takahashi , (2010) Computational identification of gene–social environment interaction at the human IL6 locus. Proc Natl Acad Sci U S A 107, 56815686.

43. KM Grebe , K Takeda , HD Hickman , (2009) Cutting edge: sympathetic nervous system increases proinflammatory cytokines and exacerbates influenza A virus pathogenesis. J Immunol 184, 540544.

46. DJ Shedlock & H Shen (2003) Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300, 337339.

49. M Blazik , P Hutchinson , MD Jose , (2005) Leukocyte phenotype and function predicts infection risk in renal transplant recipients. Nephrol Dial Transplant 20, 22262230.

50. E Rodrigo , M Lopez-Hoyos , M Corral , (2012) ImmuKnow as a diagnostic tool for predicting infection and acute rejection in adult liver transplant recipients: a systematic review and meta-analysis. Liver Transpl 18, 12451253.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of Nutritional Science
  • ISSN: 2048-6790
  • EISSN: 2048-6790
  • URL: /core/journals/journal-of-nutritional-science
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 6
Total number of PDF views: 124 *
Loading metrics...

Abstract views

Total abstract views: 212 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 24th March 2017. This data will be updated every 24 hours.