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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

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  • Journal of the International Neuropsychological Society, Volume 17, Issue 6
  • November 2011, pp. 1030-1038

Establishing, versus Maintaining, Brain Function: A Neuro-computational Model of Cortical Reorganization after Injury to the Immature Brain

  • Sreedevi Varier (a1), Marcus Kaiser (a1) (a2) (a3) and Rob Forsyth (a2)
  • DOI: http://dx.doi.org/10.1017/S1355617711000993
  • Published online: 16 September 2011
Abstract
Abstract

The effect of age at injury on outcome after acquired brain injury (ABI) has been the subject of much debate. Many argue that young brains are relatively tolerant of injury. A contrasting viewpoint due to Hebb argues that greater system integrity may be required for the initial establishment of a function than for preservation of an already-established function. A neuro-computational model of cortical map formation was adapted to examine effects of focal and distributed injury at various stages of development. This neural network model requires a period of training during which it self-organizes to establish cortical maps. Injuries were simulated by lesioning the model at various stages of this process and network function was monitored as “development” progressed to completion. Lesion effects are greater for larger, earlier, and distributed (multifocal) lesions. The mature system is relatively robust, particularly to focal injury. Activities in recovering systems injured at an early stage show changes that emerge after an asymptomatic interval. Early injuries cause qualitative changes in system behavior that emerge after a delay during which the effects of the injury are latent. Functions that are incompletely established at the time of injury may be vulnerable particularly to multifocal injury. (JINS, 2011, 17, 1030–1038)

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Corresponding author
Correspondence and reprint requests to: Rob Forsyth, Institute of Neuroscience, Newcastle University, Sir James Spence Building, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, United Kingdom. E-mail: rob.forsyth@newcastle.ac.uk
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V. Anderson , M. Spencer-Smith , R. Leventer , L. Coleman , P. Anderson , J. Williams , R. Jacobs (2009a). Reply: Early plasticity versus early vulnerability: The problem of heterogeneous lesion mechanism. Brain, 132(10), e129. doi:10.1093/brain/awp199

V. Anderson , M. Spencer-Smith , R. Leventer , L. Coleman , P. Anderson , J. Williams , R. Jacobs (2009b). Childhood brain insult: Can age at insult help us predict outcome? (with corrigendium Brain (2010) vol. 133 pp. 2505)). Brain, 132(Pt 1), 4556. doi:10.1093/brain/awn293

A. Basu , S. Graziadio , M. Smith , G.J. Clowry , G. Cioni , J.A. Eyre (2010). Developmental plasticity connects visual cortex to motoneurons after stroke. Annals of Neurology, 67(1), 132136. doi:10.1002/ana.21827

Y. Chen , J.A. Reggia (1996). Alignment of coexisting cortical maps in a motor control model. Neural Comput, 8(4), 731755.

S. Cho , J.A. Reggia (1994). Map formation in proprioceptive cortex. International Journal of Neural Systems, 5(2), 87101.

S.C. Cramer , M. Chopp (2000). Recovery recapitulates ontogeny. Trends in Neurosciences, 23(6), 265271.

A.M. Devlin , J.H. Cross , W. Harkness , W.K. Chong , B. Harding , F. Vargha-Khadem , B.G. Neville (2003). Clinical outcomes of hemispherectomy for epilepsy in childhood and adolescence. Brain, 126(Pt 3), 556566.

N.U. Dosenbach , B. Nardos , A.L. Cohen , D.A. Fair , J.D. Power , J.A. Church , B.L. Schlaggar (2010). Prediction of individual brain maturity using fMRI. Science, 329(5997), 13581361. doi:10.1126/science.1194144

J.A. Eyre (2007). Corticospinal tract development and its plasticity after perinatal injury. Neuroscience and Biobehavioral Reviews, 31(8), 11361149. doi:10.1016/j.neubiorev.2007.05.011

J.A. Eyre , M. Smith , L. Dabydeen , G.J. Clowry , E. Petacchi , R. Battini , G. Cioni (2007). Is hemiplegic cerebral palsy equivalent to amblyopia of the corticospinal system? Annals of Neurology, 62(5), 493503. doi:10.1002/ana.21108

D.A. Fair , A.H. Choi , Y.B. Dosenbach , R.S. Coalson , F.M. Miezin , S.E. Petersen , B.L. Schlaggar (2010). The functional organization of trial-related activity in lexical processing after early left hemispheric brain lesions: An event-related fMRI study. Brain and Language, 114(2), 135146. doi:10.1016/j.bandl.2009.09.001

S. Goodall , J.A. Reggia , Y. Chen , E. Ruppin , C. Whitney (1997). A computational model of acute focal cortical lesions. Stroke, 28(1), 101109.

D. Graham , T. McIntosh , W. Maxwell , J. Nicoll (2000). Recent advances in neurotrauma. Journal of Neuropathology and Experimental Neurology, 59(8), 641651.

C.E. Han , M.A. Arbib , N. Schweighofer (2008). Stroke rehabilitation reaches a threshold. PLoS Computational Biology, 4(8), e1000133. doi:10.1371/journal.pcbi.1000133

K. Lidzba , M. Wilke , M. Staudt , I. Krageloh-Mann (2009). Early plasticity versus early vulnerability: The problem of heterogeneous lesion types. Brain, 132(10), e128. doi:10.1093/brain/awp197

R. Nudo , E.J. Plautz , S. Frost (2001). Role of adaptive plasticity in recovery of function after damage to motor cortex. Muscle and Nerve, 24, 10001019.

R.C. O'Reilly , M.H. Johnson (1994). Object recognition and sensitive periods: A computational analysis of visual imprinting. Neural Comput, 6, 357389.

B.R. Payne , S.G. Lomber (2001). Reconstructing functional systems after lesions of cerebral cortex. Nature Reviews. Neuroscience, 2(12), 911919. doi:10.1038/35104085

K.E. Saatman , A.C. Duhaime , R. Bullock , A.I. Maas , A. Valadka , G.T. Manley , & Workshop Scientific Team and Advisory Panel Members. (2008). Classification of traumatic brain injury for targeted therapies. Journal of Neurotrauma, 25(7), 719738. doi:10.1089/neu.2008.0586

G.E. Schneider (1979). Is it really better to have your brain lesion early? A revision of the “Kennard principle”. Neuropsychologia, 17(6), 557583.

R. Stargatt , J.V. Rosenfeld , V. Anderson , T. Hassall , W. Maixner , D. Ashley (2006). Intelligence and adaptive function in children diagnosed with brain tumour during infancy. Journal of Neuro-oncology, 80(3), 295303. doi:10.1007/s11060-006-9187-0

J. Stiles , J. Reilly , B. Paul , P. Moses (2005). Cognitive development following early brain injury: Evidence for neural adaptation. Trends in Cognitive Science, 9(3), 136143. doi:10.1016/j.tics.2005.01.002

M.S. Thomas , M.H. Johnson (2006). The computational modeling of sensitive periods. Developmental Psychobiology, 48(4), 337344. doi:10.1002/dev.20134

M.S. Thomas , M.H. Johnson (2008). New advances in understanding sensitive periods in brain development. Current Directions in Psychological Science, 17(1), 15.

L.Q. Uddin (2010). Typical and atypical development of functional human brain networks: Insights from resting-state fMRI. Frontiers in Systems Neuroscience, 4, 112. doi:10.3389/fnsys.2010.00021

F. Vargha-Khadem , L.J. Carr , E. Isaacs , E. Brett , C. Adams , M. Mishkin (1997). Onset of speech after left hemispherectomy in a nine-year-old boy. Brain, 120(Pt 1), 159182.

C. Webb , F.D. Rose , D.A. Johnson , E.A. Attree (1996). Age and recovery from brain injury: Clinical opinions and experimental evidence. Brain Injury, 10(4), 303310.

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