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Memory Complaints with and without Memory Impairment: The Impact of Leukoaraiosis on Cognition

  • Melissa Lamar (a1), Thomas M. Dannhauser (a2) (a3), Zuzana Walker (a2) (a3), Joanne E. Rodda (a2) (a3), Darren J. Cutinha (a2) (a3) and Sukhwinder S. Shergill (a1)...

White matter alterations, leukoaraiosis (LA) on structural MRI, are associated with cognitive deficits and increased risk of dementia. LA may also impact on subjective memory complaints in otherwise healthy older adults. Little is known about the interplay between LA memory complaints and cognition. We investigated cognitive phenotypes associated with LA in 42 non-demented older adults categorized as having subjective cognitive complaints with no objective cognitive impairment—the subjective cognitive impairment group (SCI; n = 12), amnesic mild cognitive impairment (aMCI; n = 20), or healthy controls (HC; n = 11). We measured LA severity on MRI with a 40-point visual rating scale. Controlling for age and Mini-Mental State Examination (MMSE) score, analyses revealed multiple between-group differences. Follow-up linear regression models investigating the underlying contributors to each clinic group's cognitive profile indicated that LA contributed to learning slope variance (after accounting for age and MMSE) but only for the SCI group. Although the SCI group showed a significantly steeper learning slope when compared to HC and aMCI, increasing LA severity negatively impacted this group's rate of learning. This, in conjunction with the significant contribution of age on SCI learning slope performance variance suggests that greater LA burden at a younger age may contribute to subtle changes in learning for individuals with subjective cognitive complaints. (JINS, 2011, 17, 1104–1112)

Corresponding author
Correspondence and reprint requests to: Melissa Lamar, Department of Psychology, Institute of Psychiatry, King's College London, Box P077 De Crespigny Park, London SE5. E-mail:
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G.S. Alexopoulos , R.C. Abrams , R.C. Young , C.A. Shamoian (1988). Use of the Cornell scale in nondemented patients. Journal of the American Geriatric Society, 36(3), 230236.

L.G. Apostolova , L. Mosconi , P.M. Thompson , A.E. Green , K.S. Hwang , A. Ramirez , M.J. de Leon (2010). Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal. Neurobiology of Aging, 31(7), 10771088.

H.A. Archer , F. Macfarlane , S. Price , E.K. Moore , T. Pepple , D. Cutler , M.N. Rossor (2006). Do symptoms of memory impairment correspond to cognitive impairment: A cross sectional study of a clinical cohort. International Journal of Geriatric Psychiatry, 21(12), 12061212.

T.M. Dannhauser , S.S. Shergill , T. Stevens , L. Lee , M. Seal , R.W. Walker , Z. Walker (2008). An fMRI study of verbal episodic memory encoding in amnestic mild cognitive impairment. Cortex, 44(7), 869880.

J.C. de Groot , F.E. de Leeuw , M. Oudkerk , A. Hofman , J. Jolles , M.M. Breteler (2001). Cerebral white matter lesions and subjective cognitive dysfunction: The Rotterdam Scan Study. Neurology, 56(11), 15391545.

L. Delano-Wood , M.W. Bondi , A.J. Jak , N.R. Horne , B.C. Schweinsburg , L.R. Frank , D.P. Salmon (2008). Stroke risk modifies regional white matter differences in mild cognitive impairment. Neurobiology of Aging, 31, 17211731.

C. Dufouil , R. Fuhrer , A. Alperovitch (2005). Subjective cognitive complaints and cognitive decline: Consequence or predictor? The epidemiology of vascular aging study. Journal of the American Geriatric Society, 53(4), 616621.

M.R. Folstein , S.E. Folstein , P.R. McHugh (1975). Mini-mental state: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.

V.C. Hachinski , L.D. Iliff , E. Zilhka , G.H. Du Boulay , V.L. McAllister , J. Marshall , L. Symon (1975). Cerebral blood flow in dementia. Archives of Neurology, 32(9), 632637.

F.A. Huppert , C. Brayne , C. Gill , E.S. Paykel , L. Beardsall (1995). CAMCOG--A concise neuropsychological test to assist dementia diagnosis: Socio-demographic determinants in an elderly population sample. British Journal of Clinical Psychology, 34(Pt 4), 529541.

F. Jessen , B. Wiese , C. Bachmann , S. Eifflaender-Gorfer , F. Haller , H. Kolsch , H. Bickel (2010). Prediction of dementia by subjective memory impairment: Effects of severity and temporal association with cognitive impairment. Archives of General Psychiatry, 67(4), 414422.

C. Junque , J. Pujol , P. Vendrell , O. Bruna , M. Jodar , J. Ribas , J.L. Marti-Vilalta (1990). Leuko-araiosis on magnetic resonance imaging and speed of mental processing. Archives of Neurology, 47(2), 151156.

O.L. Lopez , W.J. Jagust , C. Dulberg , J.T. Becker , S.T. DeKosky , A. Fitzpatrick , L.H. Kuller (2003). Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: Part 2. Archives of Neurology, 60(10), 13941399.

C.G. Lyketsos , L. Toone , J. Tschanz , P.V. Rabins , M. Steinberg , C.U. Onyike , M. Williams (2005). Population-based study of medical comorbidity in early dementia and “cognitive impairment, no dementia (CIND)”: Association with functional and cognitive impairment: The Cache County Study. American Journal of Geriatric Psychiatry, 13(8), 656664.

T.S. Minett , J.L. Dean , M. Firbank , P. English , J.T. O'Brien (2005). Subjective memory complaints, white-matter lesions, depressive symptoms, and cognition in elderly patients. American Journal of Geriatric Psychiatry, 13(8), 665671.

J.C. Morris (1993). The Clinical Dementia Rating (CDR): Current version and scoring rules. Neurology, 43(11), 24122414.

M. O'Sullivan , D.K. Jones , P.E. Summers , R.G. Morris , S.C. Williams , H.S. Markus (2001). Evidence for cortical “disconnection” as a mechanism of age-related cognitive decline. Neurology, 57(4), 632638.

A. Oulhaj , G.K. Wilcock , A.D. Smith , C.A. de Jager (2009). Predicting the time of conversion to MCI in the elderly: Role of verbal expression and learning. Neurology, 73(18), 14361442.

R.C. Petersen , R. Doody , A. Kurz , R.C. Mohs , J.C. Morris , P.V. Rabins , B. Winblad (2001). Current concepts in mild cognitive impairment. Archives of Neurology, 58(12), 19851992.

R.C. Petersen , G.E. Smith , S.C. Waring , R.J. Ivnik , E.G. Tangalos , E. Kokmen (1999). Mild cognitive impairment: Clinical characterization and outcome. Archives of Neurology, 56(3), 303308.

C.C. Price , A.L. Jefferson , J.G. Merino , K.M. Heilman , D.J. Libon (2005). Subcortical vascular dementia: Integrating neuropsychological and neuroradiologic data. Neurology, 65(3), 376382.

J.E. Rodda , T.M. Dannhauser , D.J. Cutinha , S.S. Shergill , Z. Walker (2009). Subjective cognitive impairment: Increased prefrontal cortex activation compared to controls during an encoding task. International Journal of Geriatric Psychiatry, 24(8), 865874.

M. Roth , E. Tym , C.Q. Mountjoy , F.A. Huppert , H. Hendrie , S. Verma , R. Goddard (1986). CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. British Journal of Psychiatry, 149, 698709.

K. Sharpe , R. O'Carroll (1991). Estimating premorbid intellectual level in dementia using the National Adult Reading Test: A Canadian study. British Journal of Clinical Psychology, 30(Pt 4), 381384.

R. Stewart , C. Dufouil , O. Godin , K. Ritchie , P. Maillard , N. Delcroix , C. Tzourio (2008). Neuroimaging correlates of subjective memory deficits in a community population. Neurology, 70(18), 16011607.

E.C. van Straaten , D. Harvey , P. Scheltens , F. Barkhof , R.C. Petersen , L.J. Thal , C. DeCarli (2008). Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia. Journal of Neurology, 255(9), 13021308.

A.G. Yip , A.C. McKee , R.C. Green , J. Wells , H. Young , L.A. Cupples , L.A. Farrer (2005). APOE, vascular pathology, and the AD brain. Neurology, 65(2), 259265.

A.S. Zigmond , R.P. Snaith (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica, 67(6), 361370.

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Journal of the International Neuropsychological Society
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  • EISSN: 1469-7661
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