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Neuropsychological profiles of patients with obsessive-compulsive disorder: early onset versus late onset

  • SEON HEE HWANG (a1) (a2), JUN SOO KWON (a1) (a3) (a4), YONG-WOOK SHIN (a1) (a2), KYUNG JIN LEE (a4), YOUNG YOUN KIM (a1) (a4) and MYUNG-SUN KIM (a2)...

In this study, we assess the neuropsychological profiles of both early and late symptom-onset obsessive-compulsive disorder (OCD) patients. The early and late-onset OCD patients are compared to the control group with a series of neuropsychological measurements. The late-onset OCD patients exhibited impaired performance on the immediate and the delayed recall conditions of the Rey-Osterrieth Complex Figure Test (RCFT) and the letter and category fluency of the Controlled Oral Word Association Test (COWA), compared to the normal controls and the early-onset OCD patients. The controls and early-onset OCD patients did not differ on any of the neuropsychological measurements taken in this study. These results suggest that different neurophysiological mechanisms are in play in early and late-onset OCD patients, and age of onset can serve as a potential marker for the subtyping of OCD. (JINS, 2007, 13, 30–37.)

Corresponding author
Correspondence and reprint requests to: Dr. Jun Soo Kwon, Professor, Department of Psychiatry, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, Korea 110-744. E-mail:
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