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Noradrenergic Moderation of Working Memory Impairments in Adults with Autism Spectrum Disorder

  • Kimberly E. Bodner (a1), David Q. Beversdorf (a1) (a2), Sanjida S. Saklayen (a3) and Shawn E. Christ (a1)
Abstract
Abstract

In addition to having difficulties with social communications, individuals with an autism spectrum disorder (ASD) often also experience impairment in higher-order, executive skills. The present study examined the effects of pharmacological modulation of the norepinephrine system on the severity of such impairments. A sample of 14 high-functioning adults with ASD and a demographically-matched comparison group of 13 typically developing individuals participated. An AX continuous performance test (AX-CPT) was used to evaluate working memory and inhibitory control. AX-CPT performance was assessed following administration of a single dose of propranolol (a beta adrenergic antagonist) and following placebo (sugar pill) administration. Individuals with ASD performed more poorly than non-ASD individuals in the working memory condition (BX trials). Importantly, administration of propranolol attenuated this impairment, with the ASD group performing significantly better in the propranolol condition than the placebo condition. Working memory performance of the non-ASD group was unaffected by propranolol/placebo administration. No group or medication effects were observed for the inhibition condition (AY trials). The present findings suggest that norepinephrine may play a role in some, but not necessarily all, cognitive impairments associated with ASD. Additional research is needed to fully understand whether this role is primarily causal or compensatory in nature. (JINS, 2012, 18, 556–564)

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Corresponding author
Correspondence and reprint requests to: Shawn E. Christ, Department of Psychological Sciences, 210 McAlester Hall, University of Missouri, Columbia, MO 65203. E-mail: christse@missouri.edu
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N. Adleman , V. Menon , C. Blasey , C. White , I. Warsofsky , G. Glover , A. Reiss (2002). A developmental fMRI study of the Stroop color-word task. Neuroimage, 16, 6175. doi:10.1006/nimg.2001.1046

J.K. Alexander , A. Hillier , R.M. Smith , M.E. Tivarus , D.Q. Beversdorf (2007). Beta-adrenergic modulation of cognitive flexibility during stress. Journal of Cognitive Neuroscience, 19, 468478. doi:10.1162/jocn.2007.19.3.468

A.F. Arnsten (1998). Catecholamine modulation of prefrontal cortical cognitive function. Trends in Cognitive Sciences, 2, 436447. doi:10.1016/S1364-6613(98)01240-6

G. Aston-Jones , J. Rajkowski , J. Cohen (1999). Role of locus coeruleus in attention and behavioral flexibility. Biological Psychiatry, 46, 13091320. doi:10.1016/S0006-3223(99)00140-7

C. Barthelemy , N. Bruneau , J.M. Cottet-Eymard , J. Domenech-Jouve , B. Garreau , G. Lelord , L. Pyrin (1988). Urinary free and conjugated catecholamines and metabolites in autistic children. Journal of Autism and Developmental Disorders, 18, 583591. doi:10.1007/BF02211876

D.Q. Beversdorf , A.L. Carpenter , R.F. Miller , J.S. Cios , A. Hillier (2008). Effect of propranolol on verbal problem solving in autism spectrum disorder. Neurocase, 14, 378. doi:10.1080/13554790802368661

B. Buchsbaum , S. Greer , W. Chang , K. Berman (2005). Meta-analysis of neuroimaging studies of the Wisconsin Card-Sorting Task and component processes. Human Brain Mapping, 25, 3545. doi:10.1002/hbm.20128

H.L. Campbell , M.E. Tivarus , A. Hillier , D.Q. Beversdorf (2008). Increased task difficulty results in greater impact of noradrenergic modulation of cognitive flexibility. Pharmacology Biochemistry and Behavior, 88, 222229. doi:10.1016/j.pbb.2007.08.003

S.E. Christ , D.D. Holt , D.A. White , L. Green (2007). Inhibitory control in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 37, 11551165. doi:10.1007/s10803-006-0259-y

D. Chugani , O. Muzik , R. Rothermel , M. Behen , P. Chakraborty , T. Mangner , H.T. Chugani (1997). Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys. Annals of Neurology, 42, 666669. doi:10.1111/j.1460-9568.1997.tb01635.x

J.T. Coull , C.D. Frith , R.J. Dolan , R.S. Frackowiak , P.M. Grasby (1997). The neural correlates of the noradrenergic modulation of human attention, arousal and learning. European Journal of Neuroscience, 9, 589598. doi:10.1111/j.1460-9568.1997.tb01635.x

J.T. Coull , H.C. Middleton , T.W. Robbins , B.J. Sahakian (1995a). Clonidine and diazepam have differential effects on tests of attention and learning. Psychopharmacology, 120, 322332. doi:10.1007/BF02311180

J.T. Coull , H.C. Middleton , T.W. Robbins , B.J. Sahakian (1995b). Contrasting effects of clonidine and diazepam on tests of working memory and planning. Psychopharmacology, 120, 311321. doi:10.1007/BF02311179

E. Hill (2004). Executive dysfunction in autism. Trends in Cognitive Science, 8, 2632. doi:10.1016/j.tics.2003.11.003

P. Jäkälä , M. Riekkinen , J. Sirviö , E. Koivisto , K. Kejonen , M. Vanhanen , P. Riekkinen (1999). Guanfacine, but not clonidine, improves planning and working memory performance in humans. Neuropsychopharmacology, 20, 460470. doi:10.1016/S0893-133X(98)00127-4

C.A. Jaselskis , Jr. E.H. Cook , K.E. Fletcher , B.L. Leventhal (1992). Clonidine treatment of hyperactive and impulsive children with autistic disorder. Journal of Clinical Psychopharmacology, 12, 322327. doi:10.1097/00004714-199210000-00005

M.A. Just , V. Cherkassky , T. Keller , R.K. Kana , N.J. Minshew (2007). Functional and anatomical cortical underconnectivity in autism: Evidence from an fMRI study of an executive function task and corpus callosum morphometry. Cerebral Cortex, 17, 951961. doi:10.1093/cercor/bhl006

B.J. Kelley , K.R. Yeager , T.H. Pepper , R.A. Bornstein , D.Q. Beversdorf (2007). The effect of propranolol on cognitive flexibility and memory in acute cocaine withdrawal. Neurocase, 13, 320327. doi:10.1080/13554790701846148

L. Kenworthy , B. Yerys , L. Anthony , G. Wallace (2008). Understanding executive control in autism spectrum disorders in the lab and in the real world. Neuropsychology Review, 18, 320338. doi:10.1007/s11065-008-9077-7

H. Koshino , R.K. Kana , T.A. Keller , V.L. Cherkassky , N.J. Minshew , M.A. Just (2008). fMRI investigation of working memory for faces in autism: Visual coding and underconnectivity with frontal areas. Cerebral Cortex, 18, 289300. doi:10.1093/cercor/bhm054

J. Levitt , R. Blanton , S. Smalley , P. Thompson , D. Guthrie , J. McCracken , A.W. Toga (2003). Cortical sulcal maps in autism. Cerebral Cortex, 13, 728735. doi:10.1093/cercor/13.7.728

C. Lord , M. Rutter , A. Le Couteur (1994). Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659685. doi:10.1007/BF02172145

B. Milner , M. Petrides (1984). Behavioural effects of frontal-lobe lesions in man. Trends in Neurosciences, 7, 403407. doi:10.1016/S0166-2236(84)80143-5

R. Muhle , S.V. Trentacoste , I. Rapin (2004). The genetics of autism. Pediatrics, 113, e472e486. doi:10.1542/peds.113.5.e472

S.M. Myers , C.P. Johnson (2007). Management of children with autism spectrum disorders. Pediatrics, 120, 11621182. doi:10.1542/peds.2007-2362

A. Narayanan , C.A. White , S. Saklayen , M.J. Scaduto , A.L. Carpenter , A. Abduljalil , D.Q. Beversdorf (2010). Effect of propranolol on functional connectivity in autism spectrum disorder: A pilot study. Brain Imaging and Behavior, 4, 189197. doi:10.1007/s11682-010-9098-8

T. Ohnishi , H. Matsuda , T. Hashimoto , T. Kunihiro , M. Nishikawa , T. Uema , M. Sasaki (2000). Abnormal regional blood flow in childhood autism. Brain, 123, 18381844. doi:10.1093/brain/123.9.1838

B.F. Pennington , S. Ozonoff (1996). Executive functions and developmental psychopathology. Journal of Child Psychology & Psychiatry, 37, 5187. doi:10.1111/j.1469-7610.1996.tb01380.x

D.J. Posey , J.I. Puntney , T.M. Sasher , D.L. Kem , C.J. McDougle (2004). Guanfacine treatment of hyperactivity and inattention in pervasive developmental disorders: A retrospective analysis of 80 cases. Journal of Child and Adolescent Psychopharmacology, 14, 233241. doi:10.1089/1044546041649084

A.E. Purcell , O.H. Jeon , A.W. Zimmerman , M.E. Blue , J. Pevsner (2001). Postmortem brain abnormalities of the glutamate neurotransmitter system in autism. Neurology, 57, 16181628. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11706102

C.A. Riccio , C.R. Reynolds , P. Lowe , J.J. Moore (2002). The continuous performance test: A window on the neural substrates for attention? Archives of Clinical Neuropsychology, 17, 235272. doi:10.1016/S0887-6177(01)00111-1

T. Shallice (1982). Specific impairments of planning. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 298, 199209. doi:10.1098/rstb.1982.0082

D.L. Williams , G. Goldstein , N.J. Minshew (2006). The profile of memory function in children with autism. Neuropsychology, 20, 2129. doi:10.1037/0894-4105.20.1.21

D.L. Williams , G. Goldstein , P.A. Carpenter , N.J. Minshew (2005). Verbal and spatial working memory in autism. Journal of Autism and Developmental Disorders, 35, 747756. doi:10.1007/s10803-005-0021-x

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