Skip to main content
×
Home
    • Aa
    • Aa

Proactive inhibition and semantic organization Relationship with verbal memory in patients with schizophrenia

  • David A. Kareken (a1), Paul J. Moberg (a1) and Ruben C. Gur (a1)
Abstract
Abstract

Compared to other cognitive functions in schizophrenia, evidence suggests that verbal memory is particularly impaired. This study used the California Verbal Learning Test (CVLT) to examine proactive inhibition (PI) and semantic processing in verbal memory in 29 patients with schizophrenia and 29 healthy controls. Patients showed significantly less PI, but also did not organize (cluster) their recall according to semantic category. Controls and patients demonstrated small retroactive inhibition (RI) effects regardless of semantic content. Although both groups made similar types and numbers of free recall intrusion errors, patients committed more phonemic and nonshared recognition errors. Results suggest that reduced semantic processing prevented build of PI, and contributes to defective memory in schizophrenia. The anatomic-physiologic abnormalities that underlie these findings may be particularly pronounced in prefrontal and temporal-parietal cortical areas. (JINS, 1996, 2, 486–493.)

Copyright
References
Hide All
J. Brown (1958). Some tests of the decay theory of immediate memory. Quarterly Journal of Experimental Psychology, 10, 1221.

M.S. Buchsbaum , L.E. Delisi , H.H. Holcomb , J. Cappelletti , A.C. King , J. Johnson , E. Hazlet , S. Dowling-Zimmerman , R.M. Post , J. Morihisa , W.T. Carpenter Jr., R. Cohen , D. Pickar , D.R. Weinberger , R. Margolin , & R.M. Kessler (1984). Anteropostcrior gradients in cerebral glucose use in schizophrenia and affective disorder. Archives of General Psychiatry, 41, 11591165.

M.S. Buchsbaum , D.H. Ingvar , R. Kessler , R.N. Waters , J. Cap-pellctti , D.P. van Kammcn , A.C. King , J.L. Johnson , R.G. Manning , R.N. Flynn , L.S. Mann , W.E. Bunney Jr., & L. Sokoloff (1982). Cerebral glucography with positron lomography: Use in normal subjects and in patients with schizophrenia. Archives of General Psychiatry, 39, 251259.

F.I.M. Craik & J. Birtwistlc (1971). Proactive inhibition in free recall. Journal of Experimental Psychology, 91, 120123.

T.J. Crow (1990). Temporal lobe asymmetries as the key to the etiology of schizophrenia. Schizophrenia Bulletin, 16, 433443.

L.A. Cushman , P.G. Como , H. Booth , & E.D. Caine (1988). Cued recall and release from proactive interference in Alzheimer's disease. Journal of Clinical and Experimental Ncuropsychology, 10, 685692.

D.C. Delis , P.J. Massman , N. Butters , D.P. Salmon , L.S. Cermak , & J.H. Kramer (1991). Profiles of demented and amnesic patients on the California Verbal Learning Test: Implications for the assessment of memory disorders. Psychological Assessment, 3, 1926.

M. Freedman & L.S. Ccrmak (1986). Semantic encoding deficits in frontal lobe disease and amnesia. Brain and Cognition, 5, 108114.

J.M. Gold , C. Randolph , C.J. Carpenter . T.E. Goldberg , & D.R. Weinberger (1992). Forms of memory failure in schizophrenia. Journal of Abnormal Psychology, 101, 487494.

R.E. Gur , J.L. Jaggi , D.L. Shtascl , J.D. Ragland , & R.C. Gur (1994). Cerebral blood flow in schizophrenia: Effects of memory processing on regional activation. Biological Psychiatry, 35, 315.

P.D. Harvey , E.A. Earle-Boycr , M.S. Wiclgus , & J.C. Levinson (1986). Encoding, memory, and thought disorder in schizophrenia and mania. Schizophrenia Bulletin, 12, 252261.

R. Heaton , J.S. Paulsen , L. McAdams , J. Kuck , S. Zisook , D. Braff , J. Harris , & D.V. Jeste (1994). Neuropsychological deficits in schizophrenics: Relationship to age, chronicity, and dementia. Archives of General Psychiatry, 51, 469476.

J.S. Janowsky , A.P. Shimamura , M. Kritchevsky , & L.R. Squire (1989). Cognitive impairment following frontal lobe damage and its relevance to human amnesia. Behavioral Neuroscicnce, 103, 548560.

S.R. Kay (1982). Conceptual disorder in schizophrenia as a function of encoding orientation. The Journal of Nervous and Mental Disease, 170, 154163.

S.D. Koh , L. Kayton , & R. Berry (1973). Mnemonic organization in young nonpsychotic schizophrenics. Journal of Abnormal Psychology, 81, 299310.

S.D. Koh , L. Kayton , & R. Peterson (1976). Affective encoding and consequent remembering in schizophrenic young adults. Journal of Abnormal Psychology, 85, 156166.

S.D. Koh , T.Z. Marusarz , & A.J. Rosen (1980). Remembering of sentences by young schizophrenic adults. Journal of Abnormal Psychology, 89, 291294.

J.H. Kramer & D.C. Delis (1991). Interference effects on the California Verbal Learning Test: A construct validation study. Psychological Assessment, 3, 299302.

L.R. Peterson & M.J. Peterson (1959). Short-term retention of individual verbal items. Journal of Experimental Psychology, 58, 193198.

C. Raczkowski , J.W. Kalat , & R. Nebes (1974). Reliability and validity of some handedness questionnaire items. Neuropsy-chologia, 12, 4347.

C. Randolph , J.M. Gold , C.J. Carpenter , T.E. Goldberg , & D.R. Weinberger (1992). Release from proactive interference: Determinants and neuropsychological correlates. Journal of Clinical and Experimental Neuropsychology, 14, 785800.

S.M. Resnick (1992). Matching for education in studies of schizophrenia. Archives of General Psychiatry, 49, 246.

A.J. Saykin , R.C Gur , R.E. Gur , P.D. Mozley , L.H. Mozley , S.M. Resnick , D.B. Kcster , & P. Stafiniak (1991). Neuropsychological function in schizophrenia: Selective impairment in memory and learning. Archives of General Psychiatry, 48, 618624.

A.J. Saykin , D.L. Shtasel , R.E. Gur , D.B. Kester , L.H. Mozley , P. Stafiniak , & R.C Gur (1994). Neuropsychological deficits in neuroleptic naive patients with first episode schizophrenia. Archives of General Psychiatry, 51, 124131.

D.L. Shtasel , R.E. Gur , F.G. Gallacher , C. Heimberg T. Cannon , & R.C. Gur (1992). Phenomenology and functioning in first-episode schizophrenia. Schizophrenia Bulletin, 18, 449462.

D.L. Shtasel , R.E. Gur , P.D. Mozley , J. Richards , M.M. Taleff , C. Heimberg , F. Gallacher , & R.C. Gur (1991). Volunteers forbiomedical research: Recruitment and screening of normal controls. Archives of General Psychiatry, 48, 10221025.

K.L. Traupmann , M. Berzofsky , & M. Kesselman (1976). Encoding of taxonomic word categories by schizophrenics. Journal of Abnormal Psychology, 85, 350355.

B.I. Turetsky , P.E. Cowell , R.C. Gur , R.I. Grossman , D.L. Shtasel , & R.E. Gur (1995). Frontal and temporal lobe brain volumes in schizophrenia: Relationship to symptomatology and clinical subtype. Archives of General Psychiatn; 52, 10611070.

D.R. Weinberger , K.F. Berman , & R.F. Zee (1986). Physiologic dysfunction of dorsolateral prcfrontal cortex in schizophrenia: I. Regional cerebral blood flow evidence. Archives of General Psychiatn, 43, 114124.

D.D. Wickens (1970). Encoding categories of words: An empirical approach to meaning. Psychological Review, 77, 115.

F.B. Wood & L.D. Flowers (1990). Hypofrontal vs. hypo-Sylvian blood flow in schizophrenia. Schizophrenia Bulletin, 16, 413424.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of the International Neuropsychological Society
  • ISSN: 1355-6177
  • EISSN: 1469-7661
  • URL: /core/journals/journal-of-the-international-neuropsychological-society
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 10 *
Loading metrics...

Abstract views

Total abstract views: 54 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 17th October 2017. This data will be updated every 24 hours.