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The Relation Between Depressive Symptoms and Semantic Memory in Amnestic Mild Cognitive Impairment and in Late-Life Depression

  • Julie Brunet (a1) (a2), Carol Hudon (a3) (a4), Joël Macoir (a4) (a5), Sylvie Belleville (a1) (a2), François Rousseau (a4), Rémi W. Bouchard (a6), Louis Verret (a6), Howard Chertkow (a7), Céline Chayer (a8) (a9) (a10), Marie-Jeanne Kergoat (a2) (a8) (a10) and Sven Joubert (a1) (a2)...
Abstract

Semantic deficits have been documented in the prodromal phase of Alzheimer's disease, but it is unclear whether these deficits are associated with non-cognitive manifestations. For instance, recent evidence indicates that cognitive deficits in elders with amnestic mild cognitive impairment (aMCI) are modulated by concomitant depressive symptoms. The purposes of this study were to (i) investigate if semantic memory impairment in aMCI is modulated according to the presence (aMCI-D group) or absence (aMCI group) of depressive symptoms, and (ii) compare semantic memory performance of aMCI and aMCI-D groups to that of patients with late-life depression (LLD). Seventeen aMCI, 16 aMCI-D, 15 LLD, and 26 healthy control participants were administered a semantic questionnaire assessing famous person knowledge. Results showed that performance of aMCI-D patients was impaired compared to the control and LLD groups. However, in the aMCI group performance was comparable to that of all other groups. Overall, these findings suggest that semantic deficits in aMCI are somewhat associated with the presence of concomitant depressive symptoms. However, depression alone cannot account solely for the semantic deficits since LLD patients showed no semantic memory impairment in this study. Future studies should aim at clarifying the association between depression and semantic deficits in older adults meeting aMCI criteria. (JINS, 2011, 17, 865–874)

Copyright
Corresponding author
Correspondence and reprint requests to: Carol Hudon, Centre de recherche Université Laval Robert-Giffard; 2601, ch. de la Canardière (F-4500); Québec, QC, Canada G1J 2G3. E-mail: carol.hudon@psy.ulaval.ca
References
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Ahmed, S., Arnold, R., Thompson, S.A., Graham, K.S., Hodges, J.R. (2008). Naming of objects, faces and buildings in mild cognitive impairment. Cortex, 44(6), 746752.
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: APA.
Amieva, H., Le Goff, M., Millet, X., Orgogozo, J.M., Peres, K., Barberger-Gateau, P., Dartigues, J.F. (2008). Prodromal Alzheimer's disease: Successive emergence of the clinical symptoms. Annals of Neurology, 64(5), 492498.
Apostolova, L.G., Cummings, J.L. (2008). Neuropsychiatric manifestations in mild cognitive impairment: A systematic review of the literature. Dementia and Geriatric Cognitive Disorders, 25(2), 115126.
Boone, K.B., Lesser, I., Miller, B., Wohl, M., Berman, N., Lee, A., Palmer, B. (1994). Cognitive functioning in a mildly to moderately depressed geriatric sample: Relationship to chronological age. Journal of the Neuropsychiatry and Clinical Neuroscience, 6(3), 267272.
Bourque, P., Blanchard, L., Vézina, J. (1990). Étude psychométrique de l’Échelle de dépression gériatrique. Revue Canadienne du Vieillissement, 9, 348355.
Bruce, J.M., Bhalla, R., Westervelt, H.J., Davis, J., Williams, V., Tremont, G. (2008). Neuropsychological correlates of self-reported depression and self-reported cognition among patients with mild cognitive impairment. Journal of Geriatric Psychiatry and Neurology, 21(1), 3440.
Burton, A.M., Bruce, V., Johnston, R.A. (1990). Understanding face recognition with an interactive activation model. British Journal of Psychology, 81(Pt 3), 361380.
Calero, M.D., Arnedo, M.L., Navarro, E., Ruiz-Pedrosa, M., Carnero, C. (2002). Usefulness of a 15-item version of the Boston Naming Test in neuropsychological assessment of low-educational elders with dementia. Journal of Gerontology B Psychological Science, 57(2), 187191.
Consortium des Universités de Montréal et McGill. (1996). Manuel de l'Examen Neuropsychologique. Montréal: Étude Santé et Vieillissement au Canada.
Debruyne, H., Van Buggenhout, M., Le Bastard, N., Aries, M., Audenaert, K., De Deyn, P., Engelborghs, S. (2009). Is the geriatric depression scale a reliable screening tool for depressive symptoms in elderly patients with cognitive impairment? International Journal of Geriatric Psychiatry, 24, 556562.
Delis, D.C., Kaplan, E., Kramer, J.H. (2001). The Delis-Kaplan executive function system manual. San Antonio, TX: The Psychological Corporation.
Duong, A., Whitehead, V., Hanratty, K., Chertkow, H. (2006). The nature of lexico-semantic processing deficits in mild cognitive impairment. Neuropsychologia, 44(10), 19281935.
Dierckx, E., Engelborghs, S., De Raedt, R., De Deyn, P.P., Ponjaert-Kristoffersen, I. (2007). Differentiation between mild cognitive impairment, Alzheimer's disease and depression by means of cued recall. Psychological Medicine, 37(5), 747755.
Elderkin-Thompson, V., Boone, K.B., Hwang, S., Kumar, A. (2004). Neurocognitive profiles in elderly patients with frontotemporal degeneration or major depressive disorder. Journal of the International Neuropsychological Society, 10(5), 753771.
Estevez-Gonzalez, A., Garcia-Sanchez, C., Boltes, A., Otermin, P., Pascual-Sedano, B., Gironell, A., Kulisevsky, J. (2004). Semantic knowledge of famous people in mild cognitive impairment and progression to Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 17(3), 188195.
Gauthier, S., Reisberg, B., Zaudig, M., Petersen, R.C., Ritchie, K., Broich, K., Winblad, B. (2006). International Psychogeriatric Association Expert Conference on mild cognitive impairment. Mild cognitive impairment. Lancet, 367(9518), 12621270.
Georgieff, N., Dominey, P.F., Michel, F., Marie-Cardine, M., Dalery, J. (1998). Anomia in major depressive state. Psychiatry Research, 77(3), 197208.
Grober, E., Buschke, H., Crystal, H., Bang, S., Dresner, R. (1988). Sreening for dementia by memory testing. Neurology, 38(6), 900903.
Howard, D., Patterson, K. (1992). Pyramids and palm trees: A test of semantic access from pictures and words. Bury St. Edmunds, UK: Thames Valley Test Company.
Hudon, C., Belleville, S., Gauthier, S. (2008). The association between depressive and cognitive symptoms in amnestic mild cognitive impairment. International Psychogeriatric, 20(4), 710723.
Jorm, A.F. (2000). Is depression a risk factor for dementia or cognitive decline? A review. Gerontology, 46(4), 219227.
Joubert, S., Brambati, S.M., Ansado, J., Barbeau, E.J., Felician, O., Didic, M., Kergoat, M.J. (2010). The cognitive and neural expression of semantic memory impairment in mild cognitive and early Alzheimer's disease. Neuropsychologia, 48(4), 978988.
Joubert, S., Felician, O., Barbeau, E.J., Didic, M., Poncet, M., Ceccaldi, M. (2008). Patterns of semantic memory impairment in Mild Cognitive Impairment. Behavioral Neurology, 19(1–2), 3540.
King, D.A., Caine, E.D., Conwell, Y., Cox, C. (1991). The neuropsychology of depression in the elderly: A comparative study of normal aging and Alzheimer's disease. Journal of the Neuropsychiatry and Clinical Neuroscience, 3(2), 163168.
Köhler, S., Thomas, A.J., Barnett, N.A., O'Brien, J.T. (2010). The pattern and course of cognitive impairment in late-life depression. Psychological Medicine, 40(4), 591602.
Klein, L.A., Buchanan, J. (2009). Psychometric properties of the Pyramids and Palm Trees Test. Journal of Clinical and Experimental Neuropsychology, 31(7), 803808.
Modrego, P.J., Ferrandez, J. (2004). Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: A prospective cohort study. Archives of Neurology, 61(8), 12901293.
Ownby, R.L., Crocco, E., Acevedo, A., John, V., Loewenstein, D. (2006). Depression and risk for Alzheimer disease: Systematic review, meta-analysis, and metaregression analysis. Archives of General Psychiatry, 63(5), 530538.
Palmer, B.W., Boone, K.B., Lesser, I.M., Wohl, M.A., Berman, N., Miller, B.L. (1996). Neuropsychological deficits among older depressed patients with predominantly psychological or vegetative symptoms. Journal of Affective Disorders, 41(1), 1724.
Panza, F., Frisardi, V., Capurso, C., D'Introno, A., Colacicco, A.M., Imbimbo, B.P., Solfrizzi, V. (2010). Late-life depression, mild cognitive impairment, and dementia: Possible continuum? American Journal of Geriatric Psychiatry, 18(2), 98116.
Petersen, R.C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256(3), 183194.
Petersen, R.C., Smith, G.E., Waring, S.C., Ivnik, R.J., Tangalos, E.G., Kokmen, E. (1999). Mild cognitive impairment: Clinical characterization and outcome. Archives of Neurology, 56(3), 303308.
Rey, A. (1970). Test de copie et de reproduction de mémoire de figures géométriques complexes. Paris: Edition du Centre de Psychologie Appliquée.
Riddoch, M.J., Humphreys, G.W. (1993). Birmingham object recognition battery (BORB). Hillsdale, NJ: Lawrence Erlbaum associates Publishers.
Schweinberger, S.R. (1996). How Gorbachev primed Yeltsin: Analyses of associative priming in person recognition by means of reaction times and event-related brain potentials. Journal of Experimental Psychology: Learning, Memory, and Cognition, 22(6), 13831407.
Simard, M., Hudon, C., van Reekum, R. (2009). Psychological distress and risk for dementia. Current Psychiatry Reports, 11(1), 4147.
Steffens, D.C., Otey, E., Alexopoulos, G.S., Butters, M.A., Cuthbert, B., Ganguli, M., Yesavage, J. (2006). Perspectives on depression, mild cognitive impairment, and cognitive decline. Archives of General Psychiatry, 63(2), 130138.
Stone, A. (2008). Categorical priming of famous person recognition: A hitherto overlooked methodological factor can resolve a long-standing debate. Cognition, 108(3), 874880.
Thompson, S.A., Graham, K.S., Patterson, K., Sahakian, B.J., Hodges, J.R. (2002). Is knowledge of famous people disproportionately impaired in patients with early and questionable Alzheimer's disease? Neuropsychology, 16(3), 344358.
Van der Linden, M., Adam, S., Agniel, A., Baisset-Mouly, C., Bardet, F., Coyette, F., Thomas-Antérion, C. (2004). L’évaluation des troubles de la mémoire. Présentation de quatre tests de mémoire épisodique (avec leur étalonnage). Marseille: Solal.
Van Reekum, R., Binns, M., Clarke, D., Chayer, C., Conn, D., Herrmann, N., Stuss, D.T. (2005). Is late-life depression a predictor of Alzheimer's disease? Results from a historical cohort study. International Journal of Geriatric Psychiatry, 20(1), 8082.
Vogel, A., Gade, A., Stokholm, J., Waldemar, G. (2005). Semantic memory impairment in the earliest phases of Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 19(2–3), 7581.
Wiese, H., Schweinberger, S.R. (2011). Accessing semantic person knowledge: Temporal dynamics of nonstrategic categorical and associative priming. Journal of Cognitive Neuroscience, 23(2), 447459.
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Journal of the International Neuropsychological Society
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