1Lönnroth, I, Lange, S & Skadhauge, E (1988) The antisecretory factors: inducible proteins which modulate secretion in the small intestine. Comp Biochem Physiol 90, 611–617.
2Johansson, E, Lönnroth, I, Lange, S, et al. . (1995) Molecular cloning and expression of a pituitary gland protein modulating intestinal fluid secretion. J Biol Chem 270, 20615–20620.
3Lange, S, Jennische, E, Johansson, E, et al. . (1999) The antisecretory factor: synthesis and intracellular localization in porcine tissues. Cell Tissue Res 296, 607–617.
4Johansson, E, Jennische, E, Lange, S, et al. . (1997) Antisecretory factor suppresses intestinal inflammation and hypersecretion. Gut 41, 642–645.
5Lange, S & Lönnroth, I (2001) The antisecretory factor: synthesis, anatomical and cellular distribution, and biological action in experimental and clinical studies. Int Rev Cyt 210, 39–75.
6Lange, S (1982) A rat model for an in vivo assay of enterotoxic diarrhoea. FEMS Microbiol Lett 15, 239–242.
7Rapallino, MV, Cupello, A, Lange, S, et al. . (2003) Antisecretory factor peptide derivatives specifically inhibit [3H]-γ-amino-butyric acid/36Cl− out → in permeation across the isolated rabbit Deiters' neuronal membrane. Acta Physiol Scand 179, 367–371.
8Davidson, TS & Hickey, WF (2004) Distribution and immunoregulatory properties of antisecretory factor. Lab Invest 84, 307–319.
9Björck, S, Bosaeus, I, Ek, E, et al. . (2000) Food induced stimulation of the antisecretory factor can improve symptoms in human inflammatory bowel disease: a study of a concept. Gut 46, 824–829.
11Bryce, J, Boschi-Pinto, C, Shibuya, K, et al. . (2005) WHO Child Health Epidemiology Reference Group. WHO estimates of the causes of death in children. Lancet 365, 1147–1152.
12Zaman, S, Mannana, J, Lange, S, et al. . (2007) B 221, a medical food containing antisecretory factor reduces child diarrhoea – a placebo controlled trial. Acta Paediatr 96, 1655–1659.
13Laurenius, A, Wängberg, B, Lange, S, et al. . (2003) Antisecretory factor counteracts secretory diarrhoea of endocrine origin. Clin Nutr 22, 549–552.
14Lallès, JP, Bosi, P, Janczyk, P, et al. . (2009) Impact of bioactive substances on the gastrointestinal tract and performance of weaned piglets: a review. Animal 3, 1625–1643.
15Berkeveld, M, Langendijk, P, Soede, NM, et al. . (2009) Improving adaptation to weaning: effect of intermittent suckling regimens on piglet feed intake, growth, and gut characteristics. J Anim Sci 87, 3156–3166.
16Jennische, E, Hanner, P, Johansson, E, et al. . (2003) Antisecretory factor in the human cochlea and saccus endolymphaticus. Exp Clin Endocrinol Diabetes 111, 401–405.
17Johansson, E, Lange, S & Lönnroth, I (1997) Identification of an active site in the antisecretory factor protein. Biochim Biophys Acta 1362, 177–182.
18Johansson, E, Jonson, I, Bosaeus, M, et al. . (2008) Identification of flotillin-1 as an interacting protein for antisecretory factor. Regul Pept 146, 303–309.
19Vassileva, EV, Ivanov, AI & Nusrat, A (2008) Flotillin-1 stabilizes caveolin-1 in intestinal epithelial cells. Biochem Biophys Res Commun 379, 460–465.
20Langhorst, MF, Reuter, A & Stuermer, CA (2005) Scaffolding microdomains and beyond: the function of reggie/flotillin proteins. Cell Mol Life Sci 62, 2228–2240.
21Babuke, T & Tikkanen, R (2007) Dissecting the molecular function of reggie/flotillin proteins. Eur J Cell Biol 86, 525–532.
22Allen, JA, Halverson-Tamboli, RA & Rasenick, MM (2007) Lipid raft microdomains and neurotransmitter signalling. Nat Rev Neurosci 8, 128–140.
23Rossy, J, Schlicht, D, Engelhardt, B, et al. . (2009) Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod. PLoS ONE 4, e5403.
24Katoh, S, Kamimoto, T, Yamakawa, D, et al. . (2009) Lipid rafts serve as signaling platform for Tie2 receptor tyrosine kinase in vascular endothelial cells. Exp Cell Res 315, 2818–2823.
25Morgan, MJ, Kim, YS & Liu, Z (2007) Lipid rafts and oxidative stress-induced cell death. Antioxid Redox Signal 9, 1471–1483.
26Van der Goot, FG & Harder, T (2001) Raft membrane domains: from a liquid-ordered membrane phase to a site of pathogen attack. Semin Immunol 13, 89–97.
27Li, N, Mak, A, Richards, DP, et al. . (2003) Monocyte lipid rafts contain proteins implicated in vesicular trafficking and phagosome formation. Proteomics 3, 536–548.
28Davidson, TS & Hickey, WF (2004) Antisecretory factor expression is regulated by inflammatory mediators and influences the severity of experimental autoimmune encephalomyelitis. J Leukoc Biol 76, 835–844.
29Hickey, WF & Kimura, H (1988) Perivascular microglial cells of the CNS are bone marrow derived and present antigen in vivo. Science 239, 290–292.
30Fujiwara, N & Kobayashi, K (2005) Macrophages in inflammation. Curr Drug Targets Inflamm Allergy 4, 281–286.
31Galofré, M, Babot, Z, García, DA, et al. . (2009) GABAA receptor and cell membrane potential as functional endpoints in cultured neurons to evaluate chemicals for human acute toxicity. Neurotoxicol Teratol 32, 52–61.
32Madsen, KK, Larsson, OM & Schousboe, A (2008) Regulation of excitation by GABA neurotransmission: focus on metabolism and transport. Results Probl Cell Differ 44, 201–221.
33Medina, I & Chudotvorova, I (2006) GABA neurotransmission and neural cation-chloride co-transporters: actions beyond ion transport. Crit Rev Neurobiol 18, 105–112.
34Leist, M & Nicotera, P (1998) Apoptosis, excitotoxicity, and neuropathology. Exp Cell Res 239, 183–201.
35Olney, JW (2002) New insights and new issues in developmental neurotoxicology. Neurotoxicology 23, 659–668.
36Lange, S, Lönnroth, I, Palm, A, et al. . (1985) An inhibitory protein of intestinal fluid secretion reverses neuronal GABA transport. Biochem Biophys Res Commun 130, 1032–1036.
37Lange, S, Lönnroth, I, Palm, A, et al. . (1987) The effect of antisecretory factor on the permeability of nerve cell membrane to chloride ion. Pflügers Arch 410, 648–651.
38Kim, M, Wasling, P, Xiao, MY, et al. . (2005) Antisecretory factor modulates GABAergic transmission in the rat hippocampus. Regul Pept 129, 109–118.
39Gwynne, RM & Bornstein, JC (2007) Local inhibitory reflexes excited by mucosal application of nutrient amino acids in guinea pig jejunum. Am J Physiol Gastrointest Liver Physiol 292, G1660–G1670.
40Krantis, A (2000) GABA in the mammalian enteric nervous system. News Physiol Sci 15, 284–290.
41Minocha, A & Galligan, JJ (1993) Excitatory and inhibitory responses mediated by GABAA and GABAB receptors in guinea pig distal colon. Eur J Pharmacol 230, 187–193.
42Bayer, S, Crenner, F, Aunis, D, et al. . (2002) Effects of GABA on circular smooth muscle spontaneous activities of rat distal colon. Life Sci 71, 911–925.
43Harrison, AP, Bartels, EM, Erlwanger, KH, et al. . (2004) Effects of antisecretory factor-derived peptides on contractions in guinea pig colon. Comp Biochem Physiol A 139, 143–148.
44Göransson, L (1997) Alternatives to antibiotics – the influence of new feeding strategies for pigs on biology and performance. In Recent Advances in Animal Nutrition, pp. 45–56 [Garnsworthy, PC and Wiseman, J, editors]. Nottingham, UK: Nothingham University Press.
45Sigfridsson, K, Lange, S & Lönnroth, I (1995) Anti secretory factor (ASF) and feed induced lectines (FIL) in sow and suckling piglet. In Book of Abstracts of the 46th Annual Meeting of the European Association for Animal Production (EAAP), p. 165, poster M 4.23 [van Arendonk, JAM, editor]. Wageningen: Wageningen Press, .
46Lange, S, Martinsson, K, Lönnroth, I, et al. . (1993) Plasma level of antisecretory factor (ASF) and its relation to post-weaning diarrhoea in piglets. J Vet Med B 40, 13–18.
47Lönnroth, I & Lange, S (1987) Intake of monosaccharides or aminoacids induces pituitary gland synthesis of proteins regulating intestinal fluid transport. Biochim Biophys Acta 925, 117–123.
48Göransson, L, Martinsson, K, Lange, S, et al. . (1993) Feed-induced lectins in piglets. Feed-induced lectins and their effect on post weaning diarrhoea, daily weight gain and mortality. J Vet Med B 40, 478–484.
49Lange, S, Lönnroth, I & Martinsson, K (1994) Concentrations of antisecretory factor in eggs and in chicken blood plasma. Br Poult Sci 35, 615–620.
50Eriksson, A, Shafazand, M, Jennische, E, et al. . (2003) Effect of antisecretory factor in ulcerative colitis on histological and laborative outcome: a short period clinical trial. Scand J Gastroenterol 38, 1045–1049.
51Eriksson, A, Shafazand, M, Jennische, E, et al. . (2003) Antisecretory factor-induced regression of Crohn's disease in a weak responder to conventional pharmacological treatment. Infl Bow Dis 9, 398–400.
52Wapnir, RA & Teichberg, S (2002) Regulation mechanisms of intestinal secretion: implications in nutrient absorption. J Nutr Biochem 13, 190–199.
53Lundgren, O (2002) Enteric nerves and diarrhoea. Pharmacol Toxicol 90, 109–120.
54Fordtran, J (1967) Speculation on the pathogenesis of diarrhoea. Fed Proc 26, 1405–1414.
55Petri, WA Jr, Miller, M, Binder, HJ, et al. . (2008) Enteric infections, diarrhoea, and their impact on function and development. J Clin Invest 118, 1277–1290.
56Field, M, Fromm, D, al-Awqati, Q, et al. . (1972) Effect of cholera enterotoxin on ion transport across isolated ileal mucosa. J Clin Invest 51, 796–804.
57Fan, E, O'Neal, CJ, Mitchell, DD, et al. . (2004) Structural biology and structure-based inhibitor design of cholera toxin and heat-labile enterotoxin. Int J Med Microbiol 294, 217–223.
58Griffiths, SL & Critchley, DR (1991) Characterization of the binding sites for Escherichia coli heat-labile toxin type I in intestinal brush borders. Biochim Biophys Acta 1075, 154–161.
59Mourad, FH, O'Donnell, LJ, Dias, JA, et al. . (1995) Role of 5-hydroxytryptamine type 3 receptors in rat intestinal fluid and electrolyte secretion induced by cholera and Escherichia coli enterotoxins. Gut 37, 340–345.
60Moss, J & Vaughan, M (1981) Mechanism of action of choleragen and E. coli heat-labile enterotoxin: activation of adenylate cyclase by ADP-ribosylation. Mol Cell Biochem 37, 75–90.
61Cooke, HJ (1994) Neuroimmune signaling in regulation of intestinal ion transport. Am J Physiol 266, G167–G178.
62Cassuto, J, Fahrenkrug, J, Jodal, M, et al. . (1981) Release of vasoactive intestinal polypeptide from the cat small intestine exposed to cholera toxin. Gut 22, 958–963.
63Holmgren, J & Svennerholm, AM (1992) Bacterial enteric infections and vaccine development. Gastroenterol Clin North Am 21, 283–302.
64Horstman, AL & Kuehn, MJ (2000) Enterotoxigenic Escherichia coli secretes active heat-labile enterotoxin via outer membrane vesicles. J Biol Chem 275, 12489–12496.
65Kuehn, MJ & Kesty, NC (2004) Bacterial outer membrane vesicles and the host–pathogen interaction. Genes Dev 19, 2645–2655.
66Holmner, A, Askarieh, G, Okvist, M, et al. . (2007) Blood group antigen recognition by Escherichia coli heat-labile enterotoxin. J Mol Biol 371, 754–764.
67Lönnroth, I, Lange, S, Jennische, E, et al. . (2003) Cholera toxin protects against action by Clostridium difficile toxin A. The role of antisecretory factor in intestinal secretion and inflammation in rat. APMIS 111, 969–977.
68Kelly, CP & La Mont, JT (1998) Clostridium difficile infection. Annu Rev Med 49, 375–390.
69Lorrot, M & Vasseur, M (2007) How do the rotavirus NSP4 and bacterial enterotoxins lead differently to diarrhea? Virol J 21, 4–31.
70Kotloff, KL, Winickoff, JP, Ivanoff, P, et al. . (1999) Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bull World Health Organ 77, 651–666.
71Baldi, F, Bianco, MA, Nardone, G, et al. . (2009) Focus on diarrhoeal disease. World J Gastroenterol 15, 3341–3348.
72Torres, J, Jennische, E, Lange, S, et al. . (1991) Clostridium difficile toxin A indues a specific antisecretory factor which protects against intestinal mucosal damage. Gut 32, 791–795.
73Grøndahl, ML, Sorensen, H, Unmack, MA, et al. . (2002) Neuronal involvement in the effect of an antisecretory factor-derived peptide on induced secretion in the porcine small intestine. J Comp Physiol A 188, 589–594.
74Goyal, RK & Hirano, I (1996) The enteric nervous system. N Engl J Med 334, 1106–1114.
75Johansson, E, Lönnroth, I, Jonson, I, et al. . (2009) Development of monoclonal antibodies for detection of antisecretory factor activity in human plasma. J Immunol Methods 342, 64–70.
76Jennische, E, Johansson, E, Hansson, HA, et al. . (2006) Immunohistochemical staining patterns using epitope-specific antibodies indicate conformation variants of antisecretory factor/S5a in the CNS. APMIS 114, 529–538.
77Ferguson, LR, Shelling, AN, Browning, BL, et al. . (2007) Genes, diet and inflammatory bowel disease. Mutat Res 622, 70–83.
78Fiasse, R, Denis, MA & Dewit, O (2010) Chronic inflammatory bowel disease: Crohn's disease and ulcerative colitis (article in French). J Pharm Belg 1, 1–9.
79Levy, RL, Olden, KW & Naliboff, BD (2006) Psychosocial aspects of the gastrointestinal disorders. Gastroenterology 130, 1447–1458.
80Jess, T, Riis, L, Jespersgaard, C, et al. . (2005) Disease concordance, zygosity, and NOD2/CARD15 status: follow-up of a population-based cohort of Danish twins with inflammatory bowel disease. Am J Gastroenterol 100, 2486–2492.
81Loftus, EV Jr, Silverstein, MD, Sandborn, WJ, et al. . (1998) Crohn's disease in Olmsted County, Minnesota, 1940–1993: incidence, prevalence, and survival. Gastroenterology 114, 1161–1168.
82Ekesbo, R, Nilsson, PM & Sjölund, K (2008) Effects of antisecretory factor (ASF) on irritable bowel disease. Scand J Primary Health Care 26, 106–110.
83Tilg, H (2008) Short bowel syndrome: searching for the proper diet. Eur J Gastroenterol Hepatol 20, 1061–1063.
84Messing, B, Crenn, P, Beau, P, et al. . (1999) Long-term survival and parenteral nutrition dependence in adult patients with the short bowel syndrome. Gastroenterology 117, 1043–1050.
85Nightingale, JM (2001) Management of patients with short bowel. World J Gastroenterol 7, 741–751.
86Lange, S, Bosaeus, I, Jennische, E, et al. . (2003) Food-induced antisecretory factor activity is correlated to small bowel length in patients with intestinal resections. APMIS 111, 985–988.
87Pagoldh, M, Eriksson, A, Heimtun, E, et al. . (2008) Effects of supplementary diet with specially processed cereals in patients with short bowel syndrome. Eur J Gastroenterol Hepatol 20, 1085–1093.
88Dodi, G & Spencer, R (1996) Diarrhoea. In Outpatient Coloproctology, , pp. 486–489. Padova, Italy: Piccin Nuova Libraria.
89O'Toole, D, Ducreux, M, Bommelaer, G, et al. . (2000) Treatment of carcinoid syndrome: a prospective crossover evaluation of lanreotide versus octreotide in terms of efficacy, patient acceptability, and tolerance. Cancer 88, 770–776.
90Kaltsas, GA, Besser, GM & Grossman, AB (2004) The diagnosis and medical management of advanced neuroendocrine tumors. Endocr Rev 25, 458–511.
91Flemming, JB, Lee, JE, Bouvet, M, et al. . (1999) Surgical strategy for the treatment of medullary thyroid carcinoma. Ann Surg 230, 697–707.
92Wängberg, B, Westberg, G, Thylen, U, et al. . (1996) Survival of patients with disseminated midgut carcinoid tumors after aggressive tumor reduction. World J Surg 20, 892–899.
93Brown, KH (1990) Epidemiological relationship between malnutrition and chronic diarrhoea in infants and children. In Malnutrition in Chronic Diet-Associated Infantile Diarrhoea. Diagnosis and Management, pp. 209–234 [Lifschitz, CH and Nicols, B, editors]. San Diego, CA: Academic Press.
94Mihrshahi, S, Oddy, WH, Peat, JK, et al. . (2008) Association between infant feeding patterns and diarrhoeal and respiratory illness: a cohort study in Chittagong, Bangladesh. Int Breastfeed J 3, 28.
95Ziyane, IS (1999) The relationship between infant feeding practices and diarrhoeal infections. J Adv Nurs 29, 721–726.
96Saleemi, MA, Zaman, S, Akhtar, HZ, et al. . (2004) Feeding patterns, diarrhoeal illness and linear growth in 0–24-month-old children. J Trop Pediatr 50, 164–169.
97Svensson, K, Lange, S, Lönnroth, I, et al. . (2004) Induction of antisecretory factor in human milk may prevent mastitis. Acta Pædiatr 93, 1228–1231.
98Hanner, P, Jennische, E, Lange, S, et al. . (2004) Increased antisecretory factor reduces vertigo in patients with Meniere's disease: a pilot study. Hear Res 190, 31–36.
99Hanner, P, Rask-Andersen, H, Lange, S, et al. . (2010) Antisecretory factor-inducing therapy improves the clinical out come in patients with Ménière's disease. Acta Otolaryngol 28, 223–227.
100Vink, R, Young, A, Bennett, CJ, et al. . (2003) Neuropeptide release influences brain edema formation after diffuse traumatic brain injury. Acta Neurochir Suppl 86, 257–260.
101Hoane, MR, Kaplan, SA & Ellis, AL (2006) The effects of nicotinamide on apoptosis and blood–brain barrier breakdown following traumatic brain injury. Brain Res 1125, 185–193.
102Säljö, A, Svensson, B, Mayorga, M, et al. . (2009) Low levels of blast raises intracranial pressure and impairs cognitive function in rats. J Neurotrauma 27, 1345–1352.
103Säljö, A, Bolouri, H, Mayorga, M, et al. . (2010) Low levels of blast raises intracranial pressure and impairs cognitive function in rats: prophylaxis with fermented cereal feed. J Neurotrauma 27, 383–389.
104Jennische, E, Bergström, T, Johansson, M, et al. . (2008) The peptide AF-16 abolishes sickness and death at experimental encephalitis by reducing increase of intracranial pressure. Brain Res 1227, 189–197.
105Armonda, RA, Bell, RS, Vo, AH, et al. . (2006) Wartime traumatic cerebral vasospasm: recent review of combat casualties. Neurosurgery 59, 1215–1225.
106Jantzen, JP (2007) Prevention and treatment of intracranial hypertension. Best Pract Res Clin Anaesthesiol 21, 517–538.
107Gallois, M, Rothköttera, HJ, Baileya, M, et al. . (2009) Natural alternatives to in-feed antibiotics in pig production: can immunomodulators play a role? Animal 3, 1644–1661.
108Florkowski, WJ, Elnagheeb, AH & Huang, CL (1998) Risk perception and new food production technologies. Appl Econ Lett 5, 69–73.
109Jondreville, C, Revy, PS & Dourmad, JY (2003) Dietary means to better control the environmental impact of copper and zinc by pigs from weaning to slaughter. Livest Prod Sci 84, 147–156.
110Ulgheri, C, Grilli, E, Rossi, F, et al. . (2010) Effect of hydrothermally processed cereals on the performance of weaned piglets. Livest Sci .
111Finkel, Y, Bjarnason, I, Lindblad, A, et al. . (2004) Specially processed cereals: a clinical innovation for children suffering from inflammatory bowel disease? Scand J Gastroenterol 39, 87–88.