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4 F Magkos & SA Kavouras (2005) Caffeine use in sports, pharmacokinetics in man, and cellular mechanisms of action. Crit Rev Food Sci Nutr 45, 535–562.
8 HJ Smit & PJ Rogers (2000) Effects of low doses of caffeine on cognitive performance, mood and thirst in low and higher caffeine consumers. Psychopharmacology (Berl) 152, 167–173.
9 A Smith , W Sturgess , J Gallagher , et al. (1999) Effects of a low dose of caffeine given in different drinks on mood and performance. Hum Psychopharmacol 14, 473–482.
10 PJ Durlach , R Edmunds , L Howard , et al. (2002) A rapid effect of caffeinated beverages on two choice reaction time tasks. Nutr Neurosci 5, 433–442.
13 JE James (1994) Does caffeine enhance or merely restore degraded psychomotor performance? Neuropsychobiology 30, 124–125.
16 MA Addicott & PJ Laurienti (2009) A comparison of the effects of caffeine following abstinence and normal caffeine use. Psychopharmacology (Berl) 207, 423–431.
17 CF Haskell , DO Kennedy , KA Wesnes , et al. (2005) Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Psychopharmacology (Berl) 179, 813–825.
18 P Hewlett & A Smith (2006) Acute effects of caffeine in volunteers with different patterns of regular consumption. Hum Psychopharmacol 21, 167–180.
21 MG Ferruzzi (2010) The influence of beverage composition on delivery of phenolic compounds from coffee and tea. Physiol Behav 100, 33–41.
22 KA Cooper , E Campos-Gimenez , DJ Alvarez , et al. (2007) Rapid reversed phase ultra-performance liquid chromatography analysis of the major cocoa polyphenols and inter-relationships of their concentrations in chocolate. J Agric Food Chem 55, 2841–2847.
23 A Magna , AA Salamao , M Vila , et al. (2003) Comparative study of two spectrophotometric reagents for catechol analysis in guarana seeds powder. J Braz Chem Soc 14, 129–132.
24 A Farah , T De Paulis , LC Trugo , et al. (2005) Effect of roasting on the formation of chlorogenic acid lactones in coffee. J Agric Food Chem 53, 1505–1513.
26 JPE Spencer , K Vafeiadou , RJ Williams , et al. (2012) Neuroinflammation: modulation by flavonoids and mechanisms of action. Mol Aspects Med 33, 83–97.
27 RJ Williams & JPE Spencer (2012) Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease. Free Radic Biol Med. 52, 35–45.
29 L Arab , W Liu , D Elashoff , et al. (2009) Green and black tea consumption and risk of stroke: a meta-analysis. Stroke 40, 1786–1792.
30 K Rezai-Zadeh , GW Arendash , H Hou , et al. (2008) Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain Res 1214, 177–187.
31 YK Lee , DY Yuk , JW Lee , et al. (2009) ( − )-Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of beta-amyloid generation and memory deficiency. Brain Res 1250, 164–174.
33 SJ Kim , HJ Jeong , KM Lee , et al. (2007) Epigallocatechin-3-gallate suppresses NF-κB activation and phosphorylation of p38 MAPK and JNK in human astrocytoma U373MG cells. J Nutr Biochem 18, 587–596.
35 Y Levites , O Weinreb , G Maor , et al. (2001) Green tea polyphenol ( − )-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration. J Neurochem 78, 1073–1082.
36 SK Katiyar , F Afaq , A Perez , et al. (2001) Green tea polyphenol ( − )-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress. Carcinogenesis 22, 287–294.
37 FP Chou , YC Chu , JD Hsu , et al. (2000) Specific induction of glutathione S-transferase GSTM2 subunit expression by epigallocatechin gallate in rat liver. Biochem Pharmacol 60, 643–650.
38 Y Xu , S Li , R Chen , et al. (2010) Antidepressant-like effect of low molecular proanthocyanidin in mice: involvement of monoaminergic system. Pharmacol Biochem Behav 94, 447–453.
39 YB Choi , YI Kim , KS Lee , et al. (2004) Protective effect of epigallocatechin gallate on brain damage after transient middle cerebral artery occlusion in rats. Brain Res 1019, 47–54.
44 JF Stevens , CL Miranda , KR Wolthers , et al. (2002) Identification and in vitro biological activities of hop proanthocyanidins: inhibition of nNOS activity and scavenging of reactive nitrogen species. J Agric Food Chem 50, 3435–3443.
45 M Lorenz , S Wessler , E Follmann , et al. (2004) A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. J Biol Chem 279, 6190–6195.
46 M Lorenz , J Urban , U Engelhardt , et al. (2009) Green and black tea are equally potent stimuli of NO production and vasodilation: new insights into tea ingredients involved. Basic Res Cardiol 104, 100–110.
49 ME Widlansky , NM Hamburg , E Anter , et al. (2007) Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease. J Am Coll Nutr 26, 95–102.
51 N Alexopoulos , C Vlachopoulos , K Aznaouridis , et al. (2008) The acute effect of green tea consumption on endothelial function in healthy individuals. Eur J Cardiovasc Prev Rehabil 15, 300–305.
52 N Nagaya , H Yamamoto , M Uematsu , et al. (2004) Green tea reverses endothelial dysfunction in healthy smokers. Heart 90, 1485–1486.
53 B Buijsse , EJM Feskens , FJ Kok , et al. (2006) Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen Elderly Study. Arch Intern Med 166, 411–417.
56 CG Fraga , L Actis-Goretta , JI Ottaviani , et al. (2005) Regular consumption of a flavanol-rich chocolate can improve oxidant stress in young soccer players. Clin Dev Immunol 12, 11–17.
62 C Heiss , S Jahn , M Taylor , et al. (2010) Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. J Am Coll Cardiol 56, 218–224.
64 M Monagas , N Khan , C Andres-Lacueva , et al. (2009) Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease. Am J Clin Nutr 90, 1144–1150.
65 K Davison , AM Coates , JD Buckley , et al. (2008) Effect of cocoa flavanols and exercise on cardiometabolic risk factors in overweight and obese subjects. Int J Obes 32, 1289–1296.
67 DD Mellor , T Sathyapalan , ES Kilpatrick , et al. (2010) High-cocoa polyphenol-rich chocolate improves HDL cholesterol in type 2 diabetes patients. Diabet Med 27, 1318–1321.
71 D Taubert , R Roesen , C Lehmann , et al. (2007) Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial. JAMA 298, 49–60.
72 K Ried , T Sullivan , P Fakler , et al. (2010) Does chocolate reduce blood pressure? A meta-analysis. BMC Med 8, 8–39.
73 S Desch , D Kobler , J Schmidt , et al. (2010) Low v. higher-dose dark chocolate and blood pressure in cardiovascular high-risk patients. Am J Hypertens 23, 694–700.
77 E Mostofsky , EB Levitan , A Wolk , et al. (2010) Chocolate intake and incidence of heart failure: a population-based prospective study of middle-aged and elderly women. Circ Heart Fail 3, 612–616.
78 JR Lewis , RL Prince , K Zhu , et al. (2010) Habitual chocolate intake and vascular disease: a prospective study of clinical outcomes in older women. Arch Intern Med 170, 1857–1858.
80 A Buitrago-Lopez , J Sanderson , L Johnson , et al. (2011) Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis. BMJ 343, d4488.
82 YF Chu , PH Brown , BJ Lyle , et al. (2009) Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees. J Agric Food Chem 57, 9801–9808.
84 PJ Nathan , K Lu , M Gray , et al. (2006) The neuropharmacology of l-theanine(N-ethyl-l-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother 6, 21–30.
86 R Kimura & T Murata (1971) Influence of alkylamides of glutamic acid and related compounds on the central nervous system. 1. Central depressant effect of theanine. Chem Pharm Bull (Tokyo) 19, 1257–1261.
91 MJ Jarvis (1993) Does caffeine intake enhance absolute levels of cognitive performance. Psychopharmacology (Berl) 110, 45–52.
92 P Hameleers , MPJ Van Boxtel , E Hogervorst , et al. (2000) Habitual caffeine consumption and its relation to memory, attention, planning capacity and psychomotor performance across multiple age groups. Hum Psychopharmacol 15, 573–581.
93 MPJ van Boxtel , JAJ Schmitt , H Bosma , et al. (2003) The effects of habitual caffeine use on cognitive change: a longitudinal perspective. Pharmacol Biochem Behav 75, 921–927.
94 K Ritchie , I Carriere , A de Mendonca , et al. (2007) The neuroprotective effects of caffeine – a prospective population study (the Three City Study). Neurology 69, 536–545.
95 L Maia & A de Mendonca (2002) Does caffeine intake protect from Alzheimer's disease? Eur J Neurol 9, 377–382.
98 M Johnson-Kozlow , D Kritz-Silverstein , E Barrett-Connor , et al. (2002) Coffee consumption and cognitive function among older adults. Am J Epidemiol 156, 842–850.
100 M-S Wu , T-H Lan , C-M Chen , et al. (2011) Socio-demographic and health-related factors associated with cognitive impairment in the elderly in Taiwan. BMC Public Health 11, 22.
103 M Shimbo , K Nakamura , HJ Shi , et al. (2005) Green tea consumption in everyday life and mental health. Public Health Nutr 8, 1300–1306.
107 D Commenges , V Scotet , S Renaud , et al. (2000) Intake of flavonoids and risk of dementia. Eur J Epidemiol 16, 357–363.
108 L Letenneur , C Proust-Lima , A Le Gouge , et al. (2007) Flavonoid intake and cognitive decline over a 10-year period. Am J Epidemiol 165, 1364–1371.
111 TY Wu , SE Hankinson , WC Willett , et al. (2005) Caffeinated coffee, decaffeinated coffee, and caffeine in relation to plasma C-peptide levels, a marker of insulin secretion, in US women. Diabetes Care 28, 1390–1396.
112 RC Loopstra-Masters , AD Liese , SM Haffner , et al. (2011) Associations between the intake of caffeinated and decaffeinated coffee and measures of insulin sensitivity and beta cell function. Diabetologia 54, 320–328.
114 M Hasenfratz & K Battig (1994) Acute dose–effect relationships of caffeine and mental performance, EEG, cardiovascular and subjective parameters. Psychopharmacology (Berl) 114, 281–287.
117 I Hindmarch , U Rigney , N Stanley , et al. (2000) A naturalistic investigation of the effects of day-long consumption of tea, coffee and water on alertness, sleep onset and sleep quality. Psychopharmacology (Berl) 149, 203–216.
120 J Kim , S Lee , J Shim , et al. (2012) Caffeinated coffee, decaffeinated coffee, and the phenolic phytochemical chlorogenic acid up-regulate NQO1 expression and prevent H2O2-induced apoptosis in primary cortical neurons. Neurochem Int 60, 466–474.
122 Y Nakajima , M Shimazawa , S Mishima , et al. (2007) Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions. Life Sci 80, 370–377.
124 KJ Lee & HG Jeong (2007) Protective effects of kahweol and cafestol against hydrogen peroxide-induced oxidative stress and DNA damage. Toxicol Lett 173, 80–87.
125 JY Kim , KS Jung , HG Jeong , et al. (2004) Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages. FEBS Lett 569, 321–326.
127 P Quinlan , J Lane , L Aspinall , et al. (1997) Effects of hot tea, coffee and water ingestion on physiological responses and mood: the role of caffeine, water and beverage type. Psychopharmacology (Berl) 134, 164–173.
128 I Hindmarch , PT Quinlan , KL Moore , et al. (1998) The effects of black tea and other beverages on aspects of cognition and psychomotor performance. Psychopharmacology (Berl) 139, 230–238.
131 A Steptoe , EL Gibson , R Vounonvirta , et al. (2007) The effects of tea on psychophysiological stress responsivity and post-stress recovery: a randomised double-blind trial. Psychopharmacology (Berl) 190, 81–89.
134 K Kobayashi , Y Nagato , N Aoi , et al. (1998) Effects of l-theanine on the release of alpha-brain waves in human volunteers. Nippon Nogeikagaku Kaishi 72, 153–157.
136 M Gomez-Ramirez , BA Higgins , JA Rycroft , et al. (2007) The deployment of intersensory selective attention: a high-density electrical mapping study of the effects of theanine. Clin Neuropharmacol 30, 25–38.
137 M Gomez-Ramirez , SP Kelly , JL Montesi , et al. (2009) The effects of l-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task. Brain Topogr 22, 44–51.
142 CF Haskell , DO Kennedy , AL Milne , et al. (2008) The effects of l-theanine, caffeine and their combination on cognition and mood. Biol Psychol 77, 113–122.
148 A Scholey , LA Downey , J Ciorciari , et al. (2012) Acute neurocognitive effects of epigallocatechin gallate (EGCG). Appetite 58, 767–770.
149 NDL Fisher , M Hughes , M Gerhard-Herman , et al. (2003) Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J Hypertens 21, 2281–2286.
150 AJ Flammer , F Hermann , I Sudano , et al. (2007) Dark chocolate improves coronary vasomotion and reduces platelet reactivity. Circulation 116, 2376–2382.
152 DT Field , CM Williams , LT Butler , et al. (2011) Consumption of cocoa flavanols results in an acute improvement in visual and cognitive functions. Physiol Behav 103, 255–260.
157 OG Cameron , JG Modell , M Hariharan , et al. (1990) Caffeine and human cerebral blood-flow – a positron emission tomography study. Life Sci 47, 1141–1146.
160 DO Kennedy & CF Haskell (2011) Cerebral blood flow and behavioural effects of caffeine in habitual and non-habitual consumers of caffeine: a near infrared spectroscopy study. Biol Psychol 86, 298–306.
161 AS Field , PJ Laurienti , YF Yen , et al. (2003) Dietary caffeine consumption and withdrawal: confounding variables in quantitative cerebral perfusion studies? Radiology 227, 129–135.
166 CS Weckerle , MA Stutz & TW Baumann (2003) Purine alkaloids in Paullinia. Phytochemistry 64, 735–742.
171 JC Galduróz & EA Carlini (1996) The effects of long-term administration of guarana on the cognition of normal, elderly volunteers. Sao Paulo Med J 114, 1073–1078.
176 S Langer , LJ Marshall , AJ Day , et al. (2011) Flavanols and methylxanthines in commercially available dark chocolate: a study of the correlation with nonfat cocoa solids. J Agric Food Chem 59, 8435–8441.