Adams, H., Vaughan, J. G. & Fenwick, G. R. (1989). The use of glucosinolates for cultivar identification in swede, Brassica napus L var napobrassica (L) Peterm. Journal of the Science of Food and Agriculture 46, 319–324.
Akiba, Y. & Matsumoto, T. (1976). Antithyroid activity of goitrin in chicks. Poultry Science 55, 716–719.
Aspry, K. E. & Bjeldanes, L. F. (1983). Effects of dietary broccoli and butylated hydroxyanisole on liver-mediated metabolism of benzo[α]pyrene. Food and Chemical Toxicology 21, 133–142.
Astwood, E. B., Greer, M. A. & Ettlinger, M. G. (1949). 1-5-vinyl-2-thiooxazolidone, an antithyroid compound from yellow turnip and from brassica seeds. Journal of Biological Chemistry 181, 121–130.
Austin, F. L., Gent, C. A. & Wolff, I. A. (1968). Degradation of natural thioglucosides with ferrous salts. Journal of Agricultural and Food Chemisty 16, 752–755.
Babish, J. G. & Stoewsand, G. S. (1978). Effect of dietary indole-3-carbinol on the induction of the mixed-function oxidases of rat tissue. Food and Cosmetics Toxicology 16, 151–155.
Beaune, P. (1982). Les cytochromes P450 des microsomes de foie humain: activités monooxygénasiques et purification partielle (Microsomal P450 Cytochromes in Human Liver: Monoxygenase Activities and Partial Purification), PhD thesis, University of Paris 6, 139 pp.
Beaune, P. (1986). [Liver P450 cytochromes in humans.] Médecine/Sciences 2, 358–363.
Bèll, J. M. (1984). Nutrients and toxicants in rapeseed meal: a review. Journal of Animal Science 58, 996–1010.
Bell, J. M., Benjamin, B. R. & Giovannetti, P. M. (1972). Histopathology of thyroids and livers of rats and mice fed diets containing Brassica glucosinolates. Canadian Journal of Animal Science 52, 395–406.
Benns, G. B., Hall, J. W. & Beare-Rogers, J. L. (1978). Intake of brassicaceous vegetables in Canada. Canadian Journal of Public Health 69, 64–66.
Bille, N., Eggum, B. O., Jacobsen, I., Olsen, O. & Sorensen, H. (1983). Antinutritional and toxic effects in rats of individual glucosinolates (± myrosinases) added to a standard diet. 1. Effects on protein utilization and organ weights. Zeitschrift für Tierphysiolgie, Tierernährung und Futtermittelkunde 49, 195–210.
Birt, D. F., Pelling, J. C., Pour, P. M., Tibbels, M. G., Schweickert, L. & Bresnick, E. (1987). Enhanced pancreatic and skin tumorigenesis in cabbage fed hamsters and mice. Carcinogenesis 8, 913–917.
Bjerg, B. & Sørensen, H. (1987). Quantitative analysis of glucosinolates in oilseed rape based on HPLC of desulfoglucosinolates and HPLC of intact glucosinolates. World Crops: Production, Utilization and Description 13, 125–150.
Bock, K. W., Josting, D., Lilienblum, W. & Pfeil, H. (1979). Purification of rat-liver microsomal UDP-glucuronyltransferase: separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital European Journal of Biochemistry 98, 19–26.
Bock, K. W., Lilienblum, W., Fischer, G., Schirmer, G. & Bock-Hennig, B. S. (1987). Induction and inhibition of conjugating enzymes with emphasis on UDP-glucuronyltransferases. Pharmacology and Therapeutics 33, 23–27.
Booth, E. J., Walker, K. C. & Griffiths, D. W. (1990). Effect of harvest date and pod position on glucosinolates in oilseed rape (Brassica napus). Journal of the Science of Food and Agriculture 53, 43–61.
Bourdon, D., Perez, J.-M. & Baudet, J.-J. (1981). [New types of rapeseed meal fed to growing-finishing pigs: influence of glucosinolates and dehulling]. Journées de la Recherche Porcine en France 13, 163–178.
Boyd, J. N., Babish, J. G. & Stoewsand, G. S. (1982). Modification by beet and cabbage diets of aflatoxin B1-induced rat plasma α-foetoprotein elevation, hepatic tumorogenesis, and mutagenicity of urine. Food and Chemical Toxicology 20, 47–52.
Bradfield, C. A. & Bjeldanes, L. F. (1984). Effect of dietary indole-3-carbinol on intestinal and hepatic monooxygenase, glutathione S-transferase and epoxide hydrolyase activities in the rat. Food and Chemical Toxicology 22, 977–982.
Bradfield, C. A. & Bjeldanes, L. F. (1987). High-performance liquid chromatographic analysis of anticarcinogenic indoles in Brassica oleracea. Journal of Agricultural and Food Chemistry 35, 46–49.
Bradlow, H. L., Michnovicz, J. J., Telang, N. T. & Osborne, M. P. (1991). Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice. Carcinogenesis 12, 1571–1574.
Buchwaldt, L., Larsen, L. M., Plöger, A. & Sørensen, H. (1986). Fast polymer liquid chromatography isolation and characterization of plant myrosinase, β-thioglucoside glucohydrolase, isoenzymes. Journal of Chromatography 363, 71–80.
Burchell, B., Jackson, M. R., Coughtrie, M. W. H., Harding, D., Wilson, S. & Bend, J. R. (1987). Molecular characterization of hepatic UDP-glucuronyl transferases. In Drug Metabolism: From Molecules to Man, pp. 40–54 [Benford, D.Bridges, J. W. and Gibson, G. G. editors]. London: Taylor and Francis.
Burke, M. D. & Orrenius, S. (1979). Isolation and comparison of endoplasmic reticulum membranes and their mixed function oxidase activities from mammalian extrahepatic tissues. Pharmacology and Therapeutics 7, 549–599.
Butler, E. J., Pearson, A. W. & Fenwick, G. R. (1982). Problems which limit the use of rapeseed meal as a protein source in poultry diets. Journal of the Science of Food and Agriculture 33, 866–875.
Caldwell, J. (1979). Minireview. The significance of phase II (conjugation) reactions in drug disposition and toxicity. Life Sciences 24, 571–578.
Caldwell, J. (1980). Conjugation reactions. In Concepts in Drug Metabolism, vol. 10(A), pp. 211–217 [Jenner, P. and Testa, B. editors]. Basel: Decker.
Carlson, D. G., Daxenbichler, M. E., vanEtten, C. H., Hill, C. B. & Williams, P. H. (1985). Glucosinolates in radish cultivars. Journal of the American Society for Horticultural Science 110, 634–638.
Carlson, D. G., Daxenbichler, M. E., vanEtten, C. H., Kwolek, W. F. & Williams, P. H. (1987). Glucosinolates in crucifer vegetables: broccoli, Brussels sprouts, cauliflower, collards, kale, mustard greens, and kohlrabi. Journal of the American Society for Horticultural Science 112, 173–178.
Carlson, D. G., Daxenbichler, M. E., vanEtten, C. H., Tookey, H. L. & Williams, P. H. (1981). Glucosinolates in crucifer vegetables: turnips and rutabagas. Journal of Agricultural and Food Chemistry 29, 1235–1239.
Cha, Y. N., Thompson, D. C., Heine, H. S. & Chung, J. H. (1985). Differential effects of indole, indole-3-carbinol and benzofuran on several microsomal and cytosolic enzyme activities in mouse liver. Korean Journal of Pharmacology (Taehan Yakrihak Chapchi) 21, 1–11.
Chang, Y. & Bjeldanes, L. F. (1985). Effect of dietary R-goitrin on hepatic and intestinal glutathione S-transferase, microsomal epoxide hydratase and ethoxycoumarin O-deethylase activities in the rat. Food and Chemical Toxicology 23, 905–909.
Chung, F.-L., Wang, M. & Hecht, S. S. (1985). Effects of dietary indoles and isothiocyanates on N-nitrosodimethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone α-hydroxylation and DNA methylation in rat liver. Carcinogenesis 6, 539–543.
Coles, B. & Ketterer, B. (1990). The role of glutathione and glutathione transferases in chemical carcinogenesis. CRC Critical Reviews in Biochemistry and Molecular Biology 25, 47–70.
Committee on Diet, Nutrition and Cancer, National Research Council (1982). Diet, Nutrition and Cancer. Washington DC: National Academy Press.
Conney, A. H. (1982). Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. Cancer Research 42, 4875–4917.
Daxenbichler, M. E., vanEtten, C. H. & Williams, P. H. (1979). Glucosinolates and derived products in cruciferous vegetables. Analysis of 14 varieties of Chinese cabbage. Journal of Agricultural and Food Chemistry 27, 34–37.
de Vos, R. H. & Blijleven, W. G. H. (1988). The effect of processing conditions on glucosinolates in cruciferous vegetables. Zeitschrift für Lebensmittel-Untersuchung und -Forschung 187, 525–529.
Duncan, A. J. & Milne, J. A. (1989). Glucosinolates. In Anti-nutritional Factors, Potentially Toxic Substances in Plants (Aspects of Applied Biology 19), pp. 75–92.
Duncan, A. J. & Milne, J. A. (1992). Rumen microbial degradation of allyl cyanide as a possible explanation for the tolerance of sheep to brassica-derived glucosinolates. Journal of the Science of Food and Agriculture 58, 15–19.
Elfving, S. (1980). Studies in the naturally occurring goitrogen 5-vinyl-2-thiooxazolidone. Annals of Clinical Research 12, Suppl. 28, 7–47.
Etienne, M. & Dourmad, J.-Y. (1987). [Effects of high or low-glucosinolate varieties of rapeseed meal on reproduction in sow]. Journées de la Recherche Porcine en France 19, 231–238.
Ettlinger, M. G., Dateo, G. P., Harrison, B. W., Mabry, T. J. & Thompson, C. P. (1961). Vitamin C as a coenzyme: the hydrolysis of mustard oil glucosides. Proceedings of the National Academy of Sciences, USA 47, 1875–1880.
Ettlinger, M. G. & Lundeen, A. J. (1956). The structures of sinigrin and sinalbin; an enzymatic rearrangement. Journal of the American Chemical Society 78, 4172–4173.
Fenwick, G. R., Butler, E. J. & Brewster, M. A. (1983). Are brassica vegetables aggravating factors in trimethylaminuria (fish odour syndrome)? Lancet 2, 916.
Fenwick, G. R., Heaney, R. K., Hanley, A. B. & Spinks, E. A. (1986). Glucosinolates in food plants. In Food Research Institute, Norwich, Annual Report.
Fenwick, G. R., Heaney, R. K. & Mullin, W. J. (1982). Glucosinolates and their breakdown products in food and food plants. CRC Critical Reviews in Food Science and Nutrition 18, 123–201.
Gil, V. & MacLeod, A. J. (1980). The effects of pH on glucosinolate degradation by a thioglucoside glucohydrolase preparation. Phytochemistry 19, 2547–2551.
Goeger, D. E., Shelton, D. W., Hendricks, J. D. & Bailey, G. S. (1986). Mechanisms of anti-carcinogenesis by indole-3-carbinol: effect on the distribution and metabolism of aflatoxin B1 in rainbow trout. Carcinogenesis 7, 2025–2031.
Gould, D. H., Fettman, M. J., Daxenbichler, M. E. & Bartuska, B. M. (1985). Functional and structural alterations of the rat kidney induced by the naturally occurring organonitrile, 2S-1-cyano-2-hydroxy-3,4-epithiobutane. Toxicology and Applied Pharmacology 78, 190–201.
Graham, S., Dayal, H., Swanson, M., Mittelman, A. & Wilkinson, G. (1978). Diet in the epidemiology of cancer of the colon and rectum. Journal of the National Cancer Institute 61, 709–714.
Graham, S., Schotz, W. & Martino, P. (1972). Alimentary factors in the epidemiology of gastric cancer. Cancer 30, 927–938.
Greer, M. A. (1962). The natural occurrence of goitrogenic agents. Recent Progress in Hormone Research 18, 187–219.
Greer, M. A. & Astwood, E. B. (1948). The antithyroid effect of certain foods in man as determined with radioactive iodine. Endocrinology 43, 105–119.
Greer, M. A. & Deeney, J. M. (1959). Antithyroid activity elicited by the ingestion of pure progoitrin, a naturally occurring thioglycoside of the turnip family. Journal of Clinical Investigation 38, 1465–1474.
Guengerich, F. P. (1989). Polymorphism of cytochrome P-450 in humans. Trends in Pharmacological Sciences 10, 107–109.
Guengerich, F. P., Dannan, G. A., Wright, S. T., Martin, M. V. & Kaminsky, L. S. (1982). Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immuno-chemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or β-naphthoflavone. Biochemistry 21, 6019–6030.
Habig, W. H., Pabst, M. J. & Jakoby, W. B. (1974). Glutathione-S-Transferases: the first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry 249, 7130–7139.
Haenszel, W., Locke, F. B. & Segi, M. (1980). A case-control study of large bowel cancer in Japan. Journal of the National Cancer Institute 64, 17–22.
Heaney, R. K. & Fenwick, G. R. (1980 a). Glucosinolates in Brassica vegetables. Analysis of 22 varieties of Brussels sprout (Brassica oleracea var. gemmifera). Journal of the Science of Food and Agriculture 31, 785–793.
Heaney, R. K. & Fenwick, G. R. (1980 b). The glucosinolate content of Brassica vegetables. A chemotaxonomic approach to cultivar identification. Journal of the Science of Food and Agriculture 31, 794–801.
Hendrich, S. & Bjeldanes, L. F. (1983). Effects of dietary cabbage, Brussels sprouts, Illicium verum, Schizandra chinensis and alfalfa on the benzo[a]pyrene metabolic system in mouse liver. Food and Chemical Toxicology 21, 479–486.
Jakoby, W. B. (1978). The glutathione S-transferases: a group of multifunctional detoxification proteins. Advances in Enzymology 46, 383–414.
Jakoby, W. B. (1980). Enzymatic Basis of Detoxication, vol. 1. London: Academic Press.
Josefsson, E. (1970). Glucosinolate content and amino acid composition of rapeseed (Brassica napus) meal as affected by sulphur and nitrogen nutrition. Journal of the Science of Food and Agriculture 21, 98–103.
Kato, R. (1979). Characteristics and differences in the hepatic mixed function oxidases of different species. Pharmacology and Therapeutics 6, 41–98.
Kore, A. M., Jeffery, E. H. & Wallig, M. A. (1993). Effects of 1-isothiocyanato-3-(methylsulfinyl)-propane on xenobiotic metabolizing enzymes in rats. Food and Chemical Toxicology 31, 723–729.
Krusius, F.-E. & Peltola, P. (1966). The goitrogenic effect of naturally occurring l-5-vinyl and l-5-phenyl-2-thio-oxazolidone in rats. Acta Endocrinologica 53, 342–352.
Langer, P. & Greer, M. A. (1968). Antithyroid activity of some naturally occurring isothiocyanates in vitro. Metabolism 17, 596–605.
Langer, P. & Michajlovskij, N. (1969). Studies on the antithyroid activity of naturally occurring l-5-vinyl-2-thiooxazolidone and its urinary metabolite in rats. Acta Endocrinologica 62, 21–30.
Langer, P., Michajlovskij, N., Sedlák, J. & Kutka, M. (1971). Studies on the antithyroid activity of naturally occurring l-5-vinyl-2-thiooxazolidone in man. Endokrinologie 57, 225–229.
Langer, P. & Stolc, V. (1965). Goitrogenic activity of allylisothiocyanate — a widespread natural mustard oil. Endocrinology 76, 151–155.
Lanzani, A., Piana, G., Piva, G., Cardillo, M., Rastelli, A. & Jacini, G. (1974). Changes in Brassica napus progoitrin induced by sheep rumen fluid. Journal of the American Oil Chemists' Society 51, 517–518.
Lehrmann, P. (1989). [Rapeseed: glucosinolate variability]. Cultivar 245, 44–46.
Lewis, J. & Fenwick, G. R. (1987). Glucosinolate content of Brassica vegetables: analysis of twenty-four cultivars of calabrese (green sprouting broccoli, Brassica oleracea L. var. botrytis subvar. cymosa Lam.). Food Chemistry 25, 259–268.
Lewis, J. & Fenwick, G. R. (1988). Glucosinolate content of brassica vegetables — Chinese cabbages pe-tsai (Brassica pekinensis) and pak-choi (Brassica chinensis). Journal of the Science of Food and Agriculture 45, 379–386.
Linscheid, M., Wendisch, D. & Strack, D. (1980). The structures of sinapic acid esters and their metabolism in cotyledons of Raphanus sativus. Zeitschrift für Naturforschung 35C, 907–914.
Lo, M.-T. & Bell, J. M. (1972). Effects of various dietary glucosinolates on growth, feed intake, and thyroid function of rats. Canadian Journal of Animal Science 52, 295–302.
Lo, M. T. & Hill, D. C. (1971). Effect of feeding a high level of rapeseed meal on weight gains and thyroid function of rats. Journal of Nutrition 101, 975–980.
Loub, W. D., Wattenberg, L. W. & Davis, D. W. (1975). Aryl hydrocarbon hydroxylase induction in rat tissues by naturally occurring indoles of cruciferous plants. Journal of the National Cancer Institute 54, 985–988.
McDanell, R. E., McLean, A. E. M., Hanley, A. B., Heaney, R. K. & Fenwick, G. R. (1987). Differential induction of mixed-function oxidase (MFO) activity in rat liver and intestine by diets containing processed cabbage: correlation with cabbage levels of glucosinolates and glucosinolate hydrolysis products. Food and Chemical Toxicology 25, 363–368.
McDanell, R. E., McLean, A. E. M., Hanley, A. B., Heaney, R. K. & Fenwick, G. R. (1988). Chemical and biological properties of indole glucosinolates (glucobrassicins): a review. Food and Chemical Toxiology 26, 59–70.
McDanell, R. E., McLean, A. E. M., Hanley, A. B., Heaney, R. K. & Fenwick, G. R. (1989). The effect of feeding Brassica vegetables and intact glucosinolates on mixed-function-oxidase activity in the livers and intestines of rats. Food and Chemical Toxicology 27, 289–293.
McMillan, M., Spinks, E. A. & Fenwick, G. R. (1986). Preliminary observations on the effect of dietary Brussels sprouts on thyroid function. Human Toxicology 5, 15–19.
Mannervik, B. (1985). The isoenzymes of glutathione transferase. Advances in Enzymology 57, 357–417.
Marangos, A. & Hill, R. (1974). The hydrolysis and absorption of thioglucosides of rapeseed meal. Proceedings of the Nutrition Society 33, 90A.
Michnovicz, J. J. & Bradlow, H. L. (1991). Altered estrogen metabolism and excretion in humans following consumption of indole-3-carbinol. Nutrition and Cancer 16, 59–66.
Miguchi, S., Kojima, T. & Fukuzawa, M. (1974). Goitrogenic substance in rapeseed. V. The myrosinase-like activity of intestinal bacteria of chickens. Journal of Food Science and Technology 21, 215–222.
Miller, K. W. & Stoewsand, G. S. (1983). Hepatic polysubstrate monooxygenase activities in different strains of rats fed cabbage (Brassica oleracea). Drug and Chemical Toxicology 6, 93–110.
Mullin, W. J. & Sahasrabudhe, M. R. (1978). An estimate of the average daily intake of glucosinolates via cruciferous vegetables. Nutrition Reports international 18, 273–279.
Muztar, A. J., Huque, T., Ahmad, P. & Slinger, S. J. (1979). Effect of allyl isothiocyanate on plasma and urinary concentrations of some biochemical entities in the rat. Canadian Journal of Physiology and Pharmacology 57, 504–509.
Nebert, D. W., Nelson, D. R., Adesnik, M., Coon, M. J., Estabrook, R. W., Gonzalez, F. J., Guengerich, F. P., Gunsalus, I. C., Johnson, E. F., Kemper, B., Levin, W., Phillips, I. R., Sato, R. & Waterman, M. R. (1989). The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromsomal loci. DNA 8, 1–13.
Nishie, K. & Daxenbichler, M. E. (1980). Toxicology of glucosinolates, related compounds (nitriles, R-goitrin, isothiocyanates) and vitamin U found in Cruciferae. Food and Cosmetic Toxicology 18, 159–172.
Nugon-Baudon, L., Rabot, S., Flinois, J. P., Beaune, P. & Szylit, O. (1991). Glucosinolate interactions with the hepatic xenobiotic metabolizing enzymes (XME): influence of the intestinal microflora. In Proceedings of the GCIRC 8th International Rapeseed Congress, pp. 402–407 [McGregor, , editor].
Nugon-Baudon, L., Rabot, S., Szylit, O. & Raibaud, P. (1990 a). Glucosinolates toxicity in growing rats: interactions with the hepatic detoxification system. Xenobiotica 20, 223–230.
Nugon-Baudon, L., Rabot, S., Wal, J.-M. & Szylit, O. (1990 b). Interactions of the intestinal microflora with glucosinolates in rapeseed meal toxicity: first evidence of an intestinal lactobacillus possessing a myrosinase-like activity in vivo. Journal of the Science of Food and Agriculture 52, 547–559.
Nugon-Baudon, L., Szylit, O. & Raibaud, P. (1988). Production of toxic glucosinolate derivatives from rapeseed meal by intestinal microflora of rat and chicken. Journal of the Science of Food and Agriculture 43, 299–308.
Oginsky, E. L., Stein, A. E. & Greer, M. A. (1965). Myrosinase activity in bacteria as demonstrated by the conversion of progoitrin to goitrin. Proceedings of the Society for Experimental Biology and Medicine 119, 360–364.
Ohtsuru, M. & Hata, T. (1979). The interaction of L-ascorbic acid with the active center of myrosinase. Biochimica et Biophysica Acta 567, 384–391.
Ozierenski, B., Plass, R. & Lewerenz, H.-J. (1993). Effects of glucosinolate breakdown products on the hepatic biotransformation system in male rats. Nahrung 37, 5–14.
Pantuck, E. J., Hsiao, K.-C., Loub, W. D., Wattenberg, L. W., Kuntzman, R. & Canney, A. H. (1976). Stimulatory effect of vegetables on intestinal drug metabolism in the rat. Journal of Pharmacology and Experimental Therapeutics 198, 278–283.
Pantuck, E. J., Pantuck, C. B., Anderson, K. E., Wattenberg, L. W., Conney, A. H. & Kappas, A. (1984). Effect of Brussels sprouts and cabbage on drug conjugation. Clinical Pharmacology and Therapeutics 35, 161–169.
Pantuck, E. J., Pantuck, C. B., Garland, W. A., Min, B. H., Wattenberg, L. W., Anderson, K. E., Kappas, A. & Conney, A. H. (1979). Stimulatory effect of Brussels sprouts and cabbage on human drug metabolism. Clinical Pharmacology and Therapeutics 25, 88–95.
Pence, B. C., Buddingh, F. & Yang, S. P. (1986). Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: main effect of indole-3-carbinol. Journal of the National Cancer Institute 77, 269–276.
Pickett, C. B. & Lu, A. Y. H. (1989). Glutathione S-transferases: gene structure, regulation, and biological function. Annual Review of Biochemistry 58, 743–764.
Quinsac, A. (1993). Les glucosinolates et leurs dérivés dans les cruciferes. Analyse par chromatographie en phase liquide et perspectives d'utilisation de l' électrophorèse capillaire (Glucosinolates and glucosinolate derivatives in cruciferous plants. HPLC analysis and the possibilities of capillary electrophoresis), PhD Thesis, University of Orléans, 143 pp.
Rabot, S., Nugon-Baudon, L., Boutemine, Y., Raibaud, P. & Szylit, O. (1990). Incidence of three human digestive bacterial strains on rapeseed meal toxicity in gnotobiotic rats. Microecology and Therapy 20, 135–140.
Rabot, S., Nugon-Baudon, L., Popot, F. & Szylit, O. (1991). Preliminary studies on the modulation of rapeseed meal toxicity in conventional rats by poorly digestible carbohydrates. In Proceedings of the GCIRC 8th International Rapeseed Congress, pp. 1561–1566. [McGregor, , editor].
Rabot, S., Nugon-Baudon, L., Raibaud, P. & Szylit, O. (1993 a). Rapeseed meal toxicity in gnotobiotic rats: influence of a whole human faecal flora or single human strains of Escherichia coli and Bacteroides vulgatus. British Journal of Nutrition 70, 323–331.
Rabot, S., Nugon-Baudon, L. & Szylit, O. (1993 b). Alterations of the hepatic xenobiotic-metabolizing enzymes by a glucosinolate-rich diet in germ-free rats: influence of a pre-induction with phenobarbital. British Journal of Nutrition 70, 347–354.
Rowland, I. R. (1988). Interactions of the gut microflora and the host in toxicology. Toxicologic Pathology 16, 147–153.
Salbe, A. D. & Bjeldanes, L. F. (1989). Effect of diet and route of administration on the DNA binding of aflatoxin B1 in the rat. Carcinogenesis 10, 629–634.
Sang, J. P., Minchinton, I. R., Johnstone, P. K. & Truscott, R. J. W. (1984). Glucosinolate profiles in the seed, root and leaf tissue of cabbage, mustard, rapeseed, radish and swede. Canadian Journal of Plant Science 64, 77–93.
Searle, L. M., Chamberlain, K. & Butcher, D. N. (1984). Preliminary studies on the effects of copper, iron and manganese ions on the degradation of 3-indolylmethyl-glucosinolate (a constituent of Brassica spp.) by myrosinase. Journal of the Science of Food and Agriculture 35, 745–748.
Searle, L. M., Chamberlain, K., Rausch, T. & Butcher, D. N. (1982). The conversion of 3-indolylmethyl-glucosinolate to 3-indolylacetonitrile by myrosinase and its relevance to the clubroot disease of the Cruciferae. Journal of Experimental Botany 33, 935–942.
Seardic, D., Pasanen, M., Pelkonen, O. & Boobis, A. R. (1990). Differential expression and regulation of members of the cytochrome P450IA gene subfamily in human tissues. Carcinogenesis 11, 1183–1188.
Shertzer, H. G. (1982). Indole-3-carbinol and indole-3-acetonitrile influence on hepatic microsomal metabolism. Toxicology and Applied Pharmacology 64, 353–361.
Shertzer, H. G. (1983). Protection by indole-3-carbinol against covalent binding of benzo[a]pyrene Metabolites to mouse liver DNA and protein. Food and Chemical Toxicology 21, 31–35.
Shertzer, H. G. (1984). Indole-3-carbinol protects against covalent binding of benzo[a]pyrene and N-nitrosodimethylamine metabolites to mouse lever macromolecules. Chemico-Biological Interactions 48, 81–90.
Slominski, B. A. & Campbell, L. D. (1989). Formation of indole glucosinolate breakdown products in autolyzed, steamed, and cooked Brassica vegetables. Journal of Agricultural and Food Chemistry 37, 1297–1302.
Sones, K., Heaney, R. K. & Fenwick, G. R. (1984 a). An estimate of the mean daily intake of glucosinolates from cruciferous vegetables in the UK. Journal of the Science of Food and Agriculture 35, 712–720.
Sones, K., Heaney, R. K. & Fenwick, G. R. (1984 b). Glucosinolates in Brassica vegetables. Analysis of twenty-seven cauliflower cultivars (Brassica oleracea L. var. botrytis subvar. cauliflora DC). Journal of the Science of Food and Agriculture 35, 762–766.
Sparnins, V. L., Venegas, P. L. & Wattenberg, L. W. (1982). Glutathione S-transferase activity: enhancement by compounds inhibiting chemical carcinogenesis and by dietary constituents. Journal of the National Cancer Institute 68, 493–496.
Srisangnam, C., Hendricks, D. G., Sharma, R. P., Salunkhe, D. K. & Mahoney, A. W. (1980 a). Effects of dietary cabbage (Brassica oleracea L.) on the tumorigenicity of 1,2-dimethylhydrazine in mice. Journal of Food Safety 2, 235–245.
Srisangnam, C., Salunkhe, D. K., Reddy, N. R. & Dull, G. G. (1980 b). Quality of cabbage. II. Physical, chemical, and biochemical modification in processing treatments to improve flavor in blanched cabbage (Brassica oleracea L.). Journal of Food Quality 3, 233–250.
Srivastava, V. K., Philbrick, D. J. & Hill, D. C. (1975). Response of rats and chicks to rapessed meal subjected to different enzymatic treatments. Canadian Journal of Animal Science 55, 331–335.
Stoewsand, G. S., Anderson, J. L. & Munson, L. (1988). Protective effect of dietary Brussels sprouts against mammary carcinogenesis in Sprague-Dawley rats. Cancer Letters 39, 199–207.
Stoewsand, G. S., Babish, J. B. & Wimberly, H. C. (1978). Inhibition of hepatic toxicities from polybrominated biphenyls and aflatoxin, B1 in rats fed cauliflower. Journal of Environmental Pathology and Toxicology 2, 399–406.
Szabo, S., Bailey, K. A., Boor, P. J. & Jaeger, R. J. (1977). Acrylonitrile and tissue glutathione: differential effect of acute and chronic interactions. Biochemical and Biophysical Research Communications 79, 32–37.
Tanaka, T., Mori, Y., Morishita, Y., Hara, A., Ohno, T., Kojima, T. & Mori, H. (1990). Inhibitory effect of sinigrin and indole-3-carbinol on diethylnitrosamine-induced hepatocarcinogenesis in male ACI/N rats. Carcinogenesis 11, 1403–1406.
Tani, N., Ohtsuru, M. & Hata, T. (1974). Isolation of myrosinase producing microorganism. Agricultural and Biological Chemistry 38, 1617–1622.
Timms, C., Schladt, L., Robertson, L., Rauch, P., Schramm, H. & Oesch, F. (1987). The regulation of rat liver epoxide hydrolases in relation to that of other drug-metabolizing enzymes. In Drug Metabolism: From Molecules to Man, pp. 55–68 [Benford, D.Bridges, J. W. and Gibson, G. G. editors]. London: Taylor and Francis.
Tookey, H. L. (1973). Crambe thioglucoside glucohydrolase (EC 126.96.36.199): separation of a protein required for epithiobutane formation. Canadian Journal of Biochemistry 51, 1654–1660.
Tookey, H. L. & Wolff, I. A. (1970). Effect of organic reducing agents and ferrous ion on thioglucosidase activity of Crambe abyssinica seed. Canadian Journal of Biochemistry 48, 1024–1028.
Uda, Y., Kurata, T. & Arakawa, N. (1986). Effects of pH and ferrous ion on the degradation of glucosinolates by myrosinase. Agricultural and Biological Chemistry 50, 2735–2740.
Ullrich, D. & Bock, K. W. (1984). Glucuronide formation of various drugs in liver microsomes and in isolated hepatocytes from phenobarbital-and 3-methylcholanthrene-treated rats. Biochemical Pharmacology 33, 97–101.
vanEtten, C. H., Daxenbichler, M. E., Peters, J. E. & Tookey, H. L. (1966). Variation in enzymatic degradation products from the major thioglucosides in Crambe abyssinica and Brassica napus seed meals. Journal of Agricultural and Food Chemistry 14, 426–430.
vanEtten, C. H., Daxenbichler, M. E. & Wolff, I. A. (1969). Natural glucosinolates (thioglucosides) in foods and feeds. Journal of Agricultural and Food Chemistry 17, 483–491.
Vermorel, M., Davicco, M.-J. & Evrard, J. (1987). Valorization of rapeseed meal. 3. Effects of glucosinolate content on food intake, weight gain, liver weight and plasma thyroid hormone levels in growing rats. Reproduction, Nutrition, Développment 27, 57–66.
Vermorel, M. & Evard, J. (1987). Valorization of rapeseed meal. 4. Effects of iodine, copper and ferrous salt supplementation in growing rats. Reproduction, Nutrition, Développment 27, 769–779.
Vermorel, M., Heaney, R. K. & Fenwick, G. R. (1986). Nutritive value of rapeseed meal: effects of individual glucosinolates. Journal of the Science of Food and Agriculture 37, 1197–1202.
Wattenberg, L. W. (1971). Studies of polycyclic hydrocarbon hydroxylases of the intestine possibly related to cancer. Effect of diet on benzpyrene hydroxylase activity. Cancer 28, 99–102.
Watenberg, L. W., Hanley, A. B., Barany, G., Sparnins, V. L., Lam, L. K. T. & Fenwick, G. R. (1986). Inhibition of carcinogenesis by some minor dietary components. In Diet, Nutrition and Cancer, pp. 13–21 [Hayashi, Y. et al. editors]. Tokyo: VNU Science.
Wattenberg, L. W. & Loub, W. D. (1978). Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally-occurring indoles. Cancer Research 38, 1410–1413.
Wishart, G. J. (1978). Demonstration of functional heterogeneity of hepatic uridine diphosphate glucuronosyl-transferase activities after administration of 3-methylcholanthrene and phenobarbital to rats. Biochemical Journal 174, 671–672.
Wortelboer, H. M. (1991). Primary hepatocyte cultures as a model system for the determination of induction of biotransformation enzymes. Effects of glucosinolate hydrolysis products. PhD Thesis, University of Utrecht, 145 pp.
Wortelboer, H. M., de Kruif, C. A., van Iersel, A. A. J., Noordhoek, J., Blaauboer, B. J., van Bladeren, P. J. & Falke, H. E. (1992). Effects of cooked Brussels sprouts on cytochrome P-450 profile and phase II enzymes in liver and small intestinal mucosa of the rat. Food and Chemical Toxicology 30, 17–27.
Wrighton, S. A., Campanile, C., Thomas, P. E., Maines, S. L., Watkins, P. B., Parker, G., Mendez-Picon, G., Haniu, M., Shively, J. E., Levin, W. & Guzelian, P. S. (1986). Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat. Molecular Pharmacology 29, 405–410.
Youngs, C. G. & Perlin, A. S. (1967). Fe(II)-catalyzed decomposition of sinigrin and related thioglycosides. Canadian Journal of Chemistry 45, 1801–1804.
Zhang, Y., Talalay, P., Cho, C.-G. & Posner, G. H. (1992). A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proceedings of the National Academy of Sciences, USA 89, 2399–2403.