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A review and meta-analysis of red and processed meat consumption and breast cancer

  • Dominik D. Alexander (a1), Libby M. Morimoto (a2), Pamela J. Mink (a3) and Colleen A. Cushing (a1)
Abstract

The relationship between meat consumption and breast cancer has been the focus of several epidemiological investigations, yet there has been no clear scientific consensus as to whether red or processed meat intake increases the risk of breast cancer. We conducted a comprehensive meta-analysis incorporating data from several recently published prospective studies of red or processed meat intake and breast cancer. In the meta-analysis utilising data from the Pooling Project publication (includes data from eight cohorts) combined with data from nine studies published between 2004 and 2009 and one study published in 1996, the fixed-effect summary relative risk estimate (SRRE) for red meat intake (high v. low) and breast cancer was 1·02 (95 % CI 0·98, 1·07; P value for heterogeneity = 0·001) and the random-effects SRRE was 1·07 (95 % CI 0·98, 1·17). The SRRE for each 100 g increment of red meat was 1·04 (95 % CI 1·00, 1·07), based on a fixed-effects model, and 1·12 (95 % CI 1·03, 1·23) based on a random-effects model. No association was observed for each 100 g increment of red meat among premenopausal women (SRRE 1·01; 95 % CI 0·92, 1·11) but a statistically significant SRRE of 1·22 (95 % CI 1·04, 1·44) was observed among postmenopausal women using a random-effects model. However, the association for postmenopausal women was attenuated and non-significant when using a fixed-effects model (SRRE 1·03; 95 % CI 0·98, 1·08). The fixed- and random-effect SRRE for high (v. low) processed meat intake and breast cancer were 1·00 (95 % CI 0·98, 1·01; P value for heterogeneity = 0·005) and 1·08 (95 % CI 1·01, 1·16), respectively. The fixed- and random-effect SRRE for each 30 g increment of processed meat were 1·03 (95 % CI 1·00, 1·06) and 1·06 (95 % CI 0·99, 1·14), respectively. Overall, weak positive summary associations were observed across all meta-analysis models, with the majority being non-statistically significant. Heterogeneity was evident in most analyses, summary associations were sensitive to the choice of analytical model (fixed v. random effects), and publication bias appeared to have produced slightly elevated summary associations. On the basis of this quantitative assessment, red meat and processed meat intake does not appear to be independently associated with increasing the risk of breast cancer, although further investigations of potential effect modifiers, such as analyses by hormone receptor status, may provide valuable insight to potential patterns of associations.

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Corresponding author
*Corresponding author: Dr Dominik D. Alexander, email dalexander@exponent.com
References
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1Linos E & Willett W (2009) Meat, dairy and breast cancer: do we have an answer? Am J Clin Nutr 90, 455456.
2Hems G (1970) Epidemiological characteristics of breast cancer in middle and late age. Br J Cancer 24, 226234.
3Armstrong B & Doll R (1975) Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer 15, 617631.
4La Vecchia C & Pampallona S (1986) Age at first birth, dietary practices and breast cancer mortality in various Italian regions. Oncology 43, 16.
5Serra-Majem L, La Vecchia C, Ribas-Barba L, et al. . (1993) Changes in diet and mortality from selected cancers in southern Mediterranean countries, 1960–1989. Eur J Clin Nutr 47, Suppl. 1, S25S34.
6Gray GE, Pike MC & Henderson BE (1979) Breast-cancer incidence and mortality rates in different countries in relation to known risk factors and dietary practices. Br J Cancer 39, 17.
7Boyd NF, Martin LJ, Noffel M, et al. . (1993) A meta-analysis of studies of dietary fat and breast cancer risk. Br J Cancer 68, 627636.
8Missmer SA, Smith-Warner SA, Spiegelman D, et al. . (2002) Meat and dairy food consumption and breast cancer: a pooled analysis of cohort studies. Int J Epidemiol 31, 7885.
9Taylor VH, Misra M & Mukherjee SD (2009) Is red meat intake a risk factor for breast cancer among premenopausal women? Breast Cancer Res Treat 117, 18.
10Kabat GC, Cross AJ, Park Y, et al. . (2009) Meat intake and meat preparation in relation to risk of postmenopausal breast cancer in the NIH-AARP Diet and Health Study. Int J Cancer 124, 24302435.
11Cross AJ, Leitzmann MF, Gail MH, et al. . (2007) Prospective study of red and processed meat intake in relation to cancer risk. PLoS Med 4, e325.
12Larsson SC, Bergkvist L & Wolk A (2009) Long-term meat intake and risk of breast cancer by oestrogen and progesterone receptor status in a cohort of Swedish women. Eur J Cancer 45, 30423046.
13Pala V, Krogh V, Berrino F, et al. . (2009) Meat, eggs, dairy products, and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am J Clin Nutr 90, 602612.
14Ferrucci LM, Cross AJ, Graubard BI, et al. . (2009) Intake of meat, meat mutagens, and iron and the risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Br J Cancer 101, 178184.
15Egeberg R, Olsen A, Autrup H, et al. . (2008) Meat consumption, N-acetyl transferase 1 and 2 polymorphism and risk of breast cancer in Danish postmenopausal women. Eur J Cancer Prev 17, 3947.
16Shannon J, Ray R, Wu C, et al. . (2005) Food and botanical groupings and risk of breast cancer: a case–control study in Shanghai, China. Cancer Epidemiol Biomarkers Prev 14, 8190.
17Taylor EF, Burley VJ, Greenwood DC, et al. . (2007) Meat consumption and risk of breast cancer in the UK Women's Cohort Study. Br J Cancer 96, 11391146.
18van der Hel OL, Peeters PH, Hein DW, et al. . (2004) GSTM1 null genotype, red meat consumption and breast cancer risk (The Netherlands). Cancer Causes Control 15, 295303.
19Cho E, Chen WY, Hunter DJ, et al. . (2006) Red meat intake and risk of breast cancer among premenopausal women. Arch Intern Med 166, 22532259.
20Frazier AL, Li L, Cho E, et al. . (2004) Adolescent diet and risk of breast cancer. Cancer Causes Control 15, 7382.
21Michels KB, Rosner BA, Chumlea WC, et al. . (2006) Preschool diet and adult risk of breast cancer. Int J Cancer 118, 749754.
22Holmes MD, Colditz GA, Hunter DJ, et al. . (2003) Meat, fish and egg intake and risk of breast cancer. Int J Cancer 104, 221227.
23Warriss PD (2000) Meat Science: An Introductory Text. Wallingford, UK: CABI Publishing.
24Santarelli RL, Pierre F & Corpet DE (2008) Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence. Nutr Cancer 60, 131144.
25Pooling Project of Prospective Studies of Diet and Cancer (2003) Brief description of the Pooling Project and component studies. http://www.hsph.harvard.edu/poolingproject/about.html.
26Gertig DM, Hankinson SE, Hough H, et al. . (1999) N-acetyl transferase 2 genotypes, meat intake and breast cancer risk. Int J Cancer 80, 1317.
27Mills PK, Beeson WL, Phillips RL, et al. . (1989) Dietary habits and breast cancer incidence among Seventh-Day Adventists. Cancer 64, 582590.
28Voorrips LE, Brants HA, Kardinaal AF, et al. . (2002) Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands Cohort Study on Diet and Cancer. Am J Clin Nutr 76, 873882.
29Greenland S & Longnecker MP (1992) Methods for trend estimation from summarized dose–response data, with applications to meta-analysis. Am J Epidemiol 135, 13011309.
30Berlin JA, Longnecker MP & Greenland S (1993) Meta-analysis of epidemiologic dose–response data. Epidemiology 4, 218228.
31Rothstein HR, Sutton AJ & Borenstein M (2005) Publication Bias in Meta-Analysis: Prevention, Assessments, and Adjustments. Chichester, UK: John Wiley and Sons, Ltd.
32Rothman K (2004) Episheet software: spreadsheets for the analysis of epidemiologic data. http://members.aol.com/krothman/episheet.xls.
33Byrne C, Ursin G & Ziegler RG (1996) A comparison of food habit and food frequency data as predictors of breast cancer in the NHANES I/NHEFS cohort. J Nutr 126, 27572764.
34Linos E & Willett WC (2007) Diet and breast cancer risk reduction. J Natl Compr Canc Netw 5, 711718.
35De Stefani E, Ronco A, Mendilaharsu M, et al. . (1997) Meat intake, heterocyclic amines, and risk of breast cancer: a case–control study in Uruguay. Cancer Epidemiol Biomarkers Prev 6, 573581.
36Steck SE, Gaudet MM, Eng SM, et al. . (2007) Cooked meat and risk of breast cancer – lifetime versus recent dietary intake. Epidemiology 18, 373382.
37Sinha R, Gustafson DR, Kulldorff M, et al. . (2000) 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, a carcinogen in high-temperature-cooked meat, and breast cancer risk. J Natl Cancer Inst 92, 13521354.
38Delfino RJ, Sinha R, Smith C, et al. . (2000) Breast cancer, heterocyclic aromatic amines from meat and N-acetyltransferase 2 genotype. Carcinogenesis 21, 607615.
39Deitz AC, Zheng W, Leff MA, et al. . (2000) N-acetyltransferase-2 genetic polymorphism, well-done meat intake, and breast cancer risk among postmenopausal women. Cancer Epidemiol Biomarkers Prev 9, 905910.
40Han DF, Ma J, Zhou X, et al. . (2004) A case–control study on the risk of female breast cancer in Wuhan area (article in Chinese). Zhonghua Liu Xing Bing Xue Za Zhi 25, 256260.
41Zheng W, Gustafson DR, Sinha R, et al. . (1998) Well-done meat intake and the risk of breast cancer. J Natl Cancer Inst 90, 17241729.
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Nutrition Research Reviews
  • ISSN: 0954-4224
  • EISSN: 1475-2700
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