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A centenary of Robert T. Leiper's lasting legacy on schistosomiasis and a COUNTDOWN on control of neglected tropical diseases

  • J. RUSSELL STOTHARD (a1), NARCIS B. KABATEREINE (a2), JOHN ARCHER (a1), HAJRI AL-SHEHRI (a1), LOUIS ALBERT TCHUEM-TCHUENTÉ (a3), MARGARET GYAPONG (a4) and AMAYA L. BUSTINDUY (a5)...
Summary
SUMMARY

Part of Robert T. Leiper's (1881–1969) lasting legacy in medical helminthology is grounded on his pioneering work on schistosomiasis (Bilharzia). Having undertaken many expeditions to the tropics, his fascination with parasite life cycles typically allowed him to devise simple preventive measures that curtailed transmission. Building on his formative work with others in Africa and Asia, and again in Egypt in 1915, he elucidated the life cycles of African schistosomes. His mandate, then commissioned by the British War Office, was to prevent and break transmission of this disease in British troops. This he did by raising standing orders based on simple water hygiene measures. Whilst feasible in military camp settings, today their routine implementation is sadly out of reach for millions of Africans living in poverty. Whilst we celebrate the centenary of Leiper's research we draw attention to some of his lesser known colleagues, then focus on schistosomiasis in Uganda discussing why expanded access to treatment with praziquantel is needed now. Looking to WHO 2020 targets for neglected tropical diseases, we introduce COUNTDOWN, an implementation research consortium funded by DFID, UK, which fosters the scale-up of interventions and confirm the current relevance of Leiper's original research.

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This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http://creativecommons.org/licenses/by-nc-sa/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is included and the original work is properly cited. The written permission of Cambridge University Press must be obtained for commerical re-use.
Corresponding author
*Corresponding author. Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK. Tel: +44 (151) 705-3724. E-mail: Russell.Stothard@lstmed.ac.uk
References
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Adriko M., Standley C. J., Tinkitina B., Mwesigwa G., Kristensen T. K., Stothard J. R. and Kabatereine N. B. (2013). Compatibility of Ugandan Schistosoma mansoni isolates with Biomphalaria snail species from Lake Albert and Lake Victoria. Acta Tropica 128, 303308.
Allen T. and Parker M. (2011). The ‘Other Diseases’ of the millennium development goals: rhetoric and reality of free drug distribution to cure the poor's parasites. Third World Quarterly 32, 91117.
Andrade Z. A. (2008). Schistosomiasis and hepatic fibrosis regression. Acta Tropica 108, 7982.
Atkinson E. A. (1916). An expedition to the Far East to investigate the spread of trematode diseases, with special reference to Schistosoma japonicum, and with a note on some protozoa as causes of dysentery. Journal of the Royal Navy Medical Service 2, 485490.
Barrett M. P., Innes E. A. and Cox F. E. G. (2015). The Scottish Encounter with Tropical Diseases. University of Glasgow, Glasgow, Scotland.
Bustinduy A. L., Luzinda K., Mpoya S., Gothard P., Stone N., Wright S. and Stothard J. R. (2014). Case Report: Endomyocardial Fibrosis (EMF) in a Ugandan child with advanced hepatosplenic schistosomiasis: coincidence or connection? American Journal of Tropical Medicine and Hygiene 91, 798800.
Callaway E. (2016). Dogs thwart effort to eradicate Guinea worm. Nature 529, 1011.
Campbell W. C. (1988). Heather and ice: an excursion in historical parasitology. Journal of Parasitology 74, 212.
Campbell W. C. and Overstreet R. M. (1994). Historial basis of binomials assigned to helminths collected on Scott's last Antarctic expedition. Journal of the Helminthological Society of Washington 61, 111.
Christinet V., Calmy A., Odermatt P. and O'Brien D. (2015). Female genital schistosomiasis and human immunodeficiency virus infection: a systematic literature review. Tropical Medicine & International Health 20, 6565.
Christinet V., Lazdins-Helds J. K., Stothard J. R. and Reinhard-Rupp J. (2016). Female genital schistosomiasis (FGS), will it remain the forgotten gynaecological disease of the future? International Journal for Parasitology 46, 395404.
Cook G. C. (2007). Tropical Medicine: An Illustrated History of the Pioneers. Academic Press, London.
Cox F. E. G. (in press). Conributions of Robert Leiper, William Leishman and Muriel Robertson to parasitology in the tropics. Parasitology.
de Moira A. P., Kabatereine N. B., Dunne D. W. and Booth M. (2011). Understanding ethnic differences in behaviour relating to Schistosoma mansoni re-infection after mass treatment. Journal of Biosocial Science 43, 185209.
Dunne D. W., Vennervald B. J., Booth M., Joseph S., Fitzsimmons C. M., Cahen P., Sturrock R. F., Ouma J. H., Mwatha J. K., Kimani G., Kariuki H. C., Kazibwe F., Tukahebwa E. and Kabatereine N. B. (2006). Applied and basic research on the epidemiology, morbidity, and immunology of schistosomiasis in fishing communities on Lake Albert, Uganda. Transactions of the Royal Society of Tropical Medicine and Hygiene 100, 216223.
Farley J. (1991). Bilharzia: A History of Imperial Tropical Medicine. Cambridge University Press, UK.
Fenwick A., Webster J. P., Bosque-Oliva E., Blair L., Fleming F. M., Zhang Y., Garba A., Stothard J. R., Gabrielli A. F., Clements A. C. A., Kabatereine N. B., Toure S., Dembele R., Nyandindi U., Mwansa J. and Koukounari A. (2009). The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002–2008. Parasitology 136, 17191730.
Fleming F. M., Fenwick A., Tukahebwa E. M., Lubanga R. G. N., Namwangye H., Zaramba S. and Kabatereine N. B. (2009). Process evaluation of schistosomiasis control in Uganda, 2003 to 2006: perceptions, attitudes and constraints of a national programme. Parasitology 136, 17591769.
Garnham P. C. C. (1970). Robert Thomson Leiper, 1881–1969. Biographical Memoirs of Fellows of the Royal Society. Royal Society (Great Britain) 16, 385404.
Goodwin L. G. (1996). Schistosomiasis. In The Wellcome Trust Illustrated History of Tropical Diseases (ed. Cox F. E. G..), pp. 264273. The Wellcome Trust, London.
Grove D. I. (1990). A History of Human Helminthology. CAB International, Oxford, UK.
Gyapong M., Marfo B., Theobold S., Hawking K., Page S., Osei-Atweneboanaa M. and Stothard J. R. (2015). The double jeopardy of having female genital schistosomiasis in poorly informed and resourced health systems in Ghana. Tropical Medicine & International Health 20, 77.
Hamilton Fairley N. (1951). Schistosomiasis and some of its problems. Transactions of the Royal Society of Tropical Medicine and Hygiene 45, 279303.
Hotez P. J. (2013). Forgotten People, Forgotten Diseases: The Neglected Tropical Diseases and their Impact on Global Health and Development. American Society for Microbiology, USA.
Jordan P. (2000). From Katayama to the Dakhla Oasis: the beginning of epidemiology and control of bilharzia. Acta Tropica 77, 940.
Jorgensen A., Kristensen T. K. and Stothard J. R. (2007). Phylogeny and biogeography of African Biomphalaria (Gastropoda : Planorbidae), with emphasis on endemic species of the great East African lakes. Zoological Journal of the Linnean Society 151, 337349.
Kabatereine N. B., Ariho C. and Christensen N. O. (1992). Schistosoma mansoni in Pachwach, Nebbi-District, Uganda, 40 years after Nelson. Tropical Medicine and Parasitology 43, 162166.
Kabatereine N. B., OdongoAginya E. I. and Lakwo T. L. (1996). Schistosoma mansoni along Lake Albert, Kibale district, western Uganda. East African Medical Journal 73, 502504.
Kabatereine N. B., Brooker S., Koukounari A., Kazibwe F., Tukahebwa E. M., Fleming F. M., Zhang Y., Webster J. P., Stothard J. R. and Fenwick A. (2007). Impact of a national helminth control programme on infection and morbidity in Ugandan school children. Bulletin of the World Health Organization 85, 9199.
Katz N. (2008). The discovery of Schistosomiasis mansoni in Brazil. Acta Tropica 108, 6971.
Leiper R. T. (1910). Guinea-worm in domesticated animals with a note of its discovery, by Mr C. Grey in a leopard. Journal of Tropical Medicine and Hygiene 13, 6566.
Leiper R. T. and Atkinson E. A. (1915 a). British Antarctic (“Terra Nova”) Expedition, 1910. Natural History Report. Parasitic worms with a note on a free-living nematode. British Museum (Natural History) ; Zoology 2, 1960.
Leiper R. T. and Atkinson E. L. (1915 b). Observations on the spread of Asiatic schistosomaisis. British Medical Journal 1, 201–192·204.
LeRoux P. L. (1961). Some problems in Bilharziasis in Africa and the adjoining countries. Journal of Helminthology 35 (Suppl. S1), 117126.
Levitz S., Standley C. J., Adriko M., Kabatereine N. B. and Stothard J. R. (2013). Environmental epidemiology of intestinal schistosomiasis and genetic diversity of Schistosoma mansoni infections in snails at Bugoigo village, Lake Albert. Acta Tropica 128, 284291.
Lockyer A. E., Jones C. S., Noble L. R. and Rollinson D. (2004). Trematodes and snails: an intimate association. Canadian Journal of Zoology 82, 251269.
Loewenberg S. (2014). Uganda's struggle with schistosomiasis. Lancet 383, 17071708.
Manson-Bahr P. (1961). Robert Thomson Leiper. Supplement in honour of R.T. Leiper on the occasion of his 80th Birthday. Journal of Helminthology 35, xvi.
Nelson G. S. (1958). Schistosoma mansoni infection in the West Nile District of Uganda. I. The incidence of S. mansoni infection. East African Medical Journal 35, 311319.
Nelson G. S. (1977). A Milestone on the road to discovery of life cycles of human schistosomes. American Journal of Tropical Medicine and Hygiene 26, 10931100.
Nelson G. S. (1990). Microepidemiology, the key to the control of parastic infections. Transactions of the Royal Society of Tropical Medicine and Hygiene 84, 313.
Norseth H. M., Ndhlovu P. D., Kleppa E., Randrianasolo B. S., Jourdan P. M., Roald B., Holmen S. D., Gundersen S. G., Bagratee J., Onsrud M. and Kjetland E. F. (2014). The colposcopic atlas of schistosomiasis in the lower female genital tract based on studies in Malawi, Zimbabwe, Madagascar and South Africa. Plos Neglected Tropical Diseases 8. doi: 10.1371/journal.pntd.0003229.
Ongom V. L. and Bradley D. J. (1972). Epidemiology and consequences of Schistosoma mansoni infection in West Nile, Uganda. 1. Field studies of a community in Panyagoro. Transactions of the Royal Society of Tropical Medicine and Hygiene 66, 835851.
Parker M. and Allen T. (2011). Does mass drug administration for the integrated treatment of neglected tropical diseases really work? Assessing evidence for the control of schistosomiasis and soil-transmitted helminths in Uganda. Health Research Policy and Systems 9. doi: 10.1186/1478-4505-9-3.
Parker M., Allen T. and Hastings J. (2008). Resisting control of neglected tropical diseases: dilemmas in the mass treatment of schistosomiasis and soil-transmitted helminths in north-west Uganda. Journal of Biosocial Science 40, 161181.
Rollinson D. (2009). A wake up call for urinary schistosomiasis: reconciling research effort with public health importance. Parasitology 136, 15931610.
Rollinson D., Knopp S., Levitz S., Stothard J. R., Tchuente L.-A. T., Garba A., Mohammed K. A., Schur N., Person B., Colley D. G. and Utzinger J. (2013). Time to set the agenda for schistosomiasis elimination. Acta Tropica 128, 423440.
Rowel C., Fred B., Betson M., Sousa-Figueiredo J. C., Kabatereine N. B. and Stothard J. R. (2015). Environmental epidemiology of intestinal schistosomiasis in Uganda: population dynamics of Biomphalaria (Gastropoda: Planorbidae) in Lake Albert and Lake Victoria with observations on natural infections with digenetic trematodes. Biomed Research International. doi: 10.1155/2015/717261.
Savioli L., Fenwick A., Rollinson D., Albonico M. and Ame S. M. (2015). An achievable goal: control and elimination of schistosomiasis. Lancet 386, 739739.
Seto E. Y. W., Sousa-Figueiredo J. C., Betson M., Byalero C., Kabatereine N. B. and Stothard J. R. (2012). Patterns of intestinal schistosomiasis among mothers and young children from Lake Albert, Uganda: water contact and social networks inferred from wearable global positioning system dataloggers. Geospatial Health 7, 113.
Southgate V. R., Rollinson D., Tchuente L. A. T. and Hagan P. (2005). Towards control of schistosomiasis in sub-Saharan Africa. Journal of Helminthology 79, 181185.
Stothard J. R., Sousa-Figueiredo J. C., Betson M., Green H. K., Seto E. Y. W., Garba A., Sacko M., Mutapi F., Nery S. V., Amin M. A., Mutumba-Nakalembe M., Navaratnam A., Fenwick A., Kabatereine N. B., Gabrielli A. F. and Montresor A. (2011). Closing the praziquantel treatment gap: new steps in epidemiological monitoring and control of schistosomiasis in African infants and preschool-aged children. Parasitology 138, 15931606.
Stothard J. R., Sousa-Figueiredo J. C., Betson M., Bustinduy A. and Reinhard-Rupp J. (2013). Schistosomiasis in African infants and preschool children: let them now be treated! Trends in Parasitology 29, 197205.
Stothard J. R., Bustinduy A. and Montresor A. (2014 a). Preventive chemotherapy for schistosomiasis and soil-transmitted helminthiasis by cotreatment with praziquantel and albendazole. Clinical Investigation 4, 163176.
Stothard J. R., Stanton M. C., Bustinduy A. L., Sousa-Figueiredo J. C., Van Dam G. J., Betson M., Waterhouse D., Ward S., Allan F., Hassan A. A., Al-Helal M. A., Memish Z. A. and Rollinson D. (2014 b). Diagnostics for schistosomiasis in Africa and Arabia: a review of present options in control and future needs for elimination. Parasitology 141, 19471961.
Tanaka H. and Tsuji M. (1997). From discovery to eradication of schistosomiasis in Japan: 1847–1996. International Journal for Parasitology 27, 14651480.
WHO (2013). Schistosomiasis: Progress report 2001–2011 and Strategic Plan 2012–2020. WHO, Geneva, Switzerland.
WHO (2015). Investing to Overcome the Global Impact of Tropical Diseases: Third Report on Nelgected Tropical Diseases 2015. WHO, Geneva, Switzerland.
Willmott S. (1981). Leiper, Robert Thomson, 1881–1969 - Centenary biographical note. International Journal for Parasitology 11, 423424.
Zou L. and Ruan S. G. (2015). Schistosomiasis transmission and control in China. Acta Tropica 143, 5157.
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