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Moderate to heavy infections of Trichuris trichiura affect cognitive function in Jamaican school children

  • C. Nokes (a1), S. M. Grantham-McGregor (a2), A. W. Sawyer (a1), E. S. Cooper (a1), B. A. Robinson (a3) and D. A. P. Bundy (a3)...
Abstract

A double-blind placebo trial was conducted to determine the effect of moderate to high loads of Trichuris trichiura (whipworm) infection on the cognitive functions of 159 school children (age 9–12 years) in Jamaica. Infected children were randomly assigned to Treatment or Placebo groups. A third group of randomly selected uninfected children were assigned to a Control for comparative purposes. The improvement in cognitive function was evaluated using a stepwise multiple linear regression, designed to control for any confounding variables. The expulsion of worms led to a significant improvement in tests of auditory short-term memory (P < 0.02; P < 0.01), and a highly significant improvement in the scanning and retrieval of long-term memory (P < 0.001). After 9 weeks, treated children were no longer significantly different from an uninfected Control group in these three tests of cognitive function. The removal of T. trichiura was more important than Ascaris lumbricoides in determining this improvement. The results suggest that whipworm infection has an adverse effect on certain cognitive functions which is reversible by therapy.

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D. A. P. Bundy (1986). Epidemiological aspects of Trichuris and trichuriasis in Caribbean communities. Transactions of the Royal Society of Tropical Medicine and Hygiene 80, 706–18.

D. A. P. Bundy , M. S. Wong & J. Horton (1990). Control of geohelminths by delivery of targeted chemotherapy through schools. Transactions of the Royal Society of Medicine and Hygiene 84, 115–20.

N. M. A. Clarke , S. M. Grantham-McGregor & C. Powell (1991). Nutrition and health predictors of school failure in Jamaican children. Ecology of Food and Nutrition 26, 111.

M. W. Eysenck (1986). Arousal, learning and memory. Psychological Bulletin 83, 389404.

R. H. Gilman , Y. H. Chong , C. Davis , B. Greenberg , H. K. Virik & H. B. Dixon (1983). The adverse consequences of heavy Trichuris infection. Transactions of the Royal Society of Tropical Medicine and Hygiene 77, 432–8.

A. Hall (1981). Quantitative variability of nematode egg counts in faeces: a study among rural Kenyans. Transactions of the Royal Society of Tropical Medicine and Hygiene 75, 682–7.

M. E. Halloran , D. A. P. Bundy & E. Pollitt (1989). Infectious disease and the Unesco basic education initiative. Parasitology Today 5, 359–62.

J. T. Jolliffe (1986). Principal Components as a small number of interpretable variables: some examples. In Principal Component Analysis, (ed. J. T. Jolliffe ), pp. 50–8. Springer Series in Statistics: Berlin: Springer-Verlag.

J. Kagan , B. Rosman , D. Day , J. Albert & W. Phillips (1964). Information processing in the child: significance of analytic and reflective attitudes. Psychological Monographs 78, 578615.

C. Nokes , E. S. Cooper , B. A. Robinson & D. A. P. Bundy (1991). Geohelminth infection and academic assessment in Jamaican children. Transactions of the Royal Society of Tropical Medicine and Hygiene 85, 272–3.

L. S. Stephenson , M. C. Latham & M. L. Oduori (1980). Costs, prevalence and approaches for control of Ascaris infection in Kenya. Journal of Tropical Paediatrics 26, 246–62.

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Parasitology
  • ISSN: 0031-1820
  • EISSN: 1469-8161
  • URL: /core/journals/parasitology
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