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Histological changes in mosquito flight muscle fibres associated with parasitization by filarial larvae

  • Evelyn B. Beckett (a1)
Abstract

1. Serial sections were examined of thoraces of a selected strain of Aedes aegypti infected with either Brugia pahangi or subperiodic B. malayi and of wild-caught Mansonia uniformis infected with the latter parasite.

2. A few badly damaged flight muscle fibres are seen in the early stages of infection but many more fibres are destroyed at the time when the mature filarial larvae leave the muscle and enter the haemocoel. In the intervening period, when the larvae are growing within the muscle fibres, only minor damage develops, affecting nuclei and/or mitochondria. The nature of such minor damage and the mechanism of complete muscle breakdown differs in the two species of mosquitoes.

3. It was concluded that the muscle damage was sufficiently severe to explain the significant mortality often observed among experimentally infected mosquitoes at the time when the mature filarial larvae enter the haemocoel.

I am very grateful to Dr W. W. Macdonald, of the Liverpool School of Tropical Medicine, who supplied the Aedes aegypti mosquitoes and who has given invaluable help and advice throughout this study. Mr Cheong Weng Hooi and his colleagues in Kuala Lumpur kindly supplied, and partly processed, the Mansonia uniformis mosquitoes. Miss M. A. Johnson assisted with the care of the A. aegypti colony and Mrs J. Oliver helped with some of the histological work.

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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

E. B. Beckett (1965). Histochemieal observations on Aedes aegypti infected with larvae of Brugia malayi. Transactions of the Royal Society of Tropical Medicine and Hygiene 59, 461–71.

E. B. Beckett & W. W. Macdonald (1971). The survival and development of subperiodic Brugia malayi and B. pahangi larvae in a selected strain of Aedes aegypti. Transactions of the Royal Society of Tropical Medicine and Hygiene (in the Press).

M. M. J. Lavoipiere (1958b). Studies on the host-parasite relationships of filarial nematodes and their arthropod hosts. II. The arthropod as a host to the nematode: a brief appraisal of our present knowledge based on a study of the more important literature from 1878 to 1957. Annals of Tropical Medicine and Parasitology 52, 326–45.

W. W. Macdonald & C. P. Ramachandran (1965). The influence of the gene fm (filarial susceptibility, Brugia malayi) on the susceptibility of Aedes aegypti to seven strains of Brugia, Wuchereria & Dirofllaria. Annals of Tropical Medicine and Parasitology, 59, 6473.

H. Townson (1971). Mortality of various genotypes of the mosquito Aedes aegypti following the uptake of microfilariae of Brugia pahangi. Annals of Tropical Medicine and, Parasitology 65, 93106.

R. H. Wharton (1957). Studies on filariasis in Malaya: the efficiency of Mansonia longipalpis as an experimental vector of Wuchereria malayi. Annals of Tropical Medicine and Parasitology. 51, 422–39.

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Parasitology
  • ISSN: 0031-1820
  • EISSN: 1469-8161
  • URL: /core/journals/parasitology
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