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    Saracino, María P. Calcagno, Marcela A. Beauche, Emilia Bilen Garnier, Ariel Vila, Cecilia C. Granchetti, Hugo Taus, María R. and Venturiello, Stella M. 2016. Trichinella spiralis infection and transplacental passage in human pregnancy. Veterinary Parasitology,

    Gentilini, María V. Nuñez, Guillermo G. Roux, María E. and Venturiello, Stella M. 2011. Trichinella spiralis infection rapidly induces lung inflammatory response. Immunobiology, Vol. 216, Issue. 9, p. 1054.

    Hernández-Bello, Romel Ramirez-Nieto, Ricardo Muñiz-Hernández, Saé Nava-Castro, Karen Pavón, Lenin Sánchez-Acosta, Ana Gabriela and Morales-Montor, Jorge 2011. Sex Steroids Effects on the Molting Process of the Helminth Human ParasiteTrichinella spiralis. Journal of Biomedicine and Biotechnology, Vol. 2011, p. 1.

    Nuñez, Guillermo G. Costantino, Susana N. Gentile, Teresa and Venturiello, Stella M. 2008. Immunoparasitological evaluation of Trichinella spiralis infection during human pregnancy: a small case series. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 102, Issue. 7, p. 662.


In vitro and in vivo effects of progesterone on Trichinella spiralis newborn larvae

  • G. G. NUÑEZ (a1), T. GENTILE (a1), S. N. COSTANTINO (a1), M. I. SARCHI (a2) and S. M. VENTURIELLO (a1)
  • DOI:
  • Published online: 01 April 2005

We have previously demonstrated that during pregnancy there exists an increased parasiticide activity against Trichinella spiralis newborn larvae (NBL) in infected rats. In this work we analysed the contribution of peritoneal cells from non-infected pregnant rats to the mortality of the NBL in cytotoxicity assays, and evaluated the role of progesterone in this effector mechanism. Our findings suggest that progesterone can induce activation of effector peritoneal cells to destroy the NBL in a rapid and antibody-independent manner. The administration of progesterone to ovariectomized rats also led to a significant decrease in the parasite load of the animals, thus demonstrating that progesterone induces the increase of the parasiticide activity of the leukocytes involved in the mechanisms of NBL death.

Corresponding author
Departmento de Microbiología, Inmunología y Biotecnologíá, Facultad de Farmacia y Bioquímica, Junín 956, (1113) Buenos Aires, Argentina. Fax: +54 11 4964 0024. E-mail:
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  • ISSN: 0031-1820
  • EISSN: 1469-8161
  • URL: /core/journals/parasitology
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