Skip to main content Accessibility help
×
Home

Increased pregnancy weight gain in women with latent toxoplasmosis and RhD-positivity protection against this effect

  • Š. KAŇKOVÁ (a1) (a2), J. ŠULC (a3) and J. FLEGR (a2)

Summary

Objective. RhD-positive subjects are protected against toxoplasmosis-associated impairment of psychomotor performance. Here we searched for RhD-positivity-associated maternal protection against the effects of toxoplasmosis. Methods. In the present retrospective cohort study, we analysed data from 785 (139 RhD-negative) Toxoplasma-free and 194 (27 RhD-negative) Toxoplasma-infected pregnant women. We searched for effects of toxoplasmosis and Rhd-phenotype on maternal weight before pregnancy, pregnancy weight gain, fetal ultrasound data (biparietal diameter, abdominal circumference, femur length) and on birth length and weight. Results. At pregnancy week 16, the RhD-negative mothers with toxoplasmosis gained more weight than others (P<0·001). The difference of about 1600 g remained approximately constant from pregnancy week 16 until the end of pregnancy. Neither toxoplasmosis nor RhD phenotype had any effect on fetal bioparameter data or birth length and weight. Conclusion. The most parsimonious explanation for the observed data is that the RhD-positive phenotype might protect infected subjects against a broad spectrum of detrimental effects of latent toxoplasmosis, including excessive gestational weight gain.

Copyright

Corresponding author

*Corresponding author: Department of Philosophy and History of Science, Charles University, Viničná 7, CZ-128 44 Praha 2, Czech Republic. Tel: +420 221951821. Fax: +420 224919704. E-mail: flegr@cesnet.cz

References

Hide All
Abrams, B. and Selvin, S. (1995). Maternal weight gain pattern and birth weight. Obstetrics & Gynecology 86, 163169.
Abrams, B., Carmichael, M. S. and Selvin, S. (1995). Factors associated with the pattern of maternal weight gain during pregnancy. Obstetrics & Gynecology 86, 170176.
Dawes, M. G. and Grudzinskas, J. G. (1991). Patterns of maternal weight gain in pregnancy. International Journal of Obstetrics and Gynaecology 98, 195201.
Flegr, J., Hrdá, Š. and Kodym, P. (2005). Influence of latent toxoplasmosis on human health. Folia Parasitologica 52, 199204.
Flegr, J. and Hrdý, I. (1994). Influence of chronic toxoplasmosis on some human personality factors. Folia Parasitologica 41, 122126.
Flegr, J., Klose, J., Novotna, M., Berenreitterová, M. and Havlíček, J. (2009). Increased incidence of traffic accidents in Toxoplasma-infected military drivers and protective effect RhD molecule revealed by a large-scale prospective cohort study. BMC Infectious Diseases 9, 72. doi:10.1186/1471-2334-9-72
Flegr, J., Lindova, J. and Kodym, P. (2008 b). Sex-dependent toxoplasmosis-associated differences in testosterone concentration in humans. Parasitology 135, 427431.
Flegr, J., Novotná, M., Fialová, A., Kolbeková, P. and Gašová, Z. (2010). The influence of RhD phenotype on toxoplasmosis- and age-associated changes in personality profile of blood donors. Folia Parasitologica 57, 143150.
Flegr, J., Novotná, M., Lindová, J. and Havlíček, J. (2008 a). Neurophysiological effect of the Rh factor. Protective role of the RhD molecule against Toxoplasma-induced impairment of reaction times in women. Neuroendocrinology Letters 29, 475481.
Flegr, J., Zítková, S., Kodym, P. and Frynta, D. (1996). Induction of changes in human behaviour by the parasitic protozoan Toxoplasma gondii. Parasitology 133, 4954.
Giorgino, F. L. and Maga, M. (1981). Toxoplasmosis and habitual abortion. Our expedice. Clinical and Experimental Obstetrics & Gynecology 8, 132134.
Havlíček, J., Gašová, Z., Smith, A. P., Zvára, K. J. and Flegr, J. (2001). Decrease of psychomotor performance in subjects with latent ‘asymptomatic’ toxoplasmosis. Parasitology 122, 515520.
Hickey, C. A., Cliver, S. P., McNeal, S. F., Hoffman, H. J. and Goldenberg, R. L. (1996). Prenatal weight gain patterns and birth weight among nonobese black and white women. Obstetrics & Gynecology 88, 490496.
Johnson, J. W., Longmate, J. A. and Frentzen, B. (1992). Excessive maternal weight and pregnancy outcome. American Journal of Obstetrics & Gynecology 67, 353372.
Jones, J. L., Kruszon-Morgan, D., Wilson, M., McQuillan, G., Navis, T. and McAuley, J. B. (2001). Toxoplasma gondii infection in the United States: Seroprevalence and risk factors. American Journal of Epidemiology 4, 357365.
Kaňková, Š. and Flegr, J. (2007). Longer pregnancy and slower fetal development in women with latent “asymptomatic” toxoplasmosis. BMC Infection Diseases 7, 114. doi:10.1186/1471-233-7-114
Kaňková, Š., Kodym, P., Frynta, D., Vavřinová, R., Kuběna, A. and Flegr, J. (2007 b). Influence of latent toxoplasmosis on the secondary sex ratio in mice. Parasitology 134, 17091717.
Kaňková, Š., Šulc, J., Nouzová, K., Fajfrlík, K., Frynta, D. and Flegr, J. (2007 a). Women infected with parasite Toxoplasma have more sons. Naturwissenschaften 94, 122127.
Kimball, A. C., Kean, B. H. and Fuchs, F. (1971). The role of toxoplasmosis in abortion. American Journal of Obstetrics & Gynecology 111, 219226.
Lindová, J., Kuběna, A. A., Šturcová, H., Křivohlavá, R., Novotná, M., Rubešová, A., Havliček, J., Kodym, P. and Flegr, J. (2010). Pattern of money allocation in experimental games supports the stress hypothesis in gender differences in Toxoplasma gondii-induced behavioural changes. Folia Parasitologica 57, 136142.
Lindová, J., Novotná, M., Havlíček, J., Šmídová, E., Skallová, A., Kolbeková, P., Hodný, Z., Kodym, P. and Flegr, J. (2006). Gender differences in behavioural changes induced by latent toxoplasmosis. International Journal for Parasitology 36, 14851492.
Novotná, M., Havlíček, J., Smith, A. P., Kolbeková, P., Skallová, A., Klose, J., Gašová, Z., Pisačka, M., Čechovská, M. and Flegr, J.(2008). Toxoplasma and reaction time: role of toxoplasmosis in the origin, preservation and geographical distribution of Rh blood group polymorphism. Parasitology 135, 12531261.
Olson, C. M., Strawderman, M. S., Hinton, P. S. and Pearson, T. A. (2003). Gestational weight gain and postpartum behaviors associated with weight change from early pregnancy to 1 y postpartum. International Journal of Obesity 27, 117127.
Quablan, H. S., Jumaian, N., Abu-Salem, A., Hamadelil, F. Y., Mashagbeh, M. and Abdel-Ghani, F. (2002). Toxoplasmosis and habitual abortion. Journal of Obstetrics and Gynaecology 22, 296298.
Schieve, L. A., Cogswell, M. E., Scanlon, K. S., Perry, G., Ferre, C. and Blackmore-Prince, C. H. (2000). Pregnancy body mass index and pregnacy weight gain: associations with preterm delivery. Obstetrics & Gynecology 96, 194200.
Scholl, T. O., Hediger, M. L., Schall, J. I., Ances, I. G. and Smith, W. K. (1995). Gestational weight gain, pregnancy outcome, and postpartum weight retention. Obstetrics & Gynecology 86, 423427.
Strauss, R. S. and Dietz, W. H. (1999). Low maternal weight gain in the second or third trimester increases the risk for intrauterine growth retardation. Journal of Nutrition 129, 988993.
Tenter, A. M., Heckeroth, A. R. and Weiss, L. M. (2000). Toxoplasma gondii: from animal to human. International Journal for Parasitology 30, 12171258.

Keywords

Increased pregnancy weight gain in women with latent toxoplasmosis and RhD-positivity protection against this effect

  • Š. KAŇKOVÁ (a1) (a2), J. ŠULC (a3) and J. FLEGR (a2)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed