Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 95
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Collins, James J Wendt, George R Iyer, Harini and Newmark, Phillip A 2016. Stem cell progeny contribute to the schistosome host-parasite interface. eLife, Vol. 5,

    El-Moslemany, Riham M. Eissa, Maha M. Ramadan, Alyaa A. El-Khordagui, Labiba K. and El-Azzouni, Mervat Z. 2016. Miltefosine lipid nanocapsules: Intersection of drug repurposing and nanotechnology for single dose oral treatment of pre-patent schistosomiasis mansoni. Acta Tropica, Vol. 159, p. 142.

    Sotillo, Javier Pearson, Mark Becker, Luke Mulvenna, Jason and Loukas, Alex 2015. A quantitative proteomic analysis of the tegumental proteins from Schistosoma mansoni schistosomula reveals novel potential therapeutic targets. International Journal for Parasitology, Vol. 45, Issue. 8, p. 505.

    Li, Xiao Hong Stark, Meg Vance, Gillian M Cao, Jian Ping and Wilson, R Alan 2014. The anterior esophageal region of Schistosoma japonicum is a secretory organ. Parasites & Vectors, Vol. 7, Issue. 1,

    Schulte, Leigh Lovas, Erica Green, Kathryn Mulvenna, Jason Gobert, Geoffrey N. Morgan, Garry and Jones, Malcolm K. 2013. Tetraspanin-2 localisation in high pressure frozen and freeze-substituted Schistosoma mansoni adult males reveals its distribution in membranes of tegumentary vesicles. International Journal for Parasitology, Vol. 43, Issue. 10, p. 785.

    Wilson, R. Alan 2012. Virulence factors of schistosomes. Microbes and Infection, Vol. 14, Issue. 15, p. 1442.

    Ye, Qing Zhu, Jun Yong Ming, Zhen Ping Zhao, Qin Ping Grevelding, Christoph G. Liu, Rong Zhong, Qin Ping Jiang, Ming Sen and Dong, Hui Fen 2012. Studies on the establishment of a co-culture system of lung stage Schistosoma japonicum with host cells. Parasitology Research, Vol. 111, Issue. 2, p. 735.

    Castro-Borges, William Simpson, Deborah M. Dowle, Adam Curwen, Rachel S. Thomas-Oates, Jane Beynon, Robert J. and Wilson, R. Alan 2011. Abundance of tegument surface proteins in the human blood fluke Schistosoma mansoni determined by QconCAT proteomics. Journal of Proteomics, Vol. 74, Issue. 9, p. 1519.

    Wilson, R. Alan Wright, Janelle M. de Castro-Borges, William Parker-Manuel, Sophie J. Dowle, Adam A. Ashton, Peter D. Young, Neil D. Gasser, Robin B. and Spithill, Terry W. 2011. Exploring the Fasciola hepatica tegument proteome. International Journal for Parasitology, Vol. 41, Issue. 13-14, p. 1347.

    Mulvenna, Jason Moertel, Luke Jones, Malcolm K. Nawaratna, Sujeevi Lovas, Erica M. Gobert, Geoffrey N. Colgrave, Michelle Jones, Alun Loukas, Alex and McManus, Donald P. 2010. Exposed proteins of the Schistosoma japonicum tegument. International Journal for Parasitology, Vol. 40, Issue. 5, p. 543.

    PEARCE, E. J. and FREITAS, T. C. 2008. Reverse genetics and the study of the immune response to schistosomes. Parasite Immunology, Vol. 30, Issue. 4, p. 215.

    Pérez-Sánchez, Ricardo Valero, María Luz Ramajo-Hernández, Alicia Siles-Lucas, Mar Ramajo-Martín, Vicente and Oleaga, Ana 2008. A proteomic approach to the identification of tegumental proteins of male and female Schistosoma bovis worms. Molecular and Biochemical Parasitology, Vol. 161, Issue. 2, p. 112.

    KUSEL, J. R. AL-ADHAMI, B. H. and DOENHOFF, M. J. 2007. The schistosome in the mammalian host: understanding the mechanisms of adaptation. Parasitology, Vol. 134, Issue. 11,

    Braschi, Simon Curwen, Rachel S. Ashton, Peter D. Verjovski-Almeida, Sergio and Wilson, Alan 2006. The tegument surface membranes of the human blood parasiteSchistosoma mansoni: A proteomic analysis after differential extraction. PROTEOMICS, Vol. 6, Issue. 5, p. 1471.

    Githui, Elijah K. Damian, Raymond T. and Aman, Rashid A. 2006. Schistosoma mansoni: Biochemical characterization of lactate transporters or similar proteins. Experimental Parasitology, Vol. 114, Issue. 3, p. 180.

    Skelly, Patrick J. and Alan Wilson, R. 2006. Advances in Parasitology Volume 63.

    Van Hellemond, Jaap J. Retra, Kim Brouwers, Jos F.H.M. van Balkom, Bas W.M. Yazdanbakhsh, Maria Shoemaker, Charles B. and Tielens, Aloysius G.M. 2006. Functions of the tegument of schistosomes: Clues from the proteome and lipidome. International Journal for Parasitology, Vol. 36, Issue. 6, p. 691.

    Halton, David W 2004. Microscopy and the helminth parasite. Micron, Vol. 35, Issue. 5, p. 361.

    Modha, J Redman, C.A Thornhill, J.A and Kusel, J.R 1998. Schistosomes: Unanswered Questions on the Basic Biology of the Host–Parasite Relationship. Parasitology Today, Vol. 14, Issue. 10, p. 396.

    Klag, J. Niewiadomska, K. and Czubaj, A. 1997. Ultrastructural studies on the sporocyst wall of Diplostomum pseudospathaceum Niewiadomska, 1984 (Digenea, Diplostomidae). International Journal for Parasitology, Vol. 27, Issue. 8, p. 919.


The formation and turnover of the membranocalyx on the tegument of Schistosoma mansoni

  • R. A. Wilson (a1) and P. E. Barnes (a1)
  • DOI:
  • Published online: 01 April 2009

The multilaminate vesicles present in the tegument cytoplasm appear to fuse with side channels projecting out into the cytoplasm from the base of the surface pits. Their lamellate contents then unroll and spread out to form a trilaminate membranocalyx lining the pits and covering the tegument surface. The plant lectin concanavalin A appears to stabilize the process of vesicle fusion leading to an aggregation of multilaminate vesicles trapped in the lumen of the surface pits. The membranocalyx can be labelled with cationized ferritin. Chase incubations in normal medium indicate that by 4 h most of the label and the membranocalyx to which it is bound have been lost to the medium. This suggests that under the conditions of these experiments the membranocalyx has a half-life of 2–3 h.

Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

A. Amsterdam , I. Ohad & M. Schramm (1969). Dynamic changes in the ultrastructure of the acinar cell of the rat parotid gland during the secretory cycle. Journal of Cell Biology 41, 753–73.

T. K. Chowdhury & A. K. Weiss (1975). Concanavalin A. In Advances in Experimental Medicine and Biology Vol. 55. New York and London: Plenum Press.

R. T. Damian , N. D. Greene & W. J. Hubbard (1973). Occurrence of mouse α2-macro-globulin antigenic determinants on Schistosoma mansoni adults, with evidence on their nature. Journal of Parasitology 59, 6473.

D. A. Erasmus (1967). The host-parasite interface of Cyathocotyle bushiensis Khan, 1962 (Trematoda: Strigeoidea). II. Electron microscope studies of the tegument. Journal of Parasitology 53, 703–14.

F. V. Hereward & D. H. Northcote (1972). A simple freeze-substitution method for the study of ultrastructure of plant tissues. Experimental Cell Research 70, 7380.

D. J. Hockley & D. J. McLaren (1973). Schistosoma mansoni: changes in the outer membrane of the tegument during development from cercaria to adult worm. International Journal for Parasitology 3, 1325.

D. J. Hockley , D. J. McLaren , B. H. Ward & M. V. Nermut (1975). A freeze-fracture study of the tegumental membrane of Schistosoma mansoni (Platyhelminthes: Trematoda). Tissue and Cell 7, 485–96.

J. D. Jamieson (1972). Transport and discharge of exportable proteins in pancreatic exocrine cells: in vitro studies. In Current Topics in Membranes and Transport, Vol. 3 (ed. F. Bronner and A. Kleinzeller ), pp. 273338. New York and London: Academic Press.

G. Palade (1975). Intracellular aspects of the process of protein synthesis. Science 189, 347–58.

H. Perez & R. J. Terry (1973). The killing of adult Schistosoma mansoni in vitro in the presence of antisera to host antigenic determinants and peritoneal cells. International Journal for Parasitology 3, 499503.

S. B. Smith & J. P. Revel (1972). Mapping of concanavalin A binding sites on the surface of several cell types. Developmental Biology 27, 434–41.

L. Warren & M. C. Glick (1968). Membranes of animal cells. II. The metabolism and trunover of the surface membrane. Journal of Cell Biology 37, 729–46.

M. Zalokar (1966). A simple freeze-substitution method for electron microscopy. Journal of Ultrastructure Research 15, 469–79.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

  • ISSN: 0031-1820
  • EISSN: 1469-8161
  • URL: /core/journals/parasitology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *