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Calcineurin and skeletal muscle growth

  • Robin N. Michel (a1), Shannon E. Dunn (a1) and Eva R. Chin (a2)
  • DOI: http://dx.doi.org/10.1079/PNS2004362
  • Published online: 01 March 2007
Abstract

Recruitment determines the profile of fibre-type-specific genes expressed across the range of muscle fibres associated with slow, fast fatigue-resistant and fast fatiguable motor units. Downstream signalling pathways activated by neural signalling and mechanical load have been the focus of intensive research in past years. It is now known that Ca2+-dependent calcineurin–nuclear factor of activated T cells and insulin-like growth factor 1 pathways and their downstream mediators contribute to these adaptive responses. These pathways regulate gene expression through muscle-specific (myocyte-enhancing factor 2, myoblast determination protein) and non-specific (nuclear factor of activated T cell 2, GATA-2) transcription factors. Transcriptional signals activated with increased contractile activity result in altered expression of fibre-type specific genes, including the myosin heavy chain isoforms and oxidative and glycolytic enzymes and a net change in muscle fibre-type composition. In contrast, transcriptional signals activated by increased load bearing result in hypertrophy or a growth response, a component of which involves satellite cell recruitment and fusion with existing adult myofibres. Calcineurin has been identified as a key mediator in the hypertrophic response, and the current challenge has been to determine the downstream target genes of this pathway. Exciting new data have emerged, showing that myostatin, a negative regulator of muscle growth, and utrophin, a cytoskeletal protein important in maintaining membrane integrity, are downstream targets of calcineurin signalling. Increased understanding of these mediators of muscle growth may provide strategies for the development of effective therapeutics to counter muscle weakness and muscular dystrophy.

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*Corresponding author: Dr Robin N. Michel Fax: +1 705 673 6508, Email: RNMichel@nickel.laurentian.ca
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KL Abbott , BB Friday , D Thaloor , TJ Murphy & GK Pavlath (1998) Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells. Molecular Biology of the Cell 9, 29052916.

S Adi , ZO Cheng , PL Zhang , NY Wu , SH Mellon & SM Rosenthal (2000) Opposing early inhibitory and late stimulatory effects of insulin-like growth factor-I on myogenin gene transcription. Journal of Cellular Biochemistry 78, 617626.

DL Allen , CA Sartorius , LK Sycuro & LA Leinwand (2001) Different pathways regulate expression of the skeletal myosin heavy chain genes. Journal of Biological Chemistry 276, 4352443533.

X Bigard , H Sanchez , J Zoll , P Mateo , V Rousseau , V Veksler & R Ventura-Clapier (2000) Calcineurin co-regulates contractile and metabolic components of slow muscle phenotype. Journal of Biological Chemistry 275, 1965319660.

H Bito , K Deisseroth & RW Tsien (1996) CREB phosphorylation and dephosphorylation: a CA 2+ - and stimulus duration-dependent switch for hippocampal gene expression. Cell 87, 12031214.

SC Bodine , TN Stitt , M Gonzalez , WO Kline , GL Stover , R Bauerlein , E Zlotchenko , A Scrimgeour , JC Lawrence , DJ Glass & GD Yancopoulos (2001) Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nature Cell Biology 3, 10141019.

JA Carson (1997) The regulation of gene expression in hypertrophying skeletal muscle. Exercise and Sport Sciences Reviews 25, 301320.

JV Chakkalakal , MA Stocksley , MA Harrison , LM Angus , J Deschenes-Furry , S St Pierre , LA Megheny , ER Chin , RN Michel & BJ Jasmin (2003) Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fibre types and is regulated by calcineurin. Proceedings of the National Academy of Sciences USA 100, 77917796.

ER Chin , EN Olson , JA Richardson , Q Yang , C Humphries , JM Shelton , H Wu , W Zhu , R Bassel-Duby & RS Williams (1998) A calcineurin-dependent pathway controls skeletal muscle fibre type. Genes and Development 12, 24992509.

U Delling , J Tureckova , HW Lim LJ DeWindt , P Rotwein & JD Molkentin (2000) A calcineurin-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression. Molecular and Cellular Biology 20, 66006610.

RE Dolmetsch , RS Lewis , CC Goodnow & JI Healy (1997) Differential activation of transcription factors induced by Ca 2+ response amplitude and duration. Nature 386, 855858.

SE Dunn , JL Burns & RN Michel (1999) Calcineurin is required for skeletal muscle hypertrophy. Journal of Biological Chemistry 274, 2190821912.

SE Dunn , ER Chin & RN Michel (2000) Matching of calcineurin activity to upstream effectors is critical for skeletal muscle growth. Journal of Cell Biology 151, 663672.

SE Dunn & RN Michel (1999) Differential sensitivity to myosin-heavy-chain-typed fibers to distinct aggregates of nerve-mediated activation. Pflugers Archiv 437, 432440.

SE Dunn , AR Simard , R Bassel-Duby , RS Williams & RN Michel (2001) Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers. Journal of Biological Chemistry 276, 4524345254.

SE Dunn , AR Simard , R Prud'homme & RN Michel (2002) Calcineurin and skeletal muscle growth. Nature Cell Biology 4, E46.

N Frey , JA Richardson & EN Olson (2000) Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. Proceedings of the National Academy of Sciences USA 97, 1463214637.

BB Friday , V Horsley & GK Pavlath (2000) Calcineurin activity is required for the initiation of skeletal muscle differentiation. Journal of Cell Biology 149, 657665.

V Horsley , BB Friday , S Matteson , KM Kegley , J Gephart & GK Pavlath (2001) Regulation of the growth of multinucleated muscle cells by an NFATc2-dependent pathway. Journal of Cell Biology 153, 329338.

U Kessen , R Schaloske , A Aichem & R Mutzel (1999) Ca 2+ /calmodulin-independent activation of calcineurin from Dictyostelium by unsaturated long chain fatty acids. Journal of Biological Chemistry 274, 3782137826.

J Lin , H Wu , PT Tarr , CY Zhang , Z Wu , O Boss , LF Michael , P Puigserver , E Isotani , EN Olson , BB Lowell , R Bassel-Duby & BM Spiegelman (2002) Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibers. Nature 418, 797801.

Y Liu , Z Cseresnyes , WR Randall & MF Schneider (2001) Activity-dependent nuclear translocation and intranuclear distribution of NFATc in adult skeletal muscle fibers. Journal of Cell Biology 155, 2739.

AC McPherron , AM Lawler & SJ Lee (1997) Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 387, 8390.

AC McPherron & SJ Lee (2002) Suppression of body fat accumulation in myostatin-deficient mice. Journal of Clinical Investigation 109, 595601.

JD Meissner , G Gros , RJ Scheibe , M Scholz & HP Kubis (2001) Calcineurin regulates slow myosin, but not fast or metabolic enzymes, during fast-to-slow transformation in rabbit skeletal muscle. Journal of Physiology (London) 533, 215226.

PO Mitchell , ST Mills & GK Pavlath (2002) Calcineurin differentially regulates maintenance and growth of phenotypically distinct muscles. American Journal of Physiology 282, C984C992.

JD Molkentin (2000) Calcineurin and beyond: Cardiac hypertrophic signaling. Circulation Research 87, 731738.

JD Molkentin , JR Lu , C Antos , B Markham , J Richardson , J Robbins , SR Grant & EN Olson (1998) A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93, 215228.

A Musaro , K McCullagh , A Paul , L Houghton , G Dobrowolny , M Molinaro , ER Barton , HL Sweeney & N Rosenthal (2001) Localized IGF-1 expression sustains hypertrophy and regeneration in senescent skeletal muscle. Nature Genetics 27, 195200.

F Naya , B Mercer , J Shelton , JA Richardson , RS Williams & EN Olson (2000) Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo. Journal of Biological Chemistry 275, 45454548.

EN Olson & RS Williams (2000a) Remodeling muscles with calcineurin. Bioessays 22, 510519.

R Passier , H Zeng , N Frey , FJ Naya , RL Nicol , TA McKinsey P Overbeek , JA Richardson , SR Grant & EN Olson (2000) CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo. Journal of Clinical Investigation 105, 13951406.

JN Phelan & WJ Gonyea (1997) Effect of radiation on satellite cell activity and protein expression in overloaded mammalian skeletal muscle. Anatomical Record 247, 179188.

BA Rothermel TA McKinsey , RB Vega , RL Nicol , P Mammen , J Yang , CL Antos , JM Shelton , R Bassel-Duby , EN Olson & RS Williams (2001) Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo. Proceedings of the National Academy of Sciences USA 98, 33283333.

AL Serrano , M Murgia , G Pallafacchina , E Calabria , P Coniglio , T Lomo & S Schiaffino (2001) Calcineurin controls nerve activity-dependent specification of slow skeletal muscle fibers but not muscle growth. Proceedings of the National Academy of Sciences USA 98, 1310813113.

CE Torgan & MP Daniels (2001) Regulation of myosin heavy chain expression during rat skeletal muscle development in vitro. Molecular Biology of the Cell 12, 14991508.

HH Vandenburgh , J Shansky , P Karlisch & RL Solerssi (1993) Mechanical stimulation of skeletal muscle generates lipid-related second messengers by phospholipase activation. Journal of Cellular Physiology 155, 6371.

H Wu , SB Kanatous , FA Thurmond , T Gallardo , E Isotani , R Bassel-Duby & RS Williams (2002) Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science 296, 349352.

H Wu , FJ Naya TA McKinsey B Mercer , JM Shelton , ER Chin , AR Simard , RN Michel , R Bassel-Duby , EN Olson & RS Williams (2000) MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. EMBO Journal 19, 19631973.

X Zhu , M Hadhazy , M Wehling , JG Tidball McNally EM (2000) Dominant negative myostatin produces hypertrophy without hyperplasia in muscle. FEBS Letters 474, 7175.

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