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Defining optimal body iron

  • James D. Cook (a1)
Abstract

The major liabilities of Fe lack include defects in psychomotor development in infants, impaired educational performance in schoolchildren, increased perinatal morbidity, and impaired work capacity. Few if any of the relevant investigations have demonstrated these abnormalities in the absence of anaemia. Consequently, adequate Fe nutrition can be defined as a normal haemoglobin concentration. On the other hand, optimal Fe nutrition should be regarded as sufficient body Fe to avoid any limitation in tissue Fe supply, termed Fe-deficient erythropoiesis. A variety of laboratory measurements have been used to identify this milder form of Fe deficiency, including serum ferritin, transferrin saturation, erythrocyte protoporphyrin, mean corpuscular volume, and more recently the concentration of the soluble fragment of transferrin receptor in serum. Recent studies indicate that the serum transferrin receptor is the preferred measurement, because enhanced synthesis of the transferrin receptor represent the initial cellular response to a declining Fe supply. Moreover, unlike other methods, it is not affected by chronic inflammation or infection which are often confused with Fe deficiency. In an otherwise normal healthy population the transferrin receptor: ferritin value provides a useful quantitative index of body Fe over a wide spectrum of Fe status, ranging from Fe repletion to Fe-deficiency anaemia. It is concluded that optimal Fe nutrition is best defined as a normal haemoglobin, serum ferritin and transferrin receptor concentration.

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Copyright
Corresponding author
Corresponding author: Professor James D. Cook, fax +1 913 588 3996, email jcook1@kumc.edu
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GM Addison , MR Beamish , CN Hales , M Hodgkins , A Jacobs & P Llewellin (1972) An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. Journal of Clinical Pathology 25, 326329.

LH Allen (1997) Pregnancy and iron deficiency: unresolved issues. Nutrition Reviews 55, 91101.

RD Baynes , BS Skikne & JD Cook (1994) Circulating transferr in receptors and assessment of iron status. Journal of Nutritional Biochemistry 5, 322330.

AB Bruner , A Joffe , AK Duggan , JF Casella & J Brandt (1996) Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls. Lancet 348, 992996.

JD Cook , BS Skikne & RD Baynes (1993) Serum transferrin receptor. Annual Review of Medicine 44, 6374.

I De Andraca , M Castillo & T Walter (1997) Psychomotor development and behavior in iron-deficient anemic infants. Nutrition Reviews 55, 125132.

W Doyle , MA Crawford , AHA Wynn & SW Wynn (1990) The association between maternal diet and birth dimensions. Journal of Nutrition in Medicine 1, 917.

VR Edgerton , GW Gardner , Y Ohira , KA Gunawardena & B Senewiratne (1979) Iron-deficiency anaemia and its effect on worker productivity and activity patterns. British Medical Journal 2, 15461549.

CA Finch , LR Miller , AR Inamdar , R Person , K Seiler & B Mackler (1976) Iron deficiency in the rat. X Physiological and biochemical studies of muscle dysfunction. Journal of Clinical Investigation 58, 447453.

J Fordy & D Benton (1994) Does low iron influence psychological functioning? Journal of Human Nutrition and Dietetics 7, 127133.

GH Guyatt , C Patterson , M Ali , J Singer , M Levine , I Turpie & R Meyer (1990) Diagnosis of iron-deficiency anemia in the elderly. American Journal of Medicine 88, 205209.

E Hemminki & J Merilainen (1995) Long-term follow-up of mothers and their infants in a randomized trial on iron prophylaxis during pregnancy. American Journal of Obstetrics and Gynecology 173, 205209.

E Hemminki & B Starfield (1978) Routine administration of iron and vitamins during pregnancy: review of controlled clinical trials. British Journal of Obstetrics and Gynaecology 85, 404410.

P Idjradinata & E Pollitt (1993) Reversal of developmental delays in iron-deficient anaemic infants treated with iron. Lancet 341, 14.

MA Klebanoff , PH Shiono , JV Selby , AI Trachtenberg & BI Graubard (1991) Anemia and spontaneous preterm birth. American Journal of Obstetrics and Gynecology 164, 5963.

Y Kohgo , T Nishisato , H Kondo , N Tsushima , Y Niitsu & I Urushizaki (1986) Circulating transferrin receptor in human serum. British Journal of Haematology 64, 277281.

SB Krantz (1994) Pathogenesis and treatment of the anemia of chronic disease. American Journal of the Medical Sciences 307, 353359.

HM Levin (1986) A benefit-cost analysis of nutritional programs for anaemia reduction. Research Observations 1, 219245.

DA Lipschitz (1990) The anemia of chronic disease. Journal of the American Geriatric Society 38, 12581264.

AC Looker , PR Dallman , MD Carroll , EW Gunter & CL Johnson (1997) Prevalence of iron deficiency in the United States. Journal of the American Medical Association 277, 973976.

B Lozoff , AW Wolf & E Jimenez (1996) Iron-deficiency anemia and infant development: effects of extended oral iron therapy. Journal of Pediatrics 129, 382389.

E Pollitt (1997) Iron deficiency and educational deficiency. Nutrition Reviews 55, 133141.

US Preventive Services Task Force (1993) Routine iron supplementation during pregnancy. Journal of the American Medical Association 270, 28462854.

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Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
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