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Dietary modification of inflammation with lipids


The n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoicacid (DHA) are found in high proportions in oily fish and fish oils. The n-3 PUFA are structurally and functionally distinct from the n-6 PUFA. Typically, human inflammatory cells contain high proportions of the n-6 PUFA arachidonic acid and low proportions of n-3 PUFA. The significance of this difference is that arachidonic acid is the precursor of 2-series prostaglandins and 4-series leukotrienes, which are highly-active mediators of inflammation. Feeding fish oil results in partial replacement of arachidonic acid in inflammatory cell membranes by EPA. This change leads to decreased production of arachidonic acid-derived mediators. This response alone is a potentially beneficial anti-inflammatory effect of n-3 PUFA. However, n-3 PUFA have a number of other effects which might occur downstream of altered eicosanoid production or might be independent of this activity. For example, animal and human studies have shown that dietary fish oil results in suppressed production of pro-inflammatory cytokines and can decrease adhesion molecule expression. These effects occur at the level of altered gene expression. This action might come about through antagonism of the effects of arachidonic acid-derived mediators or through more direct actions on the intracellular signalling pathways which lead to activation of transcription factors such as nuclear factor kappa B (NFêB). Recent studies have shown that n-3 PUFA can down regulate the activity of the nuclear transcription factor NFêB. Fish oil feeding has been shown to ameliorate the symptoms in some animal models of chronic inflammatory disease and to protect against the effects of endotoxin and similar inflammatory challenges. Clinical studies have reported that oral fish oil supplementation has beneficial effects in rheumatoid arthritis and among some patients with asthma, supporting the idea that the n-3 PUFA in fish oil are antiinflammatory. There are indications that inclusion of n-3 PUFA in enteral and parenteral formulas might be beneficial to patients in intensive care or post-surgery.

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Corresponding author: Professor P. C. Calder, fax +44 23 8059 4383, email
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HR Alexander , GM Doherty , CM Buresh , DJ Venzon & JA Norton (1991) A recombinant human receptor antagonist to interleukin 1 improves survival after lethal endotoxemia in mice. Journal of Experimental Medicine 173, 10291032.

F Arnalich , E Garcia-Palomero , J Lopez , M Jimenez , R Madero , J Renart , JJ Vazquez & C Montiel (2000) Predictive value of nuclear factor kB activity and plasma cytokine levels in patients with sepsis. Infection and Immunity 68, 19421945.

G Baldie , D Kaimakamis & D Rotondo (1993) Fatty acid modulation of cytokine release from human monocytic cells. Biochimica et Biophysica Acta 1179, 125133.

RG Barton , CL Wells , A Carlson , R Singh , JJ Sullivan & FB Cerra (1991) Dietary omega-3 fatty acids decrease mortality and Kupffer cell prostaglandin E2 production in a rat model of chronic sepsis. Journal of Trauma 31, 768774.

RJ Beale , DJ Bryg & DJ Bihari (1999) Immunonutrition in the critically ill: a systematic review of clinical outcome. Critical Care Medicine 27, 27992805.

L Berthou , R Saladin , P Yaqoob , D Branellec , P Calder , J-C Fruchart , P Denefle , J Auwerx & B Staels (1995) Regulation of rat liver apolipoprotein A-I, apoliporotein A-II and acyl CoA oxidase gene expression by fibrates and dietary fatty acids. European Journal of Biochemistry 232, 179187.

B Beutler , IW Milsark & AC Cerami (1985) Passive immunization against cachetin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 229, 869871.

PN Black & S Sharp (1997) Dietary fat and asthma: is there a connection? European Respiratory Journal 10, 612.

M Braga , L Gianotti , G Radaelli , A Vignali , G Mari , O Gentilini &V Di Carlo (1999) Perioperative immunonutrition in patientsundergoing cancer surgery. Archives of Surgery 134, 428433.

I Breil , T Koch , A Heller , E Schlotzer , A Grunert , K Van Ackern & H Neuhof (1996) Alteration of n-3 fatty acid composition in lung tissue after short-term infusion of fish oil emulsion attenuates inflammatory vascular reaction. Critical Care Medicine 24, 18931902.

PC Calder (1997) N-3 polyunsaturated fatty acids and cytokine production in health and disease. Annals of Nutrition and Metabolism 41, 203234.

PC Calder (1998) N-3 fatty acids and mononuclear phagocyte function. In Medicinal Fatty Acids in Inflammation, pp. 127 [JM Kremer , editor]. Basel: Birkhauser Verlag.

PC Calder (2001) n-3 Polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutrition Research 21, 309341.

PC Calder (2001) N-3 Fatty acids and rheumatoid arthritis. In Food and Nutritional Supplements in Health and Disease, pp. 175197 [JK Ransley , JK Donnelly and NW Read , editors]. London: Springer Verlag.

PC Calder , JA Bond , DJ Harvey , S Gordon & EA Newsholme (1990) Uptake of saturated and unsaturated fatty acids into macrophage lipids and their effect upon macrophage adhesion and phagocytosis. Biochemical Journal 269, 807814.

PC Calder & EA Miles (2000) Fatty acids and atopic disease. Pediatric Allergy and Immunology 11 Suppl., 2936.

PC Calder & RB Zurier (2001) Polyunsaturated fatty acids and rheumatoid arthritis. Current Opinion in Clinical Nutrition and Metabolic Care 4, 115121.

JG Cannon , RG Tompkins , JA Gelfrand , HR Michie , GG Stanford , Meer JW Van Der , S Endres , G Lonnemann , J Corsetti , B Chernow , DW Wilmore , SM Wolff , JF Burke & CA Dinarello (1990) Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. Journal of Infectious Disease 161, 7984.

B Chandrasekar & G Fernandes (1994) Decreased pro-inflammatory cytokines and increased antioxidant enzyme gene expression by ω-3 lipids in murine lupus nephritis. Biochemical and Biophysical Research Communications 200, 893898.

G Chinetti , JC Fruchart & B Staels (2000) Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflammation Research 49, 497505.

G Chinetti , S Griglio , M Antonucci , IP Torra , P Delerive , Z Majd , JC Fruchart , J Chapman , J Najib & B Staels (1998) Activation of peroxisome-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages. Journal of Biological Chemistry 273, 2557325580.

SC Chow , IJ Ansotegui & M Jondal (1990) Inhibition of receptor-mediated calcium influx in T cells by unsaturated non-esterified fatty acids. Biochemical Journal 267, 727732.

JW Christman , LH Lancaster & TS Blackwell (1998) Nuclear factor- kB: a pivotal role in systemic inflammatory response syndrome and new target for therapy. Intensive Care Medicine 24, 11311138.

AJ Chu , MA Walton , JK Prasad & A Seto (1999) Blockade by polyunsaturated n-3 fatty acids of endotoxin-induced monocytic tissue factor activation is mediated by the depressed receptor expression in THP-1 cells. Journal of Surgical Research 87, 217224.

CL Curtis , CE Hughes , CR Flannery , CB Little , JL Harwood & B Caterson (2000) n-3 Fatty acids specifically modulate catabolic factors involved in articular cartilage degradation. Journal of Biological Chemistry 275, 721724.

R De Caterina , MI Cybulsky , SK Clinton , MA Gimbrone & P Libby (1994) The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells. Arteriosclerosis and Thrombosis 14, 18291836.

R De Caterina & P Libby (1996) Control of endothelial leukocyte adhesion molecules by fatty acids. Lipids 31, S57S63.

P Delerive , JC Fruchart & B Staels (2001) Peroxisome proliferator-activated receptors in inflammation control. Journal of Endocrinology 169, 453459.

PR Devchand , H Keller , JM Peters , M Vazquez , FJ Gonzalez & W Wahli (1996) The PPARa-leukotriene B4 pathway to inflammation control. Nature 384, 3943.

T Dunder , L Kuikka , J Turtinen , L Rasanen & M Uhari (2001) Diet, serum fatty acids, and atopic diseases in childhood. Allergy 56, 425428.

S Endres , R Ghorbani , VE Kelley , K Georgilis , G Lonnemann , JMW Van Der Meer , JG Cannon , TS Rogers , MS Klempner , PC Weber , EJ Schaeffer , SM Wolff & CA Dinarello (1989) The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. New England Journal of Medicine 320, 265271.

W Ertel , MH Morrison , DR Meldrum , A Ayala & IH Chaudry (1992) Ibuprofen restores cellular immunity and decreases susceptibility to sepsis following hemorrhage. Journal of Surgical Research 53, 5561.

RJ Faull (1995) Adhesion molecules in health and disease. Australian and New Zealand Journal of Medicine 25, 720730.

M Feldmann , FM Brennan & RN Maini (1996) Role of cytokinesin rheumatoid arthritis. Annual Review of Immunology 14, 397440.

JE Gadek , SJ Demichele , MD Karlstad , ER Pacht , M Donahoe , TE Albertson , C Van Hoozen , AK Wennberg , J Nelson , M Noursalehi & the Enteral Nutrition in ARDS Study Group (1999) Effect of enteral feeding with eicosapentaenoic acid, γ-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Critical Care Medicine 27, 14091420.

V Gallai , P Sarchielli , A Trequattrini , M Franceschini , A Floridi , C Firenze , A Alberti , D Di Benedetto & E Stragliotto (1993) Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids. Journal of Neuroimmunology 56, 143153.

PP Geusens (1998) n-3 Fatty acids in the treatment of rheumatoid arthritis. In Medicinal Fatty Acids in Inflammation, pp. 111123 [JM Kremer , editor]. Basel: Birkhauser Verlag.

L Gianotti , M Braga , C Fortis , L Soldini , A Vignali , S Colombo , G Radaelli & V Di Carlo (1999) A prospective, randomised clinical trial on perioperative feeding with an arginine-, omega-3 fatty acid-, and RNA-enriched enteral diet: effect on host response and nutritional status. Journal of Parenteral and Enteral Nutrition 23, 314320.

KN Gold , CM Weyand & JJ Goronzy (1994) Modulation of helper T cell function by prostaglandins. Arthritis and Rheumatism 37, 925933.

JT Grbic , JA Mannick , DB Gough & ML Rodrick (1991) The role of prostaglandin E2 in immune suppression following injury. Annals of Surgery 214, 253263.

H Grimm , A Tibell , B Norrlind , C Blecher , S Wilker & K Schwemmle (1994) Immunoregulation by parenteral lipids: impact of the n-3 to n-6 fatty acid ratio. Journal of Parenteral and Enteral Nutrition 18, 417421.

F Grimminger , H Wahn , K Mayer , L Kiss , D Walmrath & W Seeger (1997) Impact of arachidonic acid versus eicosapentaenoic acid on exotoxin-induced lung vascular leakage – relation to 4-series versus 5-series leukotriene generation. American Journal of Respiratory and Critical Care Medicine 155, 513519.

N Hayashi , T Tashiro , H Yamamori , K Takagi , Y Morishima , Y Otsubo , T Sugiura , K Furukawa , H Nitta , N Nakajima , N Suzuki & I Ito (1998) Effects of intravenous omega-3 and omega-6 fat emulsion on cytokine production and delayed type hypersensitivity in burned rats receiving total parenteral nutrition. Journal of Parenteral and Enteral Nutrition 22, 363367.

MK Hellerstein , SN Meydani , M Meydani , K Wu & CA Dinarello (1989) Interleukin-1-induced anorexia in the rat: influence of prostaglandins. Journal of Clinical Investigation 84, 228235.

L Hodge , JK Peat & C Salome (1994) Increased consumption of polyunsaturated oils may be a cause of increased prevalence of childhood asthma. Australian and New Zealand Journal of Medicine 24, 727.

SM Jackson , F Parhami , X-P Xi , JA Berliner , WA Hsueh , RE Law & LL Demer (1999) Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte–endothelial cell interaction. Arteriosclerosis Thrombosis and Vascular Biology 19, 20942104.

MJ James & LG Cleland (1997) Dietary n-3 fatty acids and therapy for rheumatoid arthritis. Seminars in Arthritis and Rheumatism 27, 8597.

CY Jiang , AT Ting & B Seed (1998) PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391, 8286.

M Karin & Y Ben-Neriah (2000) Phosphorylation meets ubiquination: the control of NF-kappaB activity. Annual Review of Immunology 18, 621663.

M Karin & M Delhase (2000) The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Seminars in Immunology 12, 8598.

T Khair-El-Din , SC Sicher , MA Vazquez , GW Chung , KA Stallwort , K Kitamura , RT Miller & CY Lu (1996) Transcription of the murine iNOS gene is inhibited by docosahexaenoic acid, a major constituent of fetal and neonatal sera as well as fish oils. Journal of Experimental Medicine 183, 12411246.

B Khalfoun , G Thibault , P Bardos & Y Lebranchu (1996) Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte-endothelial cell adhesion. Transplantation 62, 16491657.

DN Kim , J Schmee & WA Thomas (1995) Dietary fish oil added to a hyperlipidemic diet for swine results in reduction in the excessive number of monocytes attached to the arterial endothelium. Atherosclerosis 81, 209216.

SA Kliewer , JM Lenhard , TM Willson , I Patel , DC Morris & JM Lehman (1995) A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor g and promotes adipocyte differentiation. Cell 83, 813819.

HR Knapp (1995) Omega-3 fatty-acids in respiratory diseases – A review. Journal of the American College of Nutrition 14, 1823.

JM Kremer , DA Lawrence , W Jubiz , Giacomo R Di , K Rynes , LE Bartholomew & M Sherman (1990) Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Arthritis and Rheumatism 33, 810820.

T Kumasaka , WM Quinlan , NA Doyle , NA Condon , J Sligh , F Takei , AL Beaudet , CF Bennett & CM Doerschuk (1996) Role of intercellular adhesion molecule-1 (ICAM-1) in endotoxin-induced pneumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies, and ICAM-1 mutant mice. Journal of Clinical Investigation 97, 23622369.

S Lanza-Jacoby , JT Flynn & S Miller (2001) Parenteral supplementation with a fish oil emulsion prolongs survival and improves lymphocyte function during sepsis. Nutrition 17, 112116.

TH Lee , RL Hoover , JD Williams , RI Sperling , J Ravalese , BW Spur , DR Robinson , EJ Corey , RA Lewis & KF Austen (1985) Effects of dietary enrichment with eicosapentaenoic acid and docosahexaenoic acid on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. New England Journal of Medicine 312, 12171224.

CA Leslie , WA Gonnerman , MD Ullman , KC Hayes , C Franzblau & ES Cathcart (1985) Dietary fish oil modulates macrophage fatty acids and decreases arthritis susceptibility in mice. Journal of Experimental Medicine 162, 13361349.

CJ Lo , KC Chiu , MJ Fu , A Chu & S Helton (2000) Fish oil modulates macrophage P44/42 mitogen-activated protein kinase activity induced by lipopolysaccharide. Journal of Parenteral and Enteral Nutrition 24, 159163.

AJ Mccabe , J Wallace , W Gilmore , JJ Strain & H Mcglynn (1999) The effect of eicosapentaenoic acid on matrix metalloproteinase gene expression. Lipids 34, S217S218.

ME Mccann , JN Moore , JB Carrick & MH Barton (2000) Effect of intravenous infusion of omega-3 and omega-6 lipid emulsions on equine monocyte fatty acid composition and inflammatory mediator production in vitro. Shock 14, 222228.

N Marx , GK Sukhova , T Collins , P Libby & J Plutzky (1999) PPARa activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 99, 31253131.

EA Mascioli , L Leader , E Flores , S Trimbo , B Bistrian & G Blackburn (1988) Enhanced survival to endotoxin in guinea pigs fed iv fish oil emulsion. Lipids 23, 623625.

JC Mathison , E Wolfson & RJ Ulevitch (1988) Participation of tumor necrosis factor in the mediation of Gram negative bacterial lipopolysaccharide-induced injury in rabbits. Journal of Clinical Investigation 81, 19251937.

CL May , AJ Southwoth & PC Calder (1993) Inhibition of lymphocyte protein kinase C by unsaturated fatty acids. Biochemical and Biophysical Research Communications 195, 823828.

SN Meydani , AH Lichtenstein , S Cornwall , M Meydani , BR Goldin , H Rasmussen , CA Dinarello & EJ Schaefer (1993) Immunologic effects of national cholesterol education panel step-2 diets with and without fish-derived n-3 fatty acid enrichment. Journal of Clinical Investigation 92, 105113.

EA Miles , F Thies , FA Wallace , JR Powell , TL Hirst , EA Newsholme & PC Calder (2001) Influence of age and dietary fish oil on plasma soluble adhesion molecule concentrations. Clinical Science 100, 91100.

EA Miles , FA Wallace & PC Calder (2000) Dietary fish oil reducesintercellular adhesion molecule 1 and scavenger receptor expression on murine macrophages. Atherosclerosis 152, 4350.

HM Mulrooney & RF Grimble (1993) Influence of butter and ofcorn, coconut and fish oils on the effects of recombinant human tumour necrosis factor-a in rats. Clinical Science 84, 105112.

T Obata , T Nagakura , T Masaki , K Maekawa & K Yamashita (1999) Eicosapentaenoic acid inhibits prostaglandin D2 generation by inhibiting cyclo-oxygenase-2 in cultured human mast cells. Clinical and Experimental Allergy 29, 11291135.

S Okusawa , JA Gelfrand , T Ikejima , RJ Connolly & CA Dinarello (1988) Interleukin 1 induces a shock-like state in rabbits.Synergism with tumor necrosis factor and effect of cyclooxygenase inhibition. Journal of Clinical Investigation 81, 11621172.

K Pfeffer , T Matsuyama , TM Kundig , A Wakeham , K Kishihara , A Shahinlan , K Wiegmann , PS Ohashi , M Kronke & TW Mak (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73, 457467.

J Pomposelli , EA Mascioli , BR Bistrian & SM Flores (1990) Attenuation of the febrile response in guinea pigs by fish oil enriched diets. Journal of Parenteral and Enteral Nutrition 13, 136140.

ME Poynter & RA Daynes (1998) Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor kappa B signalling, and reduces inflammatory cytokine production in aging. Journal of Biological Chemistry 273, 3283332841.

E Pscheidl , M Schywalsky , K Tschaikowsky & T Boke-Prols (2000) Fish oil-supplemented parenteral diets normalize splanchnic blood flow and improve killing of translocated bacteria in a low-dose endotoxin rat model. Critical Care Medicine 28, 14891496.

CD Raeburn , CM Calkins , MA Zimmerman , Y Song , LH Ao , A Banerjee , XZ Meng & AH Harken (2001) Vascular cell adhesion molecule-1 expression is obligatory for endotoxin-induced myocardial neutrophil accumulation and contractile dysfunction. Surgery 130, 319325.

G Renier , E Skamene , J De Sanctis & D Radzioch (1993) Dietaryn-3 polyunsaturated fatty acids prevent the developmentof atherosclerotic lesions in mice: Modulation of macrophage secretory activities. Arteriosclerosis and Thombosis 13, 15151524.

M Ricote , AC Li , TM Willson , CJ Kelly & CK Glass (1998) The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391, 7982.

DR Robinson , M Urakaze , R Huang , H Taki , E Sugiyama , CT Knoell , L Xu , ETH Yeh & PE Auron (1996) Dietary marine lipids suppress continuous expression on interleukin-1 b gene expression. Lipids 31, S23S31.

M Rola-Pleszczynski & J Stankova (1992) Cytokine gene regulation by PGE2, LTB4 and PAF. Mediators of Inflammation 1, 58.

JA Ross , AGW Moses & KCH Fearon (1999) The anti-catabolic effects of n-3 fatty acids. Current Opinion in Clinical Nutrition and Metabolic Care 2, 219226.

S Sadeghi , FA Wallace & PC Calder (1999) Dietary lipids modify the cytokine response to bacterial lipopolysaccharide in mice. Immunology 96, 404410.

P Sanderson & PC Calder (1998) Dietary fish oil diminishes lymphocyte adhesion to macrophage and endothelial cell monolayers. Immunology 94, 7987.

P Sanderson & PC Calder (1998) Dietary fish oil appears to inhibit the activation of phospholipase C- g in lymphocytes. Biochimica et Biophysica Acta 1392, 300308.

P Sanderson , P Yaqoob & PC Calder (1995) Effects of dietary lipid manipulation upon rat spleen lymphocyte functions and theexpression of lymphocyte surface molecules. Journal of Nutritional and Environmental Medicine 5, 119132.

P Sanderson , P Yaqoob & PC Calder (1995) Effects of dietary lipid manipulation upon graft vs. host and host vs. graft responses in the rat. Cellular Immunology 164, 240247.

H Sano , T Hla , JAM Maier , LJ Crofford , JP Case , T Maciag & RL Wilder (1992) In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. Journal of Clinical Investigation 89, 97108.

T Sasaki , Y Kanke , K Kudoh , M Nagahashi , M Toyokawa , M Matsuda , J Shimizu & T Takita (2000) Dietary n-3 polyunsaturated fatty acid and status of immunocompetent cells involved in innate immunity in female rats. Annals of Nutrition and Metabolism 44, 3842.

K Schoonjans , B Staels & J Auwerx (1996) The peroxisome proliferator activated receptors (PPARs) and their effects on lipidmetabolism and adipocyte differentiation. Biochimica et Biophysica Acta 1302, 93109.

B Sinha , D Stoll , PC Weber & S Endres (1991) Polyunsaturated fatty acids modulate the synthesis of TNF-a and interleukin-1 b by human mononuclear cells in vitro. Cytokine 3, 475.

RI Sperling , AI Benincaso , CT Knoell , JK Larkin , KF Austen & DR Robinson (1993) Dietary w-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils. Journal of Clinical Investigation 91, 651660.

H Takano , T Nagai , M Asakawa , T Toyozaki , T Oka , I Komuro , T Saito & Y Masuda (2000) Peroxisome proliferator-receptor activators inhibit lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiac myocytes. Circulation Research 87, 596602.

PS Tappia , WJ Man & RF Grimble (1995) Influence of unsaturated fatty acids on the production of tumour necrosis factor and interleukin-6 by rat peritoneal macrophages. Molecular and Cellular Biochemistry 143, 8998.

T Tashiro , H Yamamori , K Takagi , N Hayashi , K Furukawa & N Nakajima (1998) n-3 versus n-6 polyunsaturated fatty acids in critical illness. Nutrition 14, 551553.

R Tepaske , H Te Velthuis , M Oudemans-Van Straaten , SH Heisterkamp , SJH Van Deventer , C Ince , L Eysman & J Keseciogu (2001) Effect of preoperative oral immune-enhancing nutritional supplement on patients at risk of infection after cardiac surgery: a randomised placebo-controlled trial. Lancet 358, 696701.

LT Thomas (1972) Notes of a biology-watcher. New England Journal of Medicine 287, 553555.

SL Tilley , TM Coffman & BH Koller (2001) Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. Journal of Clinical Investigation 108, 1523.

KJ Tracey , B Beutler , SF Lowry , J Merryweather , S Wolpe , IW Milsark , RJ Hariri , TJ Fahey , A Zentella , JD Albert , GT Shires & A Cerami (1986) Shock and tissue injury induced by recombinant human cachectin. Science 234, 470474.

KJ Tracey , Y Fong , DG Hesse , KR Manogue , AT Lee , GC Kuo , SF Lowry & AC Cerami (1987) Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 330, 662664.

MG Vervloet , LG Thijs & CE Hack (1998) Derangements of coagulation and fibrinoloysis in critically ill patients with sepsis andseptic shock. Seminars in Thrombosis and Hemostasis 24, 3344.

D Volker & M Garg (1996) Dietary n-3 fatty acid supplementation in rheumatoid arthritis – mechanisms, clinical outcomes, controversies, and future directions. Journal of Clinical and Biochemical Nutrition 20, 8397.

P Wachtler , W Konig , M Senkal , M Kemen & M Koller (1997) Influence of a total parenteral nutrition enriched with w-3 fatty acids on leukotriene synthesis of peripheral leukocytes and systemic cytokine levels in patients with major surgery. Journal of Trauma 42, 191198.

FA Wallace , EA Miles & PC Calder (2000) Activation state alters the effect of dietary lipids on pro-inflammatory mediator production by murine macrophages. Cytokine 12, 13741379.

P Wang , PO Anderson , SW Chen , KM Paulsson , HO Sjogren & SL Li (2001) Inhibition of the transcription factors AP-1 and NF-kappa B in CD4 T cells by peroxisome proliferator-activated receptor gamma ligands. International Immunopharmacology 1, 803812.

GH Wu , YW Zhang & ZH Wu (2001) Modulation of postoperative immune and inflammatory response by immune-enhancing enteral diet in gastrointestinal cancer patients. World Review of Gastroenterology 7, 357362.

S Xi , D Cohen , S Barve & LH Chen (2001) Fish oil suppressed cytokines and nuclear factor kappaB induced by murine AIDS virus infection. Nutrition Research 21, 865878.

X Xu , M Otsuki , H Saito , S Sumitani , H Yamamoto , N Asanuma , H Kouhara & S Kasayama (2001) PPAR alpha and GR differentially down-regulate the expression of nuclear factor-kappa B-responsive genes in vascular endothelial cells. Endocrinology 142, 33323339.

P Yaqoob & PC Calder (1995) Effects of dietary lipid manipulationupon inflammatory mediator production by murine macrophages. Cellular Immunology 163, 120128.

P Yaqoob , HS Pala , M Cortina-Borja , EA Newsholme & PC Calder (2000) Encapsulated fish oil enriched in a-tocopherol altersplasma phospholipid and mononuclear cell fatty acid compositions but not mononuclear cell functions. European Journal of Clinical Investigation 30, 260274.

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