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Nutrition and healthy ageing: the key ingredients

  • Jessica C. Kiefte-de Jong (a1), John C. Mathers (a2) and Oscar H. Franco (a1)

Healthy longevity is a tangible possibility for many individuals and populations, with nutritional and other lifestyle factors playing a key role in modulating the likelihood of healthy ageing. Nevertheless, studies of effects of nutrients or single foods on ageing often show inconsistent results and ignore the overall framework of dietary habits. Therefore, the use of dietary patterns (e.g. a Mediterranean dietary pattern) and the specific dietary recommendations (e.g. dietary approaches to stop hypertension, Polymeal and the American Healthy Eating Index) are becoming more widespread in promoting lifelong health. A posteriori defined dietary patterns are described frequently in relation to age-related diseases but their generalisability is often a challenge since these are developed specifically for the population under study. Conversely, the dietary guidelines are often developed based on prevention of disease or nutrient deficiency, but often less attention is paid to how well these dietary guidelines promote health outcomes. In the present paper, we provide an overview of the state of the art of dietary patterns and dietary recommendations in relation to life expectancy and the risk of age-related disorders (with emphasis on cardiometabolic diseases and cognitive outcomes). According to both a posteriori and a priori dietary patterns, some key ‘ingredients’ can be identified that are associated consistently with longevity and better cardiometabolic and cognitive health. These include high intake of fruit, vegetables, fish, (whole) grains and legumes/pulses and potatoes, whereas dietary patterns rich in red meat and sugar-rich foods have been associated with an increased risk of mortality and cardiometabolic outcomes.

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*Corresponding author: J. C. Kiefte-de Jong, fax +31 10 7044657, email
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1.JA Salomon , H Wang , MK Freeman (2012) Healthy life expectancy for 187 countries, 1990–2010: a systematic analysis for the Global Burden Disease Study. Lancet 380, 21442162.

2.OH Franco , K Karnik , G Osborne (2009) Changing course in ageing research: the healthy ageing phenotype. Maturitas 63, 1319.

4.WC Willett (2012) Dietary fats and coronary heart disease. J Intern Med 272, 1324.

5.KN Aronis , SM Khan & CS Mantzoros (2012) Effects of trans fatty acids on glucose homeostasis: a meta-analysis of randomized, placebo-controlled clinical trials. Am J Clin Nutr 96, 10931099.

6.FB Hu (2002) Dietary pattern analysis: a new direction in nutritional epidemiology. Curr Opin Lipidol 13, 39.

7.AK Kant (2010) Dietary patterns: biomarkers and chronic disease risk. Appl Physiol Nutr Metab 35, 199206.

8.EM Jones-McLean , B Shatenstein & SJ Whiting (2010) Dietary patterns research and its applications to nutrition policy for the prevention of chronic disease among diverse North American populations. Appl Physiol Nutr Metab 35, 195198.

10.KL Tucker (2010) Dietary patterns, approaches, and multicultural perspective. Appl Physiol Nutr Metab 35, 211218.

12.EJ Feskens & D Kromhout (1993) Epidemiologic studies on Eskimos and fish intake. Ann N Y Acad Sci 683, 915.

17.TT Fung , M Schulze , JE Manson (2004) Dietary patterns, meat intake, and the risk of type 2 diabetes in women. Arch Intern Med 164, 22352240.

18.TT Fung , MJ Stampfer , JE Manson (2004) Prospective study of major dietary patterns and stroke risk in women. Stroke 35, 20142019.

19.TT Fung , WC Willett , MJ Stampfer (2001) Dietary patterns and the risk of coronary heart disease in women. Arch Intern Med 161, 18571862.

21.MD Stricker , NC Onland-Moret , JM Boer (2013) Dietary patterns derived from principal component- and k-means cluster analysis: long-term association with coronary heart disease and stroke. Nutr Metab Cardiovasc Dis 23, 250256.

22.M Ozawa , T Ninomiya , T Ohara (2013) Dietary patterns and risk of dementia in an elderly Japanese population: the Hisayama Study. Am J Clin Nutr 97, 10761082.

24.P Guallar-Castillon , F Rodriguez-Artalejo , MJ Tormo (2012) Major dietary patterns and risk of coronary heart disease in middle-aged persons from a Mediterranean country: the EPIC-Spain cohort study. Nutr Metab Cardiovasc Dis 22, 192199.

26.M Hamer , SA McNaughton , CJ Bates (2010) Dietary patterns, assessed from a weighed food record, and survival among elderly participants from the United Kingdom. Eur J Clin Nutr 64, 853861.

31.J Meyer , A Doring , C Herder (2011) Dietary patterns, subclinical inflammation, incident coronary heart disease and mortality in middle-aged men from the MONICA/KORA Augsburg cohort study. Eur J Clin Nutr 65, 800807.

32.M Heroux , I Janssen , M Lam (2010) Dietary patterns and the risk of mortality: impact of cardiorespiratory fitness. Int J Epidemiol 39, 197209.

35.J Hlebowicz , M Persson , B Gullberg (2011) Food patterns, inflammation markers and incidence of cardiovascular disease: the Malmo Diet and Cancer study. J Intern Med 270, 365376.

36.Y Li , Y He , J Lai (2011) Dietary patterns are associated with stroke in Chinese adults. J Nutr 141, 18341839.

37.VS Malik , TT Fung , RM van Dam (2012) Dietary patterns during adolescence and risk of type 2 diabetes in middle-aged women. Diabetes Care 35, 1218.

38. RMvan Dam , EBRimm , WCWillett (2002) Dietary patterns and risk for type 2 diabetes mellitus in U.S. men. Ann Intern Med 136, 201209.

39.AO Odegaard , WP Koh , LM Butler (2011) Dietary patterns and incident type 2 diabetes in Chinese men and women: the Singapore Chinese health study. Diabetes Care 34, 880885.

40.E Kesse-Guyot , VA Andreeva , C Jeandel (2012) A healthy dietary pattern at midlife is associated with subsequent cognitive performance. J Nutr 142, 909915.

41.SJ Torres , NT Lautenschlager , N Wattanapenpaiboon (2012) Dietary patterns are associated with cognition among older people with mild cognitive impairment. Nutrients 4, 15421551.

42.Y Gu , JW Nieves , Y Stern (2010) Food combination and Alzheimer disease risk: a protective diet. Arch Neurol 67, 699706.

43.ET Kennedy , J Ohls , S Carlson (1995) The Healthy Eating Index: design and applications. J Am Diet Assoc 95, 11031108.

45.X Ye , T Scott , X Gao (2013) Mediterranean diet, healthy eating index 2005, and cognitive function in middle-aged and older Puerto Rican adults. J Acad Nutr Diet 113, 276281.

46.DK Tobias , FB Hu , J Chavarro (2012) Healthful dietary patterns and type 2 diabetes mellitus risk among women with a history of gestational diabetes mellitus. Arch Intern Med 172, 15661572.

47.C Agnoli , V Krogh , S Grioni (2011) A priori-defined dietary patterns are associated with reduced risk of stroke in a large Italian cohort. J Nutr 141, 15521558.

48.R Kappeler , M Eichholzer & S Rohrmann (2013) Meat consumption and diet quality and mortality in NHANES III. Eur J Clin Nutr 67, 598606.

50.AK Kant , A Schatzkin , BI Graubard (2000) A prospective study of diet quality and mortality in women. JAMA 283, 21092115.

56.T Akbaraly , S Sabia , G Hagger-Johnson (2013) Does overall diet in midlife predict future aging phenotypes? A cohort study. Am J Med 126, 411419.

58.P Huijbregts , E Feskens , L Rasanen (1997) Dietary pattern and 20 year mortality in elderly men in Finland, Italy, and The Netherlands: longitudinal cohort study. BMJ 315, 1317.

59.P Sjogren , W Becker , E Warensjo (2010) Mediterranean and carbohydrate-restricted diets and mortality among elderly men: a cohort study in Sweden. Am J Clin Nutr 92, 967974.

61.A Trichopoulou , T Costacou , C Bamia (2003) Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 348, 25992608.

62.M Osler & M Schroll (1997) Diet and mortality in a cohort of elderly people in a north European community. Int J Epidemiol 26, 155159.

66.G Behrens , B Fischer , S Kohler (2013) Healthy lifestyle behaviors and decreased risk of mortality in a large prospective study of U.S. women and men. Eur J Epidemiol 28, 361372.

69.A Salehi-Abargouei , Z Maghsoudi , F Shirani (2013) Effects of dietary approaches to stop hypertension (DASH)-style diet on fatal or nonfatal cardiovascular diseases – incidence: a systematic review and meta-analysis on observational prospective studies. Nutrition 29, 611618.

72.M Dehghan , A Mente , KK Teo (2012) Relationship between healthy diet and risk of cardiovascular disease among patients on drug therapies for secondary prevention: a prospective cohort study of 31 546 high-risk individuals from 40 countries. Circulation 126, 27052712.

73.L de Koning , SE Chiuve , TT Fung (2011) Diet-quality scores and the risk of type 2 diabetes in men. Diabetes Care 34, 11501156.

80.F Sofi , F Cesari , R Abbate (2008) Adherence to Mediterranean diet and health status: meta-analysis. BMJ 337, a1344.

81.TT Fung , KM Rexrode , CS Mantzoros (2009) Mediterranean diet and incidence of and mortality from coronary heart disease and stroke in women. Circulation 119, 10931100.

82.G Misirli , V Benetou , P Lagiou (2012) Relation of the traditional Mediterranean diet to cerebrovascular disease in a Mediterranean population. Am J Epidemiol 176, 11851192.

85.ST Chen , NM Maruthur & LJ Appel (2010) The effect of dietary patterns on estimated coronary heart disease risk: results from the Dietary Approaches to Stop Hypertension (DASH) trial. Circ Cardiovasc Qual Outcomes 3, 484489.

86.R Estruch , E Ros , J Salas-Salvado (2013) Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 368, 12791290.

87.EH Martinez-Lapiscina , P Clavero , E Toledo (2013) Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol Neurosurg Psychiatry 84, 13181325.

93.PM Guenther , KO Casavale , J Reedy (2013) Update of the Healthy Eating Index: HEI-2010. J Acad Nutr Diet 113, 569580.

96.VK Knudsen , S Fagt , E Trolle (2012) Evaluation of dietary intake in Danish adults by means of an index based on food-based dietary guidelines. Food Nutr Res 56, 18.

97.C Estaquio , E Kesse-Guyot , V Deschamps (2009) Adherence to the French Programme National Nutrition Santé Guideline Score is associated with better nutrient intake and nutritional status. J Am Diet Assoc 109, 10311041.

98.M Maynard , AR Ness , L Abraham (2005) Selecting a healthy diet score: lessons from a study of diet and health in early old age (the Boyd Orr cohort). Public Health Nutr 8, 321326.

102.A Alberti-Fidanza , F Fidanza (2004) Mediterranean Adequacy Index of Italian diets. Public Health Nutr 7, 937941.

103.S Lee , L Harnack , DR Jacobs Jr (2007) Trends in diet quality for coronary heart disease prevention between 1980–1982 and 2000–2002: The Minnesota Heart Survey. J Am Diet Assoc 107, 213222.

105.TT Fung , SE Chiuve , ML McCullough (2008) Adherence to a DASH-style diet and risk of coronary heart disease and stroke in women. Arch Intern Med 168, 713720.

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Proceedings of the Nutrition Society
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