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Energy balance in obesity

Published online by Cambridge University Press:  08 December 2008

Jonathan Webber*
School of Medical and Surgical Sciences, University of Nottingham, Nottingham, NG7 2UH, UK
Corresponding author: Dr Jonathan Webber, fax +44 (0)121 627 8589,
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The current epidemic of human obesity implies that whilst energy balance appears to be regulated, the extent of this regulatory process is being overwhelmed in large numbers of the population by environmental changes. Clearly, the shift towards positive energy balance reflects both alterations in energy intake and decreases in physical activity. Increased energy intake and, in particular, the rising proportion of energy from fat is linked with obesity. However, on a population level reduced levels of activity probably play the predominant role. It is apparent that individual susceptibility to weight gain varies enormously. The factors underlying this susceptibility are an area of intense research interest. Variations in BMR from that predicted appear to be linked to the propensity to gain weight. The genes responsible for this variation may include uncoupling proteins-2 and -3, with a number of studies showing a link with obesity. However, in vivo studies of these proteins have not yet demonstrated a physiological role for them that would explain the link with obesity. Non-exercise activity thermogenesis may also protect from weight gain, but the regulation of this type of thermogenesis is unclear, although the sympathetic nervous system may be important. A profusion of hormones, cytokines and neurotransmitters is involved in regulating energy intake, but whilst mutations in leptin and the melanocortin-3 receptor are responsible for rare monogenic forms of obesity, their wider role in common polygenic obesity is not known. Much current work is directed at examining the interplay between genetic background and environmental factors, in particular diet, that both lead to positive energy balance and seem to make it so hard for many obese subjects to lose weight.

Clinical Nutrition and Metabolism Group Symposium on ‘Control of energy balance in health and disease’
Copyright © The Nutrition Society 2003


Arner, P & Hoffstedt, J (1999) Adrenoceptor genes in human obesity, Journal of Internal Medicine 245, 667672CrossRefGoogle ScholarPubMed
Barsh, GS, Farooqi, IS, O'Rahilly, S (2000) Genetics of body weight regulation, Nature 404, 644651Google ScholarPubMed
Bolton-Smith, C & Woodward, M (1994) Dietary composition and fat to sugar ratios in relation to obesity, International Journal of Obesity 18, 820828Google ScholarPubMed
Bouchard, CA, Tremblay, A, Despres, JP, Nadeau, A, Lupien, PJ, Theriault, G, Dussault, J, Moorjani, S, Pinault, S & Fournier, G (1990) The response to long-term overfeeding in identical twins, New England Journal of Medicine 322, 14771482CrossRefGoogle ScholarPubMed
Doucet, ES, St Pierre, S, Almeras, N, Despres, JP, Bouchard, C, Tremblay, A (2001) Evidence for the existence of adaptive thermogenesis during weight loss, British Journal of Nutrition 85, 715723CrossRefGoogle ScholarPubMed
Doucet, ES, St, Pierre, S, Almeras, N, Mauriege, P, Richard, D Tremblay, A (2000) Changes in energy expenditure and substrate oxidation resulting from weight loss in obese men and women: is there an important contribution of leptin?, Journal of Clinical Endocrinology and Metabolism 85, 15501556Google ScholarPubMed
Dulloo, AG, Samec, S & Seydoux, J (2001) Uncoupling protein 3 and fatty acid metabolism, Biochemical Society Transactions 29, 785791CrossRefGoogle ScholarPubMed
Egger, GJ, Vogels, N & Westerterp, KR (2001) Estimating historical changes in physical activity levels, Medical Journal of Australia 175, 635636Google ScholarPubMed
Farooqi, IS, Jebb, SA, Langmack, G, Lawrence, E, Cheetham, CH, Prentice, AM, Hughes, IA, McCamish, MA, O'Rahilly, S (1999) Effects of recombinant leptin therapy in a child with congenital leptin deficiency, New England Journal of Medicine 341, 879884CrossRefGoogle Scholar
Filozof, CM, Murua, C, Sanchez, MP, Brailovsky, C, Perman, M, Gonzalez, CD & Ravussin, E (2000) Low plasma leptin concentration and low rates of fat oxidation in weight-stable post-obese subjects, Obesity Research 8, 205210CrossRefGoogle ScholarPubMed
French, SA, Story, M & Jeffery, RW (2001) Environmental influences on eating and physical activity, Annual Review of Public Health 22, 309335CrossRefGoogle ScholarPubMed
Froguel, P & Boutin, P (2001) Genetics of pathways regulating body weight in the development of obesity in humans, Experimental Biology and Medicine 226, 991996CrossRefGoogle ScholarPubMed
Heitmann, BL & Garby, L (2002) Composition (lean and fat tissue) of weight changes in adult Danes, American Journal of Clinical Nutrition 75, 840847Google ScholarPubMed
Leibel, RL, Rosenbaum, M & Hirsch, J (1995) Changes in energy expenditure resulting from altered body weight, New England Journal of Medicine 332, 621628CrossRefGoogle ScholarPubMed
Levine, JA, Eberhardt, NL & Jensen, MD (1999) Role of nonexercise activity thermogenesis in resistance to fat gain in humans, Science 283, 212214CrossRefGoogle ScholarPubMed
Levine, JA, Schleusner, SJ & Jensen, MD (2000) Energy expenditure of nonexercise activity, American Journal of Clinical Nutrition 72, 14511454Google ScholarPubMed
Lissner, L, Odell, PM, D'Agostino, RB, Stokes, J 3rd, Kreger, BE, BE, Belanger, AJ Brownell, KD (1991) Variability of body weight and health outcomes in the Framingham population, New England Journal of Medicine 324, 18391844CrossRefGoogle ScholarPubMed
Montague, CT, Farooqi, IS, Whitehead, JP, Soos, MA, Rau, H, Wareham, NJ, Sewter, CP, Digby, JE, Mohammed, SN, Hurst, JA, Cheetham, CH, Earley, AR, Barnett, AH, Prins, JB, O'Rahilly, S (1997) Congenital leptin deficiency is associated with severe early-onset obesity in humans, Nature 387, 903908CrossRefGoogle ScholarPubMed
Poppitt, SD, Swann, D, Black, AE & Prentice, AM (1998) Assessment of selective under-reporting of food intake by both obese and non-obese women in a metabolic facility, International Journal of Obesity 22, 303311CrossRefGoogle Scholar
Prentice, AM & Jebb, SA (1995) Obesity in Britain: gluttony or sloth?, British Medical Journal 311, 437439CrossRefGoogle ScholarPubMed
Ravussin, E, Lillioja, S, Knowler, WC, Christin, L, Freymond, D, Abbott, WGH, Boyce, V, Howard, BV & Bogardus, C (1988) Reduced rate of energy expenditure as a risk factor for bodyweight gain, New England Journal of Medicine 318, 467472CrossRefGoogle Scholar
Ravussin, E, Valencia, ME, Esparza, J, Bennett, PH & Schulz, LO (1994) Effects of a traditional lifestyle on obesity in Pima Indians, Diabetes Care 17, 10671074CrossRefGoogle ScholarPubMed
Rosenbaum, M, Hirsch, J, Murphy, E & Leibel, RL (2000) Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion and thyroid function, American Journal of Clinical Nutrition 71, 14211432Google ScholarPubMed
Stubbs, RJ, Ritz, P, Coward, WA & Prentice, AM (1995) Covert manipulation of the ratio of dietary fat to carbohydrate and energy density: effect on food intake and energy balance in free-living men eating ad libitum, American Journal of Clinical Nutrition 62, 330337Google ScholarPubMed
Van, ltallie TB (2001) Resistance to weight gain during overfeeding: a NEAT explanation, Nutrition Reviews 59, 4851Google Scholar
Walder, K, Norman, RA, Hanson, RL, Schrauwen, P, Neverova, M, Jenkinson, CP, Easlick, J, Warden, CH, Pecqueur, C, Raimbault, S, Ricquier, D, Silver, MH, Shuldiner, AR, Solanes, G, Lowell, BB, Chung, WK, Leibel, RL, Pratley, R & Ravussin, E (1998) Association between uncoupling protein polymorphisms (UCP2–UCP3) and energy metabolism/obesity in Pima Indians, Human Molecular Genetics 7, 14311435CrossRefGoogle ScholarPubMed
Weinsier, RL, Hunter, GR, Desmond, RA, Byrne, NM, Zuckerman, PA & Darnell, BE (2002) Free-living activity energy expenditure in women successful and unsuccessful at maintaining a normal body weight, American Journal of Clinical Nutrition 75, 499504Google ScholarPubMed
Weyer, C, Pratley, RE, Salbe, AD, Bogardus, C, Ravussin, E & Tataranni, PA (2000) Energy expenditure, fat oxidation, and body weight regulation: a study of metabolic adaptation to long-term weight change, Journal of Clinical Endocrinology and Metabolism 85, 10871094CrossRefGoogle ScholarPubMed
Zurlo, F, Lillioja, S, Puente, AE-D, Nyomba, BL, Raz, I, Saad, MF, Swinburn, BA, Knowler, WC, Bogardus, C & Ravussin, E (1990) Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ, American Journal of Physiology 259, E650E657Google ScholarPubMed
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