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  • Proceedings of the Nutrition Society, Volume 71, Issue 4
  • November 2012, pp. 511-520

Food-induced brain responses and eating behaviour

  • Paul A.M. Smeets (a1) (a2), Lisette Charbonnier (a1), Floor van Meer (a1), Laura N. van der Laan (a1) and Maartje S. Spetter (a1)
  • DOI:
  • Published online: 29 August 2012

The brain governs food intake behaviour by integrating many different internal and external state and trait-related signals. Understanding how the decisions to start and to stop eating are made is crucial to our understanding of (maladaptive patterns of) eating behaviour. Here, we aim to (1) review the current state of the field of ‘nutritional neuroscience’ with a focus on the interplay between food-induced brain responses and eating behaviour and (2) highlight research needs and techniques that could be used to address these. The brain responses associated with sensory stimulation (sight, olfaction and taste), gastric distension, gut hormone administration and food consumption are the subject of increasing investigation. Nevertheless, only few studies have examined relations between brain responses and eating behaviour. However, the neural circuits underlying eating behaviour are to a large extent generic, including reward, self-control, learning and decision-making circuitry. These limbic and prefrontal circuits interact with the hypothalamus, a key homeostatic area. Target areas for further elucidating the regulation of food intake are: (eating) habit and food preference formation and modification, the neural correlates of self-control, nutrient sensing and dietary learning, and the regulation of body adiposity. Moreover, to foster significant progress, data from multiple studies need to be integrated. This requires standardisation of (neuroimaging) measures, data sharing and the application and development of existing advanced analysis and modelling techniques to nutritional neuroscience data. In the next 20 years, nutritional neuroscience will have to prove its potential for providing insights that can be used to tackle detrimental eating behaviour.

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*Corresponding author: Dr Paul Smeets, fax+31 302513399, email
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2.SB Eaton & SB Eaton , III (2000) Paleolithic vs. modern diets–selected pathophysiological implications. Eur J Nutr 39, 6770.

9.LN van der Laan , DT de Ridder , MA Viergever (2010) The first taste is always with the eyes: a meta-analysis on the neural correlates of processing visual food cues. Neuroimage 55, 296303.

12.MG Veldhuizen , J Albrecht , C Zelano (2011) Identification of human gustatory cortex by activation likelihood estimation. Hum Brain Mapp 32, 22562266.

13.JN Lundstrom , S Boesveldt & J Albrecht (2011) Central processing of the chemical senses: an overview. ACS Chem Neurosci 2, 5–16.

18.MS Spetter , GC de , MA Viergever (2012) Anterior cingulate taste activation predicts ad libitum intake of sweet and savory drinks in healthy, normal-weight men. J Nutr 142, 795802.

21.DM Small , MG Veldhuizen , J Felsted (2008) Separable substrates for anticipatory and consummatory food chemosensation. Neuron 57, 786797.

23.JP O'Doherty (2004) Reward representations and reward-related learning in the human brain: insights from neuroimaging. Curr Opin Neurobiol 14, 769776.

24.GJ Wang , ND Volkow , J Logan (2001) Brain dopamine and obesity. Lancet 357, 354357.

27.E Stice , S Yokum , C Bohon (2010). Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4. Neuroimage 50, 16181625.

29.F Grabenhorst , ET Rolls & A Bilderbeck (2008) How cognition modulates affective responses to taste and flavor: top-down influences on the orbitofrontal and pregenual cingulate cortices. Cereb Cortex 18, 15491559.

30.H Plassmann , J O'Doherty , B Shiv (2008) Marketing actions can modulate neural representations of experienced pleasantness. Proc Natl Acad Sci USA 105, 10501054.

31.RA Travagli , GE Hermann , KN Browning (2006) Brainstem circuits regulating gastric function. Annu Rev Physiol 68, 279305.

32.KN Browning & RA Travagli (2011) Plasticity of vagal brainstem circuits in the control of gastrointestinal function. Auton Neurosci 161, 6–13.

42.MA Kwiatek , D Menne , A Steingoetter (2009) Effect of meal volume and calorie load on postprandial gastric function and emptying: studies under physiological conditions by combined fiber-optic pressure measurement and MRI. Am J Physiol Gastrointest Liver Physiol 297, G894G901.

43.RL Batterham , DH ffytche , JM Rosenthal (2007) PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans. Nature 450, 106109.

45.DJ Lassman , S McKie , LJ Gregory (2010) Defining the role of cholecystokinin in the lipid-induced human brain activation matrix. Gastroenterology 138, 15141524.

46.M Guthoff , Y Grichisch , C Canova (2010) Insulin modulates food-related activity in the central nervous system. J Clin Endocrinol Metab 95, 748755.

52.S Frank , M Heni , A Moss (2011) Leptin therapy in a congenital leptin-deficient patient leads to acute and long-term changes in homeostatic, reward, and food-related brain areas. J Clin Endocrinol Metab 96, E1283E1287.

53.IS Farooqi , E Bullmore , J Keogh (2007) Leptin regulates striatal regions and human eating behavior. Science 317, 1355.

55.RA Adan , LJ Vanderschuren & El Fleur (2008) Anti-obesity drugs and neural circuits of feeding. Trends Pharmacol Sci 29, 208217.

56.PC Fletcher , A Napolitano , A Skeggs (2010) Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatum. J Neurosci 30, 1434614355.

60.N Siep , A Roefs , A Roebroeck (2009) Hunger is the best spice: an fMRI study of the effects of attention, hunger and calorie content on food reward processing in the amygdala and orbitofrontal cortex. Behav Brain Res 198, 149158.

61.R Uher , J Treasure , M Heining (2006) Cerebral processing of food-related stimuli: effects of fasting and gender. Behav Brain Res 169, 111119.

63.V Bragulat , M Dzemidzic , C Bruno (2010) Food-related odor probes of brain reward circuits during hunger: a pilot FMRI study. Obesity (Silver Spring) 18, 15661571.

68.AJ Ho , CA Raji , JT Becker (2011) The effects of physical activity, education, and body mass index on the aging brain. Hum Brain Mapp 32, 13711382.

69.N Pannacciulli , PA Del , K Chen (2006) Brain abnormalities in human obesity: a voxel-based morphometric study. Neuroimage 31, 14191425.

70.K Walther , AC Birdsill , EL Glisky (2010) Structural brain differences and cognitive functioning related to body mass index in older females. Hum Brain Mapp 31, 10521064.

71.JI Cohen , KF Yates , M Duong (2011) Obesity, orbitofrontal structure and function are associated with food choice: a cross-sectional study. BMJ Open 1, e000175.

82.FI Kishinevsky , JE Cox , DL Murdaugh (2012) fMRI reactivity on a delay discounting task predicts weight gain in obese women. Appetite 58, 582592.

87.F Grabenhorst & ET Rolls (2008) Selective attention to affective value alters how the brain processes taste stimuli. Eur J Neurosci 27, 723729.

90.G Bender , MG Veldhuizen , JA Meltzer (2009) Neural correlates of evaluative compared with passive tasting. Eur J Neurosci 30, 327338.

91.JM Born , SG Lemmens , MJ Martens (2011) Differences between liking and wanting signals in the human brain and relations with cognitive dietary restraint and body mass index. Am J Clin Nutr 94, 392403.

94.RM Piech , J Lewis , CH Parkinson (2010) Neural correlates of affective influence on choice. Brain Cogn 72, 282288.

95.J Peters & C Buchel (2010) Neural representations of subjective reward value. Behav Brain Res 213, 135141.

97.DA Booth & A Nouwen (2010) Satiety. No way to slim. Appetite 55, 718721.

99.DL Murdaugh , JE Cox , EW Cook , III (2012) fMRI reactivity to high-calorie food pictures predicts short- and long-term outcome in a weight-loss program. Neuroimage 59, 27092721.

104.S Amari , F Beltrame , JG Bjaalie (2002) Neuroinformatics: the integration of shared databases and tools towards integrative neuroscience. J Integr Neurosci 1, 117128.

106.A Scott , W Courtney , D Wood . (2011) COINS: an innovative informatics and neuroimaging tool suite built for large heterogeneous datasets. Front Neuroinform 5, 33.

108.PE Turkeltaub , GF Eden , KM Jones (2002) Meta-analysis of the functional neuroanatomy of single-word reading: method and validation. Neuroimage 16, 765780.

109.SB Eickhoff , AR Laird , C Grefkes (2009) Coordinate-based activation likelihood estimation meta-analysis of neuroimaging data: a random-effects approach based on empirical estimates of spatial uncertainty. Hum Brain Mapp 30, 29072926.

110.JV Haxby , MI Gobbini , ML Furey (2001) Distributed and overlapping representations of faces and objects in ventral temporal cortex. Science 293, 24252430.

119.VA Phan , MG Ramaekers , DP Bolhuis (2012) On the use of Bayesian networks to combine raw data from related studies on sensory satiation. Food Quality and Preference 26, 119127.

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