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Is exercise best served on an empty stomach?

  • Gareth A. Wallis (a1) and Javier T. Gonzalez (a2)

Abstract

The objective of this review paper is to evaluate the impact of undertaking aerobic exercise in the overnight-fasted v. fed-state, in the context of optimising the health benefits of regular physical activity. Conducting a single bout of aerobic exercise in the overnight-fasted v. fed-state can differentially modulate the aspects of metabolism and energy balance behaviours. This includes, but is not limited to, increased utilisation of fat as a fuel source, improved plasma lipid profiles, enhanced activation of molecular signalling pathways related to fuel metabolism in skeletal muscle and adipose tissue, and reductions in energy intake over the course of a day. The impact of a single bout of overnight-fasted v. fed-state exercise on short-term glycaemic control is variable, being affected by the experimental conditions, the time frame of measurement and possibly the subject population studied. The health response to undertaking overnight-fasted v. fed-state exercise for a sustained period of time in the form of exercise training is less clear, due to a limited number of studies. From the extant literature, there is evidence that overnight-fasted exercise in young, healthy men can enhance training-induced adaptations in skeletal muscle metabolic profile, and mitigate against the negative consequences of short-term excess energy intake on glucose tolerance compared with exercising in the fed-state. Nonetheless, further long-term studies are required, particularly in populations at-risk or living with cardio-metabolic disease to elucidate if feeding status prior to exercise modulates metabolism or energy balance behaviours to an extent that could impact upon the health or therapeutic benefits of exercise.

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Corresponding author

*Corresponding author: Gareth A. Wallis, email g.a.wallis@bham.ac.uk

References

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1.Garber, CE, Blissmer, B, Deschenes, MR, et al. (2011) Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exercise 43, 13341359.
2.Colberg, SR, Sigal, RJ, Yardley, JE et al. (2016) Physical activity/exercise and diabetes: a position statement of the American Diabetes Association. Diabetes Care 39, 20652079.
3.Ross, R, Blair, SN, Arena, R et al. (2016) Importance of assessing cardiorespiratory fitness in clinical practice: a case for fitness as a clinical vital sign: a scientific statement from the American Heart Association. Circulation 134, e653e699.
4.Boulé, NG, Weisnagel, SJ, Lakka, TA et al. (2005) Effects of exercise training on glucose homeostasis. The HERITAGE Family Study. Diabetes Care 28, 108114.
5.King, NA, Hopkins, M, Caudwell, P et al. (2007) Individual variability following 12 weeks of supervised exercise: identification and characterization of compensation for exercise-induced weight loss. Int J Obes 32, 177.
6.Hawley John, A, Maughan Ronald, J & Hargreaves, M (2015) Exercise metabolism: historical perspective. Cell Metab 22, 1217.
7.Bartlett, JD, Hawley, JA & Morton, JP (2015) Carbohydrate availability and exercise training adaptation: too much of a good thing? Eur J Sport Sci 15, 312.
8.Burke, LM, Hawley, JA, Wong, SHS et al. (2011) Carbohydrates for training and competition. J Sports Sci 29, S17S27.
9.Hansen, D, De Strijcker, D & Calders, P (2017) Impact of endurance exercise training in the fasted state on muscle biochemistry and metabolism in healthy subjects: can these effects be of particular clinical benefit to type 2 diabetes mellitus and insulin-resistant patients? Sports Med 47, 415428.
10.Haxhi, J, Scotto di Palumbo, A & Sacchetti, M (2013) Exercising for metabolic control: is timing important? Ann Nutr Metab 62, 1425.
11.Genser, D (2008) Food and drug interaction: consequences for the nutrition/health status. Ann Nutr Metab 52(suppl 1), 2932.
12.Vieira, AF, Costa, RR, Macedo, RCO et al. (2016) Effects of aerobic exercise performed in fasted v. fed state on fat and carbohydrate metabolism in adults: a systematic review and meta-analysis. Br J Nutr 116, 11531164.
13.Coyle, EF, Jeukendrup, AE, Wagenmakers, AJ et al. (1997) Fatty acid oxidation is directly regulated by carbohydrate metabolism during exercise. Am J Physiol Endocrinol Metab 273, E268E275.
14.De Bock, K, Richter Erik, A, Russell Aaron, P et al. (2005) Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans. J Physiol 564, 649660.
15.Bilet, L, Brouwers, B, van Ewijk, PA et al. (2015) Acute exercise does not decrease liver fat in men with overweight or NAFLD. Sci Rep 5, 9709.
16.Melanson, EL, Gozansky, WS, Barry, DW et al. (2009) When energy balance is maintained, exercise does not induce negative fat balance in lean sedentary, obese sedentary, or lean endurance-trained individuals. J Appl Physiol 107, 18471856.
17.Iwayama, K, Kurihara, R, Nabekura, Y et al. (2015) Exercise increases 24-h fat oxidation only when it is performed before breakfast. EBioMedicine 2, 20032009.
18.Iwayama, K, Kawabuchi, R, Nabekura, Y et al. (2017) Exercise before breakfast increases 24-h fat oxidation in female subjects. PLoS ONE 12, e0180472.
19.Robinson, SL, Hattersley, J, Frost, GS et al. (2015) Maximal fat oxidation during exercise is positively associated with 24-hour fat oxidation and insulin sensitivity in young, healthy men. J Appl Physiol 118, 14151422.
20.Zurlo, F, Lillioja, S, Puente, AE-D et al. (1990) Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am J Physiol Endocrinol Metab 259, E650E657.
21.Enevoldsen, LH, Simonsen, L, Macdonald, IA et al. (2004) The combined effects of exercise and food intake on adipose tissue and splanchnic metabolism. J Physiol 561, 871882.
22.Farah, NMF & Gill, JMR (2012) Effects of exercise before or after meal ingestion on fat balance and postprandial metabolism in overweight men. Br J Nutr 109, 22972307.
23.Chacko, E (2017) A time for exercise: the exercise window. J Appl Physiol 122, 206209.
24.Poirier, P, Tremblay, A, Catellier, C et al. (2000) Impact of time interval from the last meal on glucose response to exercise in subjects with type 2 diabetes 1. J Clin Endocrinol Metab 85, 28602864.
25.Gonzalez, JT (2014) Paradoxical second-meal phenomenon in the acute postexercise period. Nutrition 30, 961967.
26.Nygaard, H, Rønnestad, BR, Hammarström, D et al. (2017) Effects of exercise in the fasted and postprandial state on interstitial glucose in hyperglycemic individuals. J Sports Sci Med 16, 254263.
27.Gonzalez, JT, Veasey, RC, Rumbold, PLS et al. (2013) Breakfast and exercise contingently affect postprandial metabolism and energy balance in physically active males. Br J Nutr 110, 721732.
28.Jean-Pierre, F (2001) Macronutrient composition and food selection. Obes Res 9, 256S262S.
29.Hopkins, M, Blundell, JE & King, NA (2014) Individual variability in compensatory eating following acute exercise in overweight and obese women. Br J Sports Med 48, 14721476.
30.López-Soldado, I, Fuentes-Romero, R, Duran, J et al. (2017) Effects of hepatic glycogen on food intake and glucose homeostasis are mediated by the vagus nerve in mice. Diabetologia 60, 10761083.
31.Bachman, JL, Deitrick, RW & Hillman, AR (2016) Exercising in the fasted state reduced 24-hour energy intake in active male adults. J Nutr Metab 2016, 1984198.
32.Hutchison, A, Wittert, G & Heilbronn, L (2017) Matching meals to body clocks – impact on weight and glucose metabolism. Nutrients 9, 222.
33.Betts, JA, Chowdhury, EA, Gonzalez, JT et al. (2016) Is breakfast the most important meal of the day? Proc Nutr Soc 75, 464474.
34.Gillen, JB, Percival, , Alison, L et al. (2013) Interval training in the fed or fasted state improves body composition and muscle oxidative capacity in overweight women. Obesity 21, 22492255.
35.Proeyen, KV, Szlufcik, K, Nielens, H et al. (2011) Beneficial metabolic adaptations due to endurance exercise training in the fasted state. J Appl Physiol 110, 236245.
36.Schoenfeld, BJ, Aragon, AA, Wilborn, CD et al. (2014) Body composition changes associated with fasted versus non-fasted aerobic exercise. J Int Soc Sports Nutr 11, 54.
37.Ross, R, Dagnone, D, Jones, PH et al. (2000) Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men: a randomized, controlled trial. Ann Intern Med 133, 92103.
38.Ross, R, Janssen, I, Dawson, J et al. (2004) Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial. Obes Res 12, 789798.
39.Hall, KD & Guo, J (2017) Obesity energetics: body weight regulation and the effects of diet composition. Gastroenterology 152, 17181727. e1713.
40.Karen, VP, Karolina, S, Henri, N et al. (2010) Training in the fasted state improves glucose tolerance during fat-rich diet. J Physiol 588, 42894302.
41.Arner, P, Bernard, S, Salehpour, M et al. (2011) Dynamics of human adipose lipid turnover in health and metabolic disease. Nature 478, 110113.
42.Frayn, K, Bernard, S, Spalding, K et al. (2012) Adipocyte triglyceride turnover is independently associated with atherogenic dyslipidemia. J Am Heart Assoc Cardiovasc Cerebrovasc Dis 1, e003467.
43.Chen, Y-C, Travers, RL, Walhin, J-P et al. (2017) Feeding influences adipose tissue responses to exercise in overweight men. Am J Physiol Endocrinol Metab 313, E84E93.
44.Civitarese, AE, Hesselink, MKC, Russell, AP et al. (2005) Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes. Am J Physiol Endocrinol Metab 289, E1023E1029.
45.Cluberton, LJ, McGee, SL, Murphy, RM et al. (2005) Effect of carbohydrate ingestion on exercise-induced alterations in metabolic gene expression. J Appl Physiol 99, 13591363.
46.Shaw, CS, Clark, J & Wagenmakers, AJM (2010) The effect of exercise and nutrition on intramuscular fat metabolism and insulin sensitivity. Annu Rev Nutr 30, 1334.
47.Bock, KD, Derave, W, Eijnde, BO et al. (2008) Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake. J Appl Physiol 104, 10451055.
48.Edinburgh, RM, Hengist, A, Smith, HA et al. (2018) Pre-exercise breakfast ingestion versus extended overnight fasting increases postprandial glucose flux after exercise in healthy men: pre-exercise feeding and postprandial glucose flux. Am J Physiol Endocrinol Metab (In the Press).
49.Hawley, JA, Lundby, C, Cotter, JD et al. (2018) Maximizing cellular adaptation to endurance exercise in skeletal muscle. Cell Metab 27, 962976.
50.Aird, TP, Davies, RW & Carson, BP (2018) Effects of fasted vs fed-state exercise on performance and post-exercise metabolism: a systematic review and meta-analysis. Scand J Med Sci Sports 28, 14761493.
51.Solomon, TPJ, Eves, FF & Laye, MJ (2018) Targeting postprandial hyperglycemia with physical activity may reduce cardiovascular disease risk. But what should we do, and when is the right time to move? Front Cardiovasc Med 5 [Epublication ahead of print version].
52.Zarins, ZA, Wallis, GA, Faghihnia, N et al. (2009) Effects of endurance training on cardiorespiratory fitness and substrate partitioning in postmenopausal women. Metab Clin Exp 58, 13381346.
53.Frawley, K, Greenwald, G, Rogers, RR et al. (2018) Effects of prior fasting on fat oxidation during resistance exercise. Int J Exerc Sci 11, 827833.

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Is exercise best served on an empty stomach?

  • Gareth A. Wallis (a1) and Javier T. Gonzalez (a2)

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