Skip to main content Accessibility help
×
Home
Hostname: page-component-846f6c7c4f-tfmpj Total loading time: 0.559 Render date: 2022-07-07T13:10:02.025Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "useNewApi": true } hasContentIssue true

Mechanotransduction and the regulation of protein synthesis in skeletal muscle

Published online by Cambridge University Press:  05 March 2007

T. A. Hornberger
Affiliation:
Muscle Biology Laboratory, School of Kinesiology (m/c 194), University of Illinois, Chicago, 901 W Roosevelt Road, Chicago, IL 60608, USA
Rights & Permissions[Opens in a new window]

Abstract

HTML view is not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Repeated bouts of resistance exercise produce an increase in skeletal muscle mass. The accumulation of protein associated with the growth process results from a net increase in protein synthesis relative to breakdown. While the effect of resistance exercise on muscle mass has long been recognized, the mechanisms underlying the link between high-resistance contractions and the regulation of protein synthesis and breakdown are, to date, poorly understood. In the present paper skeletal muscle will be viewed as a mechanosensitive cell type and the possible mechanisms through which mechanically-induced signalling events lead to changes in rates of protein synthesis will be examined.

Type
Symposium 5: Muscle hypertrophy: the signals of insulin, amino acids and exercise
Copyright
Copyright © The Nutrition Society 2004

References

Anastasi, G, Cutroneo, G, Santoro, G & Trimarchi, F (1998) The non-junctional sarcolemmal cytoskeleton: the costameres. Italian Journal of Anatomy and Embryology 103, 111.Google ScholarPubMed
Dulhunty, AF & Franzini-Armstrong, C (1975) The relative contributions of the folds and caveolae to the surface membrane of frog skeletal muscle fibres at different sarcomere lengths. Journal of Physiology (London) 250, 513539.CrossRefGoogle ScholarPubMed
Fitts, RH, Riley, DR & Widrick, JJ (2000) Physiology of a microgravity environment invited review: microgravity and skeletal muscle. Journal of Applied Physiology 89, 823839.CrossRefGoogle ScholarPubMed
Goldberg, AL (1968) Protein synthesis during work-induced growth of skeletal muscle. Journal of Cell Biology 36, 653658.CrossRefGoogle ScholarPubMed
Goldberg, AL, Etlinger, JD, Goldspink, DF & Jablecki, C (1975) Mechanism of work-induced hypertrophy of skeletal muscle. Medicine and Sport Science 7, 185198.Google ScholarPubMed
Goldspink, DF (1977) The influence of immobilization and stretch on protein turnover of rat skeletal muscle. Journal of Physiology 264, 267282.CrossRefGoogle ScholarPubMed
Gudi, S, Nolan, JP & Frangos, JA (1998) Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition. Proceedings of the National Academy of Sciences USA 95, 25152519.CrossRefGoogle ScholarPubMed
Hamill, OP & Martinac, B (2001) Molecular basis of mechanotransduction in living cells. Physiological Reviews 81, 685740.CrossRefGoogle ScholarPubMed
Herbert, TP, Kilhams, GR, Batty, IH & Proud, CG (2000) Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells. Journal of Biological Chemistry 275, 1124911256.CrossRefGoogle ScholarPubMed
Jefferies, HB, Fumagalli, S, Dennis, PB, Reinhard, C, Pearson, RB & Thomas, G (1997) Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k. EMBO Journal 16, 36933704.CrossRefGoogle ScholarPubMed
Kimball, SR, Farrell, PA & Jefferson, LS (2002) Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise. Journal of Applied Physiology 93, 11681180.CrossRefGoogle ScholarPubMed
Liu, G, Zhang, Y, Bode, AM, Ma, WY & Dong, Z (2002) Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation. Journal of Biological Chemistry 277, 88108816.CrossRefGoogle ScholarPubMed
Palmer, RM, Reeds, PJ, Atkinson, T & Smith, RH (1983) The influence of changes in tension on protein synthesis and prostaglandin release in isolated rabbit muscles. Biochemical Journal 214, 10111014.CrossRefGoogle ScholarPubMed
Plopper, GE, McNamee, HP, Dike, LE, Bojanowski, K & Ingber, DE (1995) Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Molecular Biology of the Cell 6, 13491365.CrossRefGoogle ScholarPubMed
Rando, TA (2001) The dystrophin-glycoprotein complex, cellular signaling, and the regulation of cell survival in the muscular dystrophies. Muscle Nerve 24, 15751594.CrossRefGoogle ScholarPubMed
Ruwhof, C & van der Laarse, A (2000) Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways. Cardiovascular Research 47, 2337.CrossRefGoogle ScholarPubMed
Sakamoto, K, Hirshman, MF, Aschenbach, WG & Goodyear, LJ (2002) Contraction regulation of Akt in rat skeletal muscle. Journal of Biological Chemistry 277, 1191011917.CrossRefGoogle ScholarPubMed
Schwartz, MA, Schaller, MD & Ginsberg, MH (1995) Integrins: emerging paradigms of signal transduction. Annual Review of Cell and Developmental Biology 11, 549599.CrossRefGoogle ScholarPubMed
Sonenberg, N, Hershey, JW & Mathews, MB (2000) Translation Control of Gene Expression Cold Spring Harbor, NY Cold Spring Harbor Laboratory PressGoogle Scholar
Tipton, KD & Wolfe, RR (2001) Exercise, protein metabolism, and muscle growth. International Journal of Sport Nutrition and Exercise Metabolism 11, 109132.CrossRefGoogle ScholarPubMed
Vandenburgh, H, Chromiak, J, Shansky, J, Del Tatto, M & Lemaire, J (1999) Space travel directly induces skeletal muscle atrophy. FASEB Journal 13, 10311038.CrossRefGoogle ScholarPubMed
Vandenburgh, HH (1987) Motion into mass: how does tension stimulate muscle growth. Medicine and Science in Sports and Exercise 19, S142S149.Google ScholarPubMed
Vandenburgh, HH, Shansky, J, Solerssi, R & Chromiak, J (1995) Mechanical stimulation of skeletal muscle increases prostaglandin F2 alpha production, cyclooxygenase activity, and cell growth by a pertussis toxin sensitive mechanism. Journal of Cellular Physiology 163, 285294.CrossRefGoogle ScholarPubMed
Wang, N, Butler, JP & Ingber, DE (1993) Mechanotransduction across the cell surface and through the cytoskeleton. Science 260, 11241127.CrossRefGoogle Scholar
Wymann, MP & Pirola, L (1998) Structure and function of phosphoinositide 3-kinases. Biochimica et Biophysica Acta 1436, 127150.CrossRefGoogle ScholarPubMed
You have Access
60
Cited by

Save article to Kindle

To save this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Mechanotransduction and the regulation of protein synthesis in skeletal muscle
Available formats
×

Save article to Dropbox

To save this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about saving content to Dropbox.

Mechanotransduction and the regulation of protein synthesis in skeletal muscle
Available formats
×

Save article to Google Drive

To save this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about saving content to Google Drive.

Mechanotransduction and the regulation of protein synthesis in skeletal muscle
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *