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    Lou, Mei-Fang Shen, Wei Fu, Rong-Shu Zhang, Xue-Ying and Wang, De-Hua 2015. Maternal dietary protein supplement confers long-term sex-specific beneficial consequences of obesity resistance and glucose tolerance to the offspring in Brandt's voles. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, Vol. 182, p. 38.


    Blumfield, Michelle Hure, Alexis MacDonald-Wicks, Lesley Smith, Roger Simpson, Stephen Raubenheimer, David and Collins, Clare 2012. The Association between the Macronutrient Content of Maternal Diet and the Adequacy of Micronutrients during Pregnancy in the Women and Their Children’s Health (WATCH) Study. Nutrients, Vol. 4, Issue. 12, p. 1958.


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  • Proceedings of the Nutrition Society, Volume 71, Issue 1
  • February 2012, pp. 198-203

The influence of maternal protein nutrition on offspring development and metabolism: the role of glucocorticoids

  • K. Almond (a1) (a2), P. Bikker (a3), M. Lomax (a2), M. E. Symonds (a1) and A. Mostyn (a4)
  • DOI: http://dx.doi.org/10.1017/S0029665111003363
  • Published online: 29 November 2011
Abstract

The consequences of sub-optimal nutrition through alterations in the macronutrient content of the maternal diet will not simply be reflected in altered neonatal body composition and increased mortality, but are likely to continue into adulthood and confer greater risk of metabolic disease. One mechanism linking manipulations of the maternal environment to an increased risk of later disease is enhanced fetal exposure to glucocorticoids (GC). Tissue sensitivity to cortisol is regulated, in part, by the GC receptor and 11β-hydroxysteroid dehydrogenase (11β-HSD) types 1 and 2. Several studies have shown the effects of maternal undernutrition, particularly low-protein diets, on the programming of GC action in the offspring; however, dietary excess is far more characteristic of the diets consumed by contemporary pregnant women. This study investigated the programming effects of moderate protein supplementation in pigs throughout pregnancy. We have demonstrated an up-regulation of genes involved in GC sensitivity, such as GC receptor and 11β-HSD, in the liver, but have yet to detect any other significant changes in these piglets, with no differences observed in body weight or composition. This increase in GC sensitivity was similar to the programming effects observed following maternal protein restriction or global undernutrition during pregnancy.

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Corresponding author
*Corresponding author: K. Almond, Present address: Primary Diets, Melmerby Industrial Estate, Melmerby, Ripon, North Yorkshire HG4 5HP, UK, fax+44 (0)1765 640636, email kayleigh.almond@abagri.com
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1.DJP Barker , C Bull , C Osmund (1990) Fetal and placental size and risk of hypertension in later life. Br Med J 301, 259262.

2.CN Hales , DJP Barker , PMS Clark (1991) Fetal and infant growth and impaired glucose tolerance at age 64. Br Med J 303, 10191022.

3.DJP Barker (1995) Fetal origins of coronary heart disease. Br Med J 311, 171174.

4.SB Serbert , NS Dellschaft , LLY Chan (2011) Maternal nutrient restriction during late gestation and early postnatal growth in sheep differentially reset the control of energy metabolism in gastric mucosa. Endocrinology 152, 28162826.

5.GS Goplakrishnan , DS Gardner , SM Rhind (2004) Programming of adult cardivascular function after early maternal undernutrition in sheep. Am J Physiol Regul Integr Comp Physiol 287, R12R20.

6.DS Gardner , K Tingey , BWM Van Bom (2005) Programming of glucose-insulin metabolism in adult sheep after maternal under nutrition. Am J Physiol Regul Integr Comp Physiol 289, R947R954.

10.E Miller & D Ullrey (1987) The pig as a model for human nutrition. Annu Rev Nutr 7, 361382.

11.WG Pond (1991) Of pigs and people. In Swine Nutrition [EW Miller , DE Ullrey & AJ Lewis ]. Boston, MA: Butterworth-Heinemann.

13.SC Langley-Evans , GJ Philips , R Benediktsson (1996) Protein intake during pregnancy, placental glucocorticoid metabolism, and the programming of hypertension in the rat. Placenta 17, 169172.

14.SC Langley-Evans , SJM Welham & AA Jackson (1998) Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat. Life Sci 64, 965974.

15.C Bertram , AR Trowern , N Copin (2001) The maternal diet during pregnancy programs altered expression of the glucocorticoid receptor and type 2 11{beta}-hydroxysteroid dehydrogenase: potential molecular mechanisms underlying the programming of hypertension in utero. Endocrinology 142, 28412853.

17.CB Whorwood , KM Firth , H Budge (2001) Maternal under nutrition during early to midgestation programs tissue-specific alterations in the expression of the glucocorticoid receptor, 11 β-hydroxysteroid dehydrogenase isoforms, and type 1 angiotensin II receptor in neonatal sheep. Endocrinology 142, 28542864.

18.G Arnaldi , A Angeli , AB Atkinson (2003) Diagnosis and complications of Cushing's syndrome: a consensus statement. J Clin Endocrinol Metab 88, 55935602.

19.RA Covar , DY Leung , D McCormick (2000) Risk factors associated with glucocorticoid-induced adverse effects in children with severe asthma. J Allergy Clin Immunol 106, 651659.

20.CM Bamberger , HM Schulte , GP Chrousos (1996) Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr Rev 17, 245261.

21.PM Stewart & ZS Krozowski (1997) 11 β-Hydroxysteroid dehydrogenase. Vitam Horm 57, 249324.

22.M Wang (2005) The role of glucocorticoid action in the pathophysiology of the metabolic syndrome. Nutr Metab 2, 17437075.

23.EA Walker & PM Stewart (2003) 11β-Hydroysteroid dehydrogenase: unexpected conditions. Trends Endorcinol Metab 14, 334339.

24.CRW Edwards , R Benediktsson , RA Lindsay (1996) 11β-Hydroxysteroid dehydrogenases: Key enzymes in determining tissue-specific glucocorticoid effects. Steroids 61, 263269.

25.PM Stewart , FM Rogerson & JL Mason (1995) Type 2 11 β-hydroxysteroid dehydrogenase messenger ribonucleic acid and activity in human placenta and fetal membranes: Its relationship to birth weight and putative role in fetal adrenal steroidogenesis. J Clin Endocrinol Metab 80, 885890.

26.J Condon , C Gosden , H Gardener (1998) Expression of type 2 11 β-hydroxysteroid dehydrogenase and corticosteroid hormone receptors in early human fetal life. J Clin Endocrinol Metab 83, 44904497.

27.SCN Langley-Evans & M Nwagwu (1998) Impaired growth and increased glucocorticoid-sensitive enzyme activities in tissues of rat fetuses exposed to maternal low protein diets. Life Sci 63, 605615.

29.JM Brameld , A Mostyn , J Dandrea (2000) Maternal nutrition alters the expression of insulin-like growth factors in sheep liver and skeletal muscle. J Endocrinol 167, 429437.

30.MF Rolland-Cachera , F Bellisle , M Deheeger (2000) Nutritional status and food intake in adolescents living in Western Europe. Eur J Clin Nutr 54, S41S46.

32.F Mathews , P Yudkin & A Neil (1999) Influence of maternal nutrition on outcome of pregnancy: prospective cohort studies. Br Med J 319, 339343.

34.C Thone-Reineke , P Kalk , M Dorn (2006) High-protein nutrition during pregnancy and lactation programs blood pressure, food efficiency, and body weight of the offspring in a sex-dependent manner. Am J Physiol Regul Integr Comp Physiol 291, R1025R1030.

35.MA Zimanyi , JF Bertram , MJ Black (2002) Nephron number and blood pressure in rat offspring with maternal high-protein diet. Pediatr Nephrol 17, 10001004.

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Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
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