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Vitamin D status and its relationship with parathyroid hormone and bone mineral status in older adolescents

  • Alexis M. Willett (a1)
  • DOI:
  • Published online: 01 March 2007

Osteoporosis is an important contributor to the global burden of disease, and in the UK alone results in one in three women and one in twelve men aged >50 years experiencing a fragility fracture. Optimising peak bone mass in early adulthood is thought to reduce osteoporosis risk by offsetting bone losses in later life. Ensuring sufficient vitamin D status (measured as 25-hydroxyvitamin D (25OHD) in plasma), among other factors, is believed to facilitate the achievement of optimum peak bone mass. Lower 25OHD is associated with a higher plasma concentration of parathyroid hormone (PTH). As PTH is associated with increased bone turnover and bone loss, maintenance of sufficient 25OHD is thought to have a protective effect on bone health. However, there is a lack of consensus internationally on what constitutes an optimum 25OHD concentration, and values between 30 and 80 nmol/l have been suggested. These values have been based on findings from various studies in adults in which PTH has been observed to plateau at a 25OHD concentration of >30 nmol/l; however, not all studies have found such a plateau. Although studies in younger adolescents (14–16 years) have shown an inverse relationship between PTH and 25OHD, the concentration of 25OHD required for achievement of optimum peak bone mass is unknown. The present review examines the evidence defining vitamin D insufficiency thresholds, and the relevance of such thresholds to adolescent bone health.

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Corresponding author: Alexis Willett, fax +44 1223 437515, email
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

M Ala-Houhala , MT Parviainen , K Pyykö & JK Visakorpi (1984) Serum 25-hydroxyvitamin D levels in Finnish children aged 2 to 17 years. Acta Paediatrica Scandinavica 73, 232236.

EMK Awumey , DA Mitra , BW Hollis , R Kumar & NH Bell (1998) Vitamin D metabolism is altered in Asian Indians in the southern United States: A clinical research center study. Journal of Clinical Endocrinology and Metabolism 83, 169173.

A Ballabriga (2000) Morphological and physiological changes during growth: an update. European Journal of Clinical Nutrition 54, S1S6. Suppl. 1

S Bass , PD Delmas , G Pearce , E Hendrich , A Tabensky & E Seeman (1999) The differing tempo of growth in bone size, mass, and density in girls is region-specific. Journal of Clinical Investigation 104, 795804.

N Binkley , D Krueger , CS Cowgill , L Plum , E Lake , KE Hansen , HF DeLuca & MK Drezner (2004) Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization. Journal of Clinical Endocrinology and Metabolism 89, 31523157.

J Cadogan , A Blumsohn , ME Barker & R Eastell (1998) A longitudinal study of bone gain in pubertal girls: anthropometric and biochemical correlates. Journal of Bone and Mineral Research 13, 16021612.

MC Chapuy , ME Arlot , F Duboeuf , J Brun , B Crouzet , S Arnaud , PD Delmas & PJ Meunier (1992) Vitamin D3 and calcium to prevent hip fractures in the elderly women. New England Journal of Medicine 327, 16371642.

MC Chapuy , R Pamphile , E Paris , C Kempf , M Schlichting , S Arnaud , P Garneo & P Meunier (2002) Combined calcium and vitamin D 3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: The Decalyos II Study. Osteoporosis International 13, 257264.

MC Chapuy , P Preziosi , M Maamer , S Arnaud , P Galan , S Hercberg & PJ Meunier (1997) Prevalence of vitamin D insufficiency in an adult normal population. Osteoporosis International 7, 439443.

TC Chen , KS Parsons , K Lu , JS Mathieu & MF Holick (2000) An evaluation of the biologic activity and vitamin D receptor binding affinity of the photoisomers of vitamin D 3 and previtamin D 3. Journal of Nutritional Biochemistry 11, 267272.

MR Clemens (1989) The problem of rickets in UK Asians. Journal of Human Nutrition and Dietetics 2, 105116.

TJ Cole & A Prentice (1992) Bone mineral measurements. British Medical Journal 305, 12231224.

Consensus Development Conference (1993) Diagnosis, prophylaxis and treatment of osteoporosis. American Journal of Medicine 94, 646650.

C Cooper , G Campion , LJ Melton (1992) Hip fractures in the elderly: a world-wide projection. Osteoporosis International 2, 285289.

B Cromer & Z Harel (2000) Adolescents: at increased risk for osteoporosis. Clinical Pediatrics 39, 565574.

PS Davies , CJ Bates , TJ Cole , A Prentice & PC Clarke (1999) Vitamin D: seasonal and regional differences in preschool children in Great Britain. European Journal of Clinical Nutrition 53, 195198.

MS Fewtrell (2003) Bone densitometry in children assessed by dual x ray absorptiometry: uses and pitfalls. Archives of Disease in Children 88, 795798.

DR Fraser (1994) Effect of calcium deficiency on vitamin D metabolism. In Nutrient Regulation during Pregnancy, Lactation and Infant Growth, 237241 [L Allen , J King , B Lonnerdal , editors]. New York: Plenum Press.

V Gilsanz (1998) Phenotype and genotype of osteoporosis. Trends in Endocrinology and Metabolism 9, 184190.

F Ginty , KL Rennie , L Mills , SJ Stear , SC Jones & A Prentice (2005b) Positive, site-specific associations between bone mineral status, fitness and time spent at high impact activities in 16–18 year-old boys. Bone 36, 101110.

J Guillemant , S Cabrol , A Allemandou , G Peres & S Guillemant (1995) Vitamin D-dependent seasonal variation of PTH in growing male adolescents. Bone 17, 513516.

J Le Guillemant , HT Maria , A Allemandou , A Pérès , GS Guillemant (2001) Wintertime vitamin D deficiency in male adolescents: effect on parathyroid function and response to vitamin D 3 supplements. Osteoporosis International 12, 875879.

J Guillemant , P Taupin , HT Le Allemandou , Pérès A , GS Guillemant (1999) Vitamin D status during puberty in French healthy male adolescents. Osteoporosis International 10, 222225.

A Gustavsson , K Thorsen & P Nordstrom (2003) A 3-year longitudinal study of the effect of physical activity on the accrual of bone mineral density in healthy adolescent males. Calcified Tissue International 73, 108114.

G Hampson , FC Martin , K Moffat , S Vaja , S Sankaralingam , J Cheung , GM Blake & I Fogelman (2003) Effects of dietary improvement on bone metabolism in elderly underweight women with osteoporosis: a randomised controlled trial. Osteoporosis International 14, 750756.

RP Heaney , S Abrams , B Dawson-Hughes , A Looker , R Marcus , V Matkovic & C Weaver (2000) Peak bone mass. Osteoporosis International 11, 9851009.

MF Holick (1981) The cutaneous photosynthesis of previtamin D3: a unique photoendocrine system. Journal of Investigative Dermatology 77, 5158.

MF Holick (2001) Sunlight dilemma: risk of skin cancer or bone disease and muscle weakness. Lancet 357, 46.

D Jesudason , AG Need , M Horowitz , PD O'Loughlin , HA Morris & BE Nordin (2002) Relationship between serum 25-hydroxyvitamin D and bone resorption markers in vitamin D insufficiency. Bone 31, 626630.

P Jouanny , F Guillemin , C Kuntz , C Jeandel & J Pourel (1995) Environmental and genetic factors affecting bone mass. Similarity of bone density among members of healthy families. Arthritis Rheumatology 38, 6167.

V Kantorovich , MA Gacad , LL Seeger & JS Adams (2000) Bone mineral density increases with vitamin D repletion in patients with coexistent vitamin D insufficiency and primary hyperparathyroidism. Journal of Clinical Endocrinology and Metabolism 85, 35413543.

S Krabbe , I Transbøl & C Christiansen (1982) Bone mineral homeostasis, bone growth, and mineralisation during years of pubertal growth: a unifying concept. Archives of Disease in Childhood 57, 359363.

Kristinsson , G Valdimarsson , G Sigurdsson , L Franzson , I Olafsson & L Steingrimsdottir (1998) Serum 25-hydroxyvitamin D levels and bone mineral density in 16–20 years-old girls: lack of association. Journal of Internal Medicine 243, 381388.

S Kudlacek , B Schneider , M Peterlik , G Leb , K Klaushofer , K Weber , W Woloszczuk & R Willvonseder (2003) Assessment of vitamin D and calcium status in healthy adult Austrians. European Journal of Clinical Investigation 33, 323331.

Z Kun , H Greenfield , D Xueqin & DR Fraser (2001) Improvement of bone health in childhood and adolescence. Nutrition Research Reviews 14, 114151.

CJ Lamberg-Allardt , TA Outila , MU Karkkainen , HJ Rita & LM Valsta (2001) Vitamin D deficiency and bone health in healthy adults in Finland: could this be a concern in other parts of Europe. Journal of Bone and Mineral Research 16, 20662073.

M Lawson , M Thomas & A Hardiman (1999) Dietary and lifestyle factors affecting plasma vitamin D levels in Asian children living in England. European Journal of Clinical Nutrition 53, 268272.

M Lehtónen-Veromaa , T Möttönen , K Irjala , M Kärkkäinen , C Lamberg-Allardt , P Hakola & J Viikari (1999) Vitamin D intake is low and hypovitaminosis D common in healthy 9- to 15-year-old Finnish girls. European Journal of Clinical Nutrition 53, 746751.

M Lehtónen-Veromaa , T Möttönen , I Nuotio , K Irjala & J Viikari (2002) The effect of conventional vitamin D 2 supplementation on serum 25(OH)D concentration is weak among peripubertal Finnish girls: a 3-y prospective study. European Journal of Clinical Nutrition 56, 431437.

P Lips , MC Chapuy , B Dawson-Hughes , HAP Pols & MF Holick (1999) An international comparison of serum hydroxyvitamin D measurements. Osteoporosis International 9, 394397.

AC Looker , B Dawson-Hughes , MS Calvo , EW Gunter & NR Sahyoun (2002) Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone 30, 771777.

B Lund , OH Sorensen , JE Bishop & AW Norman (1980) Vitamin D metabolism in hypoparathyroidism. Journal of Clinical Endocrinology and Metabolism 51, 606610.

A Malabanan , IE Veronikis & MF Holick (1998) Redefining vitamin D insufficiency. Lancet 351, 805806.

L Margiloff , SS Harris , S Lee , R Lechan , B Dawson-Hughes (2001) Vitamin D status of an outpatient clinic population. Calcified Tissue International 69, 263267.

HE Meyer , GB Smedshaug , E Kvaavik , JA Falch , A Tverdal & JI Pedersen (2002) Can vitamin D supplementation reduce the risk of fracture in the elderly? A randomized controlled trial. Journal of Bone and Mineral Research 17, 709715.

K Nakamura , M Nashimoto , S Matsuyama & M Yamamoto (2001) Low serum concentrations of 25-hydroxyvitamin D in young adult Japanese women: a cross sectional study. Nutrition 17, 921925.

AW Norman (1992) Bone biochemistry and physiology from the perspectives of the vitamin D endocrine system. Current Opinion in Rheumatology 4, 375382.

AW Norman (1998) Receptors for 1(alpha), 25(OH) 2 D 3 : past, present and future. Journal of Bone and Mineral Research 13, 13601369.

AE O'Hare , WS Uttley , NR Belton , A Westwood , SD Levin & F Anderson (1984) Persisting vitamin D deficiency in the Asian adolescent. Archives of Disease in Childhood 59, 766770.

MB Oliveri , A Wittich , C Mautalen , A Chaperon & A Kizlansky (2000) Peripheral bone mass is not affected by winter vitamin D deficiency in children and young adults from Ushuaia. Calcified Tissue International 67, 220224.

AM Parfitt (1994) The two faces of growth: benefits and risks to bone integrity. Osteoporosis International 4, 382398.

TJ Parsons , A Prentice , EA Smith , TJ Cole & JE Compston (1996) Bone mineral mass consolidation in young British adults. Journal of Bone and Mineral Research 11, 264274.

R Patel , D Collins , S Bullock , R Swaminathan , GM Blake & I Fogelman (2001) The effect of season and vitamin D supplementation on bone mineral density in healthy women: a double-masked crossover study. Osteoporosis International 12, 319325.

CJ Prynne , F Ginty , AA Paul , C Bolton-Smith , SJ Stear , SC Jones & A Prentice (2004) Dietary acid-base balance and intake of bone-related nutrients in Cambridge teenagers. European Journal Clinical Nutrition 58, 14621471.

DM Reid (2003) An overview of osteoporosis. In Nutritional Aspects of Bone Health, pp. 112 [SA New , J-P Bonjour , editors]. Cambridge: Royal Society of Chemistry.

BL Riggs , S Khosla , LJ Melton III (1999) The assembly of the adult skeleton during growth and maturation: implications for senile osteoporosis. Journal of Clinical Investigation 104, 671672.

LA Rubin , GA Hawker , VD Peltekova , LJ Fielding , R Ridout & DE Cole (1999) Determinants of peak bone mass: clinical and genetic analyses in a young female Canadian cohort. Journal of Bone and Mineral Research 14, 633643.

G Saggese , GI Baroncelli & S Bertelloni (2001) Osteoporosis in children and adolescents: diagnosis, risk factors, and prevention. Journal of Pediatric Endocrinology and Metabolism 14, 833859.

G Saggese , GI Baroncelli & S Bertelloni (2002) Puberty and bone development. Best Practice Research Clinical Endocrinology and Metabolism 16, 5364.

SS Sherman , BW Hollis & JD Tobin (1990) Vitamin D status related parameters in a healthy population: The effects of age, sex and season. Journal of Clinical Endocrinology and Metabolism 71, 405413.

G Sigurdsson , L Franzson , L Steingrimsdottr & H Sigvaldason (2000) The association between parathyroid hormone, vitamin D and bone mineral density in 70-year old Icelandic women. Osteoporosis International 11, 10311035.

SJ Silverberg , E Shane , DW Dempster & JP Bilezikian (1999) The effects of vitamin D insufficiency in patients with primary hyperparathyroidism. American Journal of Medicine 107, 561567.

CW Slemenda , TK Reister , SL Hui , JZ Miller , JC Christian & CC Johnston (1994) Influences on skeletal mineralization in children and adolescents: Evidence for varying effects of sexual maturation and physical activity. Journal of Pediatrics 125, 201207.

JC Souberbielle , C Cormier , C Kindermans , P Gao , T Cantor , F Forette & EE Baulieu (2001) Vitamin D status and redefining serum parathyroid hormone reference range for the elderly. Journal of Clinical Endocrinology and Metabolism 86, 30863090.

P Szulc , E Seeman & PD Delmas (2000) Biochemical measurements of bone turnover in children and adolescents. Osteoporosis International 11, 281294.

V Tangpricha , EN Pearce , TC Chen & MF Holick (2002) Vitamin D insufficiency among free-living healthy young adults. American Journal of Medicine 112, 659662.

MK Thomas , DM Lloyd-Jones , RI Thadhani , AC Shaw , DJ Deraska , BT Kitch , EC Vamvakas , IM Dick , RL Prince & JS Finkelstein (1998) Hypovitaminosis D in medical inpatients. New England Journal of Medicine 338, 777783.

DP Trivedi , R Doll & KT Khaw (2003) Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. British Medical Journal 326, 469

R Vieth & G Carter (2001) Difficulties with vitamin D nutrition research: objective targets of adequacy, and assays for 25-hydroxyvitamin D. European Journal of Clinical Nutrition 55, 221222.

R Vieth , Y Ladak & PG Walfish (2003) Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. Journal of Clinical Endocrinology and Metabolism 88, 185191.

AR Webb , BR DeCosta & MF Holick (1989) Sunlight regulates the cutaneous production of vitamin D 3 by causing its photodegradation. Journal of Clinical Endocrinology and Metabolism 68, 882887.

AR Webb & MF Holick (1988) The role of sunlight in the cutaneous production of vitamin D 3. Annual Review of Nutrition 8, 375399.

HW Woitge , C Scheidt-Nave , C Kissling , G Leidig-Bruckner , K Meyer , A Grauer , SH Scharla , R Ziegler & MJ Seibel (1998) Seasonal variation of biochemical indexes of bone turnover: results of a population-based study. Journal of Clinical Endocrinology and Metabolism 83, 6875.

HW Woitge & MJ Seibel (2001) Biochemical markers to survey bone turnover. Rheumatic Disease Clinics of North America 27, 4980.

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