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Optimal cut-off points for waist circumference in the definition of metabolic syndrome in Chile

Published online by Cambridge University Press:  03 July 2020

Fanny Petermann-Rocha
Affiliation:
Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK British Heart Foundation Glasgow, Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK
María Adela Martínez-Sanguinetti
Affiliation:
Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile
Frederick K Ho
Affiliation:
Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
Carlos Celis-Morales
Affiliation:
Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK British Heart Foundation Glasgow, Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK Centro de Investigación en Fisiología del Ejercicio (CIFE), Universidad Mayor, Santiago, Chile Research Group in Education, Physical Activity and Health (GEEAFyS), Universidad Católica del Maule, Talca, Chile
Alonso Pizarro
Affiliation:
Department of European and Mediterranean Cultures: Architecture, Environment and Cultural Heritage (DICEM), University of Basilicata, Matera, Italy
Corresponding

Abstract

Objective:

To identify sex-specific cut-off points for waist circumference (WC) in the definition of metabolic syndrome (MetS) for the Chilean adult population.

Design:

MetS was defined as the presence of at least two out of four of the following criteria: TAG ≥1·7 mmol/l; HDL-cholesterol: <1·3 mmol/l in women and <1·0 mmol/l in men; systolic blood pressure ≥130 mmHg and/or diastolic blood pressure ≥85 mmHg; and fasting glucose ≥ 5·6 mmol/l or current treatment for diabetes. The receiver operating characteristics curve and the AUC were computed to derive the specificity and sensitivity using bootstrapping (10 000 iterations restricted to have at least between 40 and 60 % of the original population). The optimal cut-off point for the Chilean population was computed by sex.

Setting:

A representative sample of the Chilean population aged ≥15 years.

Participants:

8182 participants (60 % women) from the three available Chilean National Health Surveys conducted in 2003, 2009–2010 and 2016–2017.

Results:

WC had a good predictive ability for MetS (AUC for men 0·74 (95 % CI 0·72, 0·76); AUC for women 0·71 (95 % CI 0·68, 0·73)). The optimal cut-off points for WC, in the definition of MetS, were 92·3 cm (95 % CI 90·5, 94·4) and 87·6 cm (95 % CI 85·8, 92·1) for men and women, respectively.

Conclusions:

The mentioned cut-off points should be used for WC in the definition of MetS in Chile. As a result, the current recommendation (WHO/International Diabetes Federation) for WC, in the identification of MetS, is not supported by these findings in a representative sample of the Chilean adult population.

Type
Research paper
Copyright
© The Author(s), 2020. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

C.C.-M. and A.P. contributed equally to this work and are joint senior authors.

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