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Biomarkers and the measurement of fatty acids

  • Lenore Arab (a1) (a2) and Jabar Akbar (a2)

Abstract

Objective:

To review the various biomarkers of dietary intakes of fatty acids in human populations, their measurement, limitations and analytical considerations.

Design:

Review of the literature.

Results:

Although there is no good biomarker of intake of total fat, a number of alternatives exist for assessing the intakes of exogenously produced fatty acids that are consumed. Adipose tissue, erythrocyte membrane concentrations and serum or plasma levels can reflect prior intakes over the past few hours to the past few years. The concentrations of individual fatty acids in these media generally reflect relative levels, and are influenced by a number of factors. Although relatively expensive to analyse, a single analysis by gas chromatography or high-performance liquid chromatography provides information on multiple fatty acids, and is superior to attempting to measure specific fatty acids using traditional dietary assessment methods.

Conclusions:

Biomarkers of fatty acids that reflect long-term intake are available for nutritional epidemiology purposes. Analytical methods have become very accurate and able to detect and quantify smaller families, such as trans-fatty acids.

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Copyright

Corresponding author

*Corresponding author: Email Lenore@unc.edu

References

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1Kohlmeier, L. What you should know about your marker. In: Kok, FJ, van't Veer, P, eds. Biomarkers of Dietary Exposure.Proceedings of the 3rd Meeting on Nutritional Epidemiology. London: Smith-Gordon, 1991; 1525.
2Pearce, N, de Sanjose, S, Boffetta, P, Kogevinas, M, Saracci, R, Savitz, D. Limitations of biomarkers of exposure in cancerepidemiology. Epidemiology 1995; 6: 190–4.
3Lichtman, SW, Pisarska, K, Berman, ER, Pestone, M, Dowling, H, Offenbacher, E, et al. Discrepancy between self-reportedand actual caloric intake and exercise in obese subjects. N. Engl. J. Med. 1992; 327: 1893–8.
4Hellerstein, MK. De novo lipogenesis in humans: metabolic and regulatory aspects. Eur.J. Clin. Nutr. 1999; 53(Suppl. 1): S53–65.
5Kohlmeier, L. Future of dietary exposure assessment. Am.J. Clin. Nutr. 1995; 61: 702S–9S.
6Beynen, AC, Katan, MB. Rapid sampling and long-termstorage of subcutaneous adipose-tissue biopsies for determinationof fatty acid composition. Am.J. Clin. Nutr. 1985; 42: 317–22.
7Handelman, GJ, Epstein, WL, Machlin, LJ, van Kuijk, FJGM, Dratz, EA. Biopsy method for human adipose with vitamin E and lipid measurements. Lipids 1988; 23: 598604.
8Malcom, GT, Bhattacharyya, AK, Velez-Duran, M, Guzman, MA, Oalmann, MC, Strong, JP. Fatty acid composition ofadipose tissue in humans: differences between subcutaneous sites. Am.J. Clin. Nutr. 1989; 50: 288–91.
9Hendrikse, PW, Harwood, JL, Kates, M. Analytical methods. In: Gunstone, FD, Harwood, JL, Padley, FB, eds. The LipidHandbook, 2nd ed. London: Chapman & Hall, 1994; 319–58.
10Christie, WW. Detectors for high-performance liquid chromatographyof lipids with special reference to evaporativelight-scattering detection. In: Christie, WW, ed. Advances inLipid Methodology – One. Glasgow: The Oily Press, 1992; 239–71.
11Sehat, N, Rickert, R, Mossoba, MM, Kramer, JKG, Yurawecz, MP, Roach, JAG, et al. Improved separation of conjugated fattyacid methyl esters by silver ion–high performance liquid chromatography. Lipids 1999; 34: 407–13.
12Fordyce, MK, Christakis, G, Kafatos, A, Duncan, R, Cassady, J. Adipose tissue fatty acid composition of adolescents in aUS–Greece cross-cultural study of coronary heart diseaserisk factors. J.Chronic Dis. 1983; 36: 481–6.
13Blondheim, SH, Horne, T, Davidovich, R, Kapitulnik, J, Segal, S, Kaufmann, NA. Unsaturated fatty acids in adipose tissue ofIsraeli Jews. Isr.J.Med. Sci. 1976; 12: 658–61.
14Shorland, FB, Czochanska, Z, Prior, IAM. Studies on fatty acidcomposition of adipose tissue and blood lipids ofPolynesians. Am. J. Clin. Nutr. 1969; 22: 594605.
15Moriya, K, Itoh, S. Regional and seasonal differences in thefatty acid composition of human subcutaneous fat. Int.J. Biometeorol. 1969; 13: 141–6.
16Horrobin, DF. Nutritional and medical importance of gammalinolenic acid. Prog. Lipid Res. 1992; 31: 163–94.
17 Panel on Macronutrients,Food and Nutrition Board, National Academy of Science Letter. Report on dietaryreference intakes for trans fatty acids [online]. Available at http://www.nas.org, 2002.
18Ip, C, Singh, M, Thompson, HJ, Scimeca, JA. Conjugated linoleic acid suppresses mammary carcinogenesis andproliferative activity of the mammary gland in the rat. Cancer Res. 1994; 54: 1212–5.
19Banni, S, Angioni, E, Casu, V, Melis, MP, Carta, G, Corongiu, FP, et al. Decrease in linoleic acid metabolites as a potentialmechanism in cancer risk reduction by conjugated linoleicacid. Carcinogenesis 1999; 20: 1019–24.
20Kohlmeier, L, Bellach, B. Exposure assessment error and itshandling in nutritional epidemiology. Annu. Rev. Public Health 1995; 16: 4359.
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Public Health Nutrition
  • ISSN: 1368-9800
  • EISSN: 1475-2727
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