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Comparison of the effects of four commercially available weight-loss programmes on lipid-based cardiovascular risk factors

  • LM Morgan (a1), BA Griffin (a1), DJ Millward (a1), A DeLooy (a2), KR Fox (a3), S Baic (a3), MP Bonham (a4), JMW Wallace (a4), I MacDonald (a5), MA Taylor (a5) and H Truby (a1)...
Abstract
AbstractObjective

To investigate the relative efficacy of four popular weight-loss programmes on plasma lipids and lipoproteins as measures of CVD risk.

Design

A multi-centred, randomised, controlled trial of four diets – Dr Atkins’ New Diet Revolution, The Slim-Fast Plan, Weight Watchers Pure Points programme and Rosemary Conley’s ‘Eat yourself Slim’ Diet and Fitness Plan – against a control diet, in parallel for 6 months.

Setting and subjects

The trial was conducted at five universities across the UK (Surrey, Nottingham, Ulster (Coleraine), Bristol and Edinburgh (Queen Margaret University College)) and involved the participation of 300 overweight and obese males and females aged 21–60 years in a community setting.

Results

Significant weight loss was achieved by all dieting groups (5–9 kg at 6 months) but no significant difference was observed between diets at 6 months. The Weight Watchers and Rosemary Conley (low-fat) diets were followed by significant reductions in plasma LDL cholesterol (both −12·2 % after 6 months, P < 0·01), whereas the Atkins (low-carbohydrate) and Weight Watchers diets were followed by marked reductions in plasma TAG (–38·2 % and –22·6 % at 6 months respectively, P < 0·01). These latter two diets were associated with an increase in LDL particle size, a change that has been linked to reduced CVD risk.

Conclusions

Overall, these results demonstrate the favourable effects of weight loss on lipid-mediated CVD risk factors that can be achieved through commercially available weight-loss programmes. No detrimental effects on lipid-based CVD risk factors were observed in participants consuming a low-carbohydrate diet.

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Copyright
Corresponding author
*Corresponding author: Email L.Morgan@surrey.ac.uk
References
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1.Food Standards Agency and Department of Health (2004) National Diet and Nutrition Survey: Adults Aged 19 to 64 Years. vol. 5: Summary Report. London: The Stationery Office.
2.Klein S, Burke LE, Bray GA, Blair S, Allison DB, Pi-Sunyer X, Hong Y & Eckel RH (2004) Clinical implications of obesity with specific focus on cardiovascular disease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity and Metabolism: endorsed by the American College of Cardiology Foundation. Circulation 110, 29522967.
3.Roche HM (1999) Dietary carbohydrates and triacylglycerol metabolism. Proc Nutr Soc 58, 201207.
4.Samaha FF, Iqbal N, Seshadri P, Chicano KL, Daily DA, McGrory J, Williams T, Williams M, Gracely EJ & Stern L (2003) A low-carbohydrate diet as compared with a low-fat diet in severe obesity. N Engl J Med 348, 20742081.
5.Foster GD, Wyatt HR, Hill JO, McGuckin BG, Brill C, Mohammed BS, Szapary PO, Rader DJ, Edman JS & Klein S (2003) A randomised trial of a low-carbohydrate diet for obesity. N Engl J Med 348, 20822090.
6.Larosa JC, Fry AG, Muesing R & Rosing DR (1980) Effects of high-protein, low-carbohydrate dieting on plasma lipoproteins and body weight. J Am Diet Assoc 77, 264270.
7.Brehm BJ, Seeley RJ, Daniels SR & D’Alessio DA (2003) A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular disease risk factors in healthy women. J Clin Endocrinol Metab 88, 16171623.
8.Westman EC, Yancy WS, Edman JS, Tomlin KF & Perkins CE (2002) Effect of 6-month adherence to a very low carbohydrate diet programme. Am J Med 113, 3036.
9.Austin MA, King MC, Vranizan KM & Krauss RM (1990) Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk. Circulation 82, 495506.
10.Griffin BA, Freeman DJ, Tait GW, Thomson J, Caslake MJ, Packhard CJ & Shepherd J (1994) Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions. Relative contribution of small, dense LDL subfractions to coronary heart disease risk. Atherosclerosis 106, 241253.
11.Krauss RM & Dreon DM (1995) Low-density-lipoprotein subclasses and response to a low-fat diet in healthy men. Am J Clin Nutr 62, 478S487S.
12.Dreon DM, Fernstrom HA, Miller B & Krauss RM (1995) Apolipoprotein E isoform phenotype and LDL subclass response to a reduced-fat diet. Arterioscler Thromb Vasc Biol 15, 105111.
13.Sharman MJ, Gomez AL, Kraemer WJ & Volek JS (2004) Very low-carbohydrate and low-fat diets affect fasting lipids and postprandial lipemia differently in overweight men. J Nutr 134, 880885.
14.Volek JS, Sharman MJ, Gomez AL, DiPasquale C, Roti M, Pumerantz A & Kraemer WJ (2004) Comparison of very low-carbohydrate and low-fat diets on fasting lipids, LDL subclasses, insulin resistance, and postprandial lipemic responses in young women. J Am Coll Nutr 23, 177184.
15.Dansinger ML, Gleason JA, Griffith JL, Selker HP & Schaefer EJ (2005) Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease reduction: a randomized trial. JAMA 293, 4353.
16.Boley R, Herriot A, DeLooy A, Fox K, Bonham MP, MacDonald I, Millward DJ, Morgan LM & Truby H (2004) Dietary changes induced by the Atkins diet. Proc Nutr Soc 63, 82a.
17.Truby H, Baic S, DeLooy A, Fox KR, Macdonald I, Morgan L, Taylor MA & Millward DJ (2006) A randomised controlled trial of four commercial weight loss programmes in the UK: initial findings from the BBC Diet Trials. BMJ 322, 13091311.
18.Atkins R (1999) Dr Atkins’ New Diet Revolution. South Dakota: Vermillion.
19.Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF & Turner RC (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412419.
20.Davies IG, Graham JM & Griffin BA (2003) Rapid separation of LDL subclasses by iodixanol gradient ultracentrifugation. Clin Chem 49, 18651872.
21.Griffin BA, Caslake MJ, Yip B, Tait GW, Packard CJ & Shepherd J (1990) Rapid isolation of low density lipoprotein (LDL) subfractions from plasma by density gradient ultracentrifugation. Atherosclerosis 83, 5967.
22.Newman DJ, Thakkar H, Edwards RG, Wilkie M, White T, Grubb AO & Price CP (1995) Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine. Kidney Int 47, 312318.
23.Poobalan A, Aucott L, Smith WCS, Avenell A, Jung R, Broom J & Grant AM (2004) Effects of weight loss in overweight/obese individuals and long-term lipid outcomes – a systematic review. Obes Rev 5, 4350.
24.Dattilo AM & Kris-Etherton PM (1992) Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis. Am J Clin Nutr 45, 320328.
25.Acheson KJ (2004) Carbohydrate and weight control: where do we stand? Curr Opin Clin Nutr Metab Care 7, 485492.
26.Willett WC (2004) Reduced-carbohydrate diets: no role in weight management? Ann Intern Med 18, 836837.
27.Volek JS, Sharman MJ & Forsythe CE (2005) Modification of lipoproteins by very low-carbohydrate diets. J Nutr 135, 13391342.
28.Poppitt SD, Keough GF, Prentice AM, Williams DE, Sonnemans HM, Valk EE, Robinson E & Wareham NJ (2002 ) Long-term effects of ad libitum low-fat, high-carbohydrate diets on body weight and serum lipids in overweight subjects with metabolic syndrome. Am J Clin Nutr 75, 1120.
29.Pelkman CL, Fishell VK, Maddox DH, Pearson TA, Mauger DT & Kris-Etherton PM (2004) Effects of moderate-fat (from monounsaturated fat) and low-fat weight-loss diets on serum lipid profiles in overweight and obese men and women. Am J Clin Nutr 79, 203212.
30.Zulet MA, Berkenpas ME & Martinez JA (2005) Comparison of dietary approaches to treat obesity based on different carbohydrate/fat content: impact on weight loss and lipid profile. Curr Nutr Food Sci 1, 1321.
31.Yu-Poth S, Zhao G, Etherton T, Naglak M, Jonnalagadda S & Kris-Etherton PM (1999) Effects of the National Cholesterol Education program’s Step I and Step II dietary intervention Programs on cardiovascular disease risk factors: a meta-analysis. Am J Clin Nutr 69, 632646.
32.Dreon DM, Fernstrom HA, Williams PT & Krauss RM (1997) LDL subclass patterns and lipoprotein response to a low-fat, high-carbohydrate diet in women. Arterioscler Thromb Vasc Biol 17, 707714.
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Public Health Nutrition
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