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Iodine requirements during pregnancy, lactation and the neonatal period and indicators of optimal iodine nutrition

  • François Delange (a1)

Abstract

Objective: This paper re-evaluates the requirements for iodine during pregnancy, lactation and the neonatal period, and formulates original proposals for the median concentrations of urinary iodine (UI) that indicate optimal iodine nutrition during these three critical periods of life. This paper also discusses the measurements that are used to explore thyroid functions during the same periods.

Design: An extensive and critical review of the literature on thyroid physiopathology during the perinatal period.

Setting: Human studies conducted in various regions throughout the world.

Subjects: Pregnant women, lactating women, and newborns.

Results: The following proposals are made after extensive review of the literature: the requirement for iodine by the mother during pregnancy is 250-300 μg day-1; during lactation the requirement is 225-350 μg day-1; and during the neonatal period the requirement of the infant is 90 μg day-1. The median UI that indicates an optimal iodine nutrition during these three periods should be in the range of 150-230 μg day-1. These figures are higher than recommended to date by the international agencies.

Conclusions: Pregnant women and young infants, but especially the second group, are more sensitive to the effects of an iodine deficiency (ID) than the general population because their serum thyroid-stimulating hormone (TSH) and thyroxine are increased and decreased, respectively, for degrees of ID that do not seem to affect thyroid function in the general population. Systematic neonatal thyroid screening using primary TSH could be the most sensitive indicator to monitor the process of ID control.

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References

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1WHO, UNICEF, ICCIDD. Indicators for Assessing Iodine Deficiency Disorders and their Control Through Salt Iodization. Geneva: World Health Organization, 1994 WHO/NUT/94.6, 1–55.
2Hetzel, B, Delange, F, Dunn, J, Ling, J, Mannar, V, Pandav, C. Towards the Global Elimination of Brain Damage Due to Iodine Deficiency. New Delhi: Oxford University Press, 2004.
3WHO, UNICEF, ICCIDD. Progress Towards the Elimination of Iodine Deficiency Disorders (IDD). Geneva: World Health Organization, 1999 WHO/NHD/99.4.
4Delange, F, de Benoist, B, Pretell, E, Dunn, J. Iodine deficiency in the world: where do we stand at the turn of the century? Thyroid 2001; 11: 437–47.
5Yip, R, Chen, ZP, Ling, J. People's Republic of China. In: Hetzel, B, Delange, F, Dunn, J, ling, J, Mannar, V, Pandav, C, eds. Towards the Global Elimination of Brain Damage Due to Iodine Deficiency. New Delhi: Oxford University Press, 2004; 363–95.
6Zamrazil, V, Bilek, R, Cerovska, J, Delange, F. The elimination of iodine deficiency in the Czech Republic: the steps towards success. Thyroid 2004; 14: 4956.
7www3.who.int/whosis/micronutrient (Last accessed: 6 July 2005).
8Hollowell, JG, Staehling, NW, Hannon, WH, Flanders, DW, Gunter, EW, Maberly, GF, Braverman, LE, Pino, S, Miller, DT, Garbe, P. Iodine nutrition in the United States. Trends and public health implications: iodine excretion data from National Health and Nutrition Examination Surveys I and III (1971–1974 and 1988–1994). Journal of Clinical Endocrinology and Metabolism 1998; 83: 3401–8.
9Beckers, C, Reinwein, D. The Thyroid and Pregnancy. Stuttgart: Schattauer, 1991.
10Stanbury, JB, Delange, F, Dunn, JT, Pandav, CS. Iodine in Pregnancy. New Delhi: Oxford University Press, 1998.
11Glinoer, D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocrine Reviews 1997; 18: 404–33.
12Berghout, A, Wiersinga, W. Thyroid size and thyroid function during pregnancy. In: Stanbury, JB, Delange, F, Dunn, JT, Pandav, CS, eds. Iodine in Pregnancy. New Delhi: Oxford University Press, 1998; 3554.
13DeLong, GR, Robbins, J, Condliffe, PG. Iodine and the Brain. New York: Plenum Press, 1989 1–379.
14Stanbury, JB. The Damaged Brain of Iodine Deficiency. New York: Cognizant Communication 1994.
15Morreale de Escobar, G, Obregon, MJ, Escobar del Rey, F. Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? Journal of Clinical Endocrinology and Metabolism 2000; 85: 3975–87.
16Delange, F. Iodine deficiency as a cause of brain damage. Postgraduate Medical Journal 2001; 77: 217–20.
17Lavado-Autric, R, Auso, E, Carcia-Velasco, JV, Arufe del Carmen, M, Escobar del Rey, F, Berbel, P, Morreale de Escobar, G. Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitexture of the progeny. Journal of Clinical Investigation 2003; 111: 1073–82.
18Zoeller, RT. Transplacental thyroxine and fetal brain development. Journal of Clinical Investigation 2003; 111: 954–7.
19WHO, UNICEF, ICCIDD. Assessment of the Iodine Deficiency Disorders and Monitoring Their Elimination. A Guide For Programme Managers, 2 ed.Geneva: World Health Organization, 2001 WHO/NHD/01.1.
20Institute of Medicine, Academy of Sciences, USA. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. Washington DC: National Academy Press, 2001.
21Dworkin, HJ, Jacquez, JA, Beierwaltes, WH. Relationship of iodine ingestion to iodine excretion in pregnancy. Journal of Clinical Endocrinology and Metabolism 1966; 26: 1329–42.
22Thomson, CD. Dietary recommendations of iodine around the world. IDD Newsletter 2002; 18(3): 3842.
23Ladipo, OA. Nutrition in pregnancy: mineral and vitamin supplements. American Journal of Clinical Nutrition 2000; 72: 280S–90S.
24Reinwein, D, Jaspers, C, Kirbas, C, Zorlu, A. Thyroxine substitution during pregnancy. In: Beckers, C, Reinwein, D, eds. The Thyroid and Pregnancy. Stuttgart: Schattauer, 1991; 115–24.
25Toft, A. Increased levothyroxine requirements in pregnancy. Why, when and how much? New England Journal of Medicine 2004; 351: 292–4.
26Glinoer, D. The sytematic screening and management of hypothyroidism and hyperthyroidism during pregnancy. Trends in Endocrinology and Metabolism 1998; 9: 403–11.
27Mahillon, I, Peers, W, Bourdoux, P, Delange, F. Effect of vaginal douching with povidone–iodine during early pregnancy on the iodine supply to mother and fetus. Biology of the Neonate 1989; 56: 210–7.
28Etling, N. Concentration of thyroglobulin, iodine contents of thyroglobulin and of iodo-aminoacids in human neonates thyroid glands. Acta Paediatrica Scandinavica 1977; 66: 97102.
29Costa, A, Filippis, VD, Panizzo, M, Giraudi, G. Development of thyroid function between VI–IX month of fetal life in humans. Journal of Endocronological Investigation 1986; 9: 273–80.
30Delange, F, Bourdoux, P, Laurence, M, Peneva, L, Walfish, P, Willgerodt, H. Neonatal thyroid function in iodine deficiency. In: Delange, F, Dunn, JT, Glinoer, D, eds. Iodine Deficiency in Europe. A Continuing Concern. New York: Plenum Press, 1993; 199210.
31Savin, S, Cuejic, D, Nedic, O, Radosavljevic, R. Thyroid hormone synthesis and storage in the thyroid gland of human neonates. Journal of Pediatric Endocrinology and Metabolism 2003; 16: 521–8.
32Beckers, C. Iodine economy in and around pregnancy. In: Beckers, C, Reinwein, D, eds. The Thyroid and Pregnancy. Stuttgart: Schattauer, 1991; 2534.
33Fisher, DA. Management of congenital hypothyroidism. Journal of Clinical Endocrinology and Metabolism 1991; 72: 523–9.
34Van Vliet, G. Neonatal hypothyroidism: treatment and outcome. Thyroid 1999; 9: 7984.
35Aboul-Khair, SA, Crooks, J, Turnbull, AC, Hytten, FE. The physiological changes in thyroid function during pregnancy. Clinical Science 1964; 27: 195207.
36Wayne, EJ, Koutras, DA, Alexander, WD. Clinical Aspects of Iodine Metabolism. Oxford: Blackwell, 1964.
37Dafnis, E, Sabatini, S. The effect of pregnancy on renal function: physiology and pathophysiology. American Journal of Medical Science 1992; 303: 184205.
38Lazarus, JH, Kokandi, A. Thyroid disease in relation to pregnancy: a decade of change. Clinical Endocrinology 2000; 53: 265–78.
39Liberman, CS, Pino, SC, Fang, SL, Braverman, LE, Emerson, CH. Circulating iodide concentrations during and after pregnancy. Journal of Clinical Endocrinology and Metabolism 1998; 83: 3545–9.
40Smyth, PPA, Hetherton, AMT, Smith, DF, Radcliff, M, O'Herlihy, C. Maternal iodine status and thyroid volume during pregnancy: correlation with neonatal iodine intake. Journal of Clinical Endocrinology and Metabolism 1997; 82: 2840–3.
41Smyth, PPA. Variation in iodine handling during normal pregnancy. Thyroid 1999; 9: 637–42.
42Kung, AWC, Lao, TT, Chau, MT, Tam, SCF, Low, LCK. Goitrogenesis during pregnancy and neonatal hypothyroxinaemia in a borderline iodine sufficient area. Clinical Endocrinology 2000; 53: 725–31.
43Hess, SY, Zimmermann, MB, Torresani, T, Bürgi, H, Hurrell, RF. Monitoring the adequacy of salt iodization in Switzerland: a national study of school children and pregnant women. European Journal of Clinical Nutrition 2001; 55: 162–6.
44Brander, L, Als, C, Buess, H, Haldimann, F, Harder, M, Hänggi, W, Herrmann, U, lauber, K, Niederer, U, Zurcher, T, Burgi, U, Gerber, H. Urinary iodine concentration during pregnancy in an area of unstable dietary iodine intake in Switzerland. Journal of Endocrinological Investigation 2003; 26: 389–96.
45Bürgi, H. Iodine deficiency in Switzerland. In: Elimination of Iodine Deficiency Disorders (IDD) in Central and Eastern Europe, the Commonwealth of Independent States, and the Baltic States. Delange, F, Robertson, A, McLoughney, E, Gerasimov, G, eds. Geneva: WHO publ., 1998 WHO/EURO/NUT/98.1; 1520.
46Glinoer, D, de Nayer, P, Bourdoux, P, Lemone, M, Robyn, C, Van Steirteghem, A, Kinthaert, J, Lejeune, B. Regulation of maternal thyroid during pregnancy. Journal of Clinical Endocrinology and Metabolism 1990; 71: 276–87.
47Vermiglio, F, Presti, VPL, Finocchiaro, MD, Battiato, S, Grasso, L, Ardita, FV, Mancuso, A, Trimarchi, F. Enhanced iodine concentration capacity by the mammary gland in iodine deficient lactating women of an endemic goiter region in Sicily. Journal of Endocrinological Investigation 1992; 15: 137–42.
48Caron, P, Hoff, M, Bazzi, S, Dufor, A, Faure, G, Ghandour, I, Lauzu, P, Lucas, Y, Maraval, D, Mignot, F, Ressigeac, P, Vertongen, F, Grange, V. Urinary iodine excretion during normal pregnancy in healthy women living in the Southwest of France: correlation with maternal thyroid parameters. Thyroid 1997; 7: 749–54.
49Semba, RD, Delange, F. Iodine in human milk: perspectives for human health. Nutrition Reviews 2001; 59: 269–78.
50Dorea, JG. Iodine nutrition and breast feeding. Journal of Trace Elements in Medicine and Biology 2002; 16: 207–20.
51Delange, F. Physiopathology of iodine nutrition. In: Chandra, RK, ed. Trace Elements in Nutrition of Children. New York: Raven Press, 1985; 291–9.
52Delange, F. Requirements of iodine in humans. In: Delange, F, Dunn, JT, Glinoer, D, eds. Iodine Deficiency in Europe. A Continuing Concern. New York: Plenum Press, 1993; 516.
53Delange, F. Iodine deficiency in Europe anno 2002. Thyroid International 2002; 5: 119.
54National Research Council, Food and Nutrition Board. Recommended Dietary Allowances. Washington DC: National Academy Press, 1989; 213–217 and Table p. 285.
55Azizi, F, Shaikholesmani, R, Hedayati, M, Mirmiran, P, Malekafzali, H, Kimiagar, M. Sustainable control of iodine deficiency in Iran. Journal of Endocrinological Investigation 2002; 25: 409–13.
56Azizi, F, Aminorroya, A, Hedayati, M, Rezvanian, H, Amini, M, Mirmiran, P. Urinary iodine excretion in pregnant women residing in areas with adequate iodine intake. Public Health Nutrition 2003; 6: 95–8.
57Delange, F, de Benoist, B, Bürgi, H. Median urinary iodine concentrations indicating adequate iodine intake at population level. Bulletin of the World Health Organization 2002; 80: 410–7.
58Rasmussen, LB, Ovesen, L, Christiansen, E. Day-to-day and within-day variation in urinary iodine excretion. European Journal of Clinical Nutrition 1999; 53: 401–7.
59Als, C, Helbling, A, Peter, K, Haldimann, M, Zimmerli, B, Gerber, H. Urinary iodine concentration follows a circadian rhythm: a study with 3023 spot urine samples in adults and children. Journal of Clinical Endocrinology and Metabolism 2000; 85: 1367–9.
60Bürgi, H, Bangerter, B, Siebenhüner, L. High day-to-day variability of urinary iodine excretion despite almost universal salt iodization in Switzerland. In: Geertman, RM, ed. 8th World Salt Symposium. Amsterdam: Elsevier, 2000; 961–3.
61Thomson, CD, Packer, MA, Butler, JA, Duffield, AJ, O'Donaghue, KL, Whanger, PD. Urinary selenium and iodine during pregnancy and lactation. Journal of Trace Elements in Medicine and Biology 2001; 14: 210–7.
62Delange, F, Lecomte, P. Iodine supplementation: benefits outweigh risks. Drug Safety 2000; 22: 8995.
63Braverman, LE. Adequate iodine intake-the good far outweights the bad. European Journal of Endocrinology 1998; 139: 1415.
64Glinoer, D, Delange, F, Laboureur, I, de Nayer, P, Lejeune, B, Kinthaert, J, Bourdoux, P. Maternal and neonatal thyroid function at birth in an area of marginally low iodine intake. Journal of Clinical Endocrinology and Metabolism 1992; 75: 800–5.
65Berghout, A, Endert, E, Ross, A, Hogerzell, HV, Smits, NJ, Wiersinga, WH. Thyroid function and thyroid size in normal pregnant women living in an iodine replete area. Clinical Endocrinology 1994; 41: 375–9.
66Vermiglio, F, Presti, VPL, Argentina, GS, Finocchiaro, MD, Gullo, D, Squatrito, S, Trimarchi, F. Maternal hypothyroxinemia during the first half of gestation in an iodine deficient area with endemic cretinism and related disorders. Clinical Endocrinology 1995; 42: 409–15.
67Eltom, A, Eltom, M, Elnagar, B, Elbagir, M, Gebre-Medhin, M. Changes in iodine metabolism during late pregnancy and lactation: a longitudinal study among Sudanese women. European Journal of Clinical Nutrition 2000; 54: 429–33.
68Rotondi, M, Amato, G, Biondi, B, Mazziotti, G, Buono, AD, Nicchio, MR, Balzano, S, Bellastella, A, Glinoer, D, Carella, C. Parity as a thyroid size-determining factor in areas with moderate iodine deficiency. Journal of Clinical Endocrinology and Metabolism 2000; 85: 4534–7.
69Harada, S, Ichihara, N, Arai, J, Honma, H, Matsuura, N, Fujieda, K. Influence of iodine excess due to iodine-containing antiseptics on neonatal screening for congenital hypothyroidism in Hokkaido prefecture, Japan. Screening 1994; 3: 115–23.
70Suzuki, H, Higuchi, T, Sawa, K, Ohtaki, S, Horiuchi, Y. ‘Endemic coast goitre’ in Hokkaido, Japan. Acta Endocrinologica (Copenhagen) 1965; 50: 161–76.
71Heidemann, PH, Stubbe, P, Reuss, KV, Schürnbrand, P, Larsson, A, Petrykowski, WV. Jodausscheidung und alimentäre Jodversorgung bei Neugeborenen in Jodmangelgebieten der Bundersrepublik. Deutsche Medizinische Wochenschrift 1984; 109: 773–8.
72Behrman, RE, Vaughan, VC, Nelson, WE. Nelson Textbook of Pediatrics, 13 ed.Philadelphia: Saunders, 1987.
73Delange, F, Wolff, P, Gnat, D, Dramaix, M, Pilchen, P, Vertongen, F. Iodine deficiency during infancy and early childhood in Belgium: does it pose a risk to brain development? European Journal of Pediatrics 2001; 160: 251–4.
74Bryant, WP, Zimmerman, D. Iodine-induced hyperthyroidism in a newborn. Pediatrics 1995; 95: 434–6.
75Gordon, CM, Rowitch, DH, Mitchell, ML, Kohane, IS. Topical iodine and neonatal hypothyroidism. Archives of Pediatrics and Adolescent Medicine 1995; 149: 1336–9.
76Hnikova, O, Hromadkova, M, Wiererova, O, Bilek, R. Follow-up study of iodine status in neonates and their mothers in 2 regions of the Czech Republic after a 3-year intervention. Casopsis Lekaru Ceskych 1999; 138: 272–5.
77Tajtakova, M, Capova, J, Bires, J, Sebokova, E, Petrovicova, J, Langer, P. Thyroid volume, urinary and milk iodine in mothers after delivery and their newborns in iodine-replete country. Endocrine Regulations 1999; 33: 915.
78Delange, F, Heidemann, P, Bourdoux, P, Larsson, A, Vigneri, R, Klett, M, Beckers, C, Stubbe, P. Regional variations of iodine nutrition and thyroid function during the neonatal period in Europe. Biology of the Neonate 1986; 49: 322–30.
79Gartner, R. IDD status in Germany. Journal of Endocrinological Investigation 2003; 26(Suppl. to n°9): 2223.
80Meng, W, Schindler, A. Iodine supply in Germany. In: Delange, F, Robertson, A, McLoughney, E, Gerasimov, G, eds. Elimination of Iodine Deficiency Disorders (IDD) in Central and Eastern Europe, the Commonwealth of the Independent States, and the Baltic States. Geneva: World Health Organization, 1998 WHO/EURO/NUT/98.1; 2130.
81Delange, F, Van Onderbergen, A, Shabana, W, Vandemeulebroucke, E, Vertongen, F, Gnat, D, Dramaix, M. Silent iodine prophylaxis in Western Europe only partly corrects iodine deficiency: the case of Belgium. European Journal of Endocrinology 2000; 143: 189–96.
82Glinoer, D. The regulation of thyroid function during normal pregnancy: importance of the iodine nutrition status. Best Practice and Research. Clinical Endocrinology and Metabolism 2004; 18: 133–52.
83Zimmermann, M, Delange, F. Iodine supplementation of pregnant women in Europe: a review and recommendations. European Journal of Clinical Nutrition 2004; 58: 979–84.
84Anonymous. American Thyroid Association Symposium and statement focus on maternal thyroid health. American Thyroid Assoiciation Signal. August, 2004.
85Delange, F. Screening for congenital hypothyroidism used as an indicator of IDD control. Thyroid 1998; 8: 1185–92.
86Choudhury, N, Gorman, KS. Subclinical prenatal iodine deficiency negatively affects infant development in Northern China. Journal of Nutrition 2003; 133: 3162–5.
87Ordookhani, A, Mirmiran, P, Hedayati, M, Hajipour, R, Azizi, F. An interim report of the pilot study of screening for congenital hypothyroidism in Tehran and Damavand using cord blood samples. European Journal of Pediatrics 2003; 162: 202–3.
88Bhatara, V, Sankar, R, Unutzer, J, Peabody, J. A review of the case for neonatal thyrotropin screening in developing countries: the examples of India. Thyroid 2002; 12: 591–8.
89Elnagar, B, Eltom, A, Wide, L, Gebre-Medhin, M, Karlsson, FA. Iodine status, thyroid function and pregnancy: study of Swedish and Sudanese women. European Journal of Nutrition 1998; 52: 351–5.
90Soldin, OP, Soldin, SJ, Pezzullu, JC. Urinary iodine percentile ranges in the United States. Clinica Chimica Acta 2003; 328: 185–90.
91Barnett, CA, Visser, TJ, Williams, F, Toor, HV, Duran, S, Presas, MJ, et al. . Inadequate iodine intake of 40% of pregnant women from a region of Scotland. Journal of Endocrinological Investigation 2002; P110(Suppl. to n°7): 90.
92Pearce, EN, Bazrafshan, HR, He, X, Pino, S, Braverman, LE. Dietary iodine in pregnant women from the Boston, Massachusetts area. Thyroid 2004; 14: 327–8.
93Kung, AWC, Lao, TT, Low, LCK, Pang, RWC, Robinson, JD. Iodine insufficiency and neonatal hyperthyrotropinemia in Hong Kong. Clinical Endocrinology 1997; 46: 315–9.
94Vermiglio, F, Presti, VPL, Castagna, MG, Violi, MA, Moleti, M, Finocchiaro, MD, Mattina, F, Artemisia, A, Trimarchi, F. Increased risk of maternal thyroid failure with pregnancy progression in an iodine deficient area with major iodine deficiency disorders. Thyroid 1999; 9: 1924.
95Mocan, MZ, Erem, C, Telatar, M, Mocan, H. Urinary iodine levels in pregnant women with and without goiter in the Eastern Black Sea of Turkey. Trace Elements and Electrolytes 1995; 12: 195–7.
96Pedersen, KM, Laurberg, P, Iversen, E, Knudsen, PR, Gregersen, HE, Rasmussen, OS, Larsen, KR, Eriksen, GM, Johanessen, PL. Amelioration of some pregnancy-associated variations in thyroid function by iodine supplementation. Journal of Clinical Endocrinology and Metabolism 1993; 77: 1078–83.
97Nohr, SB, Laurberg, P, Borlum, KG, Pedersen, KM, Johannesen, PL, Damm, P, Fugsland, E, Johansen, A. Iodine deficiency in pregnancy in Denmark: regional variations and frequency of individual iodine supplementation. Acta Obstetricia Gynecologica Scandinavica 1993; 72: 350–3.
98Antonangeli, L, Maccherini, D, Cavaliere, R, Giulio, CD, Reinhardt, B, Pinchera, A, Aghini-Lombardi, F. Comparison of two different doses of iodide in the prevention of gestational goiter in marginal iodine deficiency: a longitudinal study. European Journal of Endocrinology 2002; 147: 2934.
99Romano, R, Jannini, EA, Pepe, M, Grimaldi, A, Olivieri, M, Spennati, P, Cappa, F, D'Armineto, M. The effects of iodoprophylaxis on thyroid size during pregnancy. American Journal of Obstetrics and Gynecology 1991; 164: 482–5.
100Liesenkötter, KP, Göpel, W, Bogner, U, Stach, B, Grüters, A. Earliest prevention of endemic goiter by iodine supplementation during pregnancy. European Journal of Endocrinology 1996; 134: 443–8.
101Mezosi, E, Molnar, I, Jakab, A, Balogh, E, Karanyi, Z, Pakozdy, Z, Nagy, P, Gyory, F, Szabo, J, Bajnok, L, Leovey, L, Kakyk, G, Nagy, EV. Prevalence of iodine deficiency and goitre during pregnancy in East Hungary. European Journal of Endocrinology 2000; 143: 479–83.
102Brown, RS, Bloomfield, S, Bednarek, FJ, Mitchell, ML, Braverman, LE. Routine skin cleaning with povidone–iodine is not a common cause of transient neonatal hypothyroidism in North America: a prospective controlled study. Thyroid 1997; 7: 395400.
103Delange, F, Dalhem, A, Bourdoux, P, Lagasse, R, Glinoer, D, Fisher, DA, Walfish, PG, Ermans, AM. Increased risk of primary hypothyroidism in preterm infants. Journal of Pediatrics 1984; 105: 462–9.
104Bakker, B, Vulsma, T, Randamie, JD, Achterhuis, AM, Wiedijk, B, Oosting, H, Glas, C, de Vijlder, JJ. A negative iodine balance is found in healthy neonates compared with neonates with thyroid agenesis. Journal of Endocrinology 1999; 161: 115–20.
105Grebe, SF, Rebeski, F, Gent, J, Müller, KD. Iodine balance in neonates and their mothers. Klinicheskaia Laboratornaia Diagnostika 1993; 39: 143–6.
106Böhles, H, Aschenbrenner, M, Roth, M, Loewenich, Vv, Ball, F, Usadel, KH. Development of thyroid gland volume during the first 3 months of life in breast-fed versus iodine-supplemented and iodine-free formula-fed infants. Clinical Investigation 1993; 71: 1320.
107Grüters, A, Liesenkötter, KP, Willgerodt, H. Persistence of differences in iodine status in newborns after the reunification of Berlin. New England Journal of Medicine 1995; 333: 1429.
108Roth, C, Meller, J, Bobrzik, S, Thal, H, Becker, W, Kulenkampff, D, Lakomek, M, Zappel, H. Die Jodversorgung von Neugeborenen. Deutsche Medizinische Wochenschrift 2001; 126: 321–5.
109Klett, M, Ohlig, M, Manz, F, Tröger, J, Heinrich, U. Effect of iodine supply on neonatal thyroid volume and TSH. Acta Paediatrica 1999; 88: 1820.
110Ciardelli, R, Haumont, D, Gnat, D, Vertongen, F, Delange, F. The nutritional iodine supply of Belgian neonates is still insufficient. European Journal of Pediatrics 2002; 161: 519–23.
111Rapa, A, Chiorboli, E, Corbetta, C, Sacco, F, Bona, G, Study, AU. Urinary iodine excretion (UIE) screening in newborns exposed to iodine-containing antiseptics. Hormone Research 1996; 46: 74.
112Parravicini, E, Fontana, C, Paterlini, GL, Tagliabue, P, Rovelli, F, Leung, K, Stark, RI. Iodine, thyroid function and very low birth weight infants. Pediatrics 1996; 98: 730–4.
113Bona, G, Chiorboli, E, Rapa, A, Weber, G, Vigone, MC, Chiumello, G. Measurement of urinary iodine excretion to reveal iodine excess in neonatal transient hypothyroidism. Journal of Pediatric Endocrinology and Metabolism 1998; 11: 739–43.
114Barakat, M, Carson, D, Hetherton, AM, Smyth, P, Leslie, H. Hypothyroidism secondary to topical iodine treatment in infants with spina bifida. Acta Paediatrica 1994; 83: 741–3.
115Linder, N, Davidovitch, N, Reichman, B, Kuint, J, Lubin, D, Meyerovitch, J, Sela, BA, Dolfin, Z, Sack, J. Topical iodine-containing antiseptics and subclinical hypothyroidism in preterm infants. Journal of Pediatrics 1997; 131: 434–9.
116Peter, F, Muzsnai, A, Bourdoux, P. Changes of urinary iodine excretion of newborns over a period of twenty years. Journal of Endocrinological Investigation 2003; 26(Suppl. to n°2): 3942.

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Iodine requirements during pregnancy, lactation and the neonatal period and indicators of optimal iodine nutrition

  • François Delange (a1)

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