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Serum ferritin contributes to racial or geographic disparities in metabolic syndrome in Taiwan

  • Jung-Su Chang (a1), Shiue-Ming Lin (a2), Jane C-J Chao (a1), Yi-Chun Chen (a1), Chi-Mei Wang (a1), Ni-Hsin Chou (a1), Wen-Harn Pan (a3) (a4) and Chyi-Huey Bai (a2)...
Abstract
Abstract Objectives

Asians and Pacific Islanders have higher circulating serum ferritin (SF) compared with Caucasians but the clinical significance of this is unclear. There is a higher prevalence of metabolic syndrome (MetS) in Taiwanese Indigenous than Han Chinese. Genetically, Indigenous are related to Austronesians and account for 2 % of Taiwan's population. We tested the hypothesis that accumulation of Fe in the body contributes to the ethnic/racial disparities in MetS in Taiwan.

Design

A population-based, cross-sectional study.

Setting

National Nutrition and Health Survey in Taiwan and Penghu Island.

Subjects

A total of 2638 healthy adults aged ≥19 years. Three ethnic groups were included.

Results

Han Chinese and Indigenous people had comparable levels of SF. Austronesia origin was independently associated with MetS (OR = 2·61, 95 % CI 2·02, 3·36). After multiple adjustments, the odds for MetS (OR = 2·49, 95 % CI 1·15, 5·28) was significantly higher among Indigenous people in the highest SF tertile compared with those in the lowest tertile. Hakka and Penghu Islanders yielded the lowest risks (OR = 1·08, 95 % CI 0·44, 2·65 and OR = 1·21, 95 % CI 0·52, 2·78, respectively). Indigenous people in the highest SF tertile had increased risk for abnormal levels of fasting glucose (OR = 2·34, 95 % CI 1·27, 4·29), TAG (OR = 1·94, 95 % CI 1·11, 3·39) and HDL-cholesterol (OR = 2·10, 95 % CI 1·18, 3·73) than those in the lowest SF tertile.

Conclusions

Our results raise the possibility that ethnic/racial differences in body Fe store susceptibility may contribute to racial and geographic disparities in MetS.

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Copyright
Corresponding author
*Corresponding author: Email baich@tmu.edu.tw
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Public Health Nutrition
  • ISSN: 1368-9800
  • EISSN: 1475-2727
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