Skip to main content
×
Home

Urine flavonoids and plasma carotenoids in the validation of fruit, vegetable and tea intake during pregnancy in the Norwegian Mother and Child Cohort Study (MoBa)

  • Anne Lise Brantsæter (a1), Margaretha Haugen (a1), Salka E Rasmussen (a2), Jan Alexander (a1), Sven Ove Samuelsen (a3) (a4) and Helle Margrete Meltzer (a1)...
Abstract
AbstractObjective

To validate a new food-frequency questionnaire (FFQ) for measuring the intake of fruit, vegetables and tea reported by women participating in the Norwegian Mother and Child Cohort Study (MoBa).

Design

Intake of fruits, vegetables and tea estimated by the FFQ was compared with urinary flavonoid excretion, plasma carotenoid concentration and intake measured by a 4-day weighed food diary (FD). The triangular method was applied to calculate FFQ validity coefficients using two independent biomarkers.

Setting and subjects

One hundred and nineteen women participating in MoBa.

Results

The FFQ estimate of fruit intake was significantly correlated with urine phloretin (r = 0.33), citrus fruit/juice with urine hesperetin (r = 0.44), cooked vegetables with plasma α-carotene (r = 0.37), and tea with urine kaempferol (r = 0.41) (P < 0.01 for all). On average, 60% of the participants fell into the same or adjacent quintiles when classified by FFQ and biomarkers. Significant correlations between the FFQ and FD were found for fruit (r = 0.39), vegetables (r = 0.34), juices (r = 0.50) and tea (r = 0.53). The FFQ validity coefficient was 0.65 for citrus fruit/juice and 0.59 for cooked vegetables as calculated by the triangular method.

Conclusions

The validation study shows that the MoBa FFQ can be used to estimate fruit, juice, vegetable and tea intake in pregnant Norwegian women, and to rank individuals within the distribution.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Urine flavonoids and plasma carotenoids in the validation of fruit, vegetable and tea intake during pregnancy in the Norwegian Mother and Child Cohort Study (MoBa)
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Urine flavonoids and plasma carotenoids in the validation of fruit, vegetable and tea intake during pregnancy in the Norwegian Mother and Child Cohort Study (MoBa)
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Urine flavonoids and plasma carotenoids in the validation of fruit, vegetable and tea intake during pregnancy in the Norwegian Mother and Child Cohort Study (MoBa)
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Email anne.lise.brantsaeter@fhi.no
References
Hide All
1Barker DJ. Deprivation in infancy and risk of ischaemic heart disease. Lancet 1991; 337: 981.
2Godfrey K, Robinson S, Barker DJ, Osmond C, Cox V. Maternal nutrition in early and late pregnancy in relation to placental and fetal growth. British Medical Journal 1996; 312: 410–4.
3Godfrey KM, Barker DJ. Fetal programming and adult health. Public Health Nutrition 2001; 4: 611–24.
4Clausen T, Slott M, Solvoll K, Drevon CA, Vollset SE, Henriksen T. High intake of energy, sucrose, and polyunsaturated fatty acids is associated with increased risk of preeclampsia. American Journal of Obstetrics and Gynecology 2001; 185: 451–8.
5Harding JE. The nutritional basis of the fetal origins of adult disease. International Journal of Epidemiology 2001; 30: 1523.
6Cade J, Thompson R, Burley V, Warm D. Development, validation and utilisation of food-frequency questionnaires – a review. Public Health Nutrition 2002; 5: 567–87.
7Willett WC. Food frequency methods. In: Willett W, ed. Nutrition Epidemiology, 2nd ed. Oxford: Oxford University Press, 1998; 74100.
8Nelson M. The validation of dietary assessment. In: Margetts BM, Nelson M, eds. Design Concepts in Nutritional Epidemiology, 2nd ed. Oxford: Oxford University Press, 1997; 241–72.
9Ocke MC, Kaaks RJ. Biochemical markers as additional measurements in dietary validity studies: application of the method of triads with examples from the European Prospective Investigation into Cancer and Nutrition. American Journal of Clinical Nutrition 1997; 65(4 Suppl.): 1240S–5S.
10Nielsen IL, Haren GR, Magnussen EL, Dragsted LO, Rasmussen SE. Quantification of anthocyanins in commercial black currant juices by simple high-performance liquid chromatography. Investigation of their pH stability and antioxidative potency. Journal of Agricultural and Food Chemistry 2003; 51: 5861–6.
11Rasmussen SE, Breinholt VM. Non-nutritive bioactive food constituents of plants: bioavailability of flavonoids. International Journal for Vitamin and Nutrition Research 2003; 73: 101–11.
12Krogholm KS, Haraldsdottir J, Knuthsen P, Rasmussen SE. Urinary total flavonoid excretion but not 4-pyridoxic acid or potassium can be used as a biomarker for the intake of fruits and vegetables. Journal of Nutrition 2004; 134: 445–51.
13Brevik A, Rasmussen SE, Drevon CA, Andersen LF. Urinary excretion of flavonoids reflects even small changes in the dietary intake of fruits and vegetables. Cancer Epidemiology, Biomarkers & Prevention 2004; 13: 843–9.
14Hunter D. Biochemical indicators of dietary intake. In: Willett W, ed. Nutritional Epidemiology, 2nd ed. Oxford: Oxford University Press, 1998; 174243.
15Bates JC, Thurnham DI, Bingham SA, Margetts BM, Nelson M. Biochemical markers of nutrient intake. In: Margetts BM, Nelson M, eds. Design Concepts in Nutritional Epidemiology, 2nd ed. Oxford: Oxford University Press, 1997; 170240.
16Broekmans WM, Klopping-Ketelaars IA, Schuurman CR, Verhagen H, van den Berg H, Kok FJ, et al. . Fruits and vegetables increase plasma carotenoids and vitamins and decrease homocysteine in humans. Journal of Nutrition 2000; 130: 1578–83.
17van het Hof KH, Brouwer IA, West CE, Haddeman E, Steegers-Theunissen RP, van Dusseldorp M, et al. . Bioavailability of lutein from vegetables is 5 times higher than that of β-carotene. American Journal of Clinical Nutrition 1999; 70: 261–8.
18Block G, Norkus E, Hudes M, Mandel S, Helzlsouer K. Which plasma antioxidants are most related to fruit and vegetable consumption? American Journal of Epidemiology 2001; 154: 1113–8.
19El Sohemy A, Baylin A, Spiegelman D, Ascherio A, Campos H. Dietary and adipose tissue γ-tocopherol and risk of myocardial infarction. Epidemiology 2002; 13: 216–23.
20Willett WC, Lenart E. Reproducibility and validity of food-frequency questionnaires. In: Willett W, ed. Nutritional Epidemiology, 2nd ed. Oxford: Oxford University Press, 1998; 101–47.
21Magnus P, Irgens LM, Haug K, Nystad W, Skjaerven R, Stoltenberg C. The MoBa Study Group. The Norwegian Mother and Child Cohort Study (MoBa). International Journal of Epidemiology 2006; 35: 1146–50.
22Norwegian Institute of Public Health. MoBa Food Frequency Questionnaire [online]. Available athttp://www.fhi.no/dav/22CA50E0D7.pdf. Accessed February 2006.
23Lauritsen J. FoodCalc [online]. Available athttp://www.ibt.ku.dk/jesper/foodcalc. Accessed February 2006.
24Rimestad AH, Borgejordet A25CB;, Vesterhus KN, Sggnestveit K, Løken EB, Trygg K, et al. . Den store matvaretabellen/ [The Norwegian Food Table]. Oslo: Statens råd for ernæring og fysisk aktivitet, Statens næringsmiddeltilsyn, Institutt for ernæringsforskning, 2001.
25Brevik A, Andersen LF, Karlsen A, Trygg KU, Blomhoff R, Drevon CA. Six carotenoids in plasma used to assess recommended intake of fruits and vegetables in a controlled feeding study. European Journal of Clinical Nutrition 2004; 58: 1166–73.
26Kabagambe EK, Baylin A, Allan DA, Siles X, Spiegelman D, Campos H. Application of the method of triads to evaluate the performance of food frequency questionnaires and biomarkers as indicators of long-term dietary intake. American Journal of Epidemiology 2001; 154: 1126–35.
27Andersen LF, Veierød MB, Johansson L, Sakhi A, Solvoll K, Drevon CA. Evaluation of three dietary assessment methods and serum biomarkers as measures of fruit and vegetable intake, using the method of triads. British Journal of Nutrition 2005; 93: 519–27.
28McNaughton SA, Marks GC, Gaffney P, Williams G, Green A. Validation of a food-frequency questionnaire assessment of carotenoid and vitamin E intake using weighed food records and plasma biomarkers: the method of triads model. European Journal of Clinical Nutrition 2005; 59: 211–8.
29Mardia KV, Kent JT, Bibby JM. Multivariate Analysis. London: Academic Press, 1979.
30R Development Core Team. R: A Language and Environment for Statistical Computing. Vienna: R Foundation for Statistical Computing, 2005. Also available athttp://www.r-project.org/.
31Nielsen SE, Freese R, Cornett C, Dragsted LO. Identification and quantification of flavonoids in human urine samples by column-switching liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry. Analytical Chemistry 2000; 72: 1503–9.
32Nielsen SE, Freese R, Kleemola P, Mutanen M. Flavonoids in human urine as biomarkers for intake of fruits and vegetables. Cancer Epidemiology, Biomarkers & Prevention 2002; 11: 459–66.
33Al Delaimy WK, van Kappel AL, Ferrari P, Slimani N, Steghens JP, Bingham S, et al. . Plasma levels of six carotenoids in nine European countries: report from the European Prospective Investigation into Cancer and Nutrition (EPIC). Public Health Nutrition 2004; 7: 713–22.
34Billson H, Pryer JA, Nichols R. Variation in fruit and vegetable consumption among adults in Britain. An analysis from the dietary and nutritional survey of British adults. European Journal of Clinical Nutrition 1999; 53: 946–52.
35Pollard J, Greenwood D, Kirk S, Cade J. Lifestyle factors affecting fruit and vegetable consumption in the UK Women's Cohort Study. Appetite 2001; 37: 71–9.
36Michaud DS, Giovannucci EL, Ascherio A, Rimm EB, Forman MR, Sampson L, et al. . Associations of plasma carotenoid concentrations and dietary intake of specific carotenoids in samples of two prospective cohort studies using a new carotenoid database. Cancer Epidemiology, Biomarkers & Prevention 1998; 7: 283–90.
37Erkkola M, Karppinen M, Javanainen J, Rasanen L, Knip M, Virtanen SM. Validity and reproducibility of a food frequency questionnaire for pregnant Finnish women. American Journal of Epidemiology 2001; 154: 466–76.
38Robinson S, Godfrey K, Osmond C, Cox V, Barker D. Evaluation of a food frequency questionnaire used to assess nutrient intakes in pregnant women. European Journal of Clinical Nutrition 1996; 50: 302–8.
39Byers T. Food frequency dietary assessment: how bad is good enough? American Journal of Epidemiology 2001; 154: 1087–8.
40Thompson FE, Midthune D, Subar AF, Kahle LL, Schatzkin A, Kipnis V. Performance of a short tool to assess dietary intakes of fruits and vegetables, percentage energy from fat and fibre. Public Health Nutrition 2004; 7: 1097–105.
41Subar AF, Thompson FE, Kipnis V, Midthune D, Hurwitz P, McNutt S, et al. . Comparative validation of the Block, Willett, and National Cancer Institute food frequency questionnaires: the Eating at America's Table Study. American Journal of Epidemiology 2001; 154: 1089–99.
42Svilaas A, Sakhi AK, Andersen LF, Svilaas T, Strom EC, Jacobs DR Jr, et al. . Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. Journal of Nutrition 2004; 134: 562–7.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Public Health Nutrition
  • ISSN: 1368-9800
  • EISSN: 1475-2727
  • URL: /core/journals/public-health-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 10
Total number of PDF views: 136 *
Loading metrics...

Abstract views

Total abstract views: 170 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 20th November 2017. This data will be updated every 24 hours.